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This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and d... See more...
Aliases for NAT2 Gene
Aliases for NAT2 Gene
External Ids for NAT2 Gene
- HGNC: 7646
- Entrez Gene: 10
- Ensembl: ENSG00000156006
- OMIM: 612182
- UniProtKB: P11245
Previous HGNC Symbols for NAT2 Gene
- AAC2
Previous GeneCards Identifiers for NAT2 Gene
- GC08P018125
- GC08P018311
- GC08P018259
- GC08P018293
- GC08P016793
- GC08P018250
Summaries for NAT2 Gene
-
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019]
GeneCards Summary for NAT2 Gene
NAT2 (N-Acetyltransferase 2) is a Protein Coding gene. Diseases associated with NAT2 include Acetylation, Slow and Drug-Induced Hepatitis. Among its related pathways are Caffeine Pathway, Pharmacokinetics and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include acetyltransferase activity and arylamine N-acetyltransferase activity. An important paralog of this gene is NAT1.
UniProtKB/Swiss-Prot Summary for NAT2 Gene
-
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Additional gene information for NAT2 Gene
- HGNC(7646)
- Entrez Gene(10)
- Ensembl(ENSG00000156006)
- OMIM(612182)
- UniProtKB(P11245)
- Open Targets Platform(ENSG00000156006)
- Monarch Initiative
- Search for NAT2 at DataMed
- Search for NAT2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for NAT2 Gene
Genomics for NAT2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NAT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NAT2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAT2
- Top Transcription factor binding sites by QIAGEN in the NAT2 gene promoter:
-
- GATA-2
- GR-alpha
- p53
- PPAR-gamma1
- PPAR-gamma2
- Zic3
Genomic Locations for NAT2 Gene
Genomic Locations for NAT2 Gene
- chr8:18,386,585-18,401,219
- (GRCh38/hg38)
- Size:
- 14,635 bases
- Orientation:
- Plus strand
- chr8:18,248,755-18,258,728
- (GRCh37/hg19)
- Size:
- 9,974 bases
- Orientation:
- Plus strand
Genomic View for NAT2 Gene
Genes around NAT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p22 by HGNC
- 8p22 by Entrez Gene
- 8p22 by Ensembl
NAT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NAT2 Gene
Proteins for NAT2 Gene
-
Protein details for NAT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11245-ARY2_HUMAN
- Recommended name:
- Arylamine N-acetyltransferase 2
- Protein Accession:
- P11245
- O43637
- O60654
- O60655
- Q13146
- Q16697
- Q2MLE4
- Q2MLF5
- Q2MLG8
- Q2MLJ6
- Q2MLK4
- Q2MLK6
- Q2MLN7
- Q6LET4
- Q86XS0
- Q86XS1
- Q96KY8
- Q96T64
- Q96T65
- Q9H220
Protein attributes for NAT2 Gene
- Size:
- 290 amino acids
- Molecular mass:
- 33542 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAK51711.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for NAT2 Gene
Selected DME Specific Peptides for NAT2 Gene
- P11245:
-
- AYFERIGY
- IEDFESMNTYLQTSP
- SFCSLQT
- RGGWCLQVN
- WYLDQIRR
Post-translational modifications for NAT2 Gene
Other Protein References for NAT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-NAT2 (aa 233-262) polyclonal antibody
- Creative Biolabs Recombinant Mouse anti-Human NAT2 Monoclonal antibody (EML099)
-
Custom Antibody ServicesOriGene Antibodies for NAT2
- Novus Biologicals Antibodies for NAT2
-
Abcam antibodies for NAT2
- Invitrogen Antibodies for NAT2 (AFLGC-NAT2)
-
Boster Bio Antibodies for NAT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NAT2
Protein Products
- Creative Biomart Recombinant Human NAT2
-
OriGene Purified Proteins for NAT2
- Search Origene for MassSpec and Protein Over-expression Lysates for NAT2
- Origene Custom Protein Services for NAT2
- antibodies-online: Show 11 available NAT2 Proteins ranked by validation data
- Compare Top NAT2 Proteins
-
Quality Products:
-
Signalway Proteins for NAT2
-
Abcam proteins for NAT2
Assay Products
- antibodies-online: Show 7 available NAT2 Elisa Kits ranked by validation data
- Compare Top NAT2 Elisa Kits
-
Quality Products:
Domains & Families for NAT2 Gene
Gene Families for NAT2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for NAT2 Gene
- InterPro:
- Blocks:
-
- Arylamine N-acetyltransferase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for NAT2 Gene
- GenScript: Design optimal peptide antigens:
-
- Arylamine N-acetyltransferase 2 (A4Z6T7_HUMAN)
- Arylamine N-acetyltransferase 2 (A4Z6T8_HUMAN)
- N-acetyltransferase 2 (Arylamine N-acetyltransferase), isoform CRA_b (A4Z6T9_HUMAN)
- Arylamine N-acetyltransferase 2 (A4Z6U4_HUMAN)
- Arylamine N-acetyltransferase 2 (A4Z6U6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P11245- Family:
-
- Belongs to the arylamine N-acetyltransferase family.
