Aliases for NAPB Gene
External Ids for NAPB Gene
Previous GeneCards Identifiers for NAPB Gene
This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017]
GeneCards Summary for NAPB Gene
NAPB (NSF Attachment Protein Beta) is a Protein Coding gene. Diseases associated with NAPB include Amyotrophy, Hereditary Neuralgic and Neurodegeneration With Brain Iron Accumulation 6. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. An important paralog of this gene is NAPA.
UniProtKB/Swiss-Prot Summary for NAPB Gene
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.