Aliases for NBPF11 Gene

Aliases for NBPF11 Gene

  • NBPF Member 11 2 3 5
  • Neuroblastoma Breakpoint Family, Member 24 2 3
  • Neuroblastoma Breakpoint Family Member 11 3 4
  • NBPF24 3 4
  • Neuroblastoma Breakpoint Family Member 24 4
  • NBPF11 5

External Ids for NBPF11 Gene

Previous HGNC Symbols for NBPF11 Gene

  • NBPF24

Previous GeneCards Identifiers for NBPF11 Gene

  • GC01M143503
  • GC01M144744
  • GC01M146040
  • GC01M147574

Summaries for NBPF11 Gene

GeneCards Summary for NBPF11 Gene

NBPF11 (NBPF Member 11) is a Protein Coding gene. Diseases associated with NBPF11 include Neuroblastoma and Hydrolethalus Syndrome 1. An important paralog of this gene is NBPF12.

Additional gene information for NBPF11 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NBPF11 Gene

Genomics for NBPF11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NBPF11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J148149 Promoter 1.4 EPDnew Ensembl 600.7 +1.3 1321 4 PRDM10 ZNF692 BACH1 LARP7 PRDM1 ZNF143 ZIC2 ZNF501 HDAC1 POLR2A LOC105371227 NBPF11 piR-57616-003 BCL9 ENSG00000227733 ABHD17AP1 piR-33324 GPR89B
GH01J148131 Promoter/Enhancer 0.5 EPDnew Ensembl 600.4 +20.7 20721 1.2 piR-41732-005 NBPF11 PFN1P4 GPR89B
GH01J149079 Promoter 0.3 EPDnew 600 -926.7 -926745 0.1 NONHSAG002673.2-001 NBPF11 piR-61860-009 NBPF9 PDE4DIP
GH01J148262 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 0.1 -111.8 -111778 3 BRCA1 ARHGAP35 CREB1 HNRNPL TEAD4 PRDM10 ZNF629 RFX1 LEF1 IKZF1 TRQ-CTG4-1 RNVU1-22 lnc-NBPF11-8 ENSG00000225871 GPR89B ACP6 BCL9 LINC01731 NBPF11 PPIAL4G
GH01J148153 Promoter 0.3 Ensembl 0.7 -2.1 -2079 2 LINC02805 piR-56014-002 LOC105371227 NBPF11 PPIAL4G
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NBPF11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NBPF11

Top Transcription factor binding sites by QIAGEN in the NBPF11 gene promoter:
  • AhR
  • AML1a
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • HTF
  • NF-kappaB
  • NF-kappaB1
  • p53
  • RelA

Genomic Locations for NBPF11 Gene

Genomic Locations for NBPF11 Gene
50,277 bases
Minus strand
50,224 bases
Minus strand

Genomic View for NBPF11 Gene

Genes around NBPF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBPF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBPF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBPF11 Gene

Proteins for NBPF11 Gene

  • Protein details for NBPF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuroblastoma breakpoint family member 11
    Protein Accession:
    Secondary Accessions:
    • B1AKG1
    • B7Z7R4
    • Q5RGN0

    Protein attributes for NBPF11 Gene

    865 amino acids
    Molecular mass:
    99433 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD89962.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAI17086.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21822.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    • Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Alternative splice isoforms for NBPF11 Gene


neXtProt entry for NBPF11 Gene

Post-translational modifications for NBPF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NBPF11 Gene

No data available for DME Specific Peptides for NBPF11 Gene

Domains & Families for NBPF11 Gene

Gene Families for NBPF11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NBPF11 Gene


Suggested Antigen Peptide Sequences for NBPF11 Gene

GenScript: Design optimal peptide antigens:
  • Neuroblastoma breakpoint family member 11 (NBPFB_HUMAN)
  • Putative neuroblastoma breakpoint family member 24 (NBPFN_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NBPF family.
  • Belongs to the NBPF family.
genes like me logo Genes that share domains with NBPF11: view

