The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008] See more...

Aliases for NCAM2 Gene

Aliases for NCAM2 Gene

  • Neural Cell Adhesion Molecule 2 2 3 4 5
  • N-CAM-2 3 4
  • NCAM-2 3 4
  • NCAM21 3 4

External Ids for NCAM2 Gene

Previous GeneCards Identifiers for NCAM2 Gene

  • GC21P019231
  • GC21P019032
  • GC21P021292
  • GC21P022370
  • GC21P007759

Summaries for NCAM2 Gene

Entrez Gene Summary for NCAM2 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCAM2 Gene

NCAM2 (Neural Cell Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs) and Prion diseases. An important paralog of this gene is NCAM1.

UniProtKB/Swiss-Prot Summary for NCAM2 Gene

  • May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

Additional gene information for NCAM2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NCAM2 Gene

Genomics for NCAM2 Gene

GeneHancer (GH) Regulatory Elements for NCAM2 Gene

Promoters and enhancers for NCAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J020998 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 506.7 +1.4 1385 5.4 EP300 CTCF REST RAD21 SMC3 HDAC2 POLR2A MYC MXI1 POLR2G NCAM2 piR-56497-093 lnc-TMPRSS15-25
GH21J021196 Enhancer 1.1 FANTOM5 ENCODE 13.7 +200.8 200821 6.1 JUND FOS POLR2A AFF1 MYC CTBP1 JUN NFRKB TAF9B HDAC3 NCAM2 RF00994-598 piR-38352-343 lnc-CHODL-10
GH21J021045 Enhancer 0.7 Ensembl ENCODE 11.4 +48.1 48086 1.6 HDAC2 GATA3 GATA2 MITF CHD7 POU5F1 NANOG ATF1 KDM1A NCAM2 lnc-CHODL-8 lnc-CHODL-10
GH21J021052 Enhancer 0.5 Ensembl 16.1 +53.3 53286 2.4 ZNF316 MAFK SPI1 MEIS2 CEBPB EMSY NCAM2 lnc-CHODL-8 lnc-CHODL-10
GH21J021101 Enhancer 0.5 Ensembl 11.2 +103.5 103486 0.4 CTCF REST SMC3 CEBPG FOXP2 RAD21 CEBPB BACH1 CREB1 HMBOX1 NCAM2 lnc-CHODL-10 lnc-CHODL-8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NCAM2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NCAM2

Top Transcription factor binding sites by QIAGEN in the NCAM2 gene promoter:
  • AML1a

Genomic Locations for NCAM2 Gene

Genomic Locations for NCAM2 Gene
chr21:20,998,315-21,543,329
(GRCh38/hg38)
Size:
545,015 bases
Orientation:
Plus strand
chr21:22,370,633-22,915,650
(GRCh37/hg19)
Size:
545,018 bases
Orientation:
Plus strand

Genomic View for NCAM2 Gene

Genes around NCAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAM2 Gene

Proteins for NCAM2 Gene

  • Protein details for NCAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15394-NCAM2_HUMAN
    Recommended name:
    Neural cell adhesion molecule 2
    Protein Accession:
    O15394
    Secondary Accessions:
    • A8MQ06
    • B7Z841
    • Q7Z7F2

    Protein attributes for NCAM2 Gene

    Size:
    837 amino acids
    Molecular mass:
    93046 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NCAM2 Gene

    Alternative splice isoforms for NCAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCAM2 Gene

Post-translational modifications for NCAM2 Gene

  • Glycosylation at Asn177, Asn219, Asn309, Asn406, Asn419, Asn445, Asn474, and Asn562
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NCAM2_HUMAN (1546)

No data available for DME Specific Peptides for NCAM2 Gene

Domains & Families for NCAM2 Gene

Gene Families for NCAM2 Gene

Protein Domains for NCAM2 Gene

Blocks:
  • Immunoglobulin C-2 type
  • Neural cell adhesion molecule signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NCAM2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53114, highly similar to Neural cell adhesion molecule 2 (B7Z841_HUMAN)
  • Neural cell adhesion molecule 2, isoform CRA_a (D3DSC5_HUMAN)
  • Neural cell adhesion molecule 2 (NCAM2_HUMAN)
genes like me logo Genes that share domains with NCAM2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NCAM2 Gene

