The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016] See more...

Aliases for NAT10 Gene

Aliases for NAT10 Gene

  • N-Acetyltransferase 10 2 3 4 5
  • 18S RRNA Cytosine Acetyltransferase 3 4
  • N-Acetyltransferase-Like Protein 3 4
  • RNA Cytidine Acetyltransferase 3 4
  • KIAA1709 2 4
  • Kre33 2 3
  • NET43 2 3
  • HALP 2 4
  • ALP 3 4
  • N-Acetyltransferase 10 (GCN5-Related) 3
  • EC 2.3.1.- 4
  • FLJ10774 2
  • FLJ12179 2
  • NAT10 5

External Ids for NAT10 Gene

Previous GeneCards Identifiers for NAT10 Gene

  • GC11P034084
  • GC11P033823

Summaries for NAT10 Gene

Entrez Gene Summary for NAT10 Gene

  • The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]

GeneCards Summary for NAT10 Gene

NAT10 (N-Acetyltransferase 10) is a Protein Coding gene. Diseases associated with NAT10 include Hutchinson-Gilford Progeria Syndrome and Embryoma. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot Summary for NAT10 Gene

  • RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603).

Gene Wiki entry for NAT10 Gene

Additional gene information for NAT10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAT10 Gene

Genomics for NAT10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NAT10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAT10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAT10

Top Transcription factor binding sites by QIAGEN in the NAT10 gene promoter:
  • AML1a
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • HOXA5
  • LCR-F1
  • Max1
  • Nkx2-5
  • S8
  • USF1

Genomic Locations for NAT10 Gene

Genomic Locations for NAT10 Gene
chr11:34,105,617-34,147,670
(GRCh38/hg38)
Size:
42,054 bases
Orientation:
Plus strand
chr11:34,127,111-34,169,217
(GRCh37/hg19)
Size:
42,107 bases
Orientation:
Plus strand

Genomic View for NAT10 Gene

Genes around NAT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT10 Gene

Proteins for NAT10 Gene

  • Protein details for NAT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0A0-NAT10_HUMAN
    Recommended name:
    RNA cytidine acetyltransferase
    Protein Accession:
    Q9H0A0
    Secondary Accessions:
    • B4DFD5
    • E7ESU4
    • E9PMN9
    • Q86WK5
    • Q9C0F4
    • Q9HA61
    • Q9NVF2

    Protein attributes for NAT10 Gene

    Size:
    1025 amino acids
    Molecular mass:
    115730 Da
    Quaternary structure:
    • Interacts with THUMPD1 (PubMed:25653167). Interacts with SUN1 (via N-terminus) (PubMed:17631499). Interacts with TERT (PubMed:18082603).
    SequenceCaution:
    • Sequence=AAO49126.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB21800.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for NAT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT10 Gene

Post-translational modifications for NAT10 Gene

  • Acetylation at Lys-426 is required to activation of rRNA transcription (PubMed:27993683). May be autoacetylated; however ability to autoacetylate in vivo requires additional evidences (PubMed:27993683).
  • Ubiquitination at Lys904 and Lys956
  • Modification sites at PhosphoSitePlus

Other Protein References for NAT10 Gene

Antibody Products

  • Abcam antibodies for NAT10
  • Boster Bio Antibodies for NAT10

No data available for DME Specific Peptides for NAT10 Gene

Domains & Families for NAT10 Gene

Gene Families for NAT10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NAT10 Gene

InterPro:
Blocks:
  • Putative ATPase DUF699
  • Domain of unknown function DUF1726
ProtoNet:

Suggested Antigen Peptide Sequences for NAT10 Gene

GenScript: Design optimal peptide antigens:
  • N-acetyltransferase 10 (NAT10_HUMAN)
  • NAT10 protein (Q05CW7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H0A0

UniProtKB/Swiss-Prot:

NAT10_HUMAN :
  • Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
Family:
  • Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
genes like me logo Genes that share domains with NAT10: view

Function for NAT10 Gene

Molecular function for NAT10 Gene

UniProtKB/Swiss-Prot Function:
RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate; Xref=Rhea:RHEA:51424, Rhea:RHEA-COMP:13575, Rhea:RHEA-COMP:13576, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; Evidence={ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000269|PubMed:25411247};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate; Xref=Rhea:RHEA:53876, Rhea:RHEA-COMP:13670, Rhea:RHEA-COMP:13671, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; Evidence={ECO:0000255|HAMAP-Rule:MF_03211};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate; Xref=Rhea:RHEA:58480, Rhea:RHEA-COMP:15145, Rhea:RHEA-COMP:15146, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:30449621};.
UniProtKB/Swiss-Prot Induction:
Transcriptionally activated by genotoxic agents; possible role in DNA damage and induction of cellular resistance to genotoxic agents.
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by remodelin (4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, monohydrobromide), a hydrobromide salt molecule (PubMed:24786082). Remodelin can improve nuclear architecture, chromatin organization and fitness of cells from patients suffering from Hutchinson-Gilford progeria syndrome (HGPS); molecular mechanisms explaining the relation between NAT10 activity and nuclear architecture are however unclear (PubMed:24786082).

