This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 201... See more...

Aliases for NCAPG Gene

Aliases for NCAPG Gene

  • Non-SMC Condensin I Complex Subunit G 2 3 4 5
  • Chromosome Condensation Protein G 2 3
  • Chromosome-Associated Protein G 3 4
  • Condensin Complex Subunit 3 3 4
  • Melanoma Antigen NY-MEL-3 3 4
  • Condensin Subunit CAP-G 3 4
  • XCAP-G Homolog 3 4
  • HCAP-G 2 4
  • CAPG 3 4
  • YCG1 2 3
  • Non-SMC Condensin I Complex, Subunit G 2
  • NY-MEL-3 3
  • FLJ12450 2
  • NYMEL3 4
  • NCAPG 5
  • CAP-G 2
  • CHCG 3

External Ids for NCAPG Gene

Previous GeneCards Identifiers for NCAPG Gene

  • GC04P017421
  • GC04P017167

Summaries for NCAPG Gene

Entrez Gene Summary for NCAPG Gene

  • This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for NCAPG Gene

NCAPG (Non-SMC Condensin I Complex Subunit G) is a Protein Coding gene. Diseases associated with NCAPG include Endometrial Mixed Adenocarcinoma and Croup. Among its related pathways are Cell Cycle, Mitotic and Aurora B signaling. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot Summary for NCAPG Gene

  • Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Wiki entry for NCAPG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCAPG Gene

Genomics for NCAPG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NCAPG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCAPG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCAPG

Top Transcription factor binding sites by QIAGEN in the NCAPG gene promoter:
  • E47
  • FOXL1
  • GATA-1
  • GATA-2
  • Hlf
  • HSF1 (long)
  • HSF1short
  • Pax-4a
  • Tal-1beta

Genomic Locations for NCAPG Gene

Latest Assembly
chr4:17,810,942-17,844,865
(GRCh38/hg38)
Size:
33,924 bases
Orientation:
Plus strand

Previous Assembly
chr4:17,812,602-17,846,488
(GRCh37/hg19 by Entrez Gene)
Size:
33,887 bases
Orientation:
Plus strand

chr4:17,812,525-17,846,485
(GRCh37/hg19 by Ensembl)
Size:
33,961 bases
Orientation:
Plus strand

Genomic View for NCAPG Gene

Genes around NCAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPG Gene

Proteins for NCAPG Gene

  • Protein details for NCAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPX3-CND3_HUMAN
    Recommended name:
    Condensin complex subunit 3
    Protein Accession:
    Q9BPX3
    Secondary Accessions:
    • Q3MJE0
    • Q96SV9
    • Q9BUR3
    • Q9BVY1
    • Q9H914
    • Q9H9Z6
    • Q9HBI9

    Protein attributes for NCAPG Gene

    Size:
    1015 amino acids
    Molecular mass:
    114334 Da
    Quaternary structure:
    • Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
    SequenceCaution:
    • Sequence=AAH00827.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14429.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB55165.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Overexpressed in some cancer lines and some tumor cells.

    Three dimensional structures from OCA and Proteopedia for NCAPG Gene

neXtProt entry for NCAPG Gene

Post-translational modifications for NCAPG Gene

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
  • Ubiquitination at Lys11, Lys235, Lys522, Lys717, and Lys852
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPG Gene

No data available for DME Specific Peptides for NCAPG Gene

Domains & Families for NCAPG Gene

Gene Families for NCAPG Gene

Protein Domains for NCAPG Gene

InterPro:
Blocks:
  • HEAT repeat

Suggested Antigen Peptide Sequences for NCAPG Gene

GenScript: Design optimal peptide antigens:
  • XCAP-G homolog (CND3_HUMAN)
  • Non-SMC condensin I complex, subunit G (Q6NUR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BPX3

UniProtKB/Swiss-Prot:

CND3_HUMAN :
  • Belongs to the CND3 (condensin subunit 3) family.
Family:
  • Belongs to the CND3 (condensin subunit 3) family.
genes like me logo Genes that share domains with NCAPG: view

Function for NCAPG Gene

Molecular function for NCAPG Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Phenotypes From GWAS Catalog for NCAPG Gene

Gene Ontology (GO) - Molecular Function for NCAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12138188
genes like me logo Genes that share ontologies with NCAPG: view
genes like me logo Genes that share phenotypes with NCAPG: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCAPG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCAPG Gene

Localization for NCAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPG Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCAPG gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NCAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000779 condensed chromosome, centromeric region IEA --
GO:0000793 condensed chromosome IBA 21873635
GO:0000796 condensin complex IEA,IDA 11136719
GO:0005634 nucleus NAS 10910072
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with NCAPG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NCAPG Gene

