Free for academic non-profit institutions. Other users need a Commercial license
This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a ... See more...
Aliases for NBR2 Gene
Subcategory (RNA class) for NBR2 Gene
lncRNA
Number of RNA Genes sources:
3 / 17
Aliases for NBR2 Gene
External Ids for NBR2 Gene
- HGNC: 20691
- Entrez Gene: 10230
- Ensembl: ENSG00000198496
- OMIM: 618708
- UniProtKB: Q6PL46
Previous GeneCards Identifiers for NBR2 Gene
- GC17P041024
- GC17P043442
- GC17P041186
- GC17P041650
- GC17P038531
- GC17P041277
- GC17P037043
Summaries for NBR2 Gene
-
This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]
GeneCards Summary for NBR2 Gene
NBR2 (Neighbor Of BRCA1 LncRNA 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NBR2 include Breast-Ovarian Cancer, Familial 1 and Bilateral Breast Cancer.
Rfam classification for NBR2 Gene
-
Neighbour of BRCA1 gene 2 converved region
Additional gene information for NBR2 Gene
- HGNC(20691)
- Entrez Gene(10230)
- Ensembl(ENSG00000198496)
- OMIM(618708)
- UniProtKB(Q6PL46)
- Open Targets Platform(ENSG00000198496)
- Search for NBR2 at DataMed
- Search for NBR2 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for NBR2 Gene
Genomics for NBR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NBR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NBR2 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the NBR2 gene promoter:
-
- ATF-2
- c-Jun
Genomic Locations for NBR2 Gene
Genomic Locations for NBR2 Gene
- chr17:43,125,551-43,153,671
- (GRCh38/hg38)
- Size:
- 28,121 bases
- Orientation:
- Plus strand
- chr17:41,277,600-41,305,688
- (GRCh37/hg19)
- Size:
- 28,089 bases
- Orientation:
- Plus strand
Genomic View for NBR2 Gene
Genes around NBR2 on UCSC Golden Path with GeneCards custom track
NBR2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 17q21.31 by HGNC
- 17q21.31 by Entrez Gene
- 17q21.31 by Ensembl
NBR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NBR2 Gene
Proteins for NBR2 Gene
-
Protein details for NBR2 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- Q6PL46-Q6PL46_HUMAN
- Recommended name:
- Neighbor of BRCA1 gene 2
- Protein Accession:
- Q6PL46
Protein attributes for NBR2 Gene
- Size:
- 64 amino acids
- Molecular mass:
- 6841 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for NBR2 Gene
No Post-translational modifications
Antibody Products
- Creative Biolabs Chicken Anti-NBR2 Polyclonal IgY
- antibodies-online: Search results for available NBR2 related products ranked by validation data
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NBR2
- Origene Custom Protein Services for NBR2
- Novus Biologicals proteins for NBR2
- antibodies-online: Search results for available NBR2 related products ranked by validation data
-
Abcam proteins for NBR2
No data available for DME Specific Peptides for NBR2 Gene
Domains & Families for NBR2 Gene
Gene Families for NBR2 Gene
Suggested Antigen Peptide Sequences for NBR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Neighbor of BRCA1 gene 2 protein (NBR2_HUMAN)
- Neighbor of BRCA1 gene 2 (Q6PL46_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NBR2 Gene
Function for NBR2 Gene
Phenotypes From GWAS Catalog for NBR2 Gene
Phenotypes for NBR2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NBR2 - Select products 50% OFF >
- * NBR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for NBR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NBR2
miRNA Products
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for NBR2
- Browse OriGene Inhibitory RNA Products For NBR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBR2
Clone Products
- Applied Biological Materials (abm): Clones for NBR2 - Select products 50% OFF >
- * NBR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NBR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NBR2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NBR2 Gene
Localization for NBR2 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| lysosome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NBR2 Gene
Transcripts for NBR2 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for NBR2 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00008B7527_9606 | lncRNA | 978 | 4 |
Ensembl: ENST00000356906 (view in UCSC) , LncBook: HSALNT0240942, LNCipedia: NBR2:5, NONCODE: NONHSAT053818.2, |
| URS0000A77648_9606 | lncRNA | 1512 | 2 |
HGNC: 20691, RefSeq: NR_003108, |
| URS0000D64D19_9606 | lncRNA | 1344 | 2 |
Ensembl: ENST00000460115 (view in UCSC) , LNCipedia: NBR2:9, |
