This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a ... See more...

Aliases for NBR2 Gene

Subcategory (RNA class) for NBR2 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for NBR2 Gene

  • Neighbor Of BRCA1 LncRNA 2 2 3 5
  • NBR2 2 5 165
  • Neighbor Of BRCA1 Gene 2 (Non-Protein Coding) 2 3
  • Neighbor Of BRCA1 Gene 2 2 13
  • NCRNA00192 2 3
  • Neighbor Of BRCA1 Gene 2 Protein 3
  • Next To BRCA1 Gene 2 Protein 3
  • Non-Protein Coding RNA 192 2
  • NONHSAG021874.2 91
  • HSALNG0116616 164

External Ids for NBR2 Gene

Previous GeneCards Identifiers for NBR2 Gene

  • GC17P041024
  • GC17P043442
  • GC17P041186
  • GC17P041650
  • GC17P038531
  • GC17P041277
  • GC17P037043

Summaries for NBR2 Gene

Entrez Gene Summary for NBR2 Gene

  • This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]

GeneCards Summary for NBR2 Gene

NBR2 (Neighbor Of BRCA1 LncRNA 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NBR2 include Breast-Ovarian Cancer, Familial 1 and Bilateral Breast Cancer.

Rfam classification for NBR2 Gene

  • Neighbour of BRCA1 gene 2 converved region

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for NBR2 Gene

Genomics for NBR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NBR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NBR2 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the NBR2 gene promoter:
  • ATF-2
  • c-Jun

Genomic Locations for NBR2 Gene

Genomic Locations for NBR2 Gene
chr17:43,125,551-43,153,671
(GRCh38/hg38)
Size:
28,121 bases
Orientation:
Plus strand
chr17:41,277,600-41,305,688
(GRCh37/hg19)
Size:
28,089 bases
Orientation:
Plus strand

Genomic View for NBR2 Gene

Genes around NBR2 on UCSC Golden Path with GeneCards custom track
NBR2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
NBR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBR2 Gene

Proteins for NBR2 Gene

  • Protein details for NBR2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q6PL46-Q6PL46_HUMAN
    Recommended name:
    Neighbor of BRCA1 gene 2
    Protein Accession:
    Q6PL46

    Protein attributes for NBR2 Gene

    Size:
    64 amino acids
    Molecular mass:
    6841 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NBR2 Gene

Post-translational modifications for NBR2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NBR2 Gene

Domains & Families for NBR2 Gene

Gene Families for NBR2 Gene

Protein Domains for NBR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NBR2 Gene

GenScript: Design optimal peptide antigens:
  • Neighbor of BRCA1 gene 2 protein (NBR2_HUMAN)
  • Neighbor of BRCA1 gene 2 (Q6PL46_HUMAN)
genes like me logo Genes that share domains with NBR2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NBR2 Gene

Function for NBR2 Gene

Phenotypes From GWAS Catalog for NBR2 Gene

genes like me logo Genes that share phenotypes with NBR2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBR2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NBR2 Gene

Localization for NBR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NBR2 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NBR2 Gene

Pathways & Interactions for NBR2 Gene

PathCards logo

SuperPathways for NBR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NBR2 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NBR2 Gene

Drugs & Compounds for NBR2 Gene

No Compound Related Data Available

Transcripts for NBR2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for NBR2 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00008B7527_9606 lncRNA 978 4

Ensembl: ENST00000356906 (view in UCSC) ,

LncBook: HSALNT0240942,

LNCipedia: NBR2:5,

NONCODE: NONHSAT053818.2,

URS0000A77648_9606 lncRNA 1512 2

HGNC: 20691,

RefSeq: NR_003108,

URS0000D64D19_9606 lncRNA 1344 2

Ensembl: ENST00000460115 (view in UCSC) ,

LNCipedia: NBR2:9,

URS0000D64165_9606 lncRNA 1158 2

Ensembl: ENST00000467245 (view in UCSC) ,

LNCipedia: NBR2:10,

URS0000EF3948_9606 lncRNA 1895 1

Ensembl: ENST00000657841 (view in UCSC) ,

NBR2 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for NBR2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBR2

Alternative Splicing Database (ASD) splice patterns (SP) for NBR2 Gene

No ASD Table

Relevant External Links for NBR2 Gene

GeneLoc Exon Structure for
NBR2

Expression for NBR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NBR2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NBR2

SOURCE GeneReport for Unigene cluster for NBR2 Gene:

Hs.373818
genes like me logo Genes that share expression patterns with NBR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NBR2 Gene

Orthologs for NBR2 Gene

Evolution for NBR2 Gene

ENSEMBL:
Gene Tree for NBR2 (if available)
TreeFam:
Gene Tree for NBR2 (if available)

No data available for Orthologs for NBR2 Gene

Paralogs for NBR2 Gene

(3) SIMAP similar genes for NBR2 Gene using alignment to 2 proteins:

  • NBR2_HUMAN
  • Q6PL46_HUMAN
genes like me logo Genes that share paralogs with NBR2: view

No data available for Paralogs for NBR2 Gene

Variants for NBR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NBR2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs112881775 Benign: Breast-ovarian cancer, familial 1 43,127,866(+) GAC/G
rs11655505 Benign: Breast-ovarian cancer, familial 1 43,126,360(+) G/A
rs12947782 Benign: Breast-ovarian cancer, familial 1 43,127,865(+) A/G
rs144412026 Benign: Breast-ovarian cancer, familial 1 43,126,870(+) C/T
rs183796323 Benign: Breast-ovarian cancer, familial 1 43,127,512(+) A/G

Additional dbSNP identifiers (rs#s) for NBR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NBR2 Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv457743 CNV loss 19166990
nsv470587 CNV loss 18288195
nsv575053 CNV loss 21841781
nsv978428 CNV duplication 23825009

Additional Variant Information for NBR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NBR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NBR2 Gene

Disorders for NBR2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NBR2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast-ovarian cancer, familial 1
  • breast-ovarian cancer, familial, susceptibility to, 1
bilateral breast cancer
  • bilateral breast carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NBR2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NBR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBR2 Gene

Publications for NBR2 Gene

  1. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. (PMID: 26999735) Liu X … Gan B (Nature cell biology 2016) 2 3
  2. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PMID: 15777733) Suen TC … Goss PE (Biochimica et biophysica acta 2005) 2 3
  3. Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PMID: 9215675) Xu CF … Solomon E (Human molecular genetics 1997) 2 3
  4. Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway. (PMID: 31888414) Yu H … Xu B (Technology in cancer research & treatment 2019) 3
  5. MiR-19a Affects Hepatocyte Autophagy via Regulating lncRNA NBR2 and AMPK/PPARα in D-GalN/Lipopolysaccharide-Stimulated Hepatocytes. (PMID: 28586153) Liu YM … Yu ZJ (Journal of cellular biochemistry 2018) 3

Products for NBR2 Gene

Sources for NBR2 Gene