Aliases for NCAPD3 Gene
External Ids for NCAPD3 Gene
Previous GeneCards Identifiers for NCAPD3 Gene
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NCAPD3 Gene
NCAPD3 (Non-SMC Condensin II Complex Subunit D3) is a Protein Coding gene. Diseases associated with NCAPD3 include Microcephaly 22, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and DNA Damage. Gene Ontology (GO) annotations related to this gene include binding and methylated histone binding. An important paralog of this gene is NCAPD2.
UniProtKB/Swiss-Prot Summary for NCAPD3 Gene
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).