Aliases for NCAPD2 Gene

Aliases for NCAPD2 Gene

  • Non-SMC Condensin I Complex Subunit D2 2 3 4 5
  • Chromosome Condensation-Related SMC-Associated Protein 1 3 4
  • Chromosome-Associated Protein D2 3 4
  • Condensin Complex Subunit 1 3 4
  • XCAP-D2 Homolog 3 4
  • HCAP-D2 3 4
  • CNAP1 3 4
  • Chromosome Condensation Related SMC Associated Protein 1 2
  • Non-SMC Condensin I Complex, Subunit D2 2
  • KIAA0159 4
  • CAP-D2 3
  • MCPH21 3
  • CAPD2 4

External Ids for NCAPD2 Gene

Previous GeneCards Identifiers for NCAPD2 Gene

  • GC12P006473
  • GC12P006602

Summaries for NCAPD2 Gene

GeneCards Summary for NCAPD2 Gene

NCAPD2 (Non-SMC Condensin I Complex Subunit D2) is a Protein Coding gene. Diseases associated with NCAPD2 include Microcephaly 21, Primary, Autosomal Recessive and Microcephaly. Among its related pathways are Aurora B signaling and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include binding and histone binding. An important paralog of this gene is NCAPD3.

UniProtKB/Swiss-Prot Summary for NCAPD2 Gene

  • Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).

Gene Wiki entry for NCAPD2 Gene

Additional gene information for NCAPD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCAPD2 Gene

Genomics for NCAPD2 Gene

GeneHancer (GH) Regulatory Elements for NCAPD2 Gene

Promoters and enhancers for NCAPD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCAPD2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCAPD2

Top Transcription factor binding sites by QIAGEN in the NCAPD2 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • Elk-1
  • GATA-1
  • NF-Y
  • Pbx1a

Genomic Locations for NCAPD2 Gene

Genomic Locations for NCAPD2 Gene
chr12:6,493,356-6,531,966
(GRCh38/hg38)
Size:
38,611 bases
Orientation:
Plus strand
chr12:6,602,522-6,641,132
(GRCh37/hg19)
Size:
38,611 bases
Orientation:
Plus strand

Genomic View for NCAPD2 Gene

Genes around NCAPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPD2 Gene

Proteins for NCAPD2 Gene

  • Protein details for NCAPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15021-CND1_HUMAN
    Recommended name:
    Condensin complex subunit 1
    Protein Accession:
    Q15021
    Secondary Accessions:
    • D3DUR4
    • Q8N6U3

    Protein attributes for NCAPD2 Gene

    Size:
    1401 amino acids
    Molecular mass:
    157182 Da
    Quaternary structure:
    • Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.
    SequenceCaution:
    • Sequence=BAA09930.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for NCAPD2 Gene

Post-translational modifications for NCAPD2 Gene

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
  • Ubiquitination at Lys35, Lys685, Lys749, Lys763, Lys855, Lys1065, Lys1110, Lys1209, Lys1288, and Lys1301
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPD2 Gene

No data available for DME Specific Peptides for NCAPD2 Gene

Domains & Families for NCAPD2 Gene

Gene Families for NCAPD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NCAPD2 Gene

Suggested Antigen Peptide Sequences for NCAPD2 Gene

GenScript: Design optimal peptide antigens:
  • NCAPD2 protein (A0PJ76_HUMAN)
  • XCAP-D2 homolog (CND1_HUMAN)
  • Condensin complex subunit 1 (F5GZJ1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15021

UniProtKB/Swiss-Prot:

CND1_HUMAN :
  • The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.
  • Belongs to the CND1 (condensin subunit 1) family.
Domain:
  • The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.
Family:
  • Belongs to the CND1 (condensin subunit 1) family.
genes like me logo Genes that share domains with NCAPD2: view

Function for NCAPD2 Gene

Molecular function for NCAPD2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).

