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Aliases for NAPSB Gene

Aliases for NAPSB Gene

  • Napsin B Aspartic Peptidase, Pseudogene 2 3 5
  • Napsin A Aspartic Peptidase Pseudogene 3
  • Napsin B Pseudogene 3
  • Napsin-A Pseudogene 3
  • Pronapsin B 3
  • Napsin 2 3
  • NAPSBP 3
  • NAP1L 3
  • NAP2 3
  • NAPB 3

External Ids for NAPSB Gene

Previous GeneCards Identifiers for NAPSB Gene

  • GC19M055530
  • GC19M055531
  • GC19M050837
  • GC19M047175

Summaries for NAPSB Gene

GeneCards Summary for NAPSB Gene

NAPSB (Napsin B Aspartic Peptidase, Pseudogene) is a Pseudogene.

Additional gene information for NAPSB Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPSB Gene

Genomics for NAPSB Gene

GeneHancer (GH) Regulatory Elements for NAPSB Gene

Promoters and enhancers for NAPSB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I050340 Enhancer 1 Ensembl ENCODE 626.1 +1.8 1770 5.6 HDGF PKNOX1 SMAD1 BMI1 ZBTB40 BATF KLF5 IRF4 ZNF121 ZNF366 NAPSB KCNC3 LOC105372437 NR1H2
GH19I050375 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 49.2 -32.1 -32054 2.1 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 NR1H2 NAPSB POLD1 NUP62 SNORD35B SNORD35A IRF3 PIH1D1 ALDH16A1 PNKP
GH19I050346 Enhancer 1.1 Ensembl ENCODE 72 -3.3 -3262 3.9 PKNOX1 FOXA2 SMAD1 ARID4B DMAP1 IRF4 ZNF48 ZNF143 ATF7 RUNX3 NAPSB KCNC3 NAPSA POLD1 JOSD2 ASPDH FAM71E1 EMC10 KLK2 NR1H2
GH19I050356 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 41.9 -13.7 -13724 3 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 E2F8 NAPSB POLD1 NUP62 ENSG00000268047 KCNC3 SNORD35A PTOV1-AS2 PNKP IRF3 SNORD35B
GH19I050368 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 40 -24.3 -24290 1.8 CLOCK ARNT SIN3A ZNF2 ZNF48 YY1 ARID2 ZNF207 ZNF143 FOS ENSG00000269392 NAPSA NAPSB NR1H2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAPSB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAPSB gene promoter:

Genomic Locations for NAPSB Gene

Genomic Locations for NAPSB Gene
chr19:50,333,796-50,344,767
(GRCh38/hg38)
Size:
10,972 bases
Orientation:
Minus strand
chr19:50,837,053-50,848,024
(GRCh37/hg19)

Genomic View for NAPSB Gene

Genes around NAPSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPSB Gene

Proteins for NAPSB Gene

Post-translational modifications for NAPSB Gene

No Post-translational modifications

No data available for DME Specific Peptides for NAPSB Gene

Domains & Families for NAPSB Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NAPSB Gene

Function for NAPSB Gene

Phenotypes From GWAS Catalog for NAPSB Gene

Phenotypes for NAPSB Gene

GenomeRNAi human phenotypes for NAPSB:
genes like me logo Genes that share phenotypes with NAPSB: view

Animal Model Products

miRNA for NAPSB Gene

miRTarBase miRNAs that target NAPSB

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAPSB Gene

Localization for NAPSB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NAPSB Gene

Pathways & Interactions for NAPSB Gene

SuperPathways for NAPSB Gene

No Data Available

Interacting Proteins for NAPSB Gene

Gene Ontology (GO) - Biological Process for NAPSB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAPSB Gene

Drugs & Compounds for NAPSB Gene

No Compound Related Data Available

Transcripts for NAPSB Gene

Unigene Clusters for NAPSB Gene

Napsin B aspartic peptidase, pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPSB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for NAPSB Gene

GeneLoc Exon Structure for
NAPSB
ECgene alternative splicing isoforms for
NAPSB

Expression for NAPSB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAPSB Gene

mRNA differential expression in normal tissues according to GTEx for NAPSB Gene

This gene is overexpressed in Spleen (x11.0), Whole Blood (x9.0), and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for NAPSB Gene

This gene is overexpressed in Lung (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for NAPSB Gene



Protein tissue co-expression partners for NAPSB Gene

NURSA nuclear receptor signaling pathways regulating expression of NAPSB Gene:

NAPSB

SOURCE GeneReport for Unigene cluster for NAPSB Gene:

Hs.636624
genes like me logo Genes that share expression patterns with NAPSB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPSB Gene

Orthologs for NAPSB Gene

Evolution for NAPSB Gene

ENSEMBL:
Gene Tree for NAPSB (if available)
TreeFam:
Gene Tree for NAPSB (if available)

No data available for Orthologs for NAPSB Gene

Paralogs for NAPSB Gene

No data available for Paralogs for NAPSB Gene

Variants for NAPSB Gene

Sequence variations from dbSNP and Humsavar for NAPSB Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000088982 -- 50,335,703(-) A/G intron_variant
rs1000121439 -- 50,335,519(-) G/T intron_variant
rs1000451456 -- 50,341,441(-) G/A intron_variant
rs1000752533 -- 50,336,812(-) C/G intron_variant
rs1000819043 -- 50,346,107(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAPSB Gene

Variant ID Type Subtype PubMed ID
nsv978835 CNV duplication 23825009
nsv953603 CNV deletion 24416366
nsv523948 CNV gain 19592680
nsv2529 CNV insertion 18451855
nsv1152956 OTHER inversion 26484159
nsv1140251 OTHER inversion 24896259
nsv1133010 OTHER inversion 24896259
nsv1066389 CNV gain 25217958

Additional Variant Information for NAPSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPSB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NAPSB Gene

Disorders for NAPSB Gene

Additional Disease Information for NAPSB

No disorders were found for NAPSB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPSB Gene

Publications for NAPSB Gene

  1. Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells. (PMID: 12151090) Cook M … Kay J (Biochimica et biophysica acta 2002) 3 22 58
  2. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. (PMID: 10591213) Yan R … Gurney ME (Nature 1999) 2 3 58
  3. Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PMID: 9877162) Tatnell PJ … Kay J (FEBS letters 1998) 2 3 58
  4. Structural and phylogenetic comparison of napsin genes: the duplication, loss of function and human-specific pseudogenization of napsin B. (PMID: 23333608) Nishishita K … Tsukuba T (Gene 2013) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for NAPSB Gene

Sources for NAPSB Gene

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