Aliases for NCAM1 Gene
Aliases for NCAM1 Gene
External Ids for NCAM1 Gene
- HGNC: 7656
- Entrez Gene: 4684
- Ensembl: ENSG00000149294
- OMIM: 116930
- UniProtKB: P13591
Previous GeneCards Identifiers for NCAM1 Gene
- GC11P115185
- GC11P114344
- GC11P112866
- GC11P112369
- GC11P112337
- GC11P112831
- GC11P108759
Summaries for NCAM1 Gene
-
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
GeneCards Summary for NCAM1 Gene
NCAM1 (Neural Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NCAM1 include Rabies and Blastic Plasmacytoid Dendritic Cell. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is NCAM2.
UniProtKB/Swiss-Prot for NCAM1 Gene
-
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
-
(Microbial infection) Acts as a receptor for rabies virus.
-
Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.
Additional gene information for NCAM1 Gene
- Monarch Initiative
- Search for NCAM1 at DataMed
- Search for NCAM1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAM1 Gene
Genomics for NCAM1 Gene
GeneHancer (GH) Regulatory Elements for NCAM1 Gene
Promoters and enhancers for NCAM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NCAM1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NCAM1 gene promoter:
Regulatory Element Products
Genomic Locations for NCAM1 Gene
Genomic Locations for NCAM1 Gene
- chr11:112,961,247-113,278,436
- (GRCh38/hg38)
- Size:
- 317,190 bases
- Orientation:
- Plus strand
- chr11:112,831,969-113,149,158
- (GRCh37/hg19)
Genomic View for NCAM1 Gene
Genes around NCAM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.2 by Ensembl
- 11q23.2 by Entrez Gene
- 11q23.2 by HGNC
NCAM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NCAM1 Gene
Proteins for NCAM1 Gene
-
Protein details for NCAM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13591-NCAM1_HUMAN
- Recommended name:
- Neural cell adhesion molecule 1
- Protein Accession:
- P13591
- A8K8T8
- P13592
- P13593
- Q05C58
- Q15829
- Q16180
- Q16209
- Q59FL7
- Q86X47
- Q96CJ3
Protein attributes for NCAM1 Gene
- Size:
- 858 amino acids
- Molecular mass:
- 94574 Da
- Quaternary structure:
-
- (Microbial infection) Interacts with rabies virus glycoprotein.
- SequenceCaution:
-
- Sequence=BAD92680.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NCAM1 Gene
Alternative splice isoforms for NCAM1 Gene
- UniProtKB/Swiss-Prot:
Protein Expression for NCAM1 Gene
Post-translational modifications for NCAM1 Gene
- Glycosylation at Thr125, Asn222, Asn315, isoforms=2, 3, 4, 5, 6347, Asn423, Asn449, and isoforms=2, 3, 4, 5478
Other Protein References for NCAM1 Gene
- ENSEMBL proteins:
-
- ENSP00000384055
- ENSP00000475074
- ENSP00000477808
- ENSP00000477835
- ENSP00000478072
- ENSP00000479241
- ENSP00000479353
- ENSP00000479687
- ENSP00000480132
- ENSP00000480269
- ENSP00000480774
- ENSP00000480797
- ENSP00000481083
- ENSP00000482205
- ENSP00000482852
- ENSP00000484481
- ENSP00000484943
- ENSP00000486241
- ENSP00000486406
- ENSP00000318472
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NCAM1 (NCAM-1/CD56)
- Cell Signaling Technology (CST) Antibodies for NCAM1 (NCAM1)
-
Custom Antibody ServicesOriGene Antibodies for NCAM1
- UM870086
- UM870084
- UM570067
- CF805476
- CF805376
- CF805375
- CF805182
- CF805047
- CF804954
- CF804953
- CF804952
- CF804951
- CF506223
- CF506208
- TA353710
- TA353364
- TA351057
- SM1142PT
- SM1142P
- SM1142B
- SM1142A
- BM6015P
- BM2401R
- BM2401PS
- BM2401F
- BM2401APC
- AP23280PU-N
- AM50240PU-T
- AM50240PU-S
- AM50240PU-N
- AM50239PU-T
- AM50239PU-S
- AM50239PU-N
- AM50146PU-T
- AM50146PU-S
- AM50146PU-N
- AM32056SU-S
- AM32056SU-N
