NAPSB Gene (Pseudogene)

Napsin B Aspartic Peptidase, Pseudogene

GC19M050333
GIFtS:
17
See more...

Aliases for NAPSB Gene

Aliases for NAPSB Gene

  • Napsin B Aspartic Peptidase, Pseudogene 2 3 5
  • NAPSBP 2 3
  • NAP1L 2 3
  • NAP2 2 3
  • NAPB 2 3
  • Napsin A Aspartic Peptidase Pseudogene 3
  • Napsin B Pseudogene 3
  • Napsin-A Pseudogene 3
  • Pronapsin B 3
  • Napsin 2 3
  • NAPSB 5

External Ids for NAPSB Gene

Previous GeneCards Identifiers for NAPSB Gene

  • GC19M055530
  • GC19M055531
  • GC19M050837
  • GC19M047175

Summaries for NAPSB Gene

GeneCards Summary for NAPSB Gene

NAPSB (Napsin B Aspartic Peptidase, Pseudogene) is a Pseudogene.

Additional gene information for NAPSB Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAPSB Gene

Genomics for NAPSB Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NAPSB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAPSB on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the NAPSB gene promoter:
  • Bach2
  • Brachyury
  • CREB
  • E47
  • NF-kappaB
  • NF-kappaB1
  • TBP

Genomic Locations for NAPSB Gene

Latest Assembly
chr19:50,333,796-50,344,767
(GRCh38/hg38)
Size:
10,972 bases
Orientation:
Minus strand

Previous Assembly
chr19:50,837,057-50,848,005
(GRCh37/hg19 by Entrez Gene)
Size:
10,949 bases
Orientation:
Minus strand

chr19:50,837,053-50,848,024
(GRCh37/hg19 by Ensembl)
Size:
10,972 bases
Orientation:
Minus strand

Genomic View for NAPSB Gene

Genes around NAPSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPSB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NAPSB Gene

Proteins for NAPSB Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

Protein Expression for NAPSB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NAPSB Gene

No Post-translational modifications

No data available for DME Specific Peptides for NAPSB Gene

Domains & Families for NAPSB Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NAPSB Gene

Function for NAPSB Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for NAPSB Gene

Phenotypes for NAPSB Gene

GenomeRNAi human phenotypes for NAPSB:
genes like me logo Genes that share phenotypes with NAPSB: view

miRNA for NAPSB Gene

miRTarBase miRNAs that target NAPSB

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAPSB Gene

Localization for NAPSB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NAPSB Gene

Pathways & Interactions for NAPSB Gene

PathCards logo

SuperPathways for NAPSB Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAPSB Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NAPSB Gene

Drugs & Compounds for NAPSB Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for NAPSB Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for NAPSB Gene

13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NAPSB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for NAPSB Gene

GeneLoc Exon Structure for
NAPSB

Expression for NAPSB Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAPSB Gene

mRNA expression in normal human tissues for NAPSB Gene
mRNA expression by GTEx for NAPSB Gene

mRNA differential expression in normal tissues according to GTEx for NAPSB Gene

This gene is overexpressed in Spleen (x11.0), Whole Blood (x9.0), and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for NAPSB Gene

This gene is overexpressed in Lung (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for NAPSB Gene



Protein tissue co-expression partners for NAPSB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAPSB

SOURCE GeneReport for Unigene cluster for NAPSB Gene:

Hs.636624
genes like me logo Genes that share expression patterns with NAPSB: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPSB Gene

Orthologs for NAPSB Gene

Evolution for NAPSB Gene

ENSEMBL:
Gene Tree for NAPSB (if available)
TreeFam:
Gene Tree for NAPSB (if available)

No data available for Orthologs for NAPSB Gene

Paralogs for NAPSB Gene

No data available for Paralogs for NAPSB Gene

Variants for NAPSB Gene

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  1. SNP Genotyping and Copy Number Assays for research

Structural Variations from Database of Genomic Variants (DGV) for NAPSB Gene

Variant ID Type Subtype PubMed ID
nsv1066389 CNV gain 25217958
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv2529 CNV insertion 18451855
nsv523948 CNV gain 19592680
nsv953603 CNV deletion 24416366
nsv978835 CNV duplication 23825009

Additional Variant Information for NAPSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPSB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for NAPSB Gene

Disorders for NAPSB Gene

Additional Disease Information for NAPSB

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NAPSB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPSB Gene

Publications for NAPSB Gene

  1. Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells. (PMID: 12151090) Cook M … Kay J (Biochimica et biophysica acta 2002) 3 23
  2. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. (PMID: 10591213) Yan R … Gurney ME (Nature 1999) 2 3
  3. Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PMID: 9877162) Tatnell PJ … Kay J (FEBS letters 1998) 2 3
  4. Structural and phylogenetic comparison of napsin genes: the duplication, loss of function and human-specific pseudogenization of napsin B. (PMID: 23333608) Nishishita K … Tsukuba T (Gene 2013) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

ExternalLinks

View latest publications for NAPSB gene in Mastermind

Products for NAPSB Gene

Sources for NAPSB Gene