Aliases for NARS1 Gene
External Ids for NARS1 Gene
Previous HGNC Symbols for NARS1 Gene
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
GeneCards Summary for NARS1 Gene
NARS1 (Asparaginyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with NARS1 include Myositis and Interstitial Lung Disease. Among its related pathways are tRNA Aminoacylation and Photodynamic therapy-induced unfolded protein response. An important paralog of this gene is NARS2.
UniProtKB/Swiss-Prot Summary for NARS1 Gene
Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211).