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This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]
NBR2 (Neighbor Of BRCA1 LncRNA 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NBR2 include Breast-Ovarian Cancer, Familial 1 and Bilateral Breast Cancer.
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00008B7527_9606 | lncRNA | 978 | 4 |
Ensembl: ENST00000356906 (view in UCSC) , LncBook: HSALNT0240942, LNCipedia: NBR2:5, NONCODE: NONHSAT053818.2, |
URS0000A77648_9606 | lncRNA | 1512 | 2 |
HGNC: 20691, RefSeq: NR_003108, |
URS0000D64D19_9606 | lncRNA | 1344 | 2 |
Ensembl: ENST00000460115 (view in UCSC) , LNCipedia: NBR2:9, |
URS0000D64165_9606 | lncRNA | 1158 | 2 |
Ensembl: ENST00000467245 (view in UCSC) , LNCipedia: NBR2:10, |
URS0000EF3948_9606 | lncRNA | 1895 | 1 |
Ensembl: ENST00000657841 (view in UCSC) , |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs112881775 | Benign: Breast-ovarian cancer, familial 1 | 43,127,866(+) | GAC/G | ||
rs11655505 | Benign: Breast-ovarian cancer, familial 1 | 43,126,360(+) | G/A | ||
rs12947782 | Benign: Breast-ovarian cancer, familial 1 | 43,127,865(+) | A/G | ||
rs144412026 | Benign: Breast-ovarian cancer, familial 1 | 43,126,870(+) | C/T | ||
rs183796323 | Benign: Breast-ovarian cancer, familial 1 | 43,127,512(+) | A/G |
Disorder | Aliases | PubMed IDs |
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breast-ovarian cancer, familial 1 |
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bilateral breast cancer |
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