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Aliases for NAT14 Gene

Aliases for NAT14 Gene

  • N-Acetyltransferase 14 (Putative) 2 3 5
  • N-Acetyltransferase 14 (GCN5-Related, Putative) 2 3
  • K562 Cell-Derived Leucine-Zipper-Like Protein 1 3 4
  • N-Acetyltransferase 14 2 3
  • KLP1 3 4
  • K562 Cells-Derived Leucine Zipper-Like Protein 1 2
  • K562 Cells-Derived Leucine-Zipper-Like Protein 1 3
  • EC 2.3.1.- 4
  • EC 2.3.1 56

External Ids for NAT14 Gene

Previous GeneCards Identifiers for NAT14 Gene

  • GC19P060689
  • GC19P055996
  • GC19P052309

Summaries for NAT14 Gene

GeneCards Summary for NAT14 Gene

NAT14 (N-Acetyltransferase 14 (Putative)) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT14 Gene

  • Probable acetyltransferase that binds the 5-GGACTACAG-3 sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.

Additional gene information for NAT14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT14 Gene

Genomics for NAT14 Gene

GeneHancer (GH) Regulatory Elements for NAT14 Gene

Promoters and enhancers for NAT14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055483 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559.7 +1.8 1756 6.4 ARID4B SIN3A POLR2B E2F8 ZNF143 ZNF548 FOS SP3 ZHX2 REST SSC5D NAT14 U2AF2 ENSG00000267523 ZNF628
GH19I055519 Enhancer 1.4 FANTOM5 Ensembl ENCODE 47.7 +35.2 35205 1 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 ZNF548 FOS ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
GH19I055503 Enhancer 1.2 Ensembl ENCODE 50.3 +19.0 18965 1.6 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF213 E2F8 U2AF2 FIZ1 ZNF667 ZNF582 ZNF582-AS1 NAT14 ZNF667-AS1 ZNF542P ZNF580 ZNF583
GH19I055283 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 27.3 -200.3 -200292 2.5 HDAC1 HDGF ZNF76 GLI4 ZNF48 ZEB1 ZNF335 GLIS2 ZNF366 CREM BRSK1 FIZ1 NAT14 ENSG00000235681 LENG8-AS1 ZNF580 ENSG00000267838 LENG8 SSC5D HSPBP1
GH19I055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 18.6 -231.1 -231145 14.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP6R1 LENG8 U2AF2 ZNF581 LENG8-AS1 ENSG00000235681 ENSG00000267523 BRSK1 HSPBP1 FIZ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAT14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAT14 gene promoter:

Genomic Locations for NAT14 Gene

Genomic Locations for NAT14 Gene
chr19:55,485,004-55,487,568
(GRCh38/hg38)
Size:
2,565 bases
Orientation:
Plus strand
chr19:55,996,371-55,998,935
(GRCh37/hg19)

Genomic View for NAT14 Gene

Genes around NAT14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT14 Gene

Proteins for NAT14 Gene

  • Protein details for NAT14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUY8-NAT14_HUMAN
    Recommended name:
    N-acetyltransferase 14
    Protein Accession:
    Q8WUY8
    Secondary Accessions:
    • Q8TDY7
    • Q9NS72

    Protein attributes for NAT14 Gene

    Size:
    206 amino acids
    Molecular mass:
    21650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAT14 Gene

Selected DME Specific Peptides for NAT14 Gene

Q8WUY8:
  • LSVREMRE
  • KLGLRARWGSLPPPGGLGGPWVAVRGSGDVCGVLALAPG

Post-translational modifications for NAT14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAT14 Gene

Domains & Families for NAT14 Gene

Gene Families for NAT14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NAT14 Gene

Suggested Antigen Peptide Sequences for NAT14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUY8

UniProtKB/Swiss-Prot:

NAT14_HUMAN :
  • Belongs to the camello family.
Family:
  • Belongs to the camello family.
genes like me logo Genes that share domains with NAT14: view

Function for NAT14 Gene

Molecular function for NAT14 Gene

UniProtKB/Swiss-Prot Function:
Probable acetyltransferase that binds the 5-GGACTACAG-3 sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.