- AM31188RP-N
- AM31188PU-N
- AM31188AF-N
- AM08327PU-N
- AM05639PU-N
- AM05639PU-L
- AM05639FC-N
- AM05195RP-N
- AM05195PU-N
- AM05195FC-N
- AM05195BT-N
- Novus Biologicals Antibodies for NCAM1
-
Abcam antibodies for NCAM1
-
Cloud-Clone Corp. Antibodies for NCAM1
- Invitrogen Antibodies for NCAM1
- GeneTex NCAM1 antibody for NCAM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NCAM1
- Sino Biological Antibodies for NCAM1
Protein Products
- R&D Systems Proteins and Enzymes for NCAM1 (NCAM-1/CD56)
-
OriGene Purified Proteins for NCAM1
- Search Origene for MassSpec and Protein Over-expression Lysates for NCAM1
- Origene Custom Protein Services for NCAM1
- Sino Biological Recombinant Proteins for NCAM1
- Sino Biological Cell Lysates for NCAM1
-
Cloud-Clone Corp. Proteins for NCAM1
- Search GeneTex for Proteins for NCAM1
-
Abcam proteins for NCAM1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for NCAM1
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for NCAM1 (NCAM-1/CD56)
- Novus Biologicals ELISA Kits for NCAM1
-
Cloud-Clone Corp. Assay Kits for NCAM1
-
Abcam assays for NCAM1
No data available for DME Specific Peptides for NCAM1 Gene
Domains & Families for NCAM1 Gene
Gene Families for NCAM1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for NCAM1 Gene
Suggested Antigen Peptide Sequences for NCAM1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for NCAM1 Gene
Function for NCAM1 Gene
Molecular function for NCAM1 Gene
- GENATLAS Biochemistry:
- cell adhesion molecule,neural,1,immunoglobulin superfamily
- UniProtKB/Swiss-Prot Function:
- This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for rabies virus.
Phenotypes From GWAS Catalog for NCAM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
Phenotypes for NCAM1 Gene
- MGI mutant phenotypes for NCAM1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for NCAM1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Synthetic lethal with Ras
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased G1 DNA content
- Decreased IL-8 secretion
- Decreased cell migration
- Decreased shRNA abundance
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased cell migration
- Decreased viability
Animal Models for NCAM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NCAM1
-
- Search ViGene Biosciences for NCAM1
CRISPR Products
-
OriGene CRISPR knockouts for NCAM1
- genomics-online: gRNA clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
- Applied Biological Materials CRISPR for NCAM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCAM1
- GenScript: Design CRISPR guide RNA sequences for NCAM1
miRNA for NCAM1 Gene
- miRTarBase miRNAs that target NCAM1
miRNA Products
- Search ViGene Biosciences for NCAM1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NCAM1
- Browse OriGene Inhibitory RNA Products For NCAM1
- genomics-online: shRNA clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
Clone Products
-
OriGene ORF clones in human for NCAM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NCAM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NCAM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NCAM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NCAM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor for NCAM1
-
Horizon Cell Lines for NCAM1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAM1 Gene
Localization for NCAM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NCAM1 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Cell membrane; Lipid-anchor, GPI-anchor.
- Isoform 4: Cell membrane; Lipid-anchor, GPI-anchor.
- Isoform 5: Secreted.
