Aliases for NCAM1 Gene
Aliases for NCAM1 Gene
External Ids for NCAM1 Gene
- HGNC: 7656
- Entrez Gene: 4684
- Ensembl: ENSG00000149294
- OMIM: 116930
- UniProtKB: P13591
Previous GeneCards Identifiers for NCAM1 Gene
- GC11P115185
- GC11P114344
- GC11P112866
- GC11P112369
- GC11P112337
- GC11P112831
- GC11P108759
Summaries for NCAM1 Gene
-
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
GeneCards Summary for NCAM1 Gene
NCAM1 (Neural Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NCAM1 include Rabies and Blastic Plasmacytoid Dendritic Cell. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is NCAM2.
UniProtKB/Swiss-Prot for NCAM1 Gene
-
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
-
(Microbial infection) Acts as a receptor for rabies virus.
-
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.
Additional gene information for NCAM1 Gene
- Monarch Initiative
- Search for NCAM1 at DataMed
- Search for NCAM1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAM1 Gene
Genomics for NCAM1 Gene
GeneHancer (GH) Regulatory Elements for NCAM1 Gene
Promoters and enhancers for NCAM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NCAM1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NCAM1 gene promoter:
-
- AML1a
Regulatory Element Products
Genomic Locations for NCAM1 Gene
Genomic Locations for NCAM1 Gene
- chr11:112,961,247-113,278,436
- (GRCh38/hg38)
- Size:
- 317,190 bases
- Orientation:
- Plus strand
- chr11:112,831,969-113,149,158
- (GRCh37/hg19)
- Size:
- 317,190 bases
- Orientation:
- Plus strand
Genomic View for NCAM1 Gene
Genes around NCAM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.2 by Entrez Gene
- 11q23.2 by HGNC
- 11q23.2 by Ensembl
NCAM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NCAM1 Gene
Proteins for NCAM1 Gene
-
Protein details for NCAM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13591-NCAM1_HUMAN
- Recommended name:
- Neural cell adhesion molecule 1
- Protein Accession:
- P13591
- A8K8T8
- P13592
- P13593
- Q05C58
- Q15829
- Q16180
- Q16209
- Q59FL7
- Q86X47
- Q96CJ3
Protein attributes for NCAM1 Gene
- Size:
- 858 amino acids
- Molecular mass:
- 94574 Da
- Quaternary structure:
-
- (Microbial infection) Interacts with rabies virus glycoprotein.
- SequenceCaution:
-
- Sequence=BAD92680.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NCAM1 Gene
Alternative splice isoforms for NCAM1 Gene
- UniProtKB/Swiss-Prot:
Protein Expression for NCAM1 Gene
Post-translational modifications for NCAM1 Gene
Other Protein References for NCAM1 Gene
- ENSEMBL proteins:
-
- ENSP00000475074
- ENSP00000482205
- ENSP00000480797
- ENSP00000484943
- ENSP00000482852
- ENSP00000480132
- ENSP00000481083
- ENSP00000479241
- ENSP00000477835
- ENSP00000479353
- ENSP00000318472
- ENSP00000480774
- ENSP00000479687
- ENSP00000486241
- ENSP00000480269
- ENSP00000478072
- ENSP00000477808
- ENSP00000384055
- ENSP00000486406
- ENSP00000484481
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NCAM1 (NCAM-1/CD56)
-
Custom Antibody ServicesOriGene Antibodies for NCAM1
- AM05195BT-N
- AM05195FC-N
- AM05195PU-N
- AM05195RP-N
- AM05639FC-N
- AM05639PU-L
- AM05639PU-N
- AM08327PU-N
- AM20647PU-N
- AM31188AF-N
- AM31188PU-N
- AM31188RP-N
- AM32056SU-N
- AM32056SU-S
- AM50146PU-N
- AM50146PU-S
- AM50146PU-T
- AM50239PU-N
- AM50239PU-S
- AM50239PU-T
- AM50240PU-N
- AM50240PU-S
- AM50240PU-T
- AP23280PU-N
- BM2401APC
- BM2401F
- BM2401PS
- BM2401R
- BM6015P
- SM1142A
- SM1142B
- SM1142P
- SM1142PT
- TA351057
- TA353364
- TA353710
- CF506208
- CF506223
- CF804951
- CF804952
- CF804953
- CF804954
- CF805047
- CF805182
- CF805375
- CF805376
- CF805476
- UM570067
- UM870084
- UM870086
- Novus Biologicals Antibodies for NCAM1
-
Abcam antibodies for NCAM1
- Invitrogen Antibodies for NCAM1
- GeneTex NCAM1 Antibody for NCAM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NCAM1
- Sino Biological Antibodies for NCAM1
Protein Products
- R&D Systems Proteins and Enzymes for NCAM1 (NCAM-1/CD56)
-
OriGene Purified Proteins for NCAM1
- Search Origene for MassSpec and Protein Over-expression Lysates for NCAM1
- Origene Custom Protein Services for NCAM1
- Sino Biological Recombinant Proteins for NCAM1
- Sino Biological Cell Lysates for NCAM1
- GeneTex Proteins for NCAM1
-
Abcam proteins for NCAM1
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for NCAM1 (NCAM-1/CD56)
- Novus Biologicals ELISA Kits for NCAM1
-
Abcam assays for NCAM1
No data available for DME Specific Peptides for NCAM1 Gene
Domains & Families for NCAM1 Gene
Gene Families for NCAM1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for NCAM1 Gene
Suggested Antigen Peptide Sequences for NCAM1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for NCAM1 Gene
Function for NCAM1 Gene
Molecular function for NCAM1 Gene
- UniProtKB/Swiss-Prot Function:
- This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for rabies virus.
- GENATLAS Biochemistry:
- cell adhesion molecule,neural,1,immunoglobulin superfamily
Phenotypes From GWAS Catalog for NCAM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for NCAM1 Gene
- MGI mutant phenotypes for NCAM1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for NCAM1:
-
- Increased G1 DNA content
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased viability
- Increased cell migration
- Decreased cell migration
- no effect
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased hepcidin::fluc mRNA expression
- Decreased IL-8 secretion
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for NCAM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NCAM1
-
CRISPR Products
-
OriGene CRISPR knockouts for NCAM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCAM1
- genomics-online: gRNA clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
- Applied Biological Materials CRISPR for NCAM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCAM1
- GenScript: Design CRISPR guide RNA sequences for NCAM1
miRNA for NCAM1 Gene
- miRTarBase miRNAs that target NCAM1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NCAM1
- Browse OriGene Inhibitory RNA Products For NCAM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCAM1
- genomics-online: shRNA clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
Clone Products
-
OriGene ORF clones in human for NCAM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NCAM1
- VectorBuilder custom plasmid, inducible vectors for NCAM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NCAM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCAM1
- Applied Biological Materials Clones for NCAM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor for NCAM1
-
Horizon Cell Lines for NCAM1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAM1 Gene
Localization for NCAM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NCAM1 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Cell membrane; Lipid-anchor, GPI-anchor.
- Isoform 4: Cell membrane; Lipid-anchor, GPI-anchor.
- Isoform 5: Secreted.