Function for NAT2 Gene
Molecular function for NAT2 Gene
- UniProtKB/Swiss-Prot Function:
- Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=acetyl-CoA + an arylamine = an N-acetylarylamine + CoA; Xref=Rhea:RHEA:16613, ChEBI:CHEBI:13790, ChEBI:CHEBI:50471, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.5;.
- GENATLAS Biochemistry:
- arylamine N-acetyltransferase 2,polymorphic,responsible for slow or rapid acetylation of arylamine and hydrazine drugs,putative susceptibility factor in squamous-cell carcinoma of the esophagus,also involved in bladder carcinogenesis and breast cancer
Enzyme Numbers (IUBMB) for NAT2 Gene
Phenotypes From GWAS Catalog for NAT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004060 | arylamine N-acetyltransferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 25640309 |
| GO:0008080 | N-acetyltransferase activity | IEA | -- |
| GO:0016407 | acetyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for NAT2 Gene
- MGI mutant phenotypes for NAT2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NAT2:
Animal Models for NAT2 Gene
- MGI Knock Outs for NAT2:
-
- Nat1 Nat1<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NAT2 - Select products 50% OFF >
- * NAT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NAT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NAT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAT2
miRNA for NAT2 Gene
- miRTarBase miRNAs that target NAT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NAT2
- Browse OriGene Inhibitory RNA Products For NAT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAT2
Clone Products
- Applied Biological Materials (abm): Clones for NAT2 - Select products 50% OFF >
- * NAT2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NAT2
- Addgene plasmids for NAT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NAT2
Cell Line Products
-
Horizon Cell Lines for NAT2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAT2 Gene
Localization for NAT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NAT2 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NAT2 Gene
Pathways & Interactions for NAT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Caffeine Pathway, Pharmacokinetics |
.01
|
|
| 2 | Drug metabolism - cytochrome P450 | ||
| 3 | Cytochrome P450 - arranged by substrate type | ||
| 4 | Metabolism |
.40
|
|
| 5 | Busulfan Pathway, Pharmacodynamics | ||
Pathways by source for NAT2 Gene
3 BioSystems pathways for NAT2 Gene
4 Reactome pathways for NAT2 Gene
3 PharmGKB pathways for NAT2 Gene
4 KEGG pathways for NAT2 Gene
Interacting Proteins for NAT2 Gene
Selected Interacting proteins:
P11245-ARY2_HUMAN
ENSP00000286479
for NAT2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NAT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006805 | xenobiotic metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for NAT2 Gene
Drugs & Compounds for NAT2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Isoniazid | Approved, Investigational | Pharma | Enzyme, substrate | 215 | ||
| Amifampridine | Approved, Investigational | Pharma | Enzyme, substrate | 22 | ||
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Enzyme, substrate | 1512 | ||
| Acetaminophen | Approved | Pharma | Enzyme, inhibitor | 1316 | ||
| Dapsone | Approved, Investigational | Pharma | Enzyme, substrate | 69 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| acetyl-coa |
|
72-89-9 | ||||
| Acetylisoniazid |
|
1078-38-2 | ||||
| Paraxanthine |
|
611-59-6 | ||||
| 2,4-Diamino-6-nitrotoluene |
|
|
||||
| 3-Aminosalicylic acid |
|
570-23-0 |
|
Drug Products
- Creative Biomart Recombinant Human NAT2
Transcripts for NAT2 Gene
mRNA/cDNA for NAT2 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000286479 1285 nts (view in UCSC)
