Aliases for NCCRP1 Gene

Aliases for NCCRP1 Gene

  • NCCRP1, F-Box Associated Domain Containing 2 3 5
  • NCCRP-1 2 3 4
  • FBXO50 2 3 4
  • Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog 3 4
  • NCC Receptor Protein 1 Homolog 3 4
  • F-Box Only Protein 50 3 4
  • Non-Specific Cytotoxic Cell Receptor Protein 1 Homolog (Zebrafish) 2
  • Nonspecific Cytotoxic Cell Receptor Protein 1 Homolog 3
  • LOC342897 2
  • NCCRP1 5

External Ids for NCCRP1 Gene

Previous GeneCards Identifiers for NCCRP1 Gene

  • GC19P044380
  • GC19P039687
  • GC19P036134

Summaries for NCCRP1 Gene

GeneCards Summary for NCCRP1 Gene

NCCRP1 (NCCRP1, F-Box Associated Domain Containing) is a Protein Coding gene. Diseases associated with NCCRP1 include Boutonneuse Fever. An important paralog of this gene is FBXO2.

UniProtKB/Swiss-Prot Summary for NCCRP1 Gene

Additional gene information for NCCRP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCCRP1 Gene

Genomics for NCCRP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NCCRP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039197 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 607.7 +0.0 37 0.8 MTA2 MTA1 ZNF747 EZH2 ZNF311 NRF1 KLF9 MGA CBX3 YBX3 NCCRP1 HNRNPL RPS16 FBL PLEKHG2 ENSG00000269688 EID2B MED29 SUPT5H DPF1
GH19J039199 Enhancer 0.7 ENCODE 608.2 -1.6 -1618 0.3 ZBTB33 PRDM10 RFX1 ZIC2 PATZ1 ESR1 NFE2 ZEB1 OSR2 KDM1A NCCRP1 lnc-PAK4-2 PAK4
GH19J039198 Enhancer 0.6 ENCODE 600.7 +1.0 992 0.2 CTCF CTBP1 ZNF217 RFX5 DPF2 NFIB MAZ FOS MTA1 RAD21 NCCRP1 SYCN
GH19J039195 Enhancer 0.4 ENCODE 600.7 -1.0 -1008 0.2 ZBTB10 ZEB1 ZBTB17 ZEB2 NCCRP1 lnc-PAK4-2 PAK4
GH19J039196 Enhancer 0.3 ENCODE 600.7 -0.5 -508 0.2 SMARCA4 NCCRP1 lnc-PAK4-2 PAK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCCRP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCCRP1

Top Transcription factor binding sites by QIAGEN in the NCCRP1 gene promoter:
  • c-Ets-1
  • CREB
  • GATA-1
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • RelA

Genomic Locations for NCCRP1 Gene

Genomic Locations for NCCRP1 Gene
4,921 bases
Plus strand
4,924 bases
Plus strand

Genomic View for NCCRP1 Gene

Genes around NCCRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCCRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCCRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCCRP1 Gene

Proteins for NCCRP1 Gene

  • Protein details for NCCRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 50
    Protein Accession:
    Secondary Accessions:
    • Q6NVV5

    Protein attributes for NCCRP1 Gene

    275 amino acids
    Molecular mass:
    30847 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCCRP1 Gene

Post-translational modifications for NCCRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NCCRP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCCRP1 Gene

Domains & Families for NCCRP1 Gene

Gene Families for NCCRP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NCCRP1 Gene

  • F-box associated region

Suggested Antigen Peptide Sequences for NCCRP1 Gene

GenScript: Design optimal peptide antigens:
  • Non-specific cytotoxic cell receptor protein 1 homolog (NCRP1_HUMAN)
genes like me logo Genes that share domains with NCCRP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NCCRP1 Gene

Function for NCCRP1 Gene

Molecular function for NCCRP1 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation.

