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Aliases for NAPEPLD Gene

Aliases for NAPEPLD Gene

  • N-Acyl Phosphatidylethanolamine Phospholipase D 2 3 4 5
  • NAPE-Hydrolyzing Phospholipase D 3 4
  • NAPE-PLD 3 4
  • C7orf18 3 4
  • Chromosome 7 Open Reading Frame 18, N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase D 2
  • N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase D 3
  • EC 4
  • FMP30 3

External Ids for NAPEPLD Gene

Previous GeneCards Identifiers for NAPEPLD Gene

  • GC07M102528
  • GC07M102742
  • GC07M097103

Summaries for NAPEPLD Gene

Entrez Gene Summary for NAPEPLD Gene

  • NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]

GeneCards Summary for NAPEPLD Gene

NAPEPLD (N-Acyl Phosphatidylethanolamine Phospholipase D) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Retinoid cycle disease events. Gene Ontology (GO) annotations related to this gene include phospholipase activity and N-acylphosphatidylethanolamine-specific phospholipase D activity.

UniProtKB/Swiss-Prot for NAPEPLD Gene

  • Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).

Additional gene information for NAPEPLD Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPEPLD Gene

Genomics for NAPEPLD Gene

GeneHancer (GH) Regulatory Elements for NAPEPLD Gene

Promoters and enhancers for NAPEPLD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J103146 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 666 -0.1 -103 7.3 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN NR2C1 PMPCB NAPEPLD LOC105375434 GC07P103150 RPL23AP95 CRYZP1 ENSG00000213385 POLR2J3 DPY19L2P2 POLR2J2
GH07J103141 Promoter 0.5 EPDnew 659.3 +7.6 7573 0.1 NAPEPLD RPL19P12 PMPCB CRYZP1
GH07J102571 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.1 +577.0 577028 1.5 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 E2F8 ZNF416 ZNF207 POLR2J3 CRYZP1 ENSG00000213385 PRKRIP1 DNAJC2 PMPCB ENSG00000239486 FAM185A NAPEPLD LRWD1
GH07J103119 Enhancer 1 dbSUPER 23.5 +29.0 29013 2.3 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 CBX5 GATA2 E2F8 ATF7 NAPEPLD ARMC10 RPL19P12 CRYZP1
GH07J103073 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +74.5 74465 2.7 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ARMC10 FBXL13 ENSG00000213385 CRYZP1 PRKRIP1 PMPCB POLR2J2 POLR2J3 FAM185A DNAJC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAPEPLD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAPEPLD gene promoter:
  • POU6F1 (c2)
  • SRF (504 AA)
  • SRF
  • AP-4
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • TBP

Genomic Locations for NAPEPLD Gene

Genomic Locations for NAPEPLD Gene
49,985 bases
Minus strand
49,985 bases
Minus strand

Genomic View for NAPEPLD Gene

Genes around NAPEPLD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPEPLD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPEPLD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPEPLD Gene

Proteins for NAPEPLD Gene

  • Protein details for NAPEPLD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
    Protein Accession:
    Secondary Accessions:
    • Q5CZ87
    • Q769K1

    Protein attributes for NAPEPLD Gene

    393 amino acids
    Molecular mass:
    45596 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NAPEPLD Gene

neXtProt entry for NAPEPLD Gene

Post-translational modifications for NAPEPLD Gene

  • Ubiquitination at Lys296 and Lys73
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAPEPLD Gene

Domains & Families for NAPEPLD Gene

Gene Families for NAPEPLD Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NAPEPLD Gene

Suggested Antigen Peptide Sequences for NAPEPLD Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NAPE-PLD family.
  • Belongs to the NAPE-PLD family.
genes like me logo Genes that share domains with NAPEPLD: view

Function for NAPEPLD Gene

Molecular function for NAPEPLD Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
An N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is stimulated by divalent cations.

Enzyme Numbers (IUBMB) for NAPEPLD Gene

Phenotypes From GWAS Catalog for NAPEPLD Gene

Gene Ontology (GO) - Molecular Function for NAPEPLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA,IBA --
GO:0042802 identical protein binding IPI 25684574
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NAPEPLD: view
genes like me logo Genes that share phenotypes with NAPEPLD: view

Animal Models for NAPEPLD Gene

MGI Knock Outs for NAPEPLD:

Animal Model Products

  • Taconic Biosciences Mouse Models for NAPEPLD

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAPEPLD Gene

Localization for NAPEPLD Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPEPLD Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAPEPLD gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
peroxisome 2
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAPEPLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0042622 photoreceptor outer segment membrane TAS --
GO:0043227 membrane-bounded organelle IEA,IBA --
genes like me logo Genes that share ontologies with NAPEPLD: view

Pathways & Interactions for NAPEPLD Gene

genes like me logo Genes that share pathways with NAPEPLD: view

Pathways by source for NAPEPLD Gene

Interacting Proteins for NAPEPLD Gene

Gene Ontology (GO) - Biological Process for NAPEPLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0007568 aging IEA --
GO:0009395 phospholipid catabolic process IEA --
genes like me logo Genes that share ontologies with NAPEPLD: view

