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Aliases for NBR1 Gene

Aliases for NBR1 Gene

  • NBR1, Autophagy Cargo Receptor 2 3 5
  • Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma Antigen CA125) 2 3
  • Cell Migration-Inducing Gene 19 Protein 3 4
  • Neighbor Of BRCA1 Gene 1 2 3
  • M17S2 3 4
  • Membrane Component Chromosome 17 Surface Marker 2 4
  • Neighbor Of BRCA1 Gene 1 Protein 4
  • Migration-Inducing Protein 19 3
  • Next To BRCA1 Gene 1 Protein 3
  • Protein 1A1-3B 4
  • B-Box Protein 3
  • KIAA0049 4
  • 1A1-3B 3
  • IAI3B 3
  • MIG19 3
  • 1A13B 4

External Ids for NBR1 Gene

Previous HGNC Symbols for NBR1 Gene

  • M17S2

Previous GeneCards Identifiers for NBR1 Gene

  • GC17P9L0001
  • GC17P038578
  • GC17P041322
  • GC17P037088

Summaries for NBR1 Gene

Entrez Gene Summary for NBR1 Gene

  • The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for NBR1 Gene

NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Synucleinopathy. Among its related pathways are Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.

UniProtKB/Swiss-Prot for NBR1 Gene

  • Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Gene Wiki entry for NBR1 Gene

Additional gene information for NBR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBR1 Gene

Genomics for NBR1 Gene

GeneHancer (GH) Regulatory Elements for NBR1 Gene

Promoters and enhancers for NBR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J043168 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.5 +0.6 595 5 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 GLIS1 NBR1 BRCA1 BRCA1P1 ENSG00000267002 LOC101929767 PIR60622 ENSG00000267340 NBR2 TMEM106A C17orf53
GH17J043124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.3 -44.9 -44890 2.8 MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A ZNF610 GLIS1 NBR2 PIR48082 PIR61659 NBR1 BRCA1 DHX8 HMGN1P29 ENSG00000267758 LINC00910 RETREG3
GH17J042386 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.5 -782.0 -782023 4.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 STAT3 GC17M042386 NBR1 ENSG00000267765 ENSG00000267002 KLHL10 HMGN1P29 ENSG00000267758 ENSG00000267340 TUBG2
GH17J043359 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 29.5 +190.6 190592 3.8 PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 IRF4 ENSG00000279602 NBR2 DHX8 ASB16-AS1 TMUB2 HMGN1P29 LINC00910 NBR1 UBTF PSME3
GH17J043322 Enhancer 1.5 Ensembl ENCODE dbSUPER 30.6 +152.7 152692 1.6 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 UBTF ASB16-AS1 ENSG00000267340 DHX8 ENSG00000267002 HMGN1P29 TMUB2 NBR2 LINC00910 PLEKHH3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NBR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NBR1 gene promoter:
  • p53
  • SRF

Genomic Locations for NBR1 Gene

Genomic Locations for NBR1 Gene
41,219 bases
Plus strand
41,211 bases
Plus strand

Genomic View for NBR1 Gene

Genes around NBR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBR1 Gene

Proteins for NBR1 Gene

  • Protein details for NBR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Next to BRCA1 gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • Q13173
    • Q15026
    • Q5J7Q8
    • Q96GB6
    • Q9NRF7

    Protein attributes for NBR1 Gene

    966 amino acids
    Molecular mass:
    107413 Da
    Quaternary structure:
    • Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.
    • Sequence=BAA06417.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NBR1 Gene

    Alternative splice isoforms for NBR1 Gene


neXtProt entry for NBR1 Gene

Post-translational modifications for NBR1 Gene

  • Ubiquitination at Lys887, Lys627, Lys537, isoforms=2515, isoforms=2499, and Lys464
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NBR1_HUMAN (363)

Antibody Products

  • Abcam antibodies for NBR1
  • Boster Bio Antibodies for NBR1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NBR1

No data available for DME Specific Peptides for NBR1 Gene

Domains & Families for NBR1 Gene

Gene Families for NBR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • The PB1 domain mediates interaction with SQSTM1.
  • The PB1 domain mediates interaction with SQSTM1.
genes like me logo Genes that share domains with NBR1: view

Function for NBR1 Gene

Molecular function for NBR1 Gene

UniProtKB/Swiss-Prot Function:
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Phenotypes From GWAS Catalog for NBR1 Gene

Gene Ontology (GO) - Molecular Function for NBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19250911
GO:0008270 zinc ion binding IEA --
GO:0043130 ubiquitin binding IDA 19427866
GO:0046872 metal ion binding IEA --
GO:0051019 mitogen-activated protein kinase binding ISS --
genes like me logo Genes that share ontologies with NBR1: view
genes like me logo Genes that share phenotypes with NBR1: view

Animal Models for NBR1 Gene

MGI Knock Outs for NBR1:
  • Nbr1 Nbr1<tm1Whca>
  • Nbr1 Nbr1<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for NBR1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBR1