- ENST00000520116 716 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NAT2 - Select products 50% OFF >
- * NAT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NAT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NAT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NAT2
- Browse OriGene Inhibitory RNA Products For NAT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAT2
Clone Products
- Applied Biological Materials (abm): Clones for NAT2 - Select products 50% OFF >
- * NAT2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NAT2
- Addgene plasmids for NAT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NAT2
Relevant External Links for NAT2 Gene
- GeneLoc Exon Structure for
- NAT2
Expression for NAT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for NAT2 Gene
This gene is overexpressed in Liver (x38.0) and Colon - Transverse (x6.1).
This gene is overexpressed in Gallbladder (42.7), Breast (11.3), and Liver (11.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NAT2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAT2
SOURCE GeneReport for Unigene cluster for NAT2 Gene:
Hs.2Evidence on tissue expression from TISSUES for NAT2 Gene
- Liver(4.6)
- Urine(2.4)
- Kidney(2.3)
- Blood(2.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for NAT2
-
OriGene qPCR primer pairs and template standards for NAT2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT2 Gene
Orthologs for NAT2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NAT2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nat1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Nat1 30 17 31 |
|
ManyToMany | |
| Nat2 31 |
|
ManyToMany | |||
| Nat3 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | NAT1 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | PNAT10 31 |
|
ManyToMany | |
| PNAT3 31 |
|
ManyToMany | |||
| NAT 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-78a14.4 31 |
|
ManyToMany | |
| si:dkey-78a14.5 31 |
|
ManyToMany | |||
| zgc:101040 31 |
|
ManyToMany | |||
| zgc:103601 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| CSA.3273 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for NAT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for NAT2 Gene
- ENSEMBL:
- Gene Tree for NAT2 (if available)
- TreeFam:
- Gene Tree for NAT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NAT2: view image
Paralogs for NAT2 Gene
(1) SIMAP similar genes for NAT2 Gene using alignment to 31 proteins:
- ARY2_HUMAN
- A4Z6T7_HUMAN
- A4Z6T8_HUMAN
- A4Z6T9_HUMAN
- A4Z6U4_HUMAN
- A4Z6U6_HUMAN
- A4Z6U7_HUMAN
- A4Z6U9_HUMAN
- A4Z6V9_HUMAN
- A4Z6Y1_HUMAN
- A4Z6Y3_HUMAN
- A4Z6Y5_HUMAN
- A4Z737_HUMAN
- A4Z787_HUMAN
- A4Z7F6_HUMAN
- A4Z7H3_HUMAN
- A4Z7J7_HUMAN
- A4Z7K4_HUMAN
- A4Z7P9_HUMAN
- A4Z7V0_HUMAN
- A4Z867_HUMAN
- A9X7Q9_HUMAN
- A9X7U6_HUMAN
- A9X7X6_HUMAN
- A9X816_HUMAN
- A9X844_HUMAN
- A9X854_HUMAN
- A9X868_HUMAN
- E7EWF9_HUMAN
- Q400I5_HUMAN
- Q400I7_HUMAN
Pseudogenes.org Pseudogenes for NAT2 Gene
Variants for NAT2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for NAT2 Gene
- ARY2_HUMAN-P11245
- Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIM:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAT2 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 719326 | Likely Benign: not provided | 18,400,582(+) | G/T | SYNONYMOUS_VARIANT | |
| 719492 | Benign: not provided | 18,400,841(+) | G/A | MISSENSE_VARIANT | |
| 783517 | Benign: not provided | 18,400,612(+) | G/T | MISSENSE_VARIANT | |
| rs1041983 | Drug Response: ethambutol, isoniazid, pyrazinamide, and rifampin response - Toxicity/ADR | 18,400,285(+) | C/T | SYNONYMOUS_VARIANT | |
| rs1208 | Drug Response: Slow acetylator due to N-acetyltransferase enzyme variant. - | 18,400,806(+) | G/.p.Lys268Arg | NO_SEQUENCE_ALTERATION |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12046n54 | CNV | gain | 21841781 |