Function for NCAM2 Gene

Molecular function for NCAM2 Gene

UniProtKB/Swiss-Prot Function:
May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
GENATLAS Biochemistry:
cell adhesion molecule,neural,2,immunoglobulin superfamily

Phenotypes From GWAS Catalog for NCAM2 Gene

Gene Ontology (GO) - Molecular Function for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 21300289
genes like me logo Genes that share ontologies with NCAM2: view
genes like me logo Genes that share phenotypes with NCAM2: view

Animal Models for NCAM2 Gene

MGI Knock Outs for NCAM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCAM2

Clone Products

  • Addgene plasmids for NCAM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAM2 Gene

Localization for NCAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAM2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCAM2 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 2
peroxisome 2
cytoskeleton 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016604 nuclear body IDA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with NCAM2: view

Pathways & Interactions for NCAM2 Gene

PathCards logo

SuperPathways for NCAM2 Gene

genes like me logo Genes that share pathways with NCAM2: view

Pathways by source for NCAM2 Gene

2 KEGG pathways for NCAM2 Gene

Gene Ontology (GO) - Biological Process for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007158 neuron cell-cell adhesion TAS 9226371
GO:0007413 axonal fasciculation IEA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with NCAM2: view

No data available for SIGNOR curated interactions for NCAM2 Gene

Drugs & Compounds for NCAM2 Gene

No Compound Related Data Available

Transcripts for NCAM2 Gene

mRNA/cDNA for NCAM2 Gene

8 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for NCAM2

Alternative Splicing Database (ASD) splice patterns (SP) for NCAM2 Gene

No ASD Table

Relevant External Links for NCAM2 Gene

GeneLoc Exon Structure for
NCAM2

Expression for NCAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NCAM2 Gene

mRNA differential expression in normal tissues according to GTEx for NCAM2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Frontal Cortex (BA9) (x5.0), Brain - Amygdala (x5.0), Brain - Hippocampus (x4.7), Brain - Hypothalamus (x4.2), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for NCAM2 Gene

This gene is overexpressed in Serum (20.2), Brain (17.7), and Frontal cortex (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCAM2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NCAM2

SOURCE GeneReport for Unigene cluster for NCAM2 Gene:

Hs.473450

mRNA Expression by UniProt/SwissProt for NCAM2 Gene:

O15394-NCAM2_HUMAN
Tissue specificity: Expressed most strongly in adult and fetal brain.

Evidence on tissue expression from TISSUES for NCAM2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with NCAM2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAM2 Gene

Orthologs for NCAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAM2 31 30
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCAM2 31 30
  • 93 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCAM2 31 30
  • 92.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ncam2 17 31 30
  • 86.85 (n)
rat
(Rattus norvegicus)
Mammalia Ncam2 30
  • 86.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NCAM2 31
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCAM2 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAM2 31 30
  • 81.72 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAM2 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncam2 30
  • 74.62 (n)
Str.11852 30
zebrafish
(Danio rerio)
Actinopterygii zgc:152904 30
  • 63.14 (n)
NCAM2 (2 of 2) 31
  • 63 (a)
OneToMany
ncam2 31 30
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Fas2 32
  • 29 (a)
CG33543 31
  • 22 (a)
ManyToMany
CG15630 31
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ncam-1 31
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
OneToMany
Species where no ortholog for NCAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAM2 Gene

ENSEMBL:
Gene Tree for NCAM2 (if available)
TreeFam:
Gene Tree for NCAM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NCAM2: view image

Paralogs for NCAM2 Gene

(4) SIMAP similar genes for NCAM2 Gene using alignment to 5 proteins:

  • NCAM2_HUMAN
  • B7Z841_HUMAN
  • D3DSC5_HUMAN
  • H9KV31_HUMAN
  • L0R512_HUMAN
genes like me logo Genes that share paralogs with NCAM2: view