Clone Products

  • Addgene plasmids for NBR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NBR1 Gene

Localization for NBR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBR1 Gene

Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911). {ECO:0000250 UniProtKB:Q501R9, ECO:0000269 PubMed:19250911}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NBR1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endosome 5
lysosome 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 colocalizes_with mitochondrion IDA 21296869
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with NBR1: view

Pathways & Interactions for NBR1 Gene

SuperPathway Contained pathways
1 Mitophagy - animal
genes like me logo Genes that share pathways with NBR1: view

Pathways by source for NBR1 Gene

1 KEGG pathway for NBR1 Gene

SIGNOR curated interactions for NBR1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016236 macroautophagy IDA 19250911
GO:0030500 regulation of bone mineralization ISS --
GO:0032872 regulation of stress-activated MAPK cascade ISS --
GO:0045668 negative regulation of osteoblast differentiation ISS --
GO:0051259 protein complex oligomerization IDA 19250911
genes like me logo Genes that share ontologies with NBR1: view

Drugs & Compounds for NBR1 Gene

No Compound Related Data Available

Transcripts for NBR1 Gene

mRNA/cDNA for NBR1 Gene

Unigene Clusters for NBR1 Gene

Neighbor of BRCA1 gene 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBR1

Clone Products

  • Addgene plasmids for NBR1

Alternative Splicing Database (ASD) splice patterns (SP) for NBR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^
SP11: - -
SP13: - - - -
SP14: - - - - - - -
SP15: - - -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP2: - - -
SP3: - - -
SP6: -
SP8: - -
SP9: - -
SP10: - - -
SP12: - -

Relevant External Links for NBR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NBR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NBR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NBR1 Gene

This gene is overexpressed in Testis (37.1) and Tlymphocyte (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NBR1 Gene

Protein tissue co-expression partners for NBR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NBR1 Gene:


SOURCE GeneReport for Unigene cluster for NBR1 Gene:


Evidence on tissue expression from TISSUES for NBR1 Gene

  • Nervous system(4.6)
  • Bone marrow(4.2)
  • Lung(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with NBR1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NBR1 Gene

Orthologs for NBR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NBR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NBR1 34 33
  • 98.62 (n)
(Bos Taurus)
Mammalia NBR1 34 33
  • 90.03 (n)
(Canis familiaris)
Mammalia NBR1 34 33
  • 88.87 (n)
(Rattus norvegicus)
Mammalia Nbr1 33
  • 86.63 (n)
(Mus musculus)
Mammalia Nbr1 16 34 33
  • 86.42 (n)
(Monodelphis domestica)
Mammalia NBR1 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia NBR1 34
  • 49 (a)
(Gallus gallus)
Aves NBR1 34 33
  • 64.34 (n)
(Anolis carolinensis)
Reptilia NBR1 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nbr1 33
  • 61.48 (n)
(Danio rerio)
Actinopterygii LOC555713 33
  • 56.22 (n)
nbr1 34
  • 39 (a)
NBR1 (2 of 2) 34
  • 39 (a)
Species where no ortholog for NBR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NBR1 Gene

Gene Tree for NBR1 (if available)
Gene Tree for NBR1 (if available)
Evolutionary constrained regions (ECRs) for NBR1: view image

Paralogs for NBR1 Gene

No data available for Paralogs for NBR1 Gene

Variants for NBR1 Gene

Sequence variations from dbSNP and Humsavar for NBR1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000049412 -- 43,182,501(+) A/G intron_variant
rs1000162940 -- 43,209,529(+) A/G intron_variant
rs1000172817 -- 43,197,983(+) C/T intron_variant
rs1000326278 -- 43,190,961(+) A/G intron_variant
rs1000345962 -- 43,170,561(+) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NBR1 Gene

Variant ID Type Subtype PubMed ID
esv2672005 CNV deletion 23128226
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
esv3640621 CNV loss 21293372
esv3640622 CNV loss 21293372
nsv1127574 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv510712 CNV deletion 20534489

Variation tolerance for NBR1 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.10; 93.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NBR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NBR1 Gene

Disorders for NBR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NBR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • alpha synucleinopathies
- elite association - COSMIC cancer census association via MalaCards
Search NBR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NBR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NBR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBR1 Gene

Publications for NBR1 Gene

  1. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. (PMID: 8069304) Campbell IG … Solomon E (Human molecular genetics 1994) 2 3 4 58
  2. The receptor proteins: pivotal roles in selective autophagy. (PMID: 26112016) Xu Z … Cao Y (Acta biochimica et biophysica Sinica 2015) 2 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover. (PMID: 19427866) Waters S … Gautel M (FEBS letters 2009) 3 4 58
  5. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. (PMID: 19250911) Kirkin V … Johansen T (Molecular cell 2009) 3 4 58

Products for NBR1 Gene

  • Addgene plasmids for NBR1

Sources for NBR1 Gene

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