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This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
NCAM1 (Neural Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NCAM1 include Rabies and Bile Duct Cancer. Among its related pathways are Neuroscience and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is NCAM2.
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0005515 | protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005576 | extracellular region | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IDA,TAS | -- |
GO:0009897 | external side of plasma membrane | IDA | 17213291 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Developmental Biology |
.51
|
|
3 | Cytokine Signaling in Immune system | ||
4 | Innate Immune System |
.61
|
|
5 | Interferon gamma signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0007155 | cell adhesion | IEA | -- |
GO:0007411 | axon guidance | TAS | -- |
GO:0016032 | viral process | IEA | -- |
GO:0046718 | viral entry into host cell | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Ac2-12 |
|
256447-08-2 |
|
|
||
Ac2-26 |
|
151988-33-9 |
|
|
||
Heparin sodium salt |
|
9041-08-1 |
|
|
||
KF 38789 |
|
257292-29-8 |
|
|
||
PM 102 |
|
1234564-95-4 |
|
|
Compound | Action | Cas Number |
---|---|---|
Ac2-12 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 256447-08-2 |
Ac2-26 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 151988-33-9 |
Heparin sodium salt | Anticoagulant | 9041-08-1 |
KF 38789 | Selective inhibitor of P-selectin-mediated cell adhesion | 257292-29-8 |
PM 102 | Antagonist of heparin (Cat. No. 2812) | 1234564-95-4 |
Compound | Action | Cas Number |
---|---|---|
Thiolutin | RNA polymerase inhibitor,antibiotic | 1987-11-6 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NCAM1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NCAM1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NCAM1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ncam1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ncam1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | NCAM1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NCAM1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NCAM1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ncam1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | NCAM 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ncam1a 30 31 |
|
OneToMany | |
ncam1b 31 |
|
OneToMany | |||
-- 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002802 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Fas2 30 31 32 |
|
ManyToMany | |
CG33543 31 |
|
ManyToMany | |||
CG15630 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ncam-1 30 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
770406 | Benign: not provided | 113,207,325(+) | C/T | SYNONYMOUS_VARIANT | |
rs17115160 | - | p.Asp260Asn | |||
rs17115280 | - | p.Glu679Asp | |||
rs17174409 | - | p.Thr834Met | |||
rs7105734 | - | p.Leu7Phe |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1279n100 | CNV | loss | 25217958 |
esv24924 | CNV | loss | 19812545 |
esv2664094 | CNV | deletion | 23128226 |
esv2745085 | CNV | deletion | 23290073 |
esv3548358 | CNV | deletion | 23714750 |
esv3627771 | CNV | loss | 21293372 |
esv3627772 | CNV | loss | 21293372 |
esv3627773 | CNV | gain | 21293372 |
esv3627774 | CNV | loss | 21293372 |
esv3627775 | CNV | loss | 21293372 |
nsv1038796 | CNV | gain | 25217958 |
nsv468870 | CNV | loss | 19166990 |
nsv483080 | CNV | loss | 15286789 |
nsv515828 | CNV | loss | 19592680 |
nsv516224 | CNV | loss | 19592680 |
nsv526604 | CNV | loss | 19592680 |
nsv556442 | CNV | loss | 21841781 |
nsv556443 | CNV | loss | 21841781 |
nsv832271 | CNV | gain | 17160897 |
nsv832272 | CNV | gain | 17160897 |
nsv951071 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rabies |
|
|
bile duct cancer |
|
|
plasma cell leukemia |
|
|
merkel cell carcinoma |
|
|
large cell neuroendocrine carcinoma |
|
|