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Aliases for NAPB Gene

Aliases for NAPB Gene

  • NSF Attachment Protein Beta 2 3 5
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Beta 2 3
  • SNAPB 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Beta 4
  • Beta-Soluble NSF Attachment Protein 3
  • Beta Soluble NSF Attachment Protein 2
  • SNAP-Beta 4

External Ids for NAPB Gene

Previous GeneCards Identifiers for NAPB Gene

  • GC17U990129
  • GC20M023303
  • GC20M023350
  • GC20M023319
  • GC20M023355

Summaries for NAPB Gene

Entrez Gene Summary for NAPB Gene

  • This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017]

GeneCards Summary for NAPB Gene

NAPB (NSF Attachment Protein Beta) is a Protein Coding gene. Diseases associated with NAPB include Neurodegeneration With Brain Iron Accumulation 6. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. An important paralog of this gene is NAPA.

UniProtKB/Swiss-Prot for NAPB Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Wiki entry for NAPB Gene

Additional gene information for NAPB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPB Gene

Genomics for NAPB Gene

GeneHancer (GH) Regulatory Elements for NAPB Gene

Promoters and enhancers for NAPB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J023419 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 669 +0.9 867 3 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 NAPB CSTL1 RNA5SP479 GC20M023381
GH20J023409 Promoter 0.6 EPDnew 650.4 +11.7 11712 0.1 POLR2A NAPB CSTL1 NXT1 ENSG00000234832 GC20M023381 RNA5SP479
GH20J023356 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.3 +61.4 61393 7.6 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 LINC01431 GZF1 NXT1 NAPB CSTL1
GH20J023348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.9 +71.0 70990 3.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B NXT1 LOC105372572 PIR48192 ENSG00000234832 NAPB CSTL1
GH20J023366 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +54.9 54862 1.3 HDAC1 ATF1 TCF12 ATF7 RUNX3 PAF1 SMARCA5 JUNB ELF1 RAD51 NAPB CSTL1 CD93 GZF1 THBD RNA5SP479 GC20M023381
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAPB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAPB gene promoter:
  • STAT1beta
  • STAT1alpha
  • STAT1
  • ATF6
  • RelA
  • RREB-1
  • En-1
  • AREB6
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)

Genomic Locations for NAPB Gene

Genomic Locations for NAPB Gene
47,001 bases
Minus strand
47,001 bases
Minus strand

Genomic View for NAPB Gene

Genes around NAPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPB Gene

Proteins for NAPB Gene

  • Protein details for NAPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-soluble NSF attachment protein
    Protein Accession:
    Secondary Accessions:
    • B4DK44
    • Q4G0M0
    • Q4G187
    • Q5JXF9
    • Q8N3C4

    Protein attributes for NAPB Gene

    298 amino acids
    Molecular mass:
    33557 Da
    Quaternary structure:
    • Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.

    Alternative splice isoforms for NAPB Gene


neXtProt entry for NAPB Gene

Post-translational modifications for NAPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAPB Gene

Domains & Families for NAPB Gene

Gene Families for NAPB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAPB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SNAP family.
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPB: view

Function for NAPB Gene

Molecular function for NAPB Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Phenotypes From GWAS Catalog for NAPB Gene

Gene Ontology (GO) - Molecular Function for NAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005483 soluble NSF attachment protein activity IBA --
GO:0005515 protein binding IEA,IPI 21516116
GO:0019905 syntaxin binding IBA,IEA --
genes like me logo Genes that share ontologies with NAPB: view
genes like me logo Genes that share phenotypes with NAPB: view

Animal Models for NAPB Gene

MGI Knock Outs for NAPB:
  • Napb Napb<tm1Rhee>

Animal Model Products

miRNA for NAPB Gene

miRTarBase miRNAs that target NAPB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAPB Gene

Localization for NAPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPB Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAPB gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005774 vacuolar membrane IBA --
GO:0016020 membrane IEA --
GO:0031201 SNARE complex IBA --
GO:0043195 terminal bouton IBA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with NAPB: view

