Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002] See more...

Aliases for NCAN Gene

Aliases for NCAN Gene

  • Neurocan 2 3 5
  • Chondroitin Sulfate Proteoglycan 3 2 4
  • Neurocan Proteoglycan 2 3
  • Neurocan Core Protein 3 4
  • CSPG3 3 4
  • Chondroitin Sulfate Proteoglycan 3 (Neurocan) 3
  • NCAN 5
  • NEUR 4

External Ids for NCAN Gene

Previous HGNC Symbols for NCAN Gene

  • CSPG3

Previous GeneCards Identifiers for NCAN Gene

  • GC19P019183
  • GC19P019322
  • GC19P018887
  • GC19P019212
  • GC19P020504
  • GC19P020647
  • GC19P020754
  • GC19P022265
  • GC19P019213
  • GC19P019364
  • GC19P019368
  • GC19P019685
  • GC19P020057
  • GC19P020366

Summaries for NCAN Gene

Entrez Gene Summary for NCAN Gene

  • Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]

GeneCards Summary for NCAN Gene

NCAN (Neurocan) is a Protein Coding gene. Diseases associated with NCAN include Low-Grade Astrocytoma and Capgras Syndrome. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix structural constituent. An important paralog of this gene is VCAN.

UniProtKB/Swiss-Prot Summary for NCAN Gene

  • May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Gene Wiki entry for NCAN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCAN Gene

Genomics for NCAN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NCAN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCAN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCAN

Top Transcription factor binding sites by QIAGEN in the NCAN gene promoter:
  • AREB6
  • c-Ets-1
  • c-Myc
  • Max1
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • POU3F2
  • Roaz
  • SRF

Genomic Locations for NCAN Gene

Genomic Locations for NCAN Gene
chr19:19,211,958-19,252,233
(GRCh38/hg38)
Size:
40,276 bases
Orientation:
Plus strand
chr19:19,322,782-19,363,061
(GRCh37/hg19)
Size:
40,280 bases
Orientation:
Plus strand

Genomic View for NCAN Gene

Genes around NCAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAN Gene

Proteins for NCAN Gene

  • Protein details for NCAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14594-NCAN_HUMAN
    Recommended name:
    Neurocan core protein
    Protein Accession:
    O14594
    Secondary Accessions:
    • Q9UPK6

    Protein attributes for NCAN Gene

    Size:
    1321 amino acids
    Molecular mass:
    143093 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCAN Gene

Post-translational modifications for NCAN Gene

  • O-glycosylated.
  • Glycosylation at Asn122, Asn340, Asn1026, and Asn1223
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for NCAN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCAN Gene

Domains & Families for NCAN Gene

Gene Families for NCAN Gene

Protein Domains for NCAN Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
  • Aspartic acid and asparagine hydroxylation site
  • EGF-like calcium-binding
  • Sushi domain/SCR domain/CCP module
  • Link domain
  • Type II antifreeze protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for NCAN Gene

GenScript: Design optimal peptide antigens:
  • Chondroitin sulfate proteoglycan 3 (NCAN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14594

UniProtKB/Swiss-Prot:

NCAN_HUMAN :
  • Belongs to the aggrecan/versican proteoglycan family.
Family:
  • Belongs to the aggrecan/versican proteoglycan family.
genes like me logo Genes that share domains with NCAN: view

Function for NCAN Gene

Molecular function for NCAN Gene

UniProtKB/Swiss-Prot Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Phenotypes From GWAS Catalog for NCAN Gene

Gene Ontology (GO) - Molecular Function for NCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005540 hyaluronic acid binding IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with NCAN: view
genes like me logo Genes that share phenotypes with NCAN: view

Animal Models for NCAN Gene

MGI Knock Outs for NCAN:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCAN

CRISPR Products

miRNA for NCAN Gene

miRTarBase miRNAs that target NCAN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCAN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAN Gene

Localization for NCAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCAN gene
Compartment Confidence
extracellular 5
plasma membrane 4
lysosome 4
golgi apparatus 4
cytoskeleton 3
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005796 Golgi lumen TAS --
GO:0031012 extracellular matrix IBA 21873635
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with NCAN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NCAN Gene

Pathways & Interactions for NCAN Gene

PathCards logo

SuperPathways for NCAN Gene

genes like me logo Genes that share pathways with NCAN: view

Pathways by source for NCAN Gene

1 GeneGo (Thomson Reuters) pathway for NCAN Gene
  • Cell adhesion_Cell-matrix glycoconjugates
13 Qiagen pathways for NCAN Gene
  • ERK Signaling
  • FAK1 Signaling
  • GnRH Signaling
  • ILK Signaling
  • Inhibition of Angiogenesis by TSP1