- Isoform 6: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| nucleus | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0009897 | external side of plasma membrane | IDA | 17213291 |
Pathways & Interactions for NCAM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Developmental Biology |
.51
|
|
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Interferon gamma signaling | ||
Pathways by source for NCAM1 Gene
3 Cell Signaling Technology pathways for NCAM1 Gene
3 BioSystems pathways for NCAM1 Gene
53 Reactome pathways for NCAM1 Gene
2 KEGG pathways for NCAM1 Gene
1 GeneGo (Thomson Reuters) pathway for NCAM1 Gene
5 R&D Systems pathways for NCAM1 Gene
- Dendritic Cells Developmental Lineage Pathway
- Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers
- Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers
- Innate Lymphoid Cell Differentiation Pathways
- Neural Stem Cell Differentiation Pathways and Lineage-specific Markers
Interacting Proteins for NCAM1 Gene
Selected Interacting proteins:
ENSP00000318472
P13591-NCAM1_HUMAN
for NCAM1 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0046718 | viral entry into host cell | IEA | -- |
No data available for SIGNOR curated interactions for NCAM1 Gene
Drugs & Compounds for NCAM1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Ac2-26 |
|
151988-33-9 |
|
|
||
| Heparin sodium salt |
|
9041-08-1 |
|
|
(5) Tocris Compounds for NCAM1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ac2-12 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 256447-08-2 |
| Ac2-26 | Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation | 151988-33-9 |
| Heparin sodium salt | Anticoagulant | 9041-08-1 |
| KF 38789 | Selective inhibitor of P-selectin-mediated cell adhesion | 257292-29-8 |
| PM 102 | Antagonist of heparin (Cat. No. 2812) | 1234564-95-4 |
(1) ApexBio Compounds for NCAM1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Thiolutin | RNA polymerase inhibitor,antibiotic | 1987-11-6 |
Transcripts for NCAM1 Gene
mRNA/cDNA for NCAM1 Gene
- (5) REFSEQ mRNAs :
- (22) Additional mRNA sequences :
- (303) Selected AceView cDNA sequences:
- (30) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NCAM1 Gene
- Neural cell adhesion molecule 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NCAM1
- genomics-online: gRNA clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
- Applied Biological Materials CRISPR for NCAM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NCAM1
- GenScript: Design CRISPR guide RNA sequences for NCAM1
miRNA Products
- Search ViGene Biosciences for NCAM1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NCAM1
- Browse OriGene Inhibitory RNA Products For NCAM1
- genomics-online: shRNA clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
Clone Products
-
OriGene ORF clones in human for NCAM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NCAM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NCAM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NCAM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NCAM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for NCAM1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
-
Cartilage (Muscoskeletal System)
- Prechondrocytes Rostral Synchondroses
- Prechondrocytes Synchondroses
- Prechondrocytes Branchial Arch 2
-
Bone (Muscoskeletal System)
- Prechondrocytes Rostral Synchondroses
- Prechondrocytes Synchondroses
- Prechondrocytes Branchial Arch 2
-
Peripheral Nervous System (Nervous System)
- Non-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
- Neurons
- Brain (Nervous System)
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Glial Cells
- Non-myelinating Schwann Cells Peripheral Nerve Domain
-
Head Mesenchyme (Muscoskeletal System)
- Prechondrocytes Branchial Arch 2
- Eye (Sensory Organs)
-
Heart (Cardiovascular System)
- Endocardial Cells Endocardium
This gene is overexpressed in Fetal Brain (17.6), Frontal cortex (11.4), Retina (11.0), and Brain (10.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCAM1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NCAM1 Gene:
NCAM1SOURCE GeneReport for Unigene cluster for NCAM1 Gene:
Hs.503878Evidence on tissue expression from TISSUES for NCAM1 Gene
- Nervous system(5)
- Bone marrow(4.6)
- Muscle(4.6)
- Liver(4.5)
- Kidney(4.4)
- Blood(3.7)
- Lung(2.9)
- Eye(2.8)
- Heart(2.8)
- Lymph node(2.7)
- Spleen(2.7)
- Adrenal gland(2.6)
- Thyroid gland(2.5)
- Intestine(2.4)
- Skin(2.4)
Primer Products
-
OriGene qPCR primer pairs for NCAM1
-
OriGene qPCR primer pairs and template standards for NCAM1
- genomics-online: primer clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAM1 Gene
Orthologs for NCAM1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NCAM1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NCAM1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NCAM1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ncam1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ncam1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | NCAM1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NCAM1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NCAM1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ncam1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | NCAM 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ncam1a 33 34 |