| URS0000D64165_9606 | lncRNA | 1158 | 2 |
Ensembl: ENST00000467245 (view in UCSC) , LNCipedia: NBR2:10, |
| URS0000EF3948_9606 | lncRNA | 1895 | 1 |
Ensembl: ENST00000657841 (view in UCSC) , |
NBR2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for NBR2 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NBR2 - Select products 50% OFF >
- * NBR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for NBR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NBR2
miRNA Products
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for NBR2
- Browse OriGene Inhibitory RNA Products For NBR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBR2
Clone Products
- Applied Biological Materials (abm): Clones for NBR2 - Select products 50% OFF >
- * NBR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NBR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NBR2
Relevant External Links for NBR2 Gene
- GeneLoc Exon Structure for
- NBR2
Expression for NBR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NBR2
SOURCE GeneReport for Unigene cluster for NBR2 Gene:
Hs.373818Primer Products
-
OriGene qPCR primer pairs for NBR2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NBR2 Gene
Orthologs for NBR2 Gene
No data available for Orthologs for NBR2 Gene
Paralogs for NBR2 Gene
(3) SIMAP similar genes for NBR2 Gene using alignment to 2 proteins:
- NBR2_HUMAN
- Q6PL46_HUMAN
No data available for Paralogs for NBR2 Gene
Variants for NBR2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NBR2 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112881775 | Benign: Breast-ovarian cancer, familial 1 | 43,127,866(+) | GAC/G | ||
| rs11655505 | Benign: Breast-ovarian cancer, familial 1 | 43,126,360(+) | G/A | ||
| rs12947782 | Benign: Breast-ovarian cancer, familial 1 | 43,127,865(+) | A/G | ||
| rs144412026 | Benign: Breast-ovarian cancer, familial 1 | 43,126,870(+) | C/T | ||
| rs183796323 | Benign: Breast-ovarian cancer, familial 1 | 43,127,512(+) | A/G |
Additional Variant Information for NBR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NBR2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NBR2 Gene
Disorders for NBR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast-ovarian cancer, familial 1 |
|
|
| bilateral breast cancer |
|
|
Search NBR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NBR2
No data available for UniProtKB/Swiss-Prot and Genatlas for NBR2 Gene
Publications for NBR2 Gene
- LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. (PMID: 26999735) Liu X … Gan B (Nature cell biology 2016) 2 3
- Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PMID: 15777733) Suen TC … Goss PE (Biochimica et biophysica acta 2005) 2 3
- Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PMID: 9215675) Xu CF … Solomon E (Human molecular genetics 1997) 2 3
- Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway. (PMID: 31888414) Yu H … Xu B (Technology in cancer research & treatment 2019) 3
- MiR-19a Affects Hepatocyte Autophagy via Regulating lncRNA NBR2 and AMPK/PPARα in D-GalN/Lipopolysaccharide-Stimulated Hepatocytes. (PMID: 28586153) Liu YM … Yu ZJ (Journal of cellular biochemistry 2018) 3
ExternalLinks
Products for NBR2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NBR2
- Origene Custom Protein Services for NBR2
- Origene shrna and RNAi products in human, mouse, rat for NBR2
- Browse OriGene Inhibitory RNA Products For NBR2
- OriGene qPCR primer pairs for NBR2
- Browse CRISPR knockouts for NBR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NBR2
- Sino Biological Human cDNA Clone for NBR2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals proteins for NBR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for NBR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for NBR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NBR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NBR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NBR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NBR2
- antibodies-online: Search results for available NBR2 related products ranked by validation data
- antibodies-online: Search results for available NBR2 related products ranked by validation data
- antibodies-online: Search results for available NBR2 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NBR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NBR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NBR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBR2
Sources for NBR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB