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Aliases for NAV2 Gene

Aliases for NAV2 Gene

  • Neuron Navigator 2 2 3 3 5
  • Pore Membrane And/Or Filament-Interacting-Like Protein 2 3 4
  • Retinoic Acid Inducible Gene In Neuroblastoma 1 2 3
  • Helicase, APC Down-Regulated 1 2 3
  • Unc-53 Homolog 2 3 4
  • Steerin-2 3 4
  • STEERIN2 3 4
  • POMFIL2 3 4
  • HELAD1 3 4
  • RAINB1 3 4
  • Pore Membrane And/Or Filament Interacting Like Protein 2 2
  • Retinoic Acid Inducible In Neuroblastoma 1 4
  • Helicase APC Down-Regulated 1 4
  • EC 4
  • KIAA1419 4
  • UNC53H2 3
  • Unc53H2 4

External Ids for NAV2 Gene

Previous GeneCards Identifiers for NAV2 Gene

  • GC11P020896
  • GC11P020678
  • GC11P019411
  • GC11P019699
  • GC11P019691
  • GC11P019056
  • GC11P019372
  • GC11P019353

Summaries for NAV2 Gene

Entrez Gene Summary for NAV2 Gene

  • This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NAV2 Gene

NAV2 (Neuron Navigator 2) is a Protein Coding gene. Diseases associated with NAV2 include Uterine Sarcoma and Neuroblastoma. Gene Ontology (GO) annotations related to this gene include heparin binding and helicase activity. An important paralog of this gene is NAV3.

UniProtKB/Swiss-Prot for NAV2 Gene

  • Possesses 3 to 5 helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.

Gene Wiki entry for NAV2 Gene

Additional gene information for NAV2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAV2 Gene

Genomics for NAV2 Gene

GeneHancer (GH) Regulatory Elements for NAV2 Gene

Promoters and enhancers for NAV2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J019344 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.7 +0.6 581 1.8 PKNOX1 NFIB SIN3A ZNF2 RAD21 ZEB1 ZNF335 GLIS2 EGR1 FOS NAV2 LOC100420121 LOC390101 LOC645397 ENSG00000256734 LDHAL6A LDHC GC11P019350 GC11P019352
GH11J019350 Promoter 0.5 EPDnew 650.4 +5.5 5538 0.1 GC11P019350 GC11P019352 NAV2
GH11J019365 Enhancer 0.9 Ensembl ENCODE 11.6 +23.5 23456 5.6 JUN MAX EBF1 YY1 CTBP1 GATA3 POLR2A FOS RXRA HLF NAV2 NAV2-AS5 NAV2-IT1 GC11P019350 GC11P019352
GH11J019380 Enhancer 0.8 Ensembl ENCODE 11.5 +35.4 35440 1.3 NCOA3 FOSL1 JUND JUN CREB1 FOSL2 ELF1 FOS GABPA NAV2-IT1 NAV2 GC11M019401 RNA5SP335
GH11J019373 Enhancer 0.7 Ensembl ENCODE 11.6 +29.3 29284 1.7 JUND JUN USF2 CEBPB FOSL2 FOS NAV2 NAV2-IT1 GC11P019350 GC11P019352
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAV2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAV2 gene promoter:
  • POU2F1
  • Pbx1a
  • Pax-3
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • Nkx2-5
  • Egr-3
  • E2F

Genomic Locations for NAV2 Gene

Genomic Locations for NAV2 Gene
776,355 bases
Plus strand
770,877 bases
Plus strand

Genomic View for NAV2 Gene

Genes around NAV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAV2 Gene

Proteins for NAV2 Gene

  • Protein details for NAV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuron navigator 2
    Protein Accession:
    Secondary Accessions:
    • A6NEC1
    • Q8IVK3
    • Q8IVK4
    • Q8IVK5
    • Q8IVK6
    • Q8IVK7
    • Q8IVK8
    • Q8NHC9
    • Q8NHD0
    • Q8TDE9
    • Q8TDF0
    • Q8TEB3
    • Q96B30
    • Q9NUZ6
    • Q9NVM7
    • Q9P2C8

    Protein attributes for NAV2 Gene

    2488 amino acids
    Molecular mass:
    268167 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92657.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB85038.1; Type=Frameshift; Positions=2074; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAV2 Gene

