Aliases for NAPRT Gene
External Ids for NAPRT Gene
Previous HGNC Symbols for NAPRT Gene
Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 126.96.36.199) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]
GeneCards Summary for NAPRT Gene
NAPRT (Nicotinate Phosphoribosyltransferase) is a Protein Coding gene. Diseases associated with NAPRT include Pellagra. Among its related pathways are Innate Immune System and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include ligase activity and nicotinate phosphoribosyltransferase activity. An important paralog of this gene is NAMPT.
UniProtKB/Swiss-Prot Summary for NAPRT Gene
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275).