This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and t... See more...

Aliases for NASP Gene

Aliases for NASP Gene

  • Nuclear Autoantigenic Sperm Protein 2 3 4 5
  • Nuclear Autoantigenic Sperm Protein (Histone-Binding) 2 3
  • NASP Histone Chaperone 2 3
  • Histone H1-Binding Protein 3
  • FLB7527 3
  • PRO1999 3
  • HMDRA1 3

External Ids for NASP Gene

Previous GeneCards Identifiers for NASP Gene

  • GC08M061216
  • GC01P045050
  • GC01P045479
  • GC01P045463
  • GC01P045718
  • GC01P045823
  • GC01P046049
  • GC01P044161

Summaries for NASP Gene

Entrez Gene Summary for NASP Gene

  • This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

GeneCards Summary for NASP Gene

NASP (Nuclear Autoantigenic Sperm Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include Hsp90 protein binding.

UniProtKB/Swiss-Prot Summary for NASP Gene

  • Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.

Gene Wiki entry for NASP Gene

Additional gene information for NASP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NASP Gene

Genomics for NASP Gene

GeneHancer (GH) Regulatory Elements for NASP Gene

Promoters and enhancers for NASP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NASP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NASP

Top Transcription factor binding sites by QIAGEN in the NASP gene promoter:
  • AP-4
  • AREB6
  • ATF6
  • C/EBPalpha
  • CHOP-10
  • HFH-1
  • Pax-4a
  • Pax-5
  • Sp1

Genomic Locations for NASP Gene

Genomic Locations for NASP Gene
chr1:45,583,846-45,618,906
(GRCh38/hg38)
Size:
35,061 bases
Orientation:
Plus strand
chr1:46,049,518-46,084,578
(GRCh37/hg19)
Size:
35,061 bases
Orientation:
Plus strand

Genomic View for NASP Gene

Genes around NASP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NASP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NASP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NASP Gene

Proteins for NASP Gene

  • Protein details for NASP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49321-NASP_HUMAN
    Recommended name:
    Nuclear autoantigenic sperm protein
    Protein Accession:
    P49321
    Secondary Accessions:
    • A8K6H2
    • B4DQP3
    • D3DQ07
    • F5H3J2
    • Q53GW5
    • Q5T622
    • Q5T625
    • Q96A69
    • Q9BTW2

    Protein attributes for NASP Gene

    Size:
    788 amino acids
    Molecular mass:
    85238 Da
    Quaternary structure:
    • Binds to linker H1 histones but not to core histones (By similarity). Interacts with histones H2A, H2B, H3 and H4 (PubMed:8724350, PubMed:27618665). Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity).

    Alternative splice isoforms for NASP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NASP Gene

Post-translational modifications for NASP Gene

  • Ubiquitination at Lys52, Lys93, Lys535, Lys643, Lys657, Lys671, and Lys698
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NASP Gene

Domains & Families for NASP Gene

Gene Families for NASP Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NASP Gene

Suggested Antigen Peptide Sequences for NASP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53176, highly similar to Nuclear autoantigenic sperm protein (B4DS57_HUMAN)
  • Nuclear autoantigenic sperm protein (NASP_HUMAN)
  • Nuclear autoantigenic sperm protein (Histone-binding) (Q5T623_HUMAN)
  • Nuclear autoantigenic sperm protein (Histone-binding), isoform CRA_a (Q5T626_HUMAN)
  • Nuclear autoantigenic sperm protein (Histone-binding) (Q5T627_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49321

UniProtKB/Swiss-Prot:

NASP_HUMAN :
  • Belongs to the NASP family.
Family:
  • Belongs to the NASP family.
genes like me logo Genes that share domains with NASP: view

Function for NASP Gene

Molecular function for NASP Gene

UniProtKB/Swiss-Prot Function:
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.

Phenotypes From GWAS Catalog for NASP Gene

Gene Ontology (GO) - Molecular Function for NASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16189514
GO:0042393 histone binding IDA 27618665
genes like me logo Genes that share ontologies with NASP: view
genes like me logo Genes that share phenotypes with NASP: view

Animal Models for NASP Gene

MGI Knock Outs for NASP:
  • Nasp Nasp<tm1Mgor>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NASP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NASP Gene

Localization for NASP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NASP Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NASP gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 14718166
GO:0005634 nucleus ISS,IBA --
GO:0005654 nucleoplasm IDA,IBA --
GO:0005737 cytoplasm IEA --
GO:0032991 protein-containing complex IDA 14718166
genes like me logo Genes that share ontologies with NASP: view

Pathways & Interactions for NASP Gene

PathCards logo

SuperPathways for NASP Gene

No Data Available

Gene Ontology (GO) - Biological Process for NASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle ISS --
GO:0001824 blastocyst development ISS --
GO:0006260 DNA replication ISS --
GO:0006335 DNA replication-dependent nucleosome assembly IDA,IBA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with NASP: view

No data available for Pathways by source and SIGNOR curated interactions for NASP Gene