Enzyme Numbers (IUBMB) for NAT14 Gene

Phenotypes From GWAS Catalog for NAT14 Gene

Gene Ontology (GO) - Molecular Function for NAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAT14: view
genes like me logo Genes that share phenotypes with NAT14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT14 Gene

Localization for NAT14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT14 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAT14 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10873651
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NAT14: view

Pathways & Interactions for NAT14 Gene

genes like me logo Genes that share pathways with NAT14: view

Pathways by source for NAT14 Gene

1 BioSystems pathway for NAT14 Gene

Interacting Proteins for NAT14 Gene

Gene Ontology (GO) - Biological Process for NAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation NAS 10873651
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated NAS 10873651
genes like me logo Genes that share ontologies with NAT14: view

No data available for SIGNOR curated interactions for NAT14 Gene

Drugs & Compounds for NAT14 Gene

(1) Drugs for NAT14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coproporphyrinogen III Experimental Pharma 0
genes like me logo Genes that share compounds with NAT14: view

Transcripts for NAT14 Gene

Unigene Clusters for NAT14 Gene

N-acetyltransferase 14 (GCN5-related, putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT14 Gene

No ASD Table

Relevant External Links for NAT14 Gene

GeneLoc Exon Structure for
NAT14
ECgene alternative splicing isoforms for
NAT14

Expression for NAT14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAT14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAT14 Gene

This gene is overexpressed in Bone (34.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAT14 Gene



Protein tissue co-expression partners for NAT14 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAT14 Gene:

NAT14

SOURCE GeneReport for Unigene cluster for NAT14 Gene:

Hs.31854

mRNA Expression by UniProt/SwissProt for NAT14 Gene:

Q8WUY8-NAT14_HUMAN
Tissue specificity: Expressed in K-562 and HeLa cell lines and in brain.

Evidence on tissue expression from TISSUES for NAT14 Gene

  • Kidney(4.2)
  • Nervous system(2.7)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with NAT14: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT14 Gene

Orthologs for NAT14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT14 33 34
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia NAT14 33 34
  • 88.83 (n)
dog
(Canis familiaris)
Mammalia NAT14 33 34
  • 88.51 (n)
mouse
(Mus musculus)
Mammalia Nat14 33 16 34
  • 87.06 (n)
rat
(Rattus norvegicus)
Mammalia Nat14 33
  • 86.41 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nat14 33
  • 58.03 (n)
zebrafish
(Danio rerio)
Actinopterygii NAT14 34
  • 28 (a)
OneToOne
Species where no ortholog for NAT14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT14 Gene

ENSEMBL:
Gene Tree for NAT14 (if available)
TreeFam:
Gene Tree for NAT14 (if available)

Paralogs for NAT14 Gene

No data available for Paralogs for NAT14 Gene

Variants for NAT14 Gene

Sequence variations from dbSNP and Humsavar for NAT14 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000057773 -- 55,483,437(+) C/T upstream_transcript_variant
rs1000216708 -- 55,485,122(+) G/A upstream_transcript_variant
rs1000306157 -- 55,484,954(+) C/G upstream_transcript_variant
rs1000774188 -- 55,488,033(+) C/A downstream_transcript_variant
rs1001275739 -- 55,483,753(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAT14 Gene

Variant ID Type Subtype PubMed ID
nsv2552 CNV insertion 18451855
nsv458833 CNV loss 19166990
nsv580343 CNV loss 21841781
nsv953624 CNV deletion 24416366

Variation tolerance for NAT14 Gene

Gene Damage Index Score: 6.19; 75.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAT14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAT14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT14 Gene

Disorders for NAT14 Gene

Additional Disease Information for NAT14

No disorders were found for NAT14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT14 Gene

Publications for NAT14 Gene

  1. Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein. (PMID: 10873651) Takahashi S … Hayashi N (Biochemical and biophysical research communications 2000) 2 3 4 22 58
  2. Genomic structure and regulation of a novel human gene, Klp1. (PMID: 11779635) Takahashi S … Sasaki T (Biochimica et biophysica acta 2001) 3 4 22 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for NAT14 Gene

Sources for NAT14 Gene

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