Free for academic non-profit institutions. Other users need a Commercial license
Aliases for NCF1B Gene
Aliases for NCF1B Gene
External Ids for NCF1B Gene
- HGNC: 32522
- Entrez Gene: 654816
- Ensembl: ENSG00000182487
- UniProtKB: A6NI72
Previous GeneCards Identifiers for NCF1B Gene
- GC07U901696
- GC07P072274
- GC07P072635
- GC07P071968
Summaries for NCF1B Gene
GeneCards Summary for NCF1B Gene
NCF1B (Neutrophil Cytosolic Factor 1B Pseudogene) is a Pseudogene. Diseases associated with NCF1B include Chronic Granulomatous Disease. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding and superoxide-generating NADPH oxidase activity.
UniProtKB/Swiss-Prot Summary for NCF1B Gene
-
May be required for activation of the latent NADPH oxidase (necessary for superoxide production).
Additional gene information for NCF1B Gene
- HGNC(32522)
- Entrez Gene(654816)
- Ensembl(ENSG00000182487)
- UniProtKB(A6NI72)
- Open Targets Platform(ENSG00000182487)
- Search for NCF1B at DataMed
- Search for NCF1B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCF1B Gene
Genomics for NCF1B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NCF1B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J073219 | Promoter | 0.3 | Ensembl | 600.7 | +0.8 | 777 | 3.2 | NCF1B lnc-FKBP6-4 piR-51671-073 RF00017-6301 SPDYE10P NSUN5 | ||
| GH07J073234 | Promoter/Enhancer | 1 | ENCODE CraniofacialAtlas | 0.4 | +15.0 | 15048 | 1.3 | SP2 CTBP1 HDGF ZBTB26 ZBTB17 RUNX1 POLR2A ZNF335 ZNF610 SKIL | piR-51671-073 NCF1B lnc-FKBP6-4 NONHSAG047983.2-001 NSUN5 SPDYE10P RF00017-6301 | |
| GH07J073216 | Promoter | 0.3 | Ensembl | 0.7 | -4.0 | -4023 | 0.4 | NCF1B piR-59275-001 RF00017-6301 SPDYE10P NSUN5 | ||
| GH07J073210 | Promoter | 0.3 | Ensembl | 0.4 | -8.4 | -8423 | 0.8 | NCF1B piR-59275-001 SPDYE10P RF00017-6301 NSUN5 | ||
| GH07J073200 | Enhancer | 0.2 | Ensembl | 0.4 | -19.5 | -19523 | 1.8 | piR-59275-001 NCF1B RF00017-6301 SPDYE10P GTF2IP4 NSUN5 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NCF1B on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the NCF1B gene promoter:
-
- aMEF-2
- AP-1
- Cdc5
- HOXA9B
- LCR-F1
- MEF-2A
- MZF-1
- Pbx1a
- TBP
- YY1
Genomic Locations for NCF1B Gene
Genomic Locations for NCF1B Gene
- chr7:73,220,624-73,235,945
- (GRCh38/hg38)
- Size:
- 15,322 bases
- Orientation:
- Plus strand
- chr7:72,634,611-72,649,979
- (GRCh37/hg19)
- Size:
- 15,369 bases
- Orientation:
- Plus strand
Genomic View for NCF1B Gene
Genes around NCF1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by HGNC
- 7q11.23 by Entrez Gene
- 7q11.23 by Ensembl
NCF1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NCF1B Gene
Proteins for NCF1B Gene
-
Protein details for NCF1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NI72-NCF1B_HUMAN
- Recommended name:
- Putative neutrophil cytosol factor 1B
- Protein Accession:
- A6NI72
Protein attributes for NCF1B Gene
- Size:
- 391 amino acids
- Molecular mass:
- 44817 Da
- Quaternary structure:
- No Data Available
Protein Expression for NCF1B Gene
Post-translational modifications for NCF1B Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NCF1B
- Origene Custom Protein Services for NCF1B
No data available for DME Specific Peptides for NCF1B Gene
Domains & Families for NCF1B Gene
Protein Domains for NCF1B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NCF1B Gene
- GenScript: Design optimal peptide antigens:
-
- Putative SH3 and PX domain-containing protein 1B (NCF1B_HUMAN)
No data available for Gene Families , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NCF1B Gene
Function for NCF1B Gene
Molecular function for NCF1B Gene
- UniProtKB/Swiss-Prot Function:
- May be required for activation of the latent NADPH oxidase (necessary for superoxide production).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016175 | superoxide-generating NADPH oxidase activity | IBA | 21873635 |
| GO:0016176 | superoxide-generating NADPH oxidase activator activity | IBA | 21873635 |
| GO:0032266 | phosphatidylinositol-3-phosphate binding | IBA | 21873635 |
| GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding | IBA | 21873635 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NCF1B - Select products 50% OFF >
- * NCF1B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for NCF1B
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for NCF1B - Select products 50% OFF >
- * NCF1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCF1B Gene
Localization for NCF1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for NCF1B Gene
- Cytoplasm.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NCF1B Gene
Pathways & Interactions for NCF1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006801 | superoxide metabolic process | IBA | 21873635 |
| GO:0043085 | positive regulation of catalytic activity | IEA | -- |
| GO:0045730 | respiratory burst | IBA | 21873635 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NCF1B Gene
Drugs & Compounds for NCF1B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| NADPH | Experimental | Pharma | 0 |
Transcripts for NCF1B Gene
mRNA/cDNA for NCF1B Gene
- 2 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000423083 1516 nts (view in UCSC)
- ENST00000432102 930 nts (view in UCSC)
- ENST00000435988 1254 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NCF1B - Select products 50% OFF >
- * NCF1B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for NCF1B
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for NCF1B - Select products 50% OFF >
- * NCF1B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for NCF1B Gene
- GeneLoc Exon Structure for
- NCF1B
Expression for NCF1B Gene
mRNA differential expression in normal tissues according to GTEx for NCF1B Gene
This gene is overexpressed in Whole Blood (x33.4) and Spleen (x5.2).
This gene is overexpressed in Cervix (34.5), Peripheral blood mononuclear cells (23.7), and Neutrophil (10.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NCF1B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCF1B
SOURCE GeneReport for Unigene cluster for NCF1B Gene:
Hs.655201Primer Products
-
OriGene qPCR primer pairs for NCF1B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCF1B Gene
Orthologs for NCF1B Gene
No data available for Orthologs for NCF1B Gene
Paralogs for NCF1B Gene
(6) SIMAP similar genes for NCF1B Gene using alignment to 1 proteins:
- NCF1B_HUMAN
No data available for Paralogs for NCF1B Gene
Variants for NCF1B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759537 | CNV | gain+loss | 17122850 |
| esv2764061 | CNV | gain+loss | 21179565 |
| esv34349 | CNV | gain | 17911159 |
| esv3613678 | CNV | loss | 21293372 |
| nsv1023115 | CNV | gain | 25217958 |
| nsv1029162 | CNV | loss | 25217958 |
| nsv1161563 | CNV | deletion | 26073780 |
| nsv428171 | CNV | gain | 18775914 |
| nsv520573 | CNV | gain+loss | 19592680 |
| nsv8139 | CNV | gain | 18304495 |
| nsv831027 | CNV | loss | 17160897 |
| nsv981526 | CNV | duplication | 23825009 |
Additional Variant Information for NCF1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NCF1B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for NCF1B Gene
Disorders for NCF1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic granulomatous disease |
|
|
Search NCF1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NCF1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NCF1B Gene
Publications for NCF1B Gene
- NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity. (PMID: 19077231) Greve B … Kremsner PG (Malaria journal 2008) 3 41
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
- Functional pseudogenes inhibit the superoxide production. (PMID: 26086043) Xu W … Song Q (Precision medicine 2015) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- Anti-inflammatory effect of interleukin-10 on human neutrophil respiratory burst involves inhibition of GM-CSF-induced p47PHOX phosphorylation through a decrease in ERK1/2 activity. (PMID: 16720733) Dang PM … El-Benna J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 3
ExternalLinks
Products for NCF1B Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NCF1B
- Origene Custom Protein Services for NCF1B
- Browse OriGene Inhibitory RNA Products For NCF1B
- OriGene qPCR primer pairs for NCF1B
- Browse CRISPR knockouts for NCF1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NCF1B
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- antibodies-online: Search results for available NCF1B related products ranked by validation data
- antibodies-online: Search results for available NCF1B related products ranked by validation data
- antibodies-online: Search results for available NCF1B related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for NCF1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for NCF1B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NCF1B
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for NCF1B
Sources for NCF1B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB