Aliases for NCF1B Gene

Aliases for NCF1B Gene

  • Neutrophil Cytosolic Factor 1B Pseudogene 2 3 5
  • SH3PXD1B 2 3 4
  • Putative SH3 And PX Domain-Containing Protein 1B 3 4
  • Putative Neutrophil Cytosol Factor 1B 3 4
  • NCF-1B 3 4
  • Neutrophil Cytosolic Factor 1B 2
  • NCF1B 5

External Ids for NCF1B Gene

Previous GeneCards Identifiers for NCF1B Gene

  • GC07U901696
  • GC07P072274
  • GC07P072635
  • GC07P071968

Summaries for NCF1B Gene

GeneCards Summary for NCF1B Gene

NCF1B (Neutrophil Cytosolic Factor 1B Pseudogene) is a Pseudogene. Diseases associated with NCF1B include Chronic Granulomatous Disease. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding and superoxide-generating NADPH oxidase activity.

UniProtKB/Swiss-Prot Summary for NCF1B Gene

  • May be required for activation of the latent NADPH oxidase (necessary for superoxide production).

Additional gene information for NCF1B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCF1B Gene

Genomics for NCF1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NCF1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J073219 Promoter 0.3 Ensembl 600.7 +0.8 777 3.2 NCF1B lnc-FKBP6-4 piR-51671-073 RF00017-6301 SPDYE10P NSUN5
GH07J073234 Promoter/Enhancer 1 ENCODE CraniofacialAtlas 0.4 +15.0 15048 1.3 SP2 CTBP1 HDGF ZBTB26 ZBTB17 RUNX1 POLR2A ZNF335 ZNF610 SKIL piR-51671-073 NCF1B lnc-FKBP6-4 NONHSAG047983.2-001 NSUN5 SPDYE10P RF00017-6301
GH07J073216 Promoter 0.3 Ensembl 0.7 -4.0 -4023 0.4 NCF1B piR-59275-001 RF00017-6301 SPDYE10P NSUN5
GH07J073210 Promoter 0.3 Ensembl 0.4 -8.4 -8423 0.8 NCF1B piR-59275-001 SPDYE10P RF00017-6301 NSUN5
GH07J073200 Enhancer 0.2 Ensembl 0.4 -19.5 -19523 1.8 piR-59275-001 NCF1B RF00017-6301 SPDYE10P GTF2IP4 NSUN5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCF1B on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the NCF1B gene promoter:
  • aMEF-2
  • AP-1
  • Cdc5
  • HOXA9B
  • LCR-F1
  • MEF-2A
  • MZF-1
  • Pbx1a
  • TBP
  • YY1

Genomic Locations for NCF1B Gene

Genomic Locations for NCF1B Gene
chr7:73,220,624-73,235,945
(GRCh38/hg38)
Size:
15,322 bases
Orientation:
Plus strand
chr7:72,634,611-72,649,979
(GRCh37/hg19)
Size:
15,369 bases
Orientation:
Plus strand

Genomic View for NCF1B Gene

Genes around NCF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCF1B Gene

Proteins for NCF1B Gene

  • Protein details for NCF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI72-NCF1B_HUMAN
    Recommended name:
    Putative neutrophil cytosol factor 1B
    Protein Accession:
    A6NI72

    Protein attributes for NCF1B Gene

    Size:
    391 amino acids
    Molecular mass:
    44817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCF1B Gene

Post-translational modifications for NCF1B Gene

No Post-translational modifications

No data available for DME Specific Peptides for NCF1B Gene

Domains & Families for NCF1B Gene

Suggested Antigen Peptide Sequences for NCF1B Gene

GenScript: Design optimal peptide antigens:
  • Putative SH3 and PX domain-containing protein 1B (NCF1B_HUMAN)
genes like me logo Genes that share domains with NCF1B: view

No data available for Gene Families , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NCF1B Gene

Function for NCF1B Gene

Molecular function for NCF1B Gene

UniProtKB/Swiss-Prot Function:
May be required for activation of the latent NADPH oxidase (necessary for superoxide production).

