Aliases for NAT9 Gene

Aliases for NAT9 Gene

  • N-Acetyltransferase 9 (Putative) 2 3 5
  • N-Acetyltransferase 9 2 3 4
  • N-Acetyltransferase 9 (GCN5-Related, Putative) 2 3
  • Embryo Brain Specific Protein 3
  • Embryo Brain-Specific Protein 4
  • EBSP, HNATL 3
  • EC 2.3.1.- 4
  • EBS 4

External Ids for NAT9 Gene

Previous GeneCards Identifiers for NAT9 Gene

  • GC17M070279
  • GC17M072766
  • GC17M068177

Summaries for NAT9 Gene

GeneCards Summary for NAT9 Gene

NAT9 (N-Acetyltransferase 9 (Putative)) is a Protein Coding gene. Diseases associated with NAT9 include Conjunctival Folliculosis and Ophthalmia Neonatorum. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and N-acetyltransferase activity.

Gene Wiki entry for NAT9 Gene

Additional gene information for NAT9 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAT9 Gene

Genomics for NAT9 Gene

GeneHancer (GH) Regulatory Elements for NAT9 Gene

Promoters and enhancers for NAT9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAT9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAT9 gene promoter:
  • GATA-2
  • GCNF
  • GCNF-1
  • GCNF-2
  • Max1
  • POU2F1
  • POU2F1a
  • RREB-1

Genomic Locations for NAT9 Gene

Genomic Locations for NAT9 Gene
chr17:74,770,547-74,776,395
(GRCh38/hg38)
Size:
5,849 bases
Orientation:
Minus strand
chr17:72,766,686-72,772,506
(GRCh37/hg19)
Size:
5,821 bases
Orientation:
Minus strand

Genomic View for NAT9 Gene

Genes around NAT9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT9 Gene

Proteins for NAT9 Gene

  • Protein details for NAT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE0-NAT9_HUMAN
    Recommended name:
    N-acetyltransferase 9
    Protein Accession:
    Q9BTE0
    Secondary Accessions:
    • B2R7F0
    • Q9BTD0
    • Q9Y3T3

    Protein attributes for NAT9 Gene

    Size:
    207 amino acids
    Molecular mass:
    23361 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAT9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT9 Gene

Post-translational modifications for NAT9 Gene

  • Ubiquitination at Lys33 and Lys118
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAT9 Gene

Domains & Families for NAT9 Gene

Gene Families for NAT9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAT9 Gene

Suggested Antigen Peptide Sequences for NAT9 Gene

GenScript: Design optimal peptide antigens:
  • Embryo brain-specific protein (NAT9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BTE0

UniProtKB/Swiss-Prot:

NAT9_HUMAN :
  • Belongs to the acetyltransferase family. GNAT subfamily.
Family:
  • Belongs to the acetyltransferase family. GNAT subfamily.
genes like me logo Genes that share domains with NAT9: view

Function for NAT9 Gene

Enzyme Numbers (IUBMB) for NAT9 Gene

Phenotypes From GWAS Catalog for NAT9 Gene

Gene Ontology (GO) - Molecular Function for NAT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA --
genes like me logo Genes that share ontologies with NAT9: view
genes like me logo Genes that share phenotypes with NAT9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAT9

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAT9

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT9 Gene

Localization for NAT9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAT9 gene
Compartment Confidence
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032991 protein-containing complex IDA --
genes like me logo Genes that share ontologies with NAT9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAT9 Gene

Pathways & Interactions for NAT9 Gene

PathCards logo

SuperPathways for NAT9 Gene

genes like me logo Genes that share pathways with NAT9: view

Pathways by source for NAT9 Gene

1 BioSystems pathway for NAT9 Gene

Gene Ontology (GO) - Biological Process for NAT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006473 protein acetylation IBA 21873635
genes like me logo Genes that share ontologies with NAT9: view