Drugs & Compounds for NASP Gene

No Compound Related Data Available

Transcripts for NASP Gene

mRNA/cDNA for NASP Gene

4 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
25 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NASP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NASP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: -
SP7: - - -
SP8: - -
SP9: - - - -
SP10: - - - -
SP11: -
SP12: - - - - - - - - - -
SP13:

ExUns: 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for NASP Gene

GeneLoc Exon Structure for
NASP

Expression for NASP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NASP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NASP Gene

This gene is overexpressed in Fetal ovary (11.7) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NASP Gene



Protein tissue co-expression partners for NASP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NASP

SOURCE GeneReport for Unigene cluster for NASP Gene:

Hs.319334

mRNA Expression by UniProt/SwissProt for NASP Gene:

P49321-NASP_HUMAN
Tissue specificity: Isoform 1 is testis- and sperm-specific.

Evidence on tissue expression from TISSUES for NASP Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Lung(4.5)
  • Eye(4.4)
  • Skin(2.9)
  • Kidney(2.2)
  • Blood(2.1)
  • Gall bladder(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with NASP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NASP Gene

Orthologs for NASP Gene

This gene was present in the common ancestor of animals.

Orthologs for NASP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NASP 31 30
  • 99.87 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NASP 31 30
  • 91.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NASP 31 30
  • 90.38 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nasp 17 31 30
  • 86.91 (n)
rat
(Rattus norvegicus)
Mammalia Nasp 30
  • 86.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NASP 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NASP 31
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves NASP 31
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NASP 31
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nasp 30
  • 64.79 (n)
Str.6461 30
African clawed frog
(Xenopus laevis)
Amphibia LOC397901 30
zebrafish
(Danio rerio)
Actinopterygii nasp 31
  • 46 (a)
OneToOne
wufd20g12 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4774 30
fruit fly
(Drosophila melanogaster)
Insecta CG8223 31
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nasp-1 31
  • 28 (a)
OneToMany
nasp-2 31
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8729 31
  • 37 (a)
OneToOne
Species where no ortholog for NASP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NASP Gene

ENSEMBL:
Gene Tree for NASP (if available)
TreeFam:
Gene Tree for NASP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NASP: view image

Paralogs for NASP Gene

(1) SIMAP similar genes for NASP Gene using alignment to 16 proteins:

  • NASP_HUMAN
  • E9PAU3_HUMAN
  • E9PI86_HUMAN
  • E9PJQ2_HUMAN
  • E9PKR5_HUMAN
  • E9PNB5_HUMAN
  • E9PPQ8_HUMAN
  • E9PPR5_HUMAN
  • E9PQG5_HUMAN
  • E9PRH9_HUMAN
  • H0YDS9_HUMAN
  • H0YF33_HUMAN
  • Q5T624_HUMAN
  • Q5T626_HUMAN
  • Q6PJY7_HUMAN
  • Q9P1N1_HUMAN

Pseudogenes.org Pseudogenes for NASP Gene

genes like me logo Genes that share paralogs with NASP: view

No data available for Paralogs for NASP Gene

Variants for NASP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NASP Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
714067 Benign: not provided 45,607,496(+) A/C SYNONYMOUS_VARIANT,INTRON_VARIANT
733493 Likely Benign: not provided 45,615,177(+) A/G MISSENSE_VARIANT
762510 Likely Benign: not provided 45,617,528(+) G/A SYNONYMOUS_VARIANT
rs34618000 - p.Val620Gly

Additional dbSNP identifiers (rs#s) for NASP Gene

Structural Variations from Database of Genomic Variants (DGV) for NASP Gene

Variant ID Type Subtype PubMed ID
esv3450766 CNV insertion 20981092
esv3585911 CNV gain 21293372
esv3893512 CNV gain 25118596
nsv1133131 CNV tandem duplication 24896259
nsv479041 CNV novel sequence insertion 20440878
nsv829726 CNV loss 17160897
nsv945920 CNV duplication 23825009

Variation tolerance for NASP Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NASP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NASP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NASP Gene

Disorders for NASP Gene

Additional Disease Information for NASP

No disorders were found for NASP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NASP Gene

Publications for NASP Gene

  1. Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein. (PMID: 1426632) O'Rand MG … Widgren EE (Developmental biology 1992) 2 3 4 23 54
  2. Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer. (PMID: 27618665) Zhang M … Niu L (Structure (London, England : 1993) 2016) 3 4 54
  3. Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP). (PMID: 20167597) Osakabe A … Kurumizaka H (The Journal of biological chemistry 2010) 3 23 54
  4. Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP. (PMID: 19439102) Alekseev OM … O'Rand MG (Reproductive biology and endocrinology : RB&E 2009) 3 23 54
  5. Expanded binding specificity of the human histone chaperone NASP. (PMID: 18782834) Wang H … Parthun MR (Nucleic acids research 2008) 3 23 54

Products for NASP Gene

Sources for NASP Gene