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Aliases for NARS Gene

Aliases for NARS Gene

  • Asparaginyl-TRNA Synthetase 2 3 4 5
  • Asparagine TRNA Ligase 1, Cytoplasmic 2 3
  • Asparaginyl-TRNA Synthetase, Cytoplasmic 3
  • Asparagine--TRNA Ligase, Cytoplasmic 3
  • EC 4
  • ASNRS 3
  • NARS1 3
  • AsnRS 4

External Ids for NARS Gene

Previous GeneCards Identifiers for NARS Gene

  • GC18M055658
  • GC18M055242
  • GC18M055052
  • GC18M053416
  • GC18M053418
  • GC18M051978
  • GC18M055267

Summaries for NARS Gene

Entrez Gene Summary for NARS Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for NARS Gene

NARS (Asparaginyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with NARS include Myositis. Among its related pathways are tRNA Aminoacylation and Photodynamic therapy-induced unfolded protein response. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and aminoacyl-tRNA ligase activity.

Gene Wiki entry for NARS Gene

Additional gene information for NARS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARS Gene

Genomics for NARS Gene

GeneHancer (GH) Regulatory Elements for NARS Gene

Promoters and enhancers for NARS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J057619 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662 +0.8 846 3.3 HDGF SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B NARS GC18M057596
GH18J057649 Enhancer 1.1 Ensembl ENCODE dbSUPER 15.9 -27.9 -27860 1.3 PKNOX1 JUN CEBPG BMI1 BATF IRF4 RAD21 BRCA1 RFX5 RCOR1 NARS RNU6-742P HMGN1P30 ENSG00000267787 LOC100505549 TRG-TCC5-1 ATP8B1
GH18J057786 Enhancer 1.1 Ensembl ENCODE dbSUPER 15.7 -166.3 -166332 4.6 KLF1 ZBTB6 ARNT JUN NFRKB ZMYM3 FEZF1 RAD21 FOSL1 E2F8 NARS RNU6-742P ATP8B1 MRPS17P7
GH18J057665 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 -44.6 -44600 2.4 HDAC1 PKNOX1 SMAD1 ATF1 ARNT TCF12 E2F8 EGR1 SCRT2 ETV6 NARS TRG-TCC5-1 ENSG00000267787 LOC100505549 ATP8B1
GH18J057819 Enhancer 1.4 Ensembl ENCODE dbSUPER 10 -197.8 -197810 1.8 PKNOX1 SMAD1 ATF1 ARNT SIN3A FEZF1 BRCA1 TCF12 ATF7 RUNX3 RNU6-742P NARS ATP8B1 GC18M057807
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NARS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NARS gene promoter:
  • Evi-1
  • TGIF
  • NRSF form 2
  • NRSF form 1
  • CHOP-10
  • C/EBPalpha
  • GATA-1

Genomic Locations for NARS Gene

Genomic Locations for NARS Gene
21,558 bases
Minus strand
21,558 bases
Minus strand

Genomic View for NARS Gene

Genes around NARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARS Gene

Proteins for NARS Gene

  • Protein details for NARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Asparagine--tRNA ligase, cytoplasmic
    Protein Accession:
    Secondary Accessions:
    • B4DG16
    • Q53GU6

    Protein attributes for NARS Gene

    548 amino acids
    Molecular mass:
    62943 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NARS Gene

    Alternative splice isoforms for NARS Gene


neXtProt entry for NARS Gene

Post-translational modifications for NARS Gene

  • Ubiquitination at Lys507, isoforms=490, Lys445, Lys104, and Lys60
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NARS Gene

Domains & Families for NARS Gene

Gene Families for NARS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-II aminoacyl-tRNA synthetase family.
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with NARS: view

Function for NARS Gene

Molecular function for NARS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).
GENATLAS Biochemistry:
asparaginyl-tRNA synthetase

Enzyme Numbers (IUBMB) for NARS Gene

Phenotypes From GWAS Catalog for NARS Gene

Gene Ontology (GO) - Molecular Function for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004816 asparagine-tRNA ligase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with NARS: view
genes like me logo Genes that share phenotypes with NARS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NARS

CRISPR Products

miRNA for NARS Gene

miRTarBase miRNAs that target NARS

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NARS

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NARS Gene

Localization for NARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NARS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NARS gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9421509
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with NARS: view

Pathways & Interactions for NARS Gene

genes like me logo Genes that share pathways with NARS: view

Pathways by source for NARS Gene

1 KEGG pathway for NARS Gene

Gene Ontology (GO) - Biological Process for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006421 asparaginyl-tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with NARS: view

