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Aliases for NBPF10 Gene

Aliases for NBPF10 Gene

  • NBPF Member 10 2 3 5
  • Neuroblastoma Breakpoint Family, Member 10 2
  • Neuroblastoma Breakpoint Family Member 10 3
  • NBPF9 3
  • AB6 3
  • AG1 3

External Ids for NBPF10 Gene

Previous GeneCards Identifiers for NBPF10 Gene

  • GC01P142784
  • GC01M016761
  • GC01P144001
  • GC01P145293
  • GC01M120910
  • GC01P145294
  • GC01P145297

Summaries for NBPF10 Gene

Entrez Gene Summary for NBPF10 Gene

  • This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for NBPF10 Gene

NBPF10 (NBPF Member 10) is a Protein Coding gene. Diseases associated with NBPF10 include Neuroblastoma. An important paralog of this gene is NBPF19.

Additional gene information for NBPF10 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBPF10 Gene

Genomics for NBPF10 Gene

GeneHancer (GH) Regulatory Elements for NBPF10 Gene

Promoters and enhancers for NBPF10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I146144 Promoter/Enhancer 1.3 EPDnew ENCODE 550.8 +0.0 44 0.2 HDGF HDAC1 ATF1 RB1 ARNT SIN3A ZNF2 RAD21 YY1 ARID2 NBPF10 PIR55278 ENSG00000213240
GH01I146145 Enhancer 0.6 ENCODE dbSUPER 550.8 -0.9 -896 0.2 NONO TSC22D4 PIR47870 NBPF10 NBPF20 PIAS3 POLR3C ENSG00000213240
GH01I146209 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -67.4 -67353 4.4 SMARCE1 ZNF174 L3MBTL2 JUN ZNF10 NFRKB CBFA2T3 ZNF316 SMARCA4 PRDM10 NOTCH2NL NBPF10 PIR33330 ENSG00000213240 PIR39582
GH01I146241 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -97.3 -97281 1 MEIS2 PKNOX1 ATF1 MAFG ZNF316 ZNF585B CREB1 ZNF143 NFE2 EMSY NOTCH2NL NBPF10 LOC105371254 LOC105371249
GH01I145976 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.9 +162.5 162521 10.6 CLOCK YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC NBPF20 POLR3C GPR89A PIAS3 ANKRD35 HFE2 RBM8A LIX1L-AS1 PEX11B ENSG00000213240
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NBPF10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NBPF10 gene promoter:

Genomic Locations for NBPF10 Gene

Genomic Locations for NBPF10 Gene
80,106 bases
Minus strand

Genomic View for NBPF10 Gene

Genes around NBPF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBPF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBPF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBPF10 Gene

Proteins for NBPF10 Gene

  • Protein details for NBPF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuroblastoma breakpoint family member 10
    Protein Accession:
    Secondary Accessions:
    • Q5RHC0
    • Q9NWN6

    Protein attributes for NBPF10 Gene

    841 amino acids
    Molecular mass:
    96426 Da
    Quaternary structure:
    No Data Available
    • Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Alternative splice isoforms for NBPF10 Gene


neXtProt entry for NBPF10 Gene

Post-translational modifications for NBPF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NBPF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NBPF10 Gene

Domains & Families for NBPF10 Gene

Gene Families for NBPF10 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for NBPF10 Gene


Suggested Antigen Peptide Sequences for NBPF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NBPF family.
  • Belongs to the NBPF family.
genes like me logo Genes that share domains with NBPF10: view

Function for NBPF10 Gene

Gene Ontology (GO) - Molecular Function for NBPF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
genes like me logo Genes that share ontologies with NBPF10: view

Phenotypes for NBPF10 Gene

GenomeRNAi human phenotypes for NBPF10:
genes like me logo Genes that share phenotypes with NBPF10: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NBPF10 Gene

Localization for NBPF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBPF10 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NBPF10 gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NBPF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NBPF10: view

Pathways & Interactions for NBPF10 Gene

SuperPathways for NBPF10 Gene

No Data Available

Interacting Proteins for NBPF10 Gene

Gene Ontology (GO) - Biological Process for NBPF10 Gene


No data available for Pathways by source and SIGNOR curated interactions for NBPF10 Gene

Drugs & Compounds for NBPF10 Gene

No Compound Related Data Available

Transcripts for NBPF10 Gene

mRNA/cDNA for NBPF10 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBPF10 Gene

No ASD Table

Relevant External Links for NBPF10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NBPF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NBPF10 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NBPF10 Gene

Protein tissue co-expression partners for NBPF10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NBPF10 Gene:

genes like me logo Genes that share expression patterns with NBPF10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NBPF10 Gene

Orthologs for NBPF10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NBPF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC458021 33
  • 85.69 (n)
Species where no ortholog for NBPF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NBPF10 Gene

Gene Tree for NBPF10 (if available)
Gene Tree for NBPF10 (if available)