No data available for SIGNOR curated interactions for NAT9 Gene

Drugs & Compounds for NAT9 Gene

No Compound Related Data Available

Transcripts for NAT9 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAT9

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - - - -
SP25: - - - - - - - - - - - - - - - -
SP26: - - - - - - - - - -
SP27: - - - - - - - - - -
SP28: - - - - - -
SP29: - - - - - - - - - - - - - - - -
SP30: - - - - - - - - - - - - - - - -
SP31: - - - - - - - - -
SP32: - - - - - - - - - - - - - - - - - - -
SP33: - - - - - - - - -
SP34: - - - - - - -
SP35: - - - - - - -
SP36: - - -
SP37: - -
SP38:

ExUns: 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h · 13i · 13j · 13k · 13l
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - - -
SP6:
SP7: -
SP8: - - -
SP9: - - - - - - - - - -
SP10: -
SP11:
SP12: - - -
SP13: - - - - - - - - - -
SP14: - - -
SP15: -
SP16: - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - - - - - -
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35:
SP36:
SP37:
SP38: -

Relevant External Links for NAT9 Gene

GeneLoc Exon Structure for
NAT9
ECgene alternative splicing isoforms for
NAT9

Expression for NAT9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAT9 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAT9 Gene



NURSA nuclear receptor signaling pathways regulating expression of NAT9 Gene:

NAT9

SOURCE GeneReport for Unigene cluster for NAT9 Gene:

Hs.144058

Evidence on tissue expression from TISSUES for NAT9 Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Lung(4.4)
  • Adrenal gland(4.3)
  • Heart(2.8)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with NAT9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT9 Gene

Orthologs for NAT9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAT9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT9 33 32
  • 99.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NAT9 33 32
  • 92.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NAT9 33 32
  • 87.42 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nat9 32
  • 86.34 (n)
mouse
(Mus musculus)
Mammalia Nat9 17 33 32
  • 85.2 (n)
oppossum
(Monodelphis domestica)
Mammalia NAT9 33
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAT9 33
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAT9 33 32
  • 73.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAT9 33
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nat9 32
  • 67.91 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100004826 32
  • 63.28 (n)
nat9 33
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11539 33 32
  • 54.32 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007378 32
  • 49.49 (n)
worm
(Caenorhabditis elegans)
Secernentea Y67D2.5 33 32
  • 52.11 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04845 32
  • 55.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC577.03c 32
  • 52.19 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03760 32
  • 47.92 (n)
Species where no ortholog for NAT9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAT9 Gene

ENSEMBL:
Gene Tree for NAT9 (if available)
TreeFam:
Gene Tree for NAT9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAT9: view image

Paralogs for NAT9 Gene

No data available for Paralogs for NAT9 Gene

Variants for NAT9 Gene

Sequence variations from dbSNP and Humsavar for NAT9 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000175461 -- 74,775,486(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000883352 -- 74,777,604(-) C/T upstream_transcript_variant
rs1001063711 -- 74,770,852(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1001480797 -- 74,773,345(-) T/A intron_variant
rs1001636969 -- 74,775,010(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAT9 Gene

Variant ID Type Subtype PubMed ID
nsv952367 CNV deletion 24416366

Variation tolerance for NAT9 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.13; 75.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAT9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAT9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT9 Gene

Disorders for NAT9 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NAT9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
conjunctival folliculosis
  • acute follicular conjunctivitis
ophthalmia neonatorum
  • gonococcal conjunctivitis
epidermolysis bullosa simplex, dowling-meara type
  • ebsdm
germ cell and embryonal cancer
  • germ cell and embryonal neoplasm
commensal bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search NAT9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAT9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NAT9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAT9 Gene

Publications for NAT9 Gene

  1. Characterization, expression profile, polymorphism and association of porcine NAT9 gene. (PMID: 21688147) Jiugang Z … Yonggang L (Molecular biology reports 2012) 2 3 56
  2. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik JS … Ridker PM (Circulation. Cardiovascular genetics 2009) 3 43 56
  3. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. (PMID: 14608357) Helms C … Bowcock AM (Nature genetics 2003) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56

Products for NAT9 Gene

Sources for NAT9 Gene