    Alternative splice isoforms for NAV2 Gene

neXtProt entry for NAV2 Gene

Post-translational modifications for NAV2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAV2 Gene

Domains & Families for NAV2 Gene

Gene Families for NAV2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NAV2 Gene

Suggested Antigen Peptide Sequences for NAV2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Nav/unc-53 family.
  • Belongs to the Nav/unc-53 family.
genes like me logo Genes that share domains with NAV2: view

Function for NAV2 Gene

Molecular function for NAV2 Gene

UniProtKB/Swiss-Prot Function:
Possesses 3 to 5 helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas.

Enzyme Numbers (IUBMB) for NAV2 Gene

Phenotypes From GWAS Catalog for NAV2 Gene

Gene Ontology (GO) - Molecular Function for NAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IEA,IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008201 heparin binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NAV2: view
genes like me logo Genes that share phenotypes with NAV2: view

Animal Model Products

miRNA for NAV2 Gene

miRTarBase miRNAs that target NAV2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAV2 Gene

Localization for NAV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAV2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAV2 gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005614 interstitial matrix IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NAV2: view

Pathways & Interactions for NAV2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback IEA --
GO:0007399 nervous system development IEA,IBA --
GO:0007605 sensory perception of sound IEA --
GO:0007608 sensory perception of smell IEA --
GO:0007626 locomotory behavior IEA --
genes like me logo Genes that share ontologies with NAV2: view

No data available for Pathways by source and SIGNOR curated interactions for NAV2 Gene

Drugs & Compounds for NAV2 Gene

(3) Drugs for NAV2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for NAV2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with NAV2: view

Transcripts for NAV2 Gene

Unigene Clusters for NAV2 Gene

Neuron navigator 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAV2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: -
SP2: - -
SP5: -
SP7: -

ExUns: 25b ^ 26 ^ 27a · 27b ^ 28a · 28b
SP1: -
SP4: -

Relevant External Links for NAV2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAV2 Gene

mRNA differential expression in normal tissues according to GTEx for NAV2 Gene

This gene is overexpressed in Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for NAV2 Gene

This gene is overexpressed in Plasma (24.2), Serum (21.5), Adipocyte (9.9), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAV2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAV2 Gene:


SOURCE GeneReport for Unigene cluster for NAV2 Gene:


mRNA Expression by UniProt/SwissProt for NAV2 Gene:

Tissue specificity: Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.

Evidence on tissue expression from TISSUES for NAV2 Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Skin(4.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with NAV2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAV2 Gene

Orthologs for NAV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAV2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAV2 34 33
  • 99.46 (n)
(Canis familiaris)
Mammalia NAV2 34 33
  • 90.81 (n)
(Monodelphis domestica)
Mammalia NAV2 34
  • 90 (a)
(Bos Taurus)
Mammalia NAV2 34 33
  • 89.58 (n)
(Ornithorhynchus anatinus)
Mammalia NAV2 34
  • 89 (a)
(Mus musculus)
Mammalia Nav2 16 34 33
  • 87.95 (n)
(Rattus norvegicus)
Mammalia Nav2 33
  • 87.7 (n)
(Gallus gallus)
Aves NAV2 34 33
  • 79.49 (n)
(Anolis carolinensis)
Reptilia NAV2 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nav2 33
  • 74.36 (n)
Str.4535 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.34129 33
(Danio rerio)
Actinopterygii NAV2 (2 of 2) 34
  • 67 (a)
nav2 33
  • 66.35 (n)
nav2b 34
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta sick 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea unc-53 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for NAV2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAV2 Gene

Gene Tree for NAV2 (if available)
Gene Tree for NAV2 (if available)
Evolutionary constrained regions (ECRs) for NAV2: view image

Paralogs for NAV2 Gene

Paralogs for NAV2 Gene

(3) SIMAP similar genes for NAV2 Gene using alignment to 5 proteins:

  • A7E2D6_HUMAN
genes like me logo Genes that share paralogs with NAV2: view

Variants for NAV2 Gene

Sequence variations from dbSNP and Humsavar for NAV2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs144875196 uncertain-significance, Hirschsprung disease 1 19,948,935(+) C/A/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, synonymous_variant
rs1000004774 -- 19,963,417(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000005922 -- 19,428,723(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000006959 -- 19,938,934(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000012375 -- 19,816,853(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NAV2 Gene

