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Aliases for NAT16 Gene

Aliases for NAT16 Gene

  • N-Acetyltransferase 16 (Putative) 2 3 5
  • N-Acetyltransferase 16 (GCN5-Related, Putative) 2 3
  • C7orf52 3 4
  • Putative N-Acetyltransferase C7orf52 3
  • Chromosome 7 Open Reading Frame 52 2
  • Probable N-Acetyltransferase 16 3
  • Putative N-Acetyltransferase 16 3
  • EC 2.3.1.- 4

External Ids for NAT16 Gene

Previous HGNC Symbols for NAT16 Gene

  • C7orf52

Previous GeneCards Identifiers for NAT16 Gene

  • GC07M100814

Summaries for NAT16 Gene

GeneCards Summary for NAT16 Gene

NAT16 (N-Acetyltransferase 16 (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include N-acetyltransferase activity and peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT16 Gene

  • Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.

Additional gene information for NAT16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT16 Gene

Genomics for NAT16 Gene

GeneHancer (GH) Regulatory Elements for NAT16 Gene

Promoters and enhancers for NAT16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I101180 Promoter/Enhancer 1 EPDnew dbSUPER 550.4 +15.6 15595 0.1 SP1 MXI1 POLR2A EZH2 NAT16 VGF
GH07I101153 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 21.9 +40.1 40134 3.9 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 AP1S1 NAT16 GIGYF1 SRRT STAG3L5P SERPINE1 PCOLCE PPP1R35 PILRB FIS1
GH07I101165 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.7 +29.4 29381 2.7 PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 VGF AP1S1 NAT16 SRRT STAG3L5P GIGYF1 MOSPD3 TSC22D4 MIR4653
GH07I101159 Enhancer 1.4 Ensembl ENCODE dbSUPER 21.8 +33.8 33814 5.5 PKNOX1 ARID4B SIN3A GLI4 ZNF121 GLIS2 ZNF143 KLF7 FOS ZNF263 AP1S1 SRRT NAT16 PPP1R35 GIGYF1 STAG3L5P MEPCE PCOLCE-AS1 FBXO24 NYAP1
GH07I101215 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 -22.3 -22275 4.7 FOXA2 PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 ZNHIT1 PLOD3 FIS1 GIGYF1 SRRT STAG3L5P PILRB PPP1R35 NAT16 EPHB4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAT16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NAT16 Gene

Genomic Locations for NAT16 Gene
25,416 bases
Minus strand

Genomic View for NAT16 Gene

Genes around NAT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT16 Gene

Proteins for NAT16 Gene

  • Protein details for NAT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable N-acetyltransferase 16
    Protein Accession:
    Secondary Accessions:
    • B3KRS2
    • Q8NDR1

    Protein attributes for NAT16 Gene

    369 amino acids
    Molecular mass:
    40521 Da
    Quaternary structure:
    No Data Available
    • NAT16 is the ortholog of the ectothermic vertebrates enzyme HISAT (AC I3J7Q8) responsible for the synthesis of N-acetyl-histidine (NAH). NAT16 protein, unlike fish HISAT, has only trace enzyme activity for NAH synthesis.

    Alternative splice isoforms for NAT16 Gene


neXtProt entry for NAT16 Gene

Post-translational modifications for NAT16 Gene

No Post-translational modifications

Other Protein References for NAT16 Gene

No data available for DME Specific Peptides for NAT16 Gene

Domains & Families for NAT16 Gene

Gene Families for NAT16 Gene

Protein Domains for NAT16 Gene

Suggested Antigen Peptide Sequences for NAT16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NAT16: view

No data available for UniProtKB/Swiss-Prot for NAT16 Gene

Function for NAT16 Gene

Molecular function for NAT16 Gene

UniProtKB/Swiss-Prot Function:
Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.

Enzyme Numbers (IUBMB) for NAT16 Gene

Phenotypes From GWAS Catalog for NAT16 Gene

Gene Ontology (GO) - Molecular Function for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IBA --
genes like me logo Genes that share ontologies with NAT16: view

Phenotypes for NAT16 Gene

genes like me logo Genes that share phenotypes with NAT16: view

Animal Model Products

miRNA for NAT16 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT16 Gene

Localization for NAT16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAT16 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NAT16 Gene

Pathways & Interactions for NAT16 Gene

SuperPathways for NAT16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006473 protein acetylation IBA --
genes like me logo Genes that share ontologies with NAT16: view

No data available for Pathways by source and SIGNOR curated interactions for NAT16 Gene

Drugs & Compounds for NAT16 Gene

No Compound Related Data Available

Transcripts for NAT16 Gene

Unigene Clusters for NAT16 Gene

N-acetyltransferase 16 (GCN5-related, putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT16 Gene

No ASD Table

Relevant External Links for NAT16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAT16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAT16 Gene

mRNA differential expression in normal tissues according to GTEx for NAT16 Gene

This gene is overexpressed in Pituitary (x11.0), Brain - Nucleus accumbens (basal ganglia) (x8.1), and Brain - Hypothalamus (x6.6).

NURSA nuclear receptor signaling pathways regulating expression of NAT16 Gene:


SOURCE GeneReport for Unigene cluster for NAT16 Gene:


Evidence on tissue expression from TISSUES for NAT16 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NAT16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT16 Gene

Orthologs for NAT16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAT16 33 34
  • 99.19 (n)
(Canis familiaris)
Mammalia NAT16 33
  • 79.78 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nat16 33
  • 59.75 (n)
(Danio rerio)
Actinopterygii LOC100003245 33
  • 59.4 (n)
NAT16 34
  • 53 (a)
Species where no ortholog for NAT16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT16 Gene

Gene Tree for NAT16 (if available)
Gene Tree for NAT16 (if available)

Paralogs for NAT16 Gene

No data available for Paralogs for NAT16 Gene

Variants for NAT16 Gene

Sequence variations from dbSNP and Humsavar for NAT16 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000275390 -- 101,174,055(-) C/T intron_variant
rs1000853888 -- 101,173,895(-) T/C intron_variant
rs1000978974 -- 101,179,537(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001031284 -- 101,179,845(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001162583 -- 101,177,969(-) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NAT16 Gene

Variant ID Type Subtype PubMed ID
nsv831075 CNV loss 17160897
nsv607974 CNV loss 21841781
nsv607973 CNV loss 21841781
nsv1030604 CNV gain 25217958
nsv1018841 CNV gain 25217958
esv2752134 CNV gain 17911159
esv2734888 CNV deletion 23290073
esv2422376 CNV duplication 17116639
dgv11534n54 CNV loss 21841781

Variation tolerance for NAT16 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAT16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT16 Gene

Disorders for NAT16 Gene

Additional Disease Information for NAT16

No disorders were found for NAT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT16 Gene

Publications for NAT16 Gene

  1. An ectotherm homologue of human predicted gene NAT16 encodes histidine N-acetyltransferase responsible for Nα-acetylhistidine synthesis. (PMID: 24121108) Yamada S … Arikawa S (Biochimica et biophysica acta 2014) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. (PMID: 22607974) Damgaard RB … Gyrd-Hansen M (Molecular cell 2012) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for NAT16 Gene

Sources for NAT16 Gene

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