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NCF1B Gene(Pseudogene)

Neutrophil Cytosolic Factor 1B Pseudogene

GCID:
GC07P073220
GIFtS:
25
Genes Participants
UDN Logo

Aliases for NCF1B Gene

Aliases for NCF1B Gene

  • Neutrophil Cytosolic Factor 1B Pseudogene 2 3 5
  • Putative SH3 And PX Domain-Containing Protein 1B 3 4
  • SH3PXD1B 3 4
  • NCF-1B 3 4
  • Putative Neutrophil Cytosol Factor 1B 3
  • Neutrophil Cytosolic Factor 1B 2

External Ids for NCF1B Gene

Previous GeneCards Identifiers for NCF1B Gene

  • GC07U901696
  • GC07P072274
  • GC07P072635
  • GC07P071968

Summaries for NCF1B Gene

GeneCards Summary for NCF1B Gene

NCF1B (Neutrophil Cytosolic Factor 1B Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding and superoxide-generating NADPH oxidase activity.

UniProtKB/Swiss-Prot for NCF1B Gene

  • May be required for activation of the latent NADPH oxidase (necessary for superoxide production).

Additional gene information for NCF1B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCF1B Gene

Genomics for NCF1B Gene

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  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for NCF1B Gene

Promoters and enhancers for NCF1B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07I073219 Enhancer 0.2 Ensembl 550.8 +1.0 977 3.6 NCF1B GTF2IRD2P1
GH07I073234 Enhancer 0.9 Ensembl ENCODE 0.4 +15.5 15470 3.8 HDGF RB1 ZNF335 CTBP1 POLR2A ATF7 SP3 MAZ NRF1 SP2 NCF1B GTF2IRD2P1
GH07I073244 Enhancer 0.4 Ensembl 0.3 +24.5 24476 0.6 KLF1 ATF1 NCF1B GTF2IRD2P1
GH07I073247 Enhancer 0.4 Ensembl 0.3 +26.9 26876 1 EGR1 FOS TYW1B POM121B NCF1B GTF2IRD2P1
GH07I073190 Enhancer 0.3 Ensembl 0.3 -29.9 -29891 1.1 MLLT1 PHBP5 NCF1B GTF2IP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NCF1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NCF1B gene promoter:

Genomic Locations for NCF1B Gene

Genomic Locations for NCF1B Gene
chr7:73,220,624-73,235,945
(GRCh38/hg38)
Size:
15,322 bases
Orientation:
Plus strand
chr7:72,634,611-72,649,979
(GRCh37/hg19)

Genomic View for NCF1B Gene

Genes around NCF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCF1B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NCF1B Gene

Proteins for NCF1B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NCF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI72-NCF1B_HUMAN
    Recommended name:
    Putative neutrophil cytosol factor 1B
    Protein Accession:
    A6NI72

    Protein attributes for NCF1B Gene

    Size:
    391 amino acids
    Molecular mass:
    44817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCF1B Gene

Protein Expression for NCF1B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NCF1B Gene

No Post-translational modifications

No data available for DME Specific Peptides for NCF1B Gene

Domains & Families for NCF1B Gene

Protein Domains for NCF1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCF1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCF1B: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NCF1B Gene

Function for NCF1B Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NCF1B Gene

UniProtKB/Swiss-Prot Function:
May be required for activation of the latent NADPH oxidase (necessary for superoxide production).

Gene Ontology (GO) - Molecular Function for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016175 superoxide-generating NADPH oxidase activity IEA --
GO:0016176 superoxide-generating NADPH oxidase activator activity IBA --
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with NCF1B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCF1B Gene

Localization for NCF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCF1B Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NCF1B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NCF1B Gene

Pathways & Interactions for NCF1B Gene

SuperPathways for NCF1B Gene

PathCards logo More details on SuperPathways for NCF1B
No Data Available

Interacting Proteins for NCF1B Gene

Selected Interacting proteins: A6NI72-NCF1B_HUMAN for NCF1B Gene via IID

Gene Ontology (GO) - Biological Process for NCF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IBA --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0055114 oxidation-reduction process IBA --
GO:0071800 podosome assembly IBA --
genes like me logo Genes that share ontologies with NCF1B: view

No data available for Pathways by source and SIGNOR curated interactions for NCF1B Gene

Drugs & Compounds for NCF1B Gene

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  1. Drug

(1) Additional Compounds for NCF1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
genes like me logo Genes that share compounds with NCF1B: view

Transcripts for NCF1B Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NCF1B Gene

(7) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCF1B Gene

Neutrophil cytosolic factor 1B pseudogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCF1B Gene

No ASD Table

Relevant External Links for NCF1B Gene

GeneLoc Exon Structure for
NCF1B
ECgene alternative splicing isoforms for
NCF1B

Expression for NCF1B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCF1B Gene

mRNA expression in normal human tissues for NCF1B Gene
mRNA expression by GTEx for NCF1B GenemRNA expression by BioGPS for NCF1B Gene

mRNA differential expression in normal tissues according to GTEx for NCF1B Gene

This gene is overexpressed in Whole Blood (x33.4) and Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for NCF1B Gene

This gene is overexpressed in Cervix (34.5), Peripheral blood mononuclear cells (23.7), and Neutrophil (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NCF1B Gene



Protein tissue co-expression partners for NCF1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NCF1B Gene:

NCF1B

SOURCE GeneReport for Unigene cluster for NCF1B Gene:

Hs.655201
genes like me logo Genes that share expression patterns with NCF1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCF1B Gene

Orthologs for NCF1B Gene

Evolution for NCF1B Gene

ENSEMBL:
Gene Tree for NCF1B (if available)
TreeFam:
Gene Tree for NCF1B (if available)

No data available for Orthologs for NCF1B Gene

Paralogs for NCF1B Gene

(6) SIMAP similar genes for NCF1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NCF1B: view

No data available for Paralogs for NCF1B Gene

Variants for NCF1B Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for NCF1B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1042501 -- 73,234,638(+) C/A/G/T non_coding_transcript_variant
rs1042504 -- 73,234,662(+) A/G non_coding_transcript_variant
rs111440324 -- 73,232,802(+) G/T intron_variant
rs111882507 -- 73,230,357(+) T/A intron_variant
rs112042649 -- 73,232,359(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NCF1B Gene

Variant ID Type Subtype PubMed ID
esv2759537 CNV gain+loss 17122850
esv2764061 CNV gain+loss 21179565
esv34349 CNV gain 17911159
esv3613678 CNV loss 21293372
nsv1023115 CNV gain 25217958
nsv1029162 CNV loss 25217958
nsv1161563 CNV deletion 26073780
nsv428171 CNV gain 18775914
nsv520573 CNV gain+loss 19592680
nsv8139 CNV gain 18304495
nsv831027 CNV loss 17160897
nsv981526 CNV duplication 23825009

Additional Variant Information for NCF1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCF1B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NCF1B Gene

Disorders for NCF1B Gene

Additional Disease Information for NCF1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NCF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCF1B Gene

Publications for NCF1B Gene

  1. NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity. (PMID: 19077231) Greve B … Kremsner PG (Malaria journal 2008) 3 44 58
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  3. Functional pseudogenes inhibit the superoxide production. (PMID: 26086043) Xu W … Song Q (Precision medicine 2015) 3 58
  4. Anti-inflammatory effect of interleukin-10 on human neutrophil respiratory burst involves inhibition of GM-CSF-induced p47PHOX phosphorylation through a decrease in ERK1/2 activity. (PMID: 16720733) Dang PM … El-Benna J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for NCF1B Gene

Sources for NCF1B Gene

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