Gene Ontology (GO) - Molecular Function for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016175 superoxide-generating NADPH oxidase activity IBA 21873635
GO:0016176 superoxide-generating NADPH oxidase activator activity IBA 21873635
GO:0032266 phosphatidylinositol-3-phosphate binding IBA 21873635
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IBA 21873635
genes like me logo Genes that share ontologies with NCF1B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCF1B Gene

Localization for NCF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCF1B Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with NCF1B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NCF1B Gene

Pathways & Interactions for NCF1B Gene

PathCards logo

SuperPathways for NCF1B Gene

No Data Available

Interacting Proteins for NCF1B Gene

Gene Ontology (GO) - Biological Process for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IBA 21873635
GO:0043085 positive regulation of catalytic activity IEA --
GO:0045730 respiratory burst IBA 21873635
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NCF1B: view

No data available for Pathways by source and SIGNOR curated interactions for NCF1B Gene

Drugs & Compounds for NCF1B Gene

(1) Drugs for NCF1B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADPH Experimental Pharma 0
genes like me logo Genes that share compounds with NCF1B: view

Transcripts for NCF1B Gene

mRNA/cDNA for NCF1B Gene

2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCF1B Gene

No ASD Table

Relevant External Links for NCF1B Gene

GeneLoc Exon Structure for
NCF1B

Expression for NCF1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCF1B Gene

mRNA differential expression in normal tissues according to GTEx for NCF1B Gene

This gene is overexpressed in Whole Blood (x33.4) and Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for NCF1B Gene

This gene is overexpressed in Cervix (34.5), Peripheral blood mononuclear cells (23.7), and Neutrophil (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NCF1B Gene



Protein tissue co-expression partners for NCF1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCF1B

SOURCE GeneReport for Unigene cluster for NCF1B Gene:

Hs.655201
genes like me logo Genes that share expression patterns with NCF1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCF1B Gene

Orthologs for NCF1B Gene

Evolution for NCF1B Gene

ENSEMBL:
Gene Tree for NCF1B (if available)
TreeFam:
Gene Tree for NCF1B (if available)

No data available for Orthologs for NCF1B Gene

Paralogs for NCF1B Gene

(6) SIMAP similar genes for NCF1B Gene using alignment to 1 proteins:

  • NCF1B_HUMAN
genes like me logo Genes that share paralogs with NCF1B: view

No data available for Paralogs for NCF1B Gene

Variants for NCF1B Gene

Structural Variations from Database of Genomic Variants (DGV) for NCF1B Gene

Variant ID Type Subtype PubMed ID
esv2759537 CNV gain+loss 17122850
esv2764061 CNV gain+loss 21179565
esv34349 CNV gain 17911159
esv3613678 CNV loss 21293372
nsv1023115 CNV gain 25217958
nsv1029162 CNV loss 25217958
nsv1161563 CNV deletion 26073780
nsv428171 CNV gain 18775914
nsv520573 CNV gain+loss 19592680
nsv8139 CNV gain 18304495
nsv831027 CNV loss 17160897
nsv981526 CNV duplication 23825009

Additional Variant Information for NCF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCF1B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for NCF1B Gene

Disorders for NCF1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCF1B Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic granulomatous disease
  • granulomatous disease, chronic, x-linked
- elite association - COSMIC cancer census association via MalaCards
Search NCF1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCF1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NCF1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCF1B Gene

Publications for NCF1B Gene

  1. NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity. (PMID: 19077231) Greve B … Kremsner PG (Malaria journal 2008) 3 41
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  3. Functional pseudogenes inhibit the superoxide production. (PMID: 26086043) Xu W … Song Q (Precision medicine 2015) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Anti-inflammatory effect of interleukin-10 on human neutrophil respiratory burst involves inhibition of GM-CSF-induced p47PHOX phosphorylation through a decrease in ERK1/2 activity. (PMID: 16720733) Dang PM … El-Benna J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 3

Products for NCF1B Gene

Sources for NCF1B Gene