Aliases for NASP Gene
External Ids for NASP Gene
Previous GeneCards Identifiers for NASP Gene
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
GeneCards Summary for NASP Gene
NASP (Nuclear Autoantigenic Sperm Protein) is a Protein Coding gene. Diseases associated with NASP include Factitious Disorder. Gene Ontology (GO) annotations related to this gene include Hsp90 protein binding.
UniProtKB/Swiss-Prot Summary for NASP Gene
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.