Phenotypes From GWAS Catalog for NCCRP1 Gene

Gene Ontology (GO) - Molecular Function for NCCRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061630 contributes_to ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with NCCRP1: view
genes like me logo Genes that share phenotypes with NCCRP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCCRP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NCCRP1 Gene

Localization for NCCRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCCRP1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCCRP1 gene
Compartment Confidence
extracellular 4
plasma membrane 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NCCRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 22087255
GO:0019005 SCF ubiquitin ligase complex IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with NCCRP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NCCRP1 Gene

Pathways & Interactions for NCCRP1 Gene

PathCards logo

SuperPathways for NCCRP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NCCRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006516 glycoprotein catabolic process IBA 21873635
GO:0008284 positive regulation of cell proliferation IDA 22087255
GO:0016567 protein ubiquitination IEA --
GO:0030433 ubiquitin-dependent ERAD pathway IBA 21873635
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA 21873635
genes like me logo Genes that share ontologies with NCCRP1: view

No data available for Pathways by source and SIGNOR curated interactions for NCCRP1 Gene

Drugs & Compounds for NCCRP1 Gene

No Compound Related Data Available

Transcripts for NCCRP1 Gene

mRNA/cDNA for NCCRP1 Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCCRP1

Alternative Splicing Database (ASD) splice patterns (SP) for NCCRP1 Gene

No ASD Table

Relevant External Links for NCCRP1 Gene

GeneLoc Exon Structure for

Expression for NCCRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCCRP1 Gene

mRNA differential expression in normal tissues according to GTEx for NCCRP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x19.1), Skin - Sun Exposed (Lower leg) (x11.2), Skin - Not Sun Exposed (Suprapubic) (x8.5), Vagina (x6.6), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for NCCRP1 Gene

This gene is overexpressed in Cervix (39.5) and Saliva (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NCCRP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCCRP1

SOURCE GeneReport for Unigene cluster for NCCRP1 Gene:


mRNA Expression by UniProt/SwissProt for NCCRP1 Gene:

Tissue specificity: Expressed in the esophagus, oral cavity, skin, tongue and reproductive organs.

Evidence on tissue expression from TISSUES for NCCRP1 Gene

  • Kidney(2.2)
genes like me logo Genes that share expression patterns with NCCRP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCCRP1 Gene

Orthologs for NCCRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCCRP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NCCRP1 30 31
  • 99.52 (n)
(Canis familiaris)
Mammalia NCCRP1 30 31
  • 86.92 (n)
(Bos Taurus)
Mammalia NCCRP1 30 31
  • 84.74 (n)
(Rattus norvegicus)
Mammalia Nccrp1 30
  • 79.57 (n)
(Mus musculus)
Mammalia Nccrp1 30 17 31
  • 78.7 (n)
(Monodelphis domestica)
Mammalia NCCRP1 31
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia NCCRP1 31
  • 50 (a)
(Anolis carolinensis)
Reptilia NCCRP1 31
  • 47 (a)
(Danio rerio)
Actinopterygii nccrp1 31
  • 39 (a)
Species where no ortholog for NCCRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NCCRP1 Gene

Gene Tree for NCCRP1 (if available)
Gene Tree for NCCRP1 (if available)
Evolutionary constrained regions (ECRs) for NCCRP1: view image

Paralogs for NCCRP1 Gene

Paralogs for NCCRP1 Gene

genes like me logo Genes that share paralogs with NCCRP1: view

Variants for NCCRP1 Gene

Additional dbSNP identifiers (rs#s) for NCCRP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NCCRP1 Gene

Variant ID Type Subtype PubMed ID
esv2658631 CNV deletion 23128226
esv2718550 CNV deletion 23290073
esv3644325 CNV loss 21293372
nsv833829 CNV loss 17160897
nsv953571 CNV deletion 24416366

Variation tolerance for NCCRP1 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCCRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCCRP1 Gene

Disorders for NCCRP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NCCRP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
boutonneuse fever
  • south african tick-bite fever
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with NCCRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCCRP1 Gene

Publications for NCCRP1 Gene

  1. Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins. (PMID: 22087255) Kallio H … Parkkila S (PloS one 2011) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3
  5. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3

Products for NCCRP1 Gene

Sources for NCCRP1 Gene