Function for NBPF11 Gene

Phenotypes for NBPF11 Gene

genes like me logo Genes that share phenotypes with NBPF11: view

Animal Model Products

CRISPR Products

miRNA for NBPF11 Gene

miRTarBase miRNAs that target NBPF11

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBPF11

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NBPF11 Gene

Localization for NBPF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBPF11 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NBPF11 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NBPF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NBPF11: view

Pathways & Interactions for NBPF11 Gene

PathCards logo

SuperPathways for NBPF11 Gene

No Data Available

Interacting Proteins for NBPF11 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000477509 Q86T75-NBPFB_HUMAN for NBPF11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NBPF11 Gene


No data available for Pathways by source and SIGNOR curated interactions for NBPF11 Gene

Drugs & Compounds for NBPF11 Gene

No Compound Related Data Available

Transcripts for NBPF11 Gene

mRNA/cDNA for NBPF11 Gene

11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NBPF11

Alternative Splicing Database (ASD) splice patterns (SP) for NBPF11 Gene

No ASD Table

Relevant External Links for NBPF11 Gene

GeneLoc Exon Structure for

Expression for NBPF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NBPF11 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NBPF11 Gene

Protein tissue co-expression partners for NBPF11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NBPF11

SOURCE GeneReport for Unigene cluster for NBPF11 Gene:


mRNA Expression by UniProt/SwissProt for NBPF11 Gene:

Tissue specificity: Expressed in spinal cord.

Evidence on tissue expression from TISSUES for NBPF11 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NBPF11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NBPF11 Gene

Orthologs for NBPF11 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NBPF11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC458021 30
  • 89.72 (n)
Species where no ortholog for NBPF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NBPF11 Gene

Gene Tree for NBPF11 (if available)
Gene Tree for NBPF11 (if available)

Paralogs for NBPF11 Gene

(17) SIMAP similar genes for NBPF11 Gene using alignment to 9 proteins:

  • H0Y3T2_HUMAN
  • S4R397_HUMAN
  • S4R3V6_HUMAN
  • S4R3X8_HUMAN
  • S4R413_HUMAN Pseudogenes for NBPF11 Gene

genes like me logo Genes that share paralogs with NBPF11: view

Variants for NBPF11 Gene

Additional dbSNP identifiers (rs#s) for NBPF11 Gene

Structural Variations from Database of Genomic Variants (DGV) for NBPF11 Gene

Variant ID Type Subtype PubMed ID
dgv185n106 CNV deletion 24896259
dgv327n100 CNV gain 25217958
dgv46e214 CNV gain 21293372
dgv66e199 CNV deletion 23128226
esv24256 CNV gain 19812545
esv2761299 CNV gain+loss 21179565
nsv1000564 CNV gain 25217958
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1078219 CNV deletion 25765185
nsv1078733 CNV deletion 25765185
nsv1078736 CNV deletion 25765185
nsv1078778 CNV deletion 25765185
nsv1112544 CNV deletion 24896259
nsv1118128 CNV deletion 24896259
nsv1126211 CNV deletion 24896259
nsv1130971 CNV deletion 24896259
nsv1132304 CNV duplication 24896259
nsv482114 CNV gain 20164927
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv511130 CNV loss 21212237
nsv511157 CNV loss 21212237
nsv946319 CNV duplication 23825009
nsv946833 CNV duplication 23825009
nsv946834 CNV duplication 23825009
nsv946835 CNV duplication 23825009
nsv946836 CNV duplication 23825009
nsv946837 CNV duplication 23825009
nsv946838 CNV duplication 23825009
nsv946839 CNV duplication 23825009
nsv946840 CNV duplication 23825009
nsv951823 CNV deletion 24416366
nsv951834 CNV deletion 24416366
nsv951835 CNV deletion 24416366

Variation tolerance for NBPF11 Gene

Gene Damage Index Score: 3.18; 51.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NBPF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NBPF11 Gene

Disorders for NBPF11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NBPF11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • nb
hydrolethalus syndrome 1
  • hls1
duodenal atresia
  • duodenal stenosis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with NBPF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBPF11 Gene

Publications for NBPF11 Gene

  1. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PMID: 16079250) Vandepoele K … van Roy F (Molecular biology and evolution 2005) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W … Gygi SP (Molecular cell 2011) 3

Products for NBPF11 Gene

Sources for NBPF11 Gene