| dgv7125n100 | CNV | gain | 25217958 |
| nsv1026366 | CNV | gain | 25217958 |
| nsv428196 | CNV | gain | 18775914 |
| nsv610717 | CNV | gain | 21841781 |
| nsv831252 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.88;
97.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NAT2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for NAT2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acetylation, slow |
|
|
| drug-induced hepatitis |
|
|
| 1,4-phenylenediamine allergic contact dermatitis |
|
|
| multiple chemical sensitivity |
|
|
| pulmonary tuberculosis |
|
Search NAT2 in MalaCards
View complete list of genes associated with diseases
Genatlas disease for NAT2 Gene
isoniazid inactivation
Additional Disease Information for NAT2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot for NAT2 Gene
Publications for NAT2 Gene
- GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population. (PMID: 19922706) Chatzimichalis M … Bibas A (The Journal of laryngology and otology 2010) 3 23 41
- Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. (PMID: 18986377) Maruyama K … Otsuki M (Alcoholism, clinical and experimental research 2010) 3 23 41
- Genetic susceptibility factors for multiple chemical sensitivity revisited. (PMID: 20185366) Berg ND … Elberling J (International journal of hygiene and environmental health 2010) 3 23 41
- Phenotyping with sulfasalazine - time dependence and relation to NAT2 pharmacogenetics. (PMID: 20040334) Kuhn UD … Blume HH (International journal of clinical pharmacology and therapeutics 2010) 3 23 41
- Smoking (active and passive), N-acetyltransferase 2, and risk of breast cancer. (PMID: 20197243) Conlon MS … Donner A (Cancer epidemiology 2010) 3 23 41
ExternalLinks
Products for NAT2 Gene
- Custom Antibody ServicesOriGene Antibodies for NAT2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NAT2
- Search Origene for MassSpec and Protein Over-expression Lysates for NAT2
- Origene Custom Protein Services for NAT2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NAT2
- Browse OriGene Inhibitory RNA Products For NAT2
- OriGene qPCR primer pairs for NAT2
- OriGene qPCR primer pairs and template standards for NAT2
- OriGene CRISPR knockouts for NAT2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NAT2
- Sino Biological Human cDNA Clone for NAT2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NAT2
- Novus Biologicals proteins and lysates for NAT2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NAT2
- Abcam proteins for NAT2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for NAT2 (AFLGC-NAT2)
- VectorBuilder Custom and pre-made DNA vectors for NAT2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NAT2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NAT2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NAT2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NAT2
- Addgene plasmids for NAT2
- antibodies-online: Show 74 available NAT2 Antibodies ranked by validation data
- Compare Top NAT2 Antibodies
- Quality Products:
- antibodies-online: Show 7 available NAT2 Elisa Kits ranked by validation data
- Compare Top NAT2 Elisa Kits
- Quality Products:
- antibodies-online: Show 11 available NAT2 Proteins ranked by validation data
- Compare Top NAT2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for NAT2
- Search Santa Cruz Biotechnology (SCBT) for NAT2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NAT2
- Horizon Cell Lines for NAT2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NAT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NAT2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NAT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAT2
- Boster Bio Antibodies for NAT2
- Browse Boster Bio ELISA Kits
Sources for NAT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB