Aliases for NAPEPLD Gene
External Ids for NAPEPLD Gene
Previous GeneCards Identifiers for NAPEPLD Gene
NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]
GeneCards Summary for NAPEPLD Gene
NAPEPLD (N-Acyl Phosphatidylethanolamine Phospholipase D) is a Protein Coding gene. Diseases associated with NAPEPLD include Cannabis Abuse and Hallucinogen Dependence. Among its related pathways are GABAergic synapse and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include phospholipase activity and N-acylphosphatidylethanolamine-specific phospholipase D activity.
UniProtKB/Swiss-Prot Summary for NAPEPLD Gene
Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid (PubMed:25684574, PubMed:14634025, PubMed:16527816). Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (PubMed:14634025). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose (By similarity).