- Isoform 6: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0009897 | external side of plasma membrane | IDA | 17213291 |
Pathways & Interactions for NCAM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Developmental Biology |
.51
|
|
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Interferon gamma signaling | ||
Pathways by source for NCAM1 Gene
3 BioSystems pathways for NCAM1 Gene
53 Reactome pathways for NCAM1 Gene
2 KEGG pathways for NCAM1 Gene
1 GeneGo (Thomson Reuters) pathway for NCAM1 Gene
5 R&D Systems pathways for NCAM1 Gene
- Dendritic Cells Developmental Lineage Pathway
- Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers
- Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers
- Innate Lymphoid Cell Differentiation Pathways
- Neural Stem Cell Differentiation Pathways and Lineage-specific Markers
3 Cell Signaling Technology pathways for NCAM1 Gene
Interacting Proteins for NCAM1 Gene
Selected Interacting proteins:
ENSP00000318472
P13591-NCAM1_HUMAN
for NCAM1 Gene via
STRING
MINT
IID
GPS-Prot Interaction Network for NCAM1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0046718 | viral entry into host cell | IEA | -- |
No data available for SIGNOR curated interactions for NCAM1 Gene
Drugs & Compounds for NCAM1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Ac2-12 |
|
256447-08-2 |
|
|
||
| Ac2-26 |
|
151988-33-9 |
|
|
||
| Heparin sodium salt |
|
9041-08-1 |
|
|
||
| KF 38789 |
|
257292-29-8 |
|
|
||
| PM 102 |
|
1234564-95-4 |
|
|
(5) Tocris Compounds for NCAM1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ac2-12 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 256447-08-2 |
| Ac2-26 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 151988-33-9 |
| Heparin sodium salt | Anticoagulant | 9041-08-1 |
| KF 38789 | Selective inhibitor of P-selectin-mediated cell adhesion | 257292-29-8 |
| PM 102 | Antagonist of heparin (Cat. No. 2812) | 1234564-95-4 |
(1) ApexBio Compounds for NCAM1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Thiolutin | RNA polymerase inhibitor,antibiotic | 1987-11-6 |
Transcripts for NCAM1 Gene
mRNA/cDNA for NCAM1 Gene
- (5) REFSEQ mRNAs :
- (22) Additional mRNA sequences :
- (303) Selected AceView cDNA sequences:
- (30) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000619839 2993 bps (uc058hjr.1)
- ENST00000401611 2510 bps (uc031yfj.2)
- ENST00000621128 4698 bps (uc058hjs.1)
- ENST00000613217 610 bps (uc058hjt.1)
- ENST00000316851 5837 bps (uc058hju.1)
Unigene Clusters for NCAM1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NCAM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NCAM1
- genomics-online: gRNA clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
- Applied Biological Materials CRISPR for NCAM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCAM1
- GenScript: Design CRISPR guide RNA sequences for NCAM1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NCAM1
- Browse OriGene Inhibitory RNA Products For NCAM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NCAM1
- genomics-online: shRNA clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
Clone Products
-
OriGene ORF clones in human for NCAM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NCAM1
- VectorBuilder custom plasmid, inducible vectors for NCAM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NCAM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NCAM1
- Applied Biological Materials Clones for NCAM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for NCAM1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
-
Cartilage (Muscoskeletal System)
- Prechondrocytes Rostral Synchondroses
- Prechondrocytes Synchondroses
- Prechondrocytes Branchial Arch 2
-
Bone (Muscoskeletal System)
- Prechondrocytes Rostral Synchondroses
- Prechondrocytes Synchondroses
- Prechondrocytes Branchial Arch 2
-
Peripheral Nervous System (Nervous System)
- Non-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
- Brain (Nervous System)
- Neurons
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Glial Cells
- Non-myelinating Schwann Cells Peripheral Nerve Domain
-
Head Mesenchyme (Muscoskeletal System)
- Prechondrocytes Branchial Arch 2
-
Heart (Cardiovascular System)
- Endocardial Cells Endocardium
- Eye (Sensory Organs)
This gene is overexpressed in Fetal Brain (17.6), Frontal cortex (11.4), Retina (11.0), and Brain (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCAM1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NCAM1 Gene:
NCAM1SOURCE GeneReport for Unigene cluster for NCAM1 Gene:
Hs.503878Evidence on tissue expression from TISSUES for NCAM1 Gene
- Nervous system(5)
- Bone marrow(4.6)
- Muscle(4.6)
- Liver(4.5)
- Kidney(4.4)
- Blood(3.7)
- Lung(2.9)
- Eye(2.8)
- Heart(2.8)
- Lymph node(2.7)
- Spleen(2.7)
- Adrenal gland(2.6)
- Thyroid gland(2.6)
- Intestine(2.4)
- Skin(2.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for NCAM1
-
OriGene qPCR primer pairs for NCAM1
