Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008] See more...

Aliases for NARS1 Gene

Aliases for NARS1 Gene

  • Asparaginyl-TRNA Synthetase 1 2 3 4 5
  • Asparagine TRNA Ligase 1, Cytoplasmic 2 3
  • Asparagine--TRNA Ligase, Cytoplasmic 3 4
  • Asparaginyl-TRNA Synthetase 2 4
  • EC 6.1.1.22 4 50
  • NARS 3 4
  • Asparaginyl-TRNA Synthetase, Cytoplasmic 3
  • NEDMILEG 3
  • NEDMILG 3
  • ASNRS 3
  • NARS1 5
  • AsnRS 4
  • NRS 4

External Ids for NARS1 Gene

Previous HGNC Symbols for NARS1 Gene

  • NARS

Summaries for NARS1 Gene

Entrez Gene Summary for NARS1 Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for NARS1 Gene

NARS1 (Asparaginyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with NARS1 include Neurodevelopmental Disorder With Microcephaly, Impaired Language, And Gait Abnormalities and Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities. Among its related pathways are tRNA Aminoacylation and Photodynamic therapy-induced unfolded protein response. An important paralog of this gene is NARS2.

UniProtKB/Swiss-Prot Summary for NARS1 Gene

  • Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211).

Gene Wiki entry for NARS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NARS1 Gene

Genomics for NARS1 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around NARS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NARS1

Genomic Locations for NARS1 Gene

Latest Assembly
chr18:57,600,656-57,622,213
(GRCh38/hg38)
Size:
21,558 bases
Orientation:
Minus strand

Previous Assembly
chr18:55,267,888-55,289,068
(GRCh37/hg19 by Entrez Gene)
Size:
21,181 bases
Orientation:
Minus strand

chr18:55,267,888-55,289,445
(GRCh37/hg19 by Ensembl)
Size:
21,558 bases
Orientation:
Minus strand

Genomic View for NARS1 Gene

Genes around NARS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NARS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NARS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARS1 Gene

Proteins for NARS1 Gene

  • Protein details for NARS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43776-SYNC_HUMAN
    Recommended name:
    Asparagine--tRNA ligase, cytoplasmic
    Protein Accession:
    O43776
    Secondary Accessions:
    • B4DG16
    • Q53GU6

    Protein attributes for NARS1 Gene

    Size:
    548 amino acids
    Molecular mass:
    62943 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Autoantibodies to NARS1, are often detected in sera from patients with interstitial lung disease (ILD).

    Three dimensional structures from OCA and Proteopedia for NARS1 Gene

    Alternative splice isoforms for NARS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARS1 Gene

Selected DME Specific Peptides for NARS1 Gene

O43776:
  • LNLTPKGKQAPGGHELSCDFWEL
  • LMFLVLRDG
  • VEGGATLFK
  • TRCFRDHFFDRGY
  • VQTQVEGG
  • LTQSSQLYLETC
  • LTESVDVLMPNVGEIVGGSMR
  • GLGLERFLTWI

Post-translational modifications for NARS1 Gene

  • Ubiquitination at Lys60, Lys104, Lys445, Lys490, and Lys507
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for NARS1
  • Boster Bio Antibodies for NARS1

Domains & Families for NARS1 Gene

Gene Families for NARS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NARS1 Gene

InterPro:
Blocks:
  • Aspartyl-tRNA synthetase signature
  • tRNA synthetase, class II (D, K and N)
  • OB-fold nucleic acid binding domain

Suggested Antigen Peptide Sequences for NARS1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52485, highly similar to Asparaginyl-tRNA synthetase, cytoplasmic (EC 6.1.1.22) (B4DG16_HUMAN)
  • cDNA FLJ52703, highly similar to Asparaginyl-tRNA synthetase, cytoplasmic (EC6.1.1.22) (B4DN60_HUMAN)
  • Asparagine--tRNA ligase (SYNC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43776

UniProtKB/Swiss-Prot:

SYNC_HUMAN :
  • The N-terminal domain (1-77) recruits and activates specific immune cells by interacting with CCR3-expressing cells.
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Domain:
  • The N-terminal domain (1-77) recruits and activates specific immune cells by interacting with CCR3-expressing cells.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with NARS1: view

Function for NARS1 Gene

Molecular function for NARS1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn); Xref=Rhea:RHEA:11180, Rhea:RHEA-COMP:9659, Rhea:RHEA-COMP:9674, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58048, ChEBI:CHEBI:78442, ChEBI:CHEBI:78515, ChEBI:CHEBI:456215; EC=6.1.1.22; Evidence={ECO:0000269|PubMed:9421509};.

Enzyme Numbers (IUBMB) for NARS1 Gene

Phenotypes From GWAS Catalog for NARS1 Gene

Gene Ontology (GO) - Molecular Function for NARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004816 asparagine-tRNA ligase activity TAS --
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with NARS1: view
genes like me logo Genes that share phenotypes with NARS1: view

Human Phenotype Ontology for NARS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for research

  • Taconic Biosciences Mouse Models for NARS1

miRNA for NARS1 Gene

miRTarBase miRNAs that target NARS1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NARS1

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NARS1 Gene

Localization for NARS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NARS1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NARS1 gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 2
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9421509
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with NARS1: view

