Aliases for NAPRT Gene
External Ids for NAPRT Gene
Previous HGNC Symbols for NAPRT Gene
Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 22.214.171.124) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]
GeneCards Summary for NAPRT Gene
NAPRT (Nicotinate Phosphoribosyltransferase) is a Protein Coding gene. Diseases associated with NAPRT include Pellagra. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and nicotinate phosphoribosyltransferase activity. An important paralog of this gene is NAMPT.
UniProtKB/Swiss-Prot Summary for NAPRT Gene
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275).