NARF Gene (Protein Coding)

Nuclear Prelamin A Recognition Factor

GC17P082458
GIFtS:
37
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins... See more...

Aliases for NARF Gene

Aliases for NARF Gene

  • Nuclear Prelamin A Recognition Factor 2 3 4 5
  • Iron-Only Hydrogenase-Like Protein 2 2 3 4
  • IOP2 3 4
  • Prenyl-Dependent Prelamin A Binding Protein 3

External Ids for NARF Gene

Previous GeneCards Identifiers for NARF Gene

  • GC17P079555
  • GC17P083333
  • GC17P080945
  • GC17P081095
  • GC17P078009
  • GC17P080416
  • GC17P075814

Summaries for NARF Gene

Entrez Gene Summary for NARF Gene

  • Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]

GeneCards Summary for NARF Gene

NARF (Nuclear Prelamin A Recognition Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include iron-sulfur cluster binding and lamin binding. An important paralog of this gene is CIAO3.

Gene Wiki entry for NARF Gene

Additional gene information for NARF Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NARF Gene

Genomics for NARF Gene

GeneHancer (GH) Regulatory Elements for NARF Gene

Promoters and enhancers for NARF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NARF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NARF gene promoter:
  • NF-E2
  • NF-E2 p45
  • NF-kappaB
  • NF-kappaB1
  • Roaz

Genomic Locations for NARF Gene

Genomic Locations for NARF Gene
chr17:82,458,180-82,490,537
(GRCh38/hg38)
Size:
32,358 bases
Orientation:
Plus strand
chr17:80,416,056-80,448,413
(GRCh37/hg19)
Size:
32,358 bases
Orientation:
Plus strand

Genomic View for NARF Gene

Genes around NARF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NARF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NARF Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NARF Gene

Proteins for NARF Gene

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  • Protein details for NARF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHQ1-NARF_HUMAN
    Recommended name:
    Nuclear prelamin A recognition factor
    Protein Accession:
    Q9UHQ1
    Secondary Accessions:
    • A6NCJ3
    • B3KPX2
    • K4DI98
    • Q96AY9
    • Q9BWC6

    Protein attributes for NARF Gene

    Size:
    456 amino acids
    Molecular mass:
    51156 Da
    Quaternary structure:
    • Interacts with LMNA and binds to the farnesylated C-terminal domain.

    Alternative splice isoforms for NARF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARF Gene

Protein Expression for NARF Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NARF Gene

  • Ubiquitination at Lys206, Lys308, and Lys394
  • Modification sites at PhosphoSitePlus

Other Protein References for NARF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NARF Gene

Domains & Families for NARF Gene

Gene Families for NARF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NARF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NARF Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55037, highly similar to Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 1, mRNA (B4DZZ6_HUMAN)
  • Nuclear prelamin A recognition factor (B5KGZ0_HUMAN)
  • Nuclear prelamin A recognition factor (B5KGZ1_HUMAN)
  • Iron-only hydrogenase-like protein 2 (NARF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHQ1

UniProtKB/Swiss-Prot:

NARF_HUMAN :
  • Belongs to the NARF family.
Family:
  • Belongs to the NARF family.
genes like me logo Genes that share domains with NARF: view

Function for NARF Gene

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Phenotypes From GWAS Catalog for NARF Gene

Gene Ontology (GO) - Molecular Function for NARF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005521 lamin binding IPI 10514485
genes like me logo Genes that share ontologies with NARF: view
genes like me logo Genes that share phenotypes with NARF: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NARF

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NARF Gene

Localization for NARF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NARF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NARF gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NARF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005638 lamin filament IDA,IBA 10514485
GO:0005652 nuclear lamina TAS 10514485
GO:0005730 nucleolus IDA --
GO:0031981 nuclear lumen IDA 10514485
genes like me logo Genes that share ontologies with NARF: view

Pathways & Interactions for NARF Gene

PathCards logo

SuperPathways for NARF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NARF Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NARF Gene

Drugs & Compounds for NARF Gene

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  1. Drug
No Compound Related Data Available

Transcripts for NARF Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NARF Gene

(4) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(371) Selected AceView cDNA sequences:
(27) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NARF

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NARF Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: -
SP7:
SP8: - - - - - - - -
SP9: - - - - -
SP10: -
SP11: -

Relevant External Links for NARF Gene

GeneLoc Exon Structure for
NARF
ECgene alternative splicing isoforms for
NARF

Expression for NARF Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NARF Gene

mRNA expression in normal human tissues for NARF Gene
mRNA expression by GTEx for NARF GenemRNA expression by BioGPS for NARF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NARF Gene

This gene is overexpressed in Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for NARF Gene

This gene is overexpressed in Amniocyte (51.7), Bone marrow mesenchymal stem cell (8.7), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NARF Gene



NURSA nuclear receptor signaling pathways regulating expression of NARF Gene:

NARF

SOURCE GeneReport for Unigene cluster for NARF Gene:

Hs.256526

mRNA Expression by UniProt/SwissProt for NARF Gene:

Q9UHQ1-NARF_HUMAN
Tissue specificity: Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.

Evidence on tissue expression from TISSUES for NARF Gene

  • Lung(4.6)
  • Nervous system(4.5)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with NARF: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NARF Gene

Orthologs for NARF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NARF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NARF 33 32
  • 94.22 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia NARF 33
  • 84 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia NARF 33 32
  • 83.92 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Narf 17 33 32
  • 82.97 (n)
rat
(Rattus norvegicus)
 Mammalia Narf 32
  • 82.75 (n)
oppossum
(Monodelphis domestica)
 Mammalia NARF 33
  • 70 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia NARF 33
  • 65 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NARF 33 32
  • 70.98 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NARF 33
  • 64 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia narf 32
  • 65.27 (n)
Str.10161 32
zebrafish
(Danio rerio)
 Actinopterygii narf 33 33 32
  • 62.23 (n)
 OneToMany
wufa03c01 32
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.3129 32
fruit fly
(Drosophila melanogaster)
 Insecta CG17683 33 34
  • 36 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea oxy-4 33
  • 30 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes NAR1 33
  • 24 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 35 (a)
 OneToMany
Species where no ortholog for NARF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARF Gene

ENSEMBL:
Gene Tree for NARF (if available)
TreeFam:
Gene Tree for NARF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NARF: view image

Paralogs for NARF Gene

Paralogs for NARF Gene

(9) SIMAP similar genes for NARF Gene using alignment to 16 proteins:

  • NARF_HUMAN
  • B4DZZ6_HUMAN
  • B5KGZ0_HUMAN
  • B5KGZ1_HUMAN
  • E7EP87_HUMAN
  • E9PH27_HUMAN
  • J3KRH7_HUMAN
  • J3KS03_HUMAN
  • J3KS48_HUMAN
  • J3KT43_HUMAN
  • J3KTG5_HUMAN
  • J3KTP5_HUMAN
  • J3QL28_HUMAN
  • J3QLT6_HUMAN
  • J3QRB0_HUMAN
  • J3QSD9_HUMAN
genes like me logo Genes that share paralogs with NARF: view

Variants for NARF Gene

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Sequence variations from dbSNP and Humsavar for NARF Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000215800 -- 82,463,774(+) C/T intron_variant
rs1000270913 -- 82,477,144(+) C/T intron_variant
rs1000342393 -- 82,471,010(+) A/G intron_variant
rs1000375311 -- 82,471,314(+) G/A intron_variant
rs1000388936 -- 82,490,966(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NARF Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2762577 CNV gain+loss 21179565
esv3641424 CNV gain 21293372
nsv1062980 CNV gain 25217958
nsv1067194 CNV gain 25217958
nsv1160502 CNV deletion 26073780
nsv428351 CNV gain 18775914
nsv469561 CNV loss 16826518
nsv828144 CNV gain 20364138
nsv833574 CNV gain 17160897

Variation tolerance for NARF Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NARF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NARF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARF Gene

Disorders for NARF Gene

Additional Disease Information for NARF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NARF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NARF Gene

Publications for NARF Gene

  1. Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PMID: 10514485) Barton RM … Worman HJ (The Journal of biological chemistry 1999) 2 3 4 23 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. Beyond DNA: RNA editing and steps toward Alu exonization in primates. (PMID: 18680752) Möller-Krull M … Schmitz J (Journal of molecular biology 2008) 3 23 56
  4. RNA-editing-mediated exon evolution. (PMID: 17326827) Lev-Maor G … Ast G (Genome biology 2007) 3 23 56
  5. Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? (PMID: 15667261) Hackstein JH (Biochemical Society transactions 2005) 2 3 56

ExternalLinks

View latest publications for NARF gene in Mastermind

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