This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-assoc... See more...

Aliases for NAPA Gene

Aliases for NAPA Gene

  • NSF Attachment Protein Alpha 2 3 5
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha 2 3
  • Alpha-Soluble NSF Attachment Protein 3 4
  • SNAPA 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Alpha 4
  • Alpha Soluble NSF Attachment Protein 2
  • Alpha-SNAP 3
  • SNAP-Alpha 4
  • Alpha SNAP 2

External Ids for NAPA Gene

Previous GeneCards Identifiers for NAPA Gene

  • GC19M048637
  • GC19M048381
  • GC19M052666
  • GC19M052682
  • GC19M052658
  • GC19M047990
  • GC19M044419

Summaries for NAPA Gene

Entrez Gene Summary for NAPA Gene

  • This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NAPA Gene

NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. Diseases associated with NAPA include Tetanus. Among its related pathways are Metabolism of proteins and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. An important paralog of this gene is NAPB.

UniProtKB/Swiss-Prot Summary for NAPA Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433).

Gene Wiki entry for NAPA Gene

Additional gene information for NAPA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAPA Gene

Genomics for NAPA Gene

GeneHancer (GH) Regulatory Elements for NAPA Gene

Promoters and enhancers for NAPA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047509 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 505.5 +2.3 2315 7.1 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G NAPA lnc-BICRA-4 KPTN CCDC9 C5AR1 DHX34 LIG1 SULT2A1 BICRA ZC3H4
GH19J047598 Promoter/Enhancer 2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 13 -85.0 -84962 4