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Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
NARF (Nuclear Prelamin A Recognition Factor) is a Protein Coding gene. Diseases associated with NARF include Posterior Dislocation Of Lens and Epileptic Encephalopathy, Early Infantile, 2. Gene Ontology (GO) annotations related to this gene include iron-sulfur cluster binding and lamin binding. An important paralog of this gene is CIAO3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005521 | lamin binding | IPI | 10514485 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005638 | lamin filament | IBA,IDA | 10514485 |
GO:0005652 | nuclear lamina | TAS | 10514485 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NARF 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NARF 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NARF 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Narf 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Narf 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | NARF 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NARF 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NARF 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NARF 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | narf 30 |
|
||
Str.10161 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | narf 30 31 31 |
|
OneToMany | |
wufa03c01 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3129 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17683 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | oxy-4 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NAR1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv21913 | CNV | gain+loss | 19812545 |
esv2762577 | CNV | gain+loss | 21179565 |
esv3641424 | CNV | gain | 21293372 |
nsv1062980 | CNV | gain | 25217958 |
nsv1067194 | CNV | gain | 25217958 |
nsv1160502 | CNV | deletion | 26073780 |
nsv428351 | CNV | gain | 18775914 |
nsv469561 | CNV | loss | 16826518 |
nsv828144 | CNV | gain | 20364138 |
nsv833574 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
posterior dislocation of lens |
|
|
epileptic encephalopathy, early infantile, 2 |
|
|
chronic closed-angle glaucoma |
|
|
aqueous misdirection |
|
|
acute retrobulbar neuritis |
|
|