Variant ID Type Subtype PubMed ID
dgv331e212 CNV loss 25503493
esv1174411 CNV insertion 17803354
esv1611893 CNV deletion 17803354
esv22357 CNV loss 19812545
esv22573 CNV loss 19812545
esv2289070 CNV deletion 18987734
esv2397419 CNV deletion 18987734
esv2617564 CNV insertion 19546169
esv2619010 CNV deletion 19546169
esv2664376 CNV deletion 23128226
esv2666507 CNV deletion 23128226
esv2667194 CNV deletion 23128226
esv2673296 CNV deletion 23128226
esv2673508 CNV deletion 23128226
esv26763 CNV gain 19812545
esv2676711 CNV deletion 23128226
esv2744179 CNV deletion 23290073
esv2744180 CNV deletion 23290073
esv2759807 CNV loss 17122850
esv2760219 CNV loss 21179565
esv29003 CNV loss 19812545
esv3305801 CNV mobile element insertion 20981092
esv3307077 CNV mobile element insertion 20981092
esv3322153 CNV insertion 20981092
esv3341232 CNV insertion 20981092
esv3347903 CNV insertion 20981092
esv3359756 CNV insertion 20981092
esv3380200 CNV insertion 20981092
esv3432438 CNV insertion 20981092
esv3547400 CNV deletion 23714750
esv3625536 CNV loss 21293372
esv3625537 CNV loss 21293372
esv3625539 CNV loss 21293372
esv3625540 CNV loss 21293372
esv3625541 CNV loss 21293372
esv3625543 CNV loss 21293372
esv3625544 CNV loss 21293372
esv3625545 CNV loss 21293372
esv3625549 CNV loss 21293372
esv3625550 CNV loss 21293372
esv3625551 CNV loss 21293372
esv3891939 CNV gain 25118596
nsv1048120 CNV gain 25217958
nsv1069566 CNV deletion 25765185
nsv1113366 CNV deletion 24896259
nsv1127167 CNV deletion 24896259
nsv1145503 CNV deletion 24896259
nsv1159848 CNV deletion 26073780
nsv467720 CNV gain 19166990
nsv469939 CNV gain 18288195
nsv473528 CNV novel sequence insertion 20440878
nsv474041 CNV novel sequence insertion 20440878
nsv478559 CNV novel sequence insertion 20440878
nsv478774 CNV novel sequence insertion 20440878
nsv516382 CNV gain 19592680
nsv518583 CNV loss 19592680
nsv519433 CNV loss 19592680
nsv522845 CNV gain 19592680
nsv523404 CNV loss 19592680
nsv524136 CNV loss 19592680
nsv524289 CNV loss 19592680
nsv524463 CNV loss 19592680
nsv524632 CNV loss 19592680
nsv526704 CNV loss 19592680
nsv528404 CNV loss 19592680
nsv553677 CNV loss 21841781
nsv553678 CNV gain 21841781
nsv7700 CNV insertion 18451855
nsv818801 CNV gain 17921354
nsv825779 CNV loss 20364138
nsv825780 CNV gain 20364138
nsv951319 CNV duplication 24416366
nsv975159 CNV duplication 23825009

Variation tolerance for NAV2 Gene

Residual Variation Intolerance Score: 1.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.67; 98.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAV2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAV2 Gene

Disorders for NAV2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAV2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
uterine sarcoma
  • uterine corpus sarcoma
  • neuroblastoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search NAV2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAV2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NAV2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAV2 Gene

Publications for NAV2 Gene

  1. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PMID: 12062803) Coy JF … Poustka A (Gene 2002) 2 3 4 58
  2. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PMID: 12079279) Maes T … Buesa C (Genomics 2002) 2 3 4 58
  3. A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos. (PMID: 11904404) Merrill RA … Clagett-Dame M (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 4 22 58
  4. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa JR … Partners in Prevention HSV/HIV Transmission Study Team (PloS one 2011) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for NAV2 Gene

Sources for NAV2 Gene

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