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Aliases for NAT6 Gene

Aliases for NAT6 Gene

  • N-Acetyltransferase 6 2 3 5
  • Protein Fusion-2 3 4
  • FUS2 3 4
  • N-Acetyltransferase 6 (GCN5-Related) 3
  • Protein Fus-2 4
  • EC 2.3.1.- 4
  • FUS-2 3

External Ids for NAT6 Gene

Previous GeneCards Identifiers for NAT6 Gene

  • GC03M050293
  • GC03M050300
  • GC03M050308
  • GC03M050333

Summaries for NAT6 Gene

Entrez Gene Summary for NAT6 Gene

  • This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAT6 Gene

NAT6 (N-Acetyltransferase 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT6 Gene

  • Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.

Additional gene information for NAT6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT6 Gene

Genomics for NAT6 Gene

GeneHancer (GH) Regulatory Elements for NAT6 Gene

Promoters and enhancers for NAT6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I050297 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 556.2 -1.5 -1494 6.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 HYAL3 HYAL1 NAT6 SEMA3F-AS1 RBM5 TMEM115 CYB561D2 AMT DAG1 RNF123
GH03I050327 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 23.3 -28.6 -28616 2 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 IRF4 ZNF48 YY1 TUSC2 NAT6 HYAL3 HYAL1 MST1 HYAL2
GH03I050234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 +54.2 54165 21.2 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 GNAI2 HYAL3 RBM5 SEMA3F-AS1 RBM6 HYAL1 CYB561D2 RHOA-IT1 AMT HEMK1
GH03I050598 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -307.1 -307066 15 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CISH MAPKAPK3 HEMK1 RBM5 RBM6 TMEM115 RAD54L2 SEMA3F-AS1 C3orf18 DOCK3
GH03I049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 +953.4 953371 14.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A USP4 AMT QRICH1 ENSG00000235236 RBM6 ATRIP RBM5 WDR6 IP6K2 ENSG00000230454
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAT6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAT6 gene promoter:

Genomic Locations for NAT6 Gene

Genomic Locations for NAT6 Gene
3,020 bases
Minus strand

Genomic View for NAT6 Gene

Genes around NAT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT6 Gene

Proteins for NAT6 Gene

  • Protein details for NAT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-acetyltransferase 6
    Protein Accession:
    Secondary Accessions:
    • Q93014

    Protein attributes for NAT6 Gene

    286 amino acids
    Molecular mass:
    31445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAT6 Gene


neXtProt entry for NAT6 Gene

Post-translational modifications for NAT6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NAT6 Gene

Domains & Families for NAT6 Gene

Gene Families for NAT6 Gene

Protein Domains for NAT6 Gene

Suggested Antigen Peptide Sequences for NAT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the acetyltransferase family.
  • Belongs to the acetyltransferase family.
genes like me logo Genes that share domains with NAT6: view

Function for NAT6 Gene

Molecular function for NAT6 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.

Enzyme Numbers (IUBMB) for NAT6 Gene

Phenotypes From GWAS Catalog for NAT6 Gene

Gene Ontology (GO) - Molecular Function for NAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IDA 10644992
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:1905502 acetyl-CoA binding IDA 10644992
genes like me logo Genes that share ontologies with NAT6: view
genes like me logo Genes that share phenotypes with NAT6: view

miRNA for NAT6 Gene

miRTarBase miRNAs that target NAT6

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT6 Gene

Localization for NAT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT6 Gene


Gene Ontology (GO) - Cellular Components for NAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10644992
genes like me logo Genes that share ontologies with NAT6: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NAT6 Gene

Pathways & Interactions for NAT6 Gene

No Data Available

Interacting Proteins for NAT6 Gene

Selected Interacting proteins: Q93015-NAT6_HUMAN for NAT6 Gene via IID

Gene Ontology (GO) - Biological Process for NAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006473 protein acetylation IDA 10644992
genes like me logo Genes that share ontologies with NAT6: view

No data available for Pathways by source and SIGNOR curated interactions for NAT6 Gene

Drugs & Compounds for NAT6 Gene

(1) Additional Compounds for NAT6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
genes like me logo Genes that share compounds with NAT6: view

Transcripts for NAT6 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT6 Gene

No ASD Table

Relevant External Links for NAT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAT6 Gene

mRNA differential expression in normal tissues according to GTEx for NAT6 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for NAT6 Gene

This gene is overexpressed in Ovary (37.8), Blymphocyte (13.6), and Frontal cortex (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAT6 Gene

Protein tissue co-expression partners for NAT6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAT6 Gene:


mRNA Expression by UniProt/SwissProt for NAT6 Gene:

Tissue specificity: Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

Evidence on tissue expression from TISSUES for NAT6 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with NAT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT6 Gene

Orthologs for NAT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAT6 33 34
  • 99.03 (n)
(Canis familiaris)
Mammalia NAT6 33
  • 86.27 (n)
(Rattus norvegicus)
Mammalia LOC100910872 33
  • 83.22 (n)
(Mus musculus)
Mammalia Nat6 33 16 34
  • 81.14 (n)
(Bos Taurus)
Mammalia NAT6 34
  • 73 (a)
(Monodelphis domestica)
Mammalia NAT6 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia NAT6 34
  • 52 (a)
(Anolis carolinensis)
Reptilia NAT6 34
  • 47 (a)
(Danio rerio)
Actinopterygii LOC101886319 33
  • 52.69 (n)
NAT6 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8481 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea C56G2.15 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for NAT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAT6 Gene

Gene Tree for NAT6 (if available)
Gene Tree for NAT6 (if available)

Paralogs for NAT6 Gene

(1) SIMAP similar genes for NAT6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NAT6: view

No data available for Paralogs for NAT6 Gene

Variants for NAT6 Gene

Sequence variations from dbSNP and Humsavar for NAT6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs117179004 likely-benign, Deficiency of hyaluronoglucosaminidase 50,300,616(-) G/A upstream_transcript_variant
rs1283 likely-benign, Deficiency of hyaluronoglucosaminidase 50,299,991(-) G/A/C/T upstream_transcript_variant
rs142342237 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,514(-) G/C upstream_transcript_variant
rs150976767 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,024(-) C/T upstream_transcript_variant
rs182987423 uncertain-significance, Deficiency of hyaluronoglucosaminidase 50,300,049(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAT6 Gene

Variant ID Type Subtype PubMed ID
nsv954855 CNV deletion 24416366
nsv834693 CNV loss 17160897
nsv834692 CNV loss 17160897
nsv590255 CNV loss 21841781
nsv523662 CNV loss 19592680
nsv523560 CNV loss 19592680
nsv470561 CNV loss 18288195
nsv460531 CNV loss 19166990
nsv3813 CNV deletion 18451855
esv2759148 CNV loss 17122850
dgv8317n54 CNV loss 21841781
dgv8316n54 CNV loss 21841781

Variation tolerance for NAT6 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT6 Gene

Disorders for NAT6 Gene

Additional Disease Information for NAT6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NAT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT6 Gene

Publications for NAT6 Gene

  1. Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer. (PMID: 15036368) Duh FM … Lerman MI (Molecular and cellular probes 2004) 3 22 44 58
  2. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. (PMID: 11085536) Lerman MI … Minna JD (Cancer research 2000) 2 3 4 58
  3. The putative tumour suppressor Fus-2 is an N-acetyltransferase. (PMID: 10644992) Zegerman P … Kouzarides T (Oncogene 2000) 3 4 22 58
  4. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PMID: 19789190) Young RP … Gamble GD (Postgraduate medical journal 2009) 3 44 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58

Products for NAT6 Gene

Sources for NAT6 Gene

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