Pathways & Interactions for NCAPG Gene

PathCards logo

SuperPathways for NCAPG Gene

genes like me logo Genes that share pathways with NCAPG: view

Pathways by source for NCAPG Gene

1 BioSystems pathway for NCAPG Gene
1 GeneGo (Thomson Reuters) pathway for NCAPG Gene
  • Cell cycle_Chromosome condensation in prometaphase

Gene Ontology (GO) - Biological Process for NCAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007076 mitotic chromosome condensation IEA,NAS 10910072
GO:0030261 chromosome condensation IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NCAPG: view

No data available for SIGNOR curated interactions for NCAPG Gene

Drugs & Compounds for NCAPG Gene

No Compound Related Data Available

Transcripts for NCAPG Gene

mRNA/cDNA for NCAPG Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCAPG

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - - -
SP2:
SP3:
SP4:
SP5:

ExUns: 21
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for NCAPG Gene

GeneLoc Exon Structure for
NCAPG

Expression for NCAPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCAPG Gene

This gene is overexpressed in Testis (x5.9).

Protein differential expression in normal tissues from HIPED for NCAPG Gene

This gene is overexpressed in Bone (38.3), Breast (8.7), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCAPG Gene



Protein tissue co-expression partners for NCAPG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCAPG

SOURCE GeneReport for Unigene cluster for NCAPG Gene:

Hs.567567

mRNA Expression by UniProt/SwissProt for NCAPG Gene:

Q9BPX3-CND3_HUMAN
Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for NCAPG Gene

  • Blood(4.4)
  • Skin(4.4)
  • Nervous system(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with NCAPG: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAPG Gene

Orthologs for NCAPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCAPG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NCAPG 29 30
  • 99.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NCAPG 29
  • 90.17 (n)
HCAP-G 30
  • 89 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia NCAPG 29 30
  • 88.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ncapg 29 16 30
  • 86.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ncapg 29
  • 86.03 (n)
Oppossum
(Monodelphis domestica)
Mammalia NCAPG 30
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NCAPG 30
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NCAPG 29 30
  • 70.79 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NCAPG 30
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ncapg 29
  • 64.65 (n)
MGC76110 29
African clawed frog
(Xenopus laevis)
Amphibia LOC398088 29
Zebrafish
(Danio rerio)
Actinopterygii ncapg 29 30
  • 59.07 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13920 29
Fruit Fly
(Drosophila melanogaster)
Insecta Cap-G 29 30
  • 40.69 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007568 29
  • 39.45 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCG1 30 32
  • 20 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 34 (a)
OneToOne
Species where no ortholog for NCAPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NCAPG Gene

ENSEMBL:
Gene Tree for NCAPG (if available)
TreeFam:
Gene Tree for NCAPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCAPG: view image
Alliance of Genome Resources:
Additional Orthologs for NCAPG

Paralogs for NCAPG Gene

Pseudogenes.org Pseudogenes for NCAPG Gene

genes like me logo Genes that share paralogs with NCAPG: view

No data available for Paralogs for NCAPG Gene

Variants for NCAPG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCAPG Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
VAR_036125 A colorectal cancer sample p.Met265Thr
rs35722563 -- p.Ala64Pro
rs3795243 -- p.Met581Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NCAPG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NCAPG Gene

Variant ID Type Subtype PubMed ID
esv2425595 CNV deletion 19546169
esv2645526 CNV deletion 19546169
esv3893889 CNV loss 25118596
nsv819190 CNV gain 19587683

Variation tolerance for NCAPG Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.86; 79.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCAPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCAPG
Leiden Open Variation Database (LOVD)
NCAPG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPG Gene

Disorders for NCAPG Gene

MalaCards: The human disease database

(3) MalaCards diseases for NCAPG Gene - From: COP and GCD

Disorder Aliases PubMed IDs
endometrial mixed adenocarcinoma
croup
  • acute laryngotracheobronchitis
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards
Search NCAPG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCAPG

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NCAPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCAPG Gene

Publications for NCAPG Gene

  1. Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. (PMID: 10910072) Jäger D … Chen YT (Cancer research 2000) 2 3 4 22
  2. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PMID: 11136719) Kimura K … Hirano T (The Journal of biological chemistry 2001) 2 3 4
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 40
  4. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y … Kamatani N (Human molecular genetics 2010) 3 40
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 40

Products for NCAPG Gene

Sources for NCAPG Gene