Aliases for NARS1 Gene
External Ids for NARS1 Gene
Previous HGNC Symbols for NARS1 Gene
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
GeneCards Summary for NARS1 Gene
NARS1 (Asparaginyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with NARS1 include Neurodevelopmental Disorder With Microcephaly, Impaired Language, And Gait Abnormalities and Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities. Among its related pathways are tRNA Aminoacylation and Photodynamic therapy-induced unfolded protein response. An important paralog of this gene is NARS2.
UniProtKB/Swiss-Prot Summary for NARS1 Gene
Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211).