This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the m... See more...

Aliases for NAPG Gene

Aliases for NAPG Gene

  • NSF Attachment Protein Gamma 2 3 5
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Gamma 2 3
  • Gamma-Soluble NSF Attachment Protein 3 4
  • SNAP-Gamma 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Gamma 4
  • Soluble NSF Attachment Protein 3
  • Gamma SNAP 2
  • GAMMASNAP 3
  • SNAPG 4

External Ids for NAPG Gene

Previous GeneCards Identifiers for NAPG Gene

  • GC18P010683
  • GC18P010582

Summaries for NAPG Gene

Entrez Gene Summary for NAPG Gene

  • This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]

GeneCards Summary for NAPG Gene

NAPG (NSF Attachment Protein Gamma) is a Protein Coding gene. Diseases associated with NAPG include African Histoplasmosis. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. An important paralog of this gene is NAPA.

UniProtKB/Swiss-Prot Summary for NAPG Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Wiki entry for NAPG Gene

Additional gene information for NAPG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAPG Gene

Genomics for NAPG Gene

GeneHancer (GH) Regulatory Elements for NAPG Gene

Promoters and enhancers for NAPG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J010524 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 551.5 +0.4 353 3.5 RXRA ZNF217 EP300 SIN3A NRF1 POLR2G GTF2E2 REST POLR2A CLOCK NAPG piR-31534-304
GH18J010523 Enhancer 0.3 Ensembl 527.3 -2.0 -1975 0.2 YY1 NAPG HSALNG0120003
GH18J010490 Enhancer 0.9 Ensembl ENCODE 45.7 -35.1 -35058 1.2 CTCF RAD21 SKI TRIM22 TEAD1 MYC CREB1 SMC3 SAP130 ARNT NAPG APCDD1 HSALNG0119999 piR-49423-111
GH18J010529 Enhancer 0.8 ENCODE 51.3 +4.0 4021 1.5 ZBTB11 CTBP1 MYC NCOR1 RELA SMC3 ZNF384 CREB3L1 GABPA TRIM28 NAPG piR-31534-304
GH18J010518 Enhancer 1 Ensembl ENCODE 41.6 -6.5 -6514 2.5 CTCF USF1 ZIC2 REST MYC RAD21 TRIM22 SMC3 ZNF316 MAFF NAPG HSALNG0120003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAPG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAPG

Top Transcription factor binding sites by QIAGEN in the NAPG gene promoter:
  • C/EBPbeta
  • E2F
  • E2F-1
  • FOXO1
  • FOXO1a
  • HOXA9
  • Pax-5
  • POU3F2

Genomic Locations for NAPG Gene

Genomic Locations for NAPG Gene
chr18:10,525,876-10,552,769
(GRCh38/hg38)
Size:
26,894 bases
Orientation:
Plus strand
chr18:10,525,873-10,552,766
(GRCh37/hg19)
Size:
26,894 bases
Orientation:
Plus strand

Genomic View for NAPG Gene

Genes around NAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPG Gene

Proteins for NAPG Gene

  • Protein details for NAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99747-SNAG_HUMAN
    Recommended name:
    Gamma-soluble NSF attachment protein
    Protein Accession:
    Q99747
    Secondary Accessions:
    • B4DFC9
    • Q9BUV1

    Protein attributes for NAPG Gene

    Size:
    312 amino acids
    Molecular mass:
    34746 Da
    Quaternary structure:
    • Binds RIP11. Interacts with VTI1A (By similarity).

    Alternative splice isoforms for NAPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAPG Gene

Post-translational modifications for NAPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAPG Gene

No data available for DME Specific Peptides for NAPG Gene

Domains & Families for NAPG Gene

Gene Families for NAPG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAPG Gene

Suggested Antigen Peptide Sequences for NAPG Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61104, highly similar to Gamma-soluble NSF attachment protein (B4DFC9_HUMAN)
  • cDNA, FLJ95310, Homo sapiens N-ethylmaleimide-sensitive factor attachment protein,gamma (NAPG), mRNA (Q6FHY4_HUMAN)
  • N-ethylmaleimide-sensitive factor attachment protein gamma (SNAG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99747

UniProtKB/Swiss-Prot:

SNAG_HUMAN :
  • Belongs to the SNAP family.
Family:
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPG: view

Function for NAPG Gene

Molecular function for NAPG Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Phenotypes From GWAS Catalog for NAPG Gene