Pathways & Interactions for NAPB Gene

genes like me logo Genes that share pathways with NAPB: view

Gene Ontology (GO) - Biological Process for NAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA,IBA --
GO:0010807 regulation of synaptic vesicle priming IBA,IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0035249 synaptic transmission, glutamatergic IEA,IBA --
genes like me logo Genes that share ontologies with NAPB: view

No data available for SIGNOR curated interactions for NAPB Gene

Drugs & Compounds for NAPB Gene

No Compound Related Data Available

Transcripts for NAPB Gene

Unigene Clusters for NAPB Gene

N-ethylmaleimide-sensitive factor attachment protein, beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - -
SP14: -
SP15: - -

ExUns: 13b · 13c · 13d

Relevant External Links for NAPB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAPB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.9), Brain - Anterior cingulate cortex (BA24) (x6.4), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for NAPB Gene

This gene is overexpressed in Brain (25.0), Frontal cortex (14.7), Retina (8.6), and Spinal cord (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NAPB Gene

Protein tissue co-expression partners for NAPB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAPB Gene:


SOURCE GeneReport for Unigene cluster for NAPB Gene:


Evidence on tissue expression from TISSUES for NAPB Gene

  • Nervous system(5)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with NAPB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPB Gene

Orthologs for NAPB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAPB 34 33
  • 99.89 (n)
(Monodelphis domestica)
Mammalia NAPB 34
  • 96 (a)
(Canis familiaris)
Mammalia NAPB 34 33
  • 93.85 (n)
(Rattus norvegicus)
Mammalia Napb 33
  • 92.06 (n)
(Mus musculus)
Mammalia Napb 16 34 33
  • 91.16 (n)
(Bos Taurus)
Mammalia NAPB 34 33
  • 89.15 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
-- 34
  • 79 (a)
(Gallus gallus)
Aves NAPB 34 33
  • 83 (n)
(Anolis carolinensis)
Reptilia NAPB 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia napb 33
  • 83.33 (n)
Str.15567 33
(Danio rerio)
Actinopterygii NAPB (2 of 2) 34
  • 88 (a)
napba 34
  • 80 (a)
zgc:158643 33
  • 78.76 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.936 33
fruit fly
(Drosophila melanogaster)
Insecta Snap 34 35
  • 62 (a)
(Caenorhabditis elegans)
Secernentea D1014.3 35
  • 50 (a)
snap-1 34
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC17 36 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2218 34
  • 59 (a)
Species where no ortholog for NAPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPB Gene

Gene Tree for NAPB (if available)
Gene Tree for NAPB (if available)
Evolutionary constrained regions (ECRs) for NAPB: view image

Paralogs for NAPB Gene

Paralogs for NAPB Gene

(1) SIMAP similar genes for NAPB Gene using alignment to 3 proteins:

  • B4DK44_HUMAN
  • Q4G0M0_HUMAN
genes like me logo Genes that share paralogs with NAPB: view

Variants for NAPB Gene

Sequence variations from dbSNP and Humsavar for NAPB Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs193921124 uncertain-significance, Malignant tumor of prostate 23,379,443(-) A/G genic_downstream_transcript_variant, splice_donor_variant
rs876661300 uncertain-significance, not provided 23,390,028(-) G/A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant, stop_gained
rs1000057573 -- 23,422,870(-) C/T upstream_transcript_variant
rs1000135428 -- 23,417,327(-) A/C intron_variant
rs1000153668 -- 23,374,408(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAPB Gene

Variant ID Type Subtype PubMed ID
esv3575364 CNV gain 25503493
nsv1063655 CNV gain 25217958

Variation tolerance for NAPB Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAPB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPB Gene

Disorders for NAPB Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAPB Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
neurodegeneration with brain iron accumulation 6
  • nbia6
- elite association - COSMIC cancer census association via MalaCards
Search NAPB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAPB

genes like me logo Genes that share disorders with NAPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAPB Gene

Publications for NAPB Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. (PMID: 9697855) Osten P … Ziff EB (Neuron 1998) 3 22 58
  5. SNAP family of NSF attachment proteins includes a brain-specific isoform. (PMID: 8455721) Whiteheart SW … Rothman JE (Nature 1993) 2 3 58

Products for NAPB Gene

Sources for NAPB Gene

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