Aliases for NAPA Gene
External Ids for NAPA Gene
Previous GeneCards Identifiers for NAPA Gene
This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
GeneCards Summary for NAPA Gene
NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. Diseases associated with NAPA include Tetanus. Among its related pathways are Metabolism of proteins and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. An important paralog of this gene is NAPB.
UniProtKB/Swiss-Prot Summary for NAPA Gene
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433).