- genomics-online: primer clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAM1 Gene
Orthologs for NCAM1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NCAM1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NCAM1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NCAM1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ncam1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ncam1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | NCAM1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NCAM1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NCAM1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ncam1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | NCAM 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ncam1a 34 33 |
|
OneToMany | |
| ncam1b 34 |
|
OneToMany | |||
| -- 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002802 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Fas2 34 35 33 |
|
ManyToMany | |
| CG33543 34 |
|
ManyToMany | |||
| CG15630 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ncam-1 34 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for NCAM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NCAM1 Gene
- ENSEMBL:
- Gene Tree for NCAM1 (if available)
- TreeFam:
- Gene Tree for NCAM1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NCAM1: view image
Paralogs for NCAM1 Gene
(5) SIMAP similar genes for NCAM1 Gene using alignment to 7 proteins:
- NCAM1_HUMAN
- H7BYX6_HUMAN
- L8EBH1_HUMAN
- L8ECP3_HUMAN
- R4GMN9_HUMAN
- S4R389_HUMAN
- S4R3Z6_HUMAN
Variants for NCAM1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000001757 | -- | 113,182,613(+) | T/C | intron_variant | |
| rs1000017383 | -- | 113,270,147(+) | T/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000063052 | -- | 113,012,056(+) | T/C | intron_variant | |
| rs1000087888 | -- | 113,194,179(+) | T/G | intron_variant | |
| rs1000090738 | -- | 113,263,846(+) | G/A | 3_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1279n100 | CNV | loss | 25217958 |
| esv24924 | CNV | loss | 19812545 |
| esv2664094 | CNV | deletion | 23128226 |
| esv2745085 | CNV | deletion | 23290073 |
| esv3548358 | CNV | deletion | 23714750 |
| esv3627771 | CNV | loss | 21293372 |
| esv3627772 | CNV | loss | 21293372 |
| esv3627773 | CNV | gain | 21293372 |
| esv3627774 | CNV | loss | 21293372 |
| esv3627775 | CNV | loss | 21293372 |
| nsv1038796 | CNV | gain | 25217958 |
| nsv468870 | CNV | loss | 19166990 |
| nsv483080 | CNV | loss | 15286789 |
| nsv515828 | CNV | loss | 19592680 |
| nsv516224 | CNV | loss | 19592680 |
| nsv526604 | CNV | loss | 19592680 |
| nsv556442 | CNV | loss | 21841781 |
| nsv556443 | CNV | loss | 21841781 |
| nsv832271 | CNV | gain | 17160897 |
| nsv832272 | CNV | gain | 17160897 |
| nsv951071 | CNV | duplication | 24416366 |
Gene Damage Index Score:
7.28;
81.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NCAM1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAM1 Gene
Disorders for NCAM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rabies |
|
|
| blastic plasmacytoid dendritic cell |
|
|
| hypoganglionosis |
|
|
| neuroendocrine tumor |
|
|
| plasma cell leukemia |
|
Search NCAM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NCAM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NCAM1 Gene
Publications for NCAM1 Gene
- Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56). (PMID: 1710251) Lanier LL … Phillips JH (Journal of immunology (Baltimore, Md. : 1950) 1991) 3 4 22 58
- Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. (PMID: 21212386) Arnett DK … Kardia SL (Circulation research 2011) 3 44 58
- Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
Products for NCAM1 Gene
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- Mammalian expression: PiggyBac
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- Yeast expression
- antibodies-online: Search results for 983 available CD56 Antibodies ranked by validation data
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- antibodies-online: Search results for 26 available CD56 Proteins ranked by validation data
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- GeneTex NCAM1 Antibody for NCAM1
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- Santa Cruz Biotechnology (SCBT) Antibodies for NCAM1
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- genomics-online: cdna clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
- orf clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
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- Overview of 149 available CD56 gene related products
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Sources for NCAM1 Gene
- (1) GeneCards
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- (68) Cloud-Clone Corp.
- (69) OCA
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- (73) Reactome
- (74) GeneGo (Thomson Reuters)
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