Gene Ontology (GO) - Molecular Function for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005483 soluble NSF attachment protein activity IBA 21873635
GO:0005515 protein binding IEA,IPI 11278501
GO:0019905 syntaxin binding IBA 21873635
genes like me logo Genes that share ontologies with NAPG: view
genes like me logo Genes that share phenotypes with NAPG: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAPG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAPG Gene

Localization for NAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPG Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAPG gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005739 mitochondrion IDA 11278501
GO:0005765 lysosomal membrane HDA 17897319
GO:0005774 vacuolar membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NAPG: view

Pathways & Interactions for NAPG Gene

genes like me logo Genes that share pathways with NAPG: view

Gene Ontology (GO) - Biological Process for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA,IEA 21873635
GO:0006891 intra-Golgi vesicle-mediated transport TAS 8455721
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0050821 protein stabilization NAS 11278501
genes like me logo Genes that share ontologies with NAPG: view

No data available for SIGNOR curated interactions for NAPG Gene

Drugs & Compounds for NAPG Gene

(3) Drugs for NAPG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NAPG: view

Transcripts for NAPG Gene

mRNA/cDNA for NAPG Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAPG

Alternative Splicing Database (ASD) splice patterns (SP) for NAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2:
SP3: -
SP4:

Relevant External Links for NAPG Gene

GeneLoc Exon Structure for
NAPG

Expression for NAPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPG Gene

This gene is overexpressed in Bone (19.2) and Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAPG Gene



Protein tissue co-expression partners for NAPG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAPG

SOURCE GeneReport for Unigene cluster for NAPG Gene:

Hs.464622

Evidence on tissue expression from TISSUES for NAPG Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with NAPG: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPG Gene

Orthologs for NAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for NAPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAPG 31 30
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NAPG 31 30
  • 91.85 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAPG 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napg 17 31 30
  • 88.25 (n)
oppossum
(Monodelphis domestica)
Mammalia NAPG 31
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAPG 31 30
  • 86 (n)
OneToOne
chicken
(Gallus gallus)
Aves NAPG 31 30
  • 80.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAPG 31
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia napg 30
  • 77.09 (n)
zebrafish
(Danio rerio)
Actinopterygii napgl 31
  • 75 (a)
OneToMany
napg 31 30
  • 70.98 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gammaSnap 31 32 30
  • 49.72 (n)
OneToMany
CG6208 31 32
  • 30 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005632 30
  • 49.55 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y59A8B.8 30
  • 48.96 (n)
Y59A8B.8 31 32
  • 34 (a)
OneToMany
Y59A8B.25 31
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToOne
Species where no ortholog for NAPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPG Gene

ENSEMBL:
Gene Tree for NAPG (if available)
TreeFam:
Gene Tree for NAPG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAPG: view image

Paralogs for NAPG Gene

Paralogs for NAPG Gene

genes like me logo Genes that share paralogs with NAPG: view

Variants for NAPG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAPG Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs2228300 - p.Pro92Ser
rs2305370 - p.Lys281Asn

Additional dbSNP identifiers (rs#s) for NAPG Gene

Structural Variations from Database of Genomic Variants (DGV) for NAPG Gene

Variant ID Type Subtype PubMed ID
esv2667923 CNV deletion 23128226
nsv1059110 CNV gain 25217958

Variation tolerance for NAPG Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPG Gene

Disorders for NAPG Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAPG Gene - From: DISEASES

Disorder Aliases PubMed IDs
african histoplasmosis
- elite association - COSMIC cancer census association via MalaCards
Search NAPG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAPG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NAPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAPG Gene

Publications for NAPG Gene

  1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PMID: 9269766) Lemons PP … Whiteheart SW (Blood 1997) 2 3 4 23 54
  2. Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder. (PMID: 16395123) Weller AE … Berrettini WH (Psychiatric genetics 2006) 3 23 41 54
  3. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. (PMID: 11278501) Chen D … Whiteheart SW (The Journal of biological chemistry 2001) 3 4 23 54
  4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PMID: 19328558) Yosifova A … Nakamura Y (Journal of affective disorders 2009) 3 41 54
  5. Association study on the NAPG gene and bipolar disorder in the Chinese Han population. (PMID: 19429185) Li X … He G (Neuroscience letters 2009) 3 41 54

Products for NAPG Gene

Sources for NAPG Gene