Phenotypes From GWAS Catalog for NCAPD2 Gene

Gene Ontology (GO) - Molecular Function for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0005515 protein binding IPI 12138188
GO:0042393 histone binding NAS 10958694
genes like me logo Genes that share ontologies with NCAPD2: view
genes like me logo Genes that share phenotypes with NCAPD2: view

Human Phenotype Ontology for NCAPD2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NCAPD2 Gene

Localization for NCAPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPD2 Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCAPD2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 colocalizes_with nuclear chromosome IDA 12138188
GO:0000779 condensed chromosome, centromeric region IBA 21873635
GO:0000793 condensed chromosome IDA 12138188
GO:0000796 condensin complex IDA 11136719
GO:0000797 condensin core heterodimer NAS 10958694
genes like me logo Genes that share ontologies with NCAPD2: view

Pathways & Interactions for NCAPD2 Gene

PathCards logo

SuperPathways for NCAPD2 Gene

genes like me logo Genes that share pathways with NCAPD2: view

Pathways by source for NCAPD2 Gene

1 BioSystems pathway for NCAPD2 Gene
1 GeneGo (Thomson Reuters) pathway for NCAPD2 Gene
  • Cell cycle_Chromosome condensation in prometaphase

Gene Ontology (GO) - Biological Process for NCAPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0007049 cell cycle IEA --
GO:0007076 mitotic chromosome condensation IEA,NAS 10958694
GO:0010032 meiotic chromosome condensation IBA 21873635
GO:0030261 chromosome condensation IEA --
genes like me logo Genes that share ontologies with NCAPD2: view

No data available for SIGNOR curated interactions for NCAPD2 Gene

Drugs & Compounds for NCAPD2 Gene

No Compound Related Data Available

Transcripts for NCAPD2 Gene

mRNA/cDNA for NCAPD2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9: -
SP10:
SP11:
SP12:

ExUns: 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NCAPD2 Gene

GeneLoc Exon Structure for
NCAPD2

Expression for NCAPD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCAPD2 Gene

Protein differential expression in normal tissues from HIPED for NCAPD2 Gene

This gene is overexpressed in Bone (43.4) and Pancreas (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCAPD2 Gene



Protein tissue co-expression partners for NCAPD2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCAPD2

SOURCE GeneReport for Unigene cluster for NCAPD2 Gene:

Hs.5719

Evidence on tissue expression from TISSUES for NCAPD2 Gene

  • Bone marrow(4.2)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with NCAPD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAPD2 Gene

Orthologs for NCAPD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NCAPD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAPD2 31 30
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPD2 31 30
  • 89.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCAPD2 31 30
  • 86.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ncapd2 17 31 30
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Ncapd2 30
  • 85.66 (n)
oppossum
(Monodelphis domestica)
Mammalia NCAPD2 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPD2 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAPD2 31 30
  • 64.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPD2 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncapd2 30
  • 63.39 (n)
Str.6498 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398080 30
zebrafish
(Danio rerio)
Actinopterygii ncapd2 31 30
  • 56.58 (n)
OneToOne
Dr.26684 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003434 30
  • 45.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CAP-D2 31 30
  • 44.86 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dpy-28 31
  • 16 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR273C 30
  • 42.99 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20119g 30
  • 41.89 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCS4 33 31 30
  • 41.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57060 30
  • 45.29 (n)
rice
(Oryza sativa)
Liliopsida Os07g0659500 30
  • 46.36 (n)
Os.9234 30
bread mold
(Neurospora crassa)
Ascomycetes NCU09297 30
  • 45.82 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cnd1 30
  • 41.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
-- 31
  • 30 (a)
OneToMany
Cin.4864 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4864 30
Species where no ortholog for NCAPD2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAPD2 Gene

ENSEMBL:
Gene Tree for NCAPD2 (if available)
TreeFam:
Gene Tree for NCAPD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCAPD2: view image

Paralogs for NCAPD2 Gene

Paralogs for NCAPD2 Gene

Pseudogenes.org Pseudogenes for NCAPD2 Gene

genes like me logo Genes that share paralogs with NCAPD2: view

Variants for NCAPD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCAPD2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
623797 Uncertain Significance: not provided 6,528,831(+) ACTT/A INFRAME_DELETION
711919 Benign: not provided 6,510,732(+) T/C SYNONYMOUS_VARIANT
732891 Likely Benign: not provided 6,529,859(+)