Variants for NCAM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NCAM2 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
710284 Benign: not provided 21,508,842(+) C/CTTTTTTTTTTTTT INTRON_VARIANT
769118 Likely Benign: not provided 21,508,840(+) TAC/T INTRON_VARIANT
rs232518 - p.Leu350Pro
rs35654962 - p.Asp347Asn

Additional dbSNP identifiers (rs#s) for NCAM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NCAM2 Gene

Variant ID Type Subtype PubMed ID
dgv2366n106 CNV tandem duplication 24896259
dgv4402n100 CNV gain 25217958
dgv4403n100 CNV loss 25217958
dgv7788n54 CNV loss 21841781
dgv803e214 CNV loss 21293372
esv1111053 CNV insertion 17803354
esv1433890 CNV insertion 17803354
esv1743038 CNV insertion 17803354
esv2462157 CNV deletion 19546169
esv2657272 CNV deletion 23128226
esv2662138 CNV deletion 23128226
esv2723243 CNV deletion 23290073
esv2723244 CNV deletion 23290073
esv2751925 CNV loss 17911159
esv3302770 CNV tandem duplication 20981092
esv3344210 CNV duplication 20981092
esv3568127 CNV loss 25503493
esv3646564 CNV gain 21293372
esv3646569 CNV loss 21293372
esv3646571 CNV loss 21293372
esv3646572 CNV loss 21293372
esv3646574 CNV loss 21293372
esv3646575 CNV loss 21293372
esv991118 CNV insertion 20482838
nsv1057445 CNV loss 25217958
nsv1057774 CNV gain 25217958
nsv1060947 CNV loss 25217958
nsv1062692 CNV loss 25217958
nsv1072594 CNV deletion 25765185
nsv1114270 CNV deletion 24896259
nsv1123541 CNV deletion 24896259
nsv1125742 CNV tandem duplication 24896259
nsv1127882 CNV deletion 24896259
nsv1127883 CNV deletion 24896259
nsv1136609 CNV deletion 24896259
nsv1136610 CNV deletion 24896259
nsv1143015 CNV tandem duplication 24896259
nsv459135 CNV loss 19166990
nsv470889 CNV gain 18288195
nsv474227 CNV novel sequence insertion 20440878
nsv478325 CNV novel sequence insertion 20440878
nsv479480 CNV novel sequence insertion 20440878
nsv507916 OTHER sequence alteration 20534489
nsv510497 OTHER sequence alteration 20534489
nsv521484 CNV loss 19592680
nsv587210 CNV loss 21841781
nsv587211 CNV loss 21841781
nsv587212 CNV loss 21841781
nsv587213 CNV loss 21841781
nsv587214 CNV loss 21841781
nsv587217 CNV loss 21841781
nsv817920 CNV gain 17921354
nsv820109 CNV gain 19587683
nsv821690 CNV loss 15273396
nsv828838 CNV gain 20364138
nsv956772 CNV insertion 24416366
nsv9859 CNV loss 18304495

Variation tolerance for NCAM2 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.53; 94.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NCAM2 Gene

Human Gene Mutation Database (HGMD)
NCAM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCAM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAM2 Gene

Disorders for NCAM2 Gene

Additional Disease Information for NCAM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NCAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAM2 Gene

Publications for NCAM2 Gene

  1. Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. (PMID: 9226371) Paoloni-Giacobino A … Antonarakis SE (Genomics 1997) 2 3 4 54
  2. A genome-wide association study on obesity and obesity-related traits. (PMID: 21552555) Wang K … Price RA (PloS one 2011) 3 41 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin AI … Ukraintseva SV (Aging 2010) 3 41 54
  5. Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study. (PMID: 20932310) Han MR … Alzheimer's Disease Neuroimaging Initiative (BMC neurology 2010) 3 41 54

Products for NCAM2 Gene

  • Signalway ELISA kits for NCAM2
  • Signalway Proteins for NCAM2

Sources for NCAM2 Gene