No data available for SIGNOR curated interactions for NAPEPLD Gene

Drugs & Compounds for NAPEPLD Gene

(5) Drugs for NAPEPLD Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cannabidiol Approved, Investigational Pharma Partial agonist, Agonist, Antagonist, Channel blocker, Activator, Enzyme 0
Nabiximols Approved, Investigational Pharma Enzyme 0
Water Approved Pharma 0
Medical Cannabis Experimental, Investigational Pharma Enzyme 0
Anandamide Pharma Antagonist, Pore Blocker, Partial agonist, Agonist, Potentiation, Allosteric regulator, Full agonist, Inhibitor, Channel blocker 0

(16) Additional Compounds for NAPEPLD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with NAPEPLD: view

Transcripts for NAPEPLD Gene

Unigene Clusters for NAPEPLD Gene

N-acyl phosphatidylethanolamine phospholipase D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPEPLD Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP2: - - -
SP3: -

Relevant External Links for NAPEPLD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAPEPLD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAPEPLD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPEPLD Gene

This gene is overexpressed in Frontal cortex (28.0), Bone marrow mesenchymal stem cell (12.6), Brain (8.3), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NAPEPLD Gene

Protein tissue co-expression partners for NAPEPLD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAPEPLD Gene:


SOURCE GeneReport for Unigene cluster for NAPEPLD Gene:


Evidence on tissue expression from TISSUES for NAPEPLD Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with NAPEPLD: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPEPLD Gene

Orthologs for NAPEPLD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPEPLD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAPEPLD 34 33
  • 99.41 (n)
(Bos Taurus)
Mammalia NAPEPLD 34 33
  • 88.29 (n)
(Mus musculus)
Mammalia Napepld 16 34 33
  • 83.97 (n)
(Rattus norvegicus)
Mammalia Napepld 33
  • 83.97 (n)
(Canis familiaris)
Mammalia NAPEPLD 34 33
  • 79.55 (n)
(Monodelphis domestica)
Mammalia NAPEPLD 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia NAPEPLD 34
  • 60 (a)
(Gallus gallus)
Aves NAPEPLD 34 33
  • 76.78 (n)
(Anolis carolinensis)
Reptilia NAPEPLD 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia napepld 33
  • 72.96 (n)
Str.17648 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33958 33
(Danio rerio)
Actinopterygii napepld 34 33
  • 64.1 (n)
wufc56b11 33
(Caenorhabditis elegans)
Secernentea nape-2 34 33
  • 51.5 (n)
nape-1 34
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP30 36 34
  • 26 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07271 33
  • 48.96 (n)
Species where no ortholog for NAPEPLD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPEPLD Gene

Gene Tree for NAPEPLD (if available)
Gene Tree for NAPEPLD (if available)
Evolutionary constrained regions (ECRs) for NAPEPLD: view image

Paralogs for NAPEPLD Gene Pseudogenes for NAPEPLD Gene

genes like me logo Genes that share paralogs with NAPEPLD: view

No data available for Paralogs for NAPEPLD Gene

Variants for NAPEPLD Gene

Sequence variations from dbSNP and Humsavar for NAPEPLD Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000037912 -- 103,106,159(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000055745 -- 103,123,323(-) AACAAAA/A intron_variant
rs1000060284 -- 103,109,016(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000147546 -- 103,112,831(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000164420 -- 103,149,614(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAPEPLD Gene

Variant ID Type Subtype PubMed ID
esv2674575 CNV deletion 23128226
esv2752138 CNV loss 17911159
esv3614368 CNV loss 21293372
esv3614369 CNV loss 21293372
nsv5882 CNV insertion 18451855
nsv831084 CNV gain 17160897
nsv970565 CNV duplication 23825009
nsv981565 CNV duplication 23825009

Variation tolerance for NAPEPLD Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAPEPLD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPEPLD Gene

Disorders for NAPEPLD Gene

Additional Disease Information for NAPEPLD

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NAPEPLD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPEPLD Gene

Publications for NAPEPLD Gene

  1. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PMID: 15820312) Curtiss NP … Shannon KM (Genomics 2005) 2 3 4 58
  2. Molecular characterization of a phospholipase D generating anandamide and its congeners. (PMID: 14634025) Okamoto Y … Ueda N (The Journal of biological chemistry 2004) 2 3 4 58
  3. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. (PMID: 18067139) Egertová M … Elphick MR (The Journal of comparative neurology 2008) 2 3 58
  4. Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. (PMID: 25684574) Magotti P … Garau G (Structure (London, England : 1993) 2015) 3 58
  5. Protein phosphatase 1γ isoforms linked interactions in the brain. (PMID: 23080069) Esteves SL … da Cruz e Silva EF (Journal of molecular neuroscience : MN 2013) 3 58

Products for NAPEPLD Gene

Sources for NAPEPLD Gene

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