No data available for SIGNOR curated interactions for NARS Gene

Drugs & Compounds for NARS Gene

(4) Drugs for NARS Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved, Investigational Nutra Target 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(5) Additional Compounds for NARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
genes like me logo Genes that share compounds with NARS: view

Transcripts for NARS Gene

mRNA/cDNA for NARS Gene

Unigene Clusters for NARS Gene

Asparaginyl-tRNA synthetase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NARS

Alternative Splicing Database (ASD) splice patterns (SP) for NARS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -

Relevant External Links for NARS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NARS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NARS Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NARS Gene

Protein tissue co-expression partners for NARS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NARS Gene:


SOURCE GeneReport for Unigene cluster for NARS Gene:


Evidence on tissue expression from TISSUES for NARS Gene

  • Nervous system(5)
  • Liver(4.7)
  • Intestine(4.6)
  • Kidney(3.8)
  • Skin(3.3)
  • Lung(3)
  • Spleen(2.9)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with NARS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NARS Gene

Orthologs for NARS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NARS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NARS 34 33
  • 99.15 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
-- 34
  • 90 (a)
(Bos Taurus)
Mammalia -- 34
  • 92 (a)
  • 87.65 (n)
-- 34
  • 83 (a)
(Canis familiaris)
Mammalia NARS 34 33
  • 90.94 (n)
(Monodelphis domestica)
Mammalia NARS 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Nars 33
  • 86.72 (n)
(Mus musculus)
Mammalia Nars 16 34 33
  • 86.68 (n)
(Gallus gallus)
Aves NARS 34 33
  • 79.87 (n)
(Anolis carolinensis)
Reptilia NARS 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nars 33
  • 74.88 (n)
(Danio rerio)
Actinopterygii nars 34 33
  • 72.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH06451 35
  • 73 (a)
Aats-asn 34 33
  • 62.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002969 33
  • 63.08 (n)
(Caenorhabditis elegans)
Secernentea nars-1 34 33
  • 58.15 (n)
nrs-1 35
  • 58 (a)
Y66D12A.23 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED81 36 34 33
  • 56.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08426g 33
  • 56.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL020W 33
  • 53.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
Cin.4788 33
bread mold
(Neurospora crassa)
Ascomycetes NCU06457 33
  • 54.31 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nrs1 33
  • 53.35 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4788 33
Species where no ortholog for NARS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARS Gene

Gene Tree for NARS (if available)
Gene Tree for NARS (if available)
Evolutionary constrained regions (ECRs) for NARS: view image

Paralogs for NARS Gene

(2) SIMAP similar genes for NARS Gene using alignment to 9 proteins:

  • B4DG16_HUMAN
  • B4DN60_HUMAN
  • K7EJ19_HUMAN
  • K7EQ35_HUMAN Pseudogenes for NARS Gene

genes like me logo Genes that share paralogs with NARS: view

No data available for Paralogs for NARS Gene

Variants for NARS Gene

Sequence variations from dbSNP and Humsavar for NARS Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000098934 -- 57,603,897(-) C/A/T intron_variant
rs1000124297 -- 57,618,551(-) G/A intron_variant
rs1000185149 -- 57,622,369(-) C/A/T upstream_transcript_variant
rs1000211991 -- 57,616,177(-) A/T intron_variant
rs1000302392 -- 57,603,531(-) TT/TTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NARS Gene

Variant ID Type Subtype PubMed ID
dgv203e215 CNV deletion 23714750
esv2751777 CNV gain 17911159
esv3328362 CNV duplication 20981092
nsv1134720 CNV deletion 24896259
nsv458086 CNV gain 19166990
nsv577032 CNV gain 21841781
nsv833663 CNV gain 17160897

Variation tolerance for NARS Gene

Residual Variation Intolerance Score: 6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NARS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARS Gene

Disorders for NARS Gene

MalaCards: The human disease database

(1) MalaCards diseases for NARS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • myopathy, familial idiopathic inflammatory; iim
- elite association - COSMIC cancer census association via MalaCards
Search NARS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NARS

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NARS Gene

Publications for NARS Gene

  1. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. (PMID: 9421509) Beaulande M … Härtlein M (Nucleic acids research 1998) 2 3 4 22 58
  2. Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family. (PMID: 9801298) Shiba K … Noda T (Nucleic acids research 1998) 3 4 22 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18. (PMID: 6836455) Cirullo RE … Wasmuth JJ (Somatic cell genetics 1983) 2 3 58

Products for NARS Gene

Sources for NARS Gene

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