Gene Ontology (GO) - Biological Process for NCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IBA 21873635
GO:0007155 cell adhesion IEA --
GO:0007417 central nervous system development IBA 21873635
GO:0030198 extracellular matrix organization TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with NCAN: view

No data available for SIGNOR curated interactions for NCAN Gene

Drugs & Compounds for NCAN Gene

(5) Drugs for NCAN Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target, binder 717
Chondroitin sulfate Approved, Investigational Nutra 0
Beta-D-Glucose Experimental Pharma Target 0
Thiodigalactoside Experimental Pharma Target 0
Chondroitin Pharma 74
genes like me logo Genes that share compounds with NCAN: view

Transcripts for NCAN Gene

mRNA/cDNA for NCAN Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCAN

Alternative Splicing Database (ASD) splice patterns (SP) for NCAN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2: -

Relevant External Links for NCAN Gene

GeneLoc Exon Structure for
NCAN

Expression for NCAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCAN Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Amygdala (x6.4), Brain - Caudate (basal ganglia) (x6.1), Brain - Cortex (x5.7), Brain - Frontal Cortex (BA9) (x5.5), Brain - Putamen (basal ganglia) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.2), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for NCAN Gene

This gene is overexpressed in Fetal Brain (23.5), Frontal cortex (14.2), Brain (11.3), and Vitreous humor (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NCAN Gene



Protein tissue co-expression partners for NCAN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCAN

SOURCE GeneReport for Unigene cluster for NCAN Gene:

Hs.169047

mRNA Expression by UniProt/SwissProt for NCAN Gene:

O14594-NCAN_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for NCAN Gene

  • Nervous system(4.7)
  • Heart(3)
  • Skin(2.3)
  • Intestine(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with NCAN: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAN Gene

Orthologs for NCAN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCAN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NCAN 30 31
  • 99.27 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NCAN 30 31
  • 83.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NCAN 30 31
  • 82.44 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ncan 30 17 31
  • 73.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ncan 30
  • 73.52 (n)
Oppossum
(Monodelphis domestica)
Mammalia NCAN 31
  • 50 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NCAN 31
  • 38 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NCAN 31
  • 43 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ncanb 31
  • 38 (a)
OneToMany
ncana 31
  • 34 (a)
OneToMany
Dr.20279 30
Species where no ortholog for NCAN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NCAN Gene

ENSEMBL:
Gene Tree for NCAN (if available)
TreeFam:
Gene Tree for NCAN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCAN: view image

Paralogs for NCAN Gene

Paralogs for NCAN Gene

(21) SIMAP similar genes for NCAN Gene using alignment to 3 proteins:

  • NCAN_HUMAN
  • F5H7X3_HUMAN
  • K7EKF8_HUMAN
genes like me logo Genes that share paralogs with NCAN: view

Variants for NCAN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCAN Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
726544 Benign: not provided 19,233,883(+) C/T SYNONYMOUS_VARIANT
775579 Benign: not provided 19,249,773(+) T/G SYNONYMOUS_VARIANT
781465 Benign: not provided 19,219,213(+) G/A SYNONYMOUS_VARIANT
rs146011974 Uncertain Significance: Developmental dyslexia 19,233,884(+) G/A MISSENSE_VARIANT
rs1064389 - p.Ala1254Val

Additional dbSNP identifiers (rs#s) for NCAN Gene

Structural Variations from Database of Genomic Variants (DGV) for NCAN Gene

Variant ID Type Subtype PubMed ID
nsv1138677 CNV deletion 24896259
nsv1151217 CNV deletion 26484159

Variation tolerance for NCAN Gene

Residual Variation Intolerance Score: 6.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCAN Gene

Human Gene Mutation Database (HGMD)
NCAN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCAN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAN Gene

Disorders for NCAN Gene

MalaCards: The human disease database

(5) MalaCards diseases for NCAN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
low-grade astrocytoma
capgras syndrome
  • capgras delusion theory
dyslexia
bipolar disorder
  • major affective disorder 1
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search NCAN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NCAN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NCAN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCAN Gene

Publications for NCAN Gene

  1. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. (PMID: 21353194) Cichon S … Nöthen MM (American journal of human genetics 2011) 2 3 41
  2. Characterization of the human neurocan gene, CSPG3. (PMID: 9795216) Prange CK … Lennon GG (Gene 1998) 3 4 23
  3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S … Cupples LA (Nature genetics 2009) 3 41
  4. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. (PMID: 19148283) Deo RC … Wilson JG (PLoS genetics 2009) 3 41
  5. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PMID: 19060911) Aulchenko YS … ENGAGE Consortium (Nature genetics 2009) 3 41

Products for NCAN Gene

Sources for NCAN Gene