Paralogs for NBPF10 Gene

Variants for NBPF10 Gene

Sequence variations from dbSNP and Humsavar for NBPF10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1043492 -- 146,066,165(-) G/T downstream_transcript_variant
rs1043495 -- 146,066,155(-) C/A/T downstream_transcript_variant
rs1043749 -- 146,066,529(-) C/A/G/T coding_sequence_variant, missense_variant
rs1043765 -- 146,066,307(-) C/A/G/T downstream_transcript_variant
rs1043767 -- 146,066,303(-) A/C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NBPF10 Gene

Variant ID Type Subtype PubMed ID
dgv18n82 CNV duplication 23825009
dgv327n100 CNV gain 25217958
dgv3n6 CNV deletion 16902084
dgv66e199 CNV deletion 23128226
esv2248028 CNV deletion 18987734
esv2667344 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
esv3540411 CNV deletion 23714750
esv3571119 CNV gain 25503493
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1075385 CNV duplication 25765185
nsv1075794 CNV duplication 25765185
nsv1076340 CNV duplication 25765185
nsv1076341 CNV duplication 25765185
nsv1076778 CNV deletion 25765185
nsv1077298 CNV duplication 25765185
nsv1077299 CNV duplication 25765185
nsv1110138 CNV duplication 24896259
nsv1118449 CNV duplication 24896259
nsv1118450 CNV duplication 24896259
nsv1124582 CNV duplication 24896259
nsv1128614 CNV duplication 24896259
nsv1132306 CNV duplication 24896259
nsv1132307 CNV duplication 24896259
nsv1132308 CNV duplication 24896259
nsv1132309 CNV duplication 24896259
nsv1146139 CNV duplication 26484159
nsv1148915 CNV duplication 26484159
nsv1151944 CNV duplication 26484159
nsv13 CNV deletion 15895083
nsv160210 CNV deletion 16902084
nsv160417 CNV deletion 16902084
nsv24 CNV insertion 15895083
nsv2677 CNV deletion 18451855
nsv2688 CNV insertion 18451855
nsv433348 CNV gain 18776910
nsv508582 CNV deletion 20534489
nsv509457 CNV insertion 20534489
nsv8091 CNV gain 18304495
nsv831337 CNV loss 17160897
nsv831348 CNV loss 17160897
nsv831359 CNV loss 17160897
nsv946760 CNV duplication 23825009
nsv946761 CNV duplication 23825009
nsv946762 CNV duplication 23825009
nsv946763 CNV duplication 23825009
nsv946764 CNV duplication 23825009
nsv946765 CNV duplication 23825009
nsv946766 CNV duplication 23825009
nsv946767 CNV duplication 23825009
nsv946768 CNV duplication 23825009
nsv946769 CNV duplication 23825009
nsv946770 CNV duplication 23825009
nsv946771 CNV duplication 23825009
nsv946772 CNV duplication 23825009
nsv946774 CNV duplication 23825009
nsv946775 CNV duplication 23825009
nsv946777 CNV duplication 23825009
nsv946778 CNV duplication 23825009
nsv946779 CNV duplication 23825009
nsv946780 CNV duplication 23825009
nsv946781 CNV duplication 23825009
nsv946782 CNV duplication 23825009
nsv946783 CNV duplication 23825009
nsv946785 CNV duplication 23825009
nsv946786 CNV duplication 23825009
nsv946787 CNV duplication 23825009
nsv946788 CNV duplication 23825009
nsv946789 CNV duplication 23825009
nsv946790 CNV duplication 23825009
nsv946791 CNV duplication 23825009
nsv946792 CNV duplication 23825009
nsv946793 CNV duplication 23825009
nsv946794 CNV duplication 23825009
nsv946795 CNV duplication 23825009
nsv946796 CNV duplication 23825009
nsv946797 CNV duplication 23825009
nsv946798 CNV duplication 23825009
nsv946799 CNV duplication 23825009
nsv946800 CNV duplication 23825009
nsv946801 CNV duplication 23825009
nsv946802 CNV duplication 23825009
nsv946803 CNV duplication 23825009
nsv946804 CNV duplication 23825009
nsv946807 CNV duplication 23825009
nsv946808 CNV duplication 23825009
nsv946813 CNV duplication 23825009
nsv946814 CNV duplication 23825009
nsv946815 CNV duplication 23825009
nsv946817 CNV duplication 23825009
nsv946818 CNV duplication 23825009
nsv946819 CNV duplication 23825009
nsv946846 CNV duplication 23825009
nsv946993 CNV duplication 23825009
nsv950946 CNV duplication 24416366
nsv952720 CNV deletion 24416366
nsv957530 CNV deletion 24416366

Variation tolerance for NBPF10 Gene

Gene Damage Index Score: 7.82; 83.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NBPF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NBPF10 Gene

Disorders for NBPF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NBPF10 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NBPF10

genes like me logo Genes that share disorders with NBPF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBPF10 Gene

Publications for NBPF10 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PMID: 16079250) Vandepoele K … van Roy F (Molecular biology and evolution 2005) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. (PMID: 24395524) Natrajan R … Reis-Filho JS (The Journal of pathology 2014) 3 58

Products for NBPF10 Gene

Sources for NBPF10 Gene

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