Pathways & Interactions for NARS1 Gene

genes like me logo Genes that share pathways with NARS1: view

Pathways by source for NARS1 Gene

1 KEGG pathway for NARS1 Gene

Gene Ontology (GO) - Biological Process for NARS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006421 asparaginyl-tRNA aminoacylation IDA 9421509
GO:0016477 cell migration IDA 9421509
genes like me logo Genes that share ontologies with NARS1: view

No data available for SIGNOR curated interactions for NARS1 Gene

Drugs & Compounds for NARS1 Gene

(4) Drugs for NARS1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Asparagine Approved, Investigational Nutra Target 40
Adenosine monophosphate Approved, Investigational Nutra 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(4) Additional Compounds for NARS1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
14000-31-8
genes like me logo Genes that share compounds with NARS1: view

Transcripts for NARS1 Gene

mRNA/cDNA for NARS1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NARS1

Alternative Splicing Database (ASD) splice patterns (SP) for NARS1 Gene

No ASD Table

Relevant External Links for NARS1 Gene

GeneLoc Exon Structure for
NARS1

Expression for NARS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NARS1

SOURCE GeneReport for Unigene cluster for NARS1 Gene:

Hs.465224

Evidence on tissue expression from TISSUES for NARS1 Gene

  • Nervous system(5)
  • Intestine(4.7)
  • Liver(4.7)
  • Kidney(3.9)
  • Skin(3.8)
  • Spleen(3)
  • Lung(3)
  • Blood(2.7)
  • Muscle(2.6)
  • Heart(2.5)
  • Lymph node(2.3)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NARS1 Gene

Orthologs for NARS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NARS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NARS 29 30
  • 99.15 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 92 (a)
OneToMany
-- 30
  • 90 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 92 (a)
OneToMany
NARS 29
  • 87.65 (n)
-- 30
  • 83 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia NARS 29 30
  • 90.94 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NARS 30
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nars 29
  • 86.72 (n)
Mouse
(Mus musculus)
Mammalia Nars 29 16 30
  • 86.68 (n)
OneToOne
Chicken
(Gallus gallus)
Aves NARS 29 30
  • 79.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NARS 30
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nars 29
  • 74.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii nars 29 30
  • 72.2 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002969 29
  • 63.08 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Aats-asn 29 30
  • 62.17 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea nars-1 29 30
  • 58.15 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED81 29 30 32
  • 56.71 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08426g 29
  • 56.46 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AEL020W 29
  • 53.38 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 66 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU06457 29
  • 54.31 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nrs1 29
  • 53.35 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4788 29
Species where no ortholog for NARS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NARS1 Gene

ENSEMBL:
Gene Tree for NARS1 (if available)
TreeFam:
Gene Tree for NARS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NARS1: view image
Alliance of Genome Resources:
Additional Orthologs for NARS1

Paralogs for NARS1 Gene

Paralogs for NARS1 Gene

Pseudogenes.org Pseudogenes for NARS1 Gene

genes like me logo Genes that share paralogs with NARS1: view

Variants for NARS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NARS1 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
977507 Pathogenic: Mitochondrial complex 1 deficiency, nuclear type 35 57,615,862(-) C/CA
NM_004548.3(NDUFB10):c.207dup (p.Glu70Ter)
FRAMESHIFT
982711 Pathogenic: Neurodevelopmental disorder; NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, IMPAIRED LANGUAGE, EPILEPSY, AND GAIT ABNORMALITIES 57,601,699(-) G/A
NM_004539.4(NARS1):c.1600C>T (p.Arg534Ter)
NONSENSE
983068 Likely Pathogenic: Neurodevelopmental disorder; NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, IMPAIRED LANGUAGE, AND GAIT ABNORMALITIES 57,606,686(-) T/G
NM_004539.4(NARS1):c.1067A>C (p.Asp356Ala)
MISSENSE
986303 Pathogenic: NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, IMPAIRED LANGUAGE, AND GAIT ABNORMALITIES 57,615,865(-) C/CT
NM_004539.4(NARS1):c.203dup (p.Met69fs)
FRAMESHIFT
986305 Pathogenic: NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, IMPAIRED LANGUAGE, AND GAIT ABNORMALITIES 57,601,666(-) G/A
NM_004539.4(NARS1):c.1633C>T (p.Arg545Cys)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NARS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NARS1 Gene

Variant ID Type Subtype PubMed ID
dgv203e215 CNV deletion 23714750
esv2751777 CNV gain 17911159
esv3328362 CNV duplication 20981092
nsv1134720 CNV deletion 24896259
nsv458086 CNV gain 19166990
nsv577032 CNV gain 21841781
nsv833663 CNV gain 17160897

Variation tolerance for NARS1 Gene

Residual Variation Intolerance Score: 6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NARS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NARS1
Leiden Open Variation Database (LOVD)
NARS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARS1 Gene

Disorders for NARS1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for NARS1 Gene - From: OMI, CVR, COP, and GCD

Additional Disease Information for NARS1

genes like me logo Genes that share disorders with NARS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NARS1 Gene

Publications for NARS1 Gene

  1. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. (PMID: 9421509) Beaulande M … Härtlein M (Nucleic acids research 1998) 2 3 4 22
  2. Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family. (PMID: 9801298) Shiba K … Noda T (Nucleic acids research 1998) 3 4 22
  3. Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly. (PMID: 32788587) Wang L … Gleeson JG (Nature communications 2020) 3 72
  4. Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity. (PMID: 30171954) Park JS … Han BW (International journal of biological macromolecules 2018) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for NARS1 Gene

Sources for NARS1 Gene