Aliases for NCAPD2 Gene
External Ids for NCAPD2 Gene
Previous GeneCards Identifiers for NCAPD2 Gene
GeneCards Summary for NCAPD2 Gene
NCAPD2 (Non-SMC Condensin I Complex Subunit D2) is a Protein Coding gene. Diseases associated with NCAPD2 include Microcephaly 21, Primary, Autosomal Recessive and Microcephaly. Among its related pathways are Aurora B signaling and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include binding and histone binding. An important paralog of this gene is NCAPD3.
UniProtKB/Swiss-Prot Summary for NCAPD2 Gene
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).