Aliases for NAT1 Gene
External Ids for NAT1 Gene
Previous HGNC Symbols for NAT1 Gene
Previous GeneCards Identifiers for NAT1 Gene
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for NAT1 Gene
NAT1 (N-Acetyltransferase 1) is a Protein Coding gene. Diseases associated with NAT1 include Ascending Cholangitis and Colorectal Adenoma. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism. Gene Ontology (GO) annotations related to this gene include acetyltransferase activity and arylamine N-acetyltransferase activity. An important paralog of this gene is NAT2.
UniProtKB/Swiss-Prot for NAT1 Gene
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.