|
||
| ncam1b 34 |
|
OneToMany | |||
| -- 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002802 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Fas2 35 33 34 |
|
||
| CG15630 34 |
|
ManyToMany | |||
| CG33543 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ncam-1 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for NCAM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NCAM1 Gene
(5) SIMAP similar genes for NCAM1 Gene using alignment to 7 proteins:
Variants for NCAM1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000001757 | -- | 113,182,613(+) | T/C | intron_variant | |
| rs1000017383 | -- | 113,270,147(+) | T/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000063052 | -- | 113,012,056(+) | T/C | intron_variant | |
| rs1000087888 | -- | 113,194,179(+) | T/G | intron_variant | |
| rs1000090738 | -- | 113,263,846(+) | G/A | 3_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv951071 | CNV | duplication | 24416366 |
| nsv832272 | CNV | gain | 17160897 |
| nsv832271 | CNV | gain | 17160897 |
| nsv556443 | CNV | loss | 21841781 |
| nsv556442 | CNV | loss | 21841781 |
| nsv526604 | CNV | loss | 19592680 |
| nsv516224 | CNV | loss | 19592680 |
| nsv515828 | CNV | loss | 19592680 |
| nsv483080 | CNV | loss | 15286789 |
| nsv468870 | CNV | loss | 19166990 |
| nsv1038796 | CNV | gain | 25217958 |
| esv3627775 | CNV | loss | 21293372 |
| esv3627774 | CNV | loss | 21293372 |
| esv3627773 | CNV | gain | 21293372 |
| esv3627772 | CNV | loss | 21293372 |
| esv3627771 | CNV | loss | 21293372 |
| esv3548358 | CNV | deletion | 23714750 |
| esv2745085 | CNV | deletion | 23290073 |
| esv2664094 | CNV | deletion | 23128226 |
| esv24924 | CNV | loss | 19812545 |
| dgv1279n100 | CNV | loss | 25217958 |
Gene Damage Index Score:
7.28;
81.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NCAM1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAM1 Gene
Disorders for NCAM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rabies |
|
|
| blastic plasmacytoid dendritic cell |
|
|
| hypoganglionosis |
|
|
| neuroendocrine tumor |
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| plasma cell leukemia |
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Search NCAM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NCAM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NCAM1 Gene
Publications for NCAM1 Gene
- Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56). (PMID: 1710251) Lanier LL … Phillips JH (Journal of immunology (Baltimore, Md. : 1950) 1991) 3 4 22 58
- Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. (PMID: 21212386) Arnett DK … Kardia SL (Circulation research 2011) 3 44 58
- Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
Products for NCAM1 Gene
- R&D Systems Antibodies for NCAM1 (NCAM-1/CD56)
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- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for NCAM1 (NCAM-1/CD56)
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- Custom Antibody ServicesOriGene Antibodies for NCAM1
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- Cloud-Clone Corp. Antibodies for NCAM1
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor for NCAM1
- Invitrogen Antibodies for NCAM1
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- VectorBuilder custom plasmid, inducible vectors for NCAM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NCAM1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 983 available CD56 Antibodies ranked by validation data
- Compare Top CD56 Antibodies
- antibodies-online: Search results for 34 available CD56 Elisa Kits ranked by validation data
- Compare Top CD56 Elisa Kits
- antibodies-online: Search results for 26 available CD56 Proteins ranked by validation data
- Compare Top CD56 Proteins
- GeneTex NCAM1 antibody for NCAM1
- Search GeneTex for Proteins for NCAM1
- Search ViGene Biosciences for NCAM1
- Santa Cruz Biotechnology (SCBT) Antibodies for NCAM1
- Search Santa Cruz Biotechnology (SCBT) for NCAM1 siRNA/shRNA
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- Horizon Cell Lines for NCAM1
- genomics-online: cdna clones - Search results for 149 available CD56 gene related products
- Overview of 149 available CD56 gene related products
- orf clones - Search results for 149 available CD56 gene related products
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- genomics-online: primer clones - Search results for 149 available CD56 gene related products
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Sources for NCAM1 Gene
- (1) GeneCards
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- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
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- (54) Leiden
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
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