Enzyme Numbers (IUBMB) for NAT10 Gene

Phenotypes From GWAS Catalog for NAT10 Gene

Gene Ontology (GO) - Molecular Function for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IBA 21873635
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25653167
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NAT10: view
genes like me logo Genes that share phenotypes with NAT10: view

Animal Models for NAT10 Gene

MGI Knock Outs for NAT10:
  • Nat10 Nat10<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAT10

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAT10 Gene

Localization for NAT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT10 Gene

Nucleus, nucleolus. Midbody. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase. {ECO:0000269 PubMed:19303003}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAT10 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Midbody (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0005634 nucleus IEA,NAS 11214970
GO:0005654 nucleoplasm TAS --
GO:0005697 telomerase holoenzyme complex IDA 18082603
GO:0005730 nucleolus IEA,IDA 18082603
genes like me logo Genes that share ontologies with NAT10: view

Pathways & Interactions for NAT10 Gene

genes like me logo Genes that share pathways with NAT10: view

Pathways by source for NAT10 Gene

Gene Ontology (GO) - Biological Process for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000154 rRNA modification IEA,TAS --
GO:0006364 rRNA processing IEA --
GO:0008033 tRNA processing IEA --
GO:0016072 rRNA metabolic process IEA --
GO:0032211 negative regulation of telomere maintenance via telomerase IMP 18082603
genes like me logo Genes that share ontologies with NAT10: view

No data available for SIGNOR curated interactions for NAT10 Gene

Drugs & Compounds for NAT10 Gene

(1) Drugs for NAT10 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Remodelin Pharma 0

(1) ApexBio Compounds for NAT10 Gene

Compound Action Cas Number
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with NAT10: view

Drug Products

Transcripts for NAT10 Gene

mRNA/cDNA for NAT10 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAT10

Alternative Splicing Database (ASD) splice patterns (SP) for NAT10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -
SP6:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for NAT10 Gene

GeneLoc Exon Structure for
NAT10

Expression for NAT10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAT10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.3), Blymphocyte (6.7), Pancreas (6.1), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAT10 Gene



Protein tissue co-expression partners for NAT10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAT10

SOURCE GeneReport for Unigene cluster for NAT10 Gene:

Hs.577281

Evidence on tissue expression from TISSUES for NAT10 Gene

  • Nervous system(4.9)
  • Intestine(2.8)
  • Blood(2.4)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with NAT10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT10 Gene

Orthologs for NAT10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAT10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NAT10 30 31
  • 99.46 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 93 (a)
OneToMany
-- 31
  • 90 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia NAT10 30 31
  • 91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NAT10 30 31
  • 90.74 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nat10 30 17 31
  • 88.88 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NAT10 31
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nat10 30
  • 86.16 (n)
Chicken
(Gallus gallus)
Aves NAT10 30 31
  • 77.84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NAT10 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nat10 30
  • 74.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13735 30
Zebrafish
(Danio rerio)
Actinopterygii nat10 30 31
  • 73.19 (n)
OneToOne
zgc66119 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010491 30
  • 57.33 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta l(1)G0020 30 31
  • 57.28 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea nath-10 30 31
  • 55.92 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR346C 30
  • 56.98 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24398g 30
  • 55.72 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRE33 30 31 33
  • 55.61 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G10490 30
  • 54.95 (n)
Rice
(Oryza sativa)
Liliopsida Os12g0170700 30
  • 49.86 (n)
Os.10295 30
Bread mold
(Neurospora crassa)
Ascomycetes NCU10654 30
  • 57.16 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC20G8.09c 30
  • 55.62 (n)
Species where no ortholog for NAT10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NAT10 Gene

ENSEMBL:
Gene Tree for NAT10 (if available)
TreeFam:
Gene Tree for NAT10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAT10: view image

Paralogs for NAT10 Gene

No data available for Paralogs for NAT10 Gene

Variants for NAT10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAT10 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
712074 Benign: not provided 34,108,810(+) T/C SYNONYMOUS_VARIANT,INTRON_VARIANT
712075 Benign: not provided 34,112,220(+) G/A SYNONYMOUS_VARIANT
715489 Benign: not provided 34,142,354(+) G/C INTRON_VARIANT
716314 Benign: not provided 34,118,293(+) C/T MISSENSE_VARIANT
732327 Likely Benign: not provided 34,112,124(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NAT10 Gene

Structural Variations from Database of Genomic Variants (DGV) for NAT10 Gene

Variant ID Type Subtype PubMed ID
esv3625907 CNV loss 21293372
nsv509400 CNV insertion 20534489
nsv951600 CNV deletion 24416366

Variation tolerance for NAT10 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAT10 Gene

Human Gene Mutation Database (HGMD)
NAT10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAT10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT10 Gene

Disorders for NAT10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NAT10 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NAT10 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NAT10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAT10 Gene

Publications for NAT10 Gene

  1. Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT. (PMID: 14592445) Lv J … Zhang B (Biochemical and biophysical research communications 2003) 2 3 4 23
  2. Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. (PMID: 25653167) Sharma S … Lafontaine DL (Nucleic acids research 2015) 2 3 4
  3. NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules. (PMID: 19303003) Shen Q … Zhang B (Experimental cell research 2009) 3 4 23
  4. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. (PMID: 17180247) Liu H … Zhang B (Molecular and cellular biochemistry 2007) 3 4 23
  5. Acetylation of Cytidine in mRNA Promotes Translation Efficiency. (PMID: 30449621) Arango D … Oberdoerffer S (Cell 2018) 3 4

Products for NAT10 Gene

  • Signalway ELISA kits for NAT10
  • Signalway Proteins for NAT10

Sources for NAT10 Gene