Aliases for NAXE Gene
External Ids for NAXE Gene
Previous HGNC Symbols for NAXE Gene
The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]
GeneCards Summary for NAXE Gene
NAXE (NAD(P)HX Epimerase) is a Protein Coding gene. Diseases associated with NAXE include Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 1 and Brain Edema. Among its related pathways are NAD metabolism and Metabolism of water-soluble vitamins and cofactors. An important paralog of this gene is YJEFN3.
UniProtKB/Swiss-Prot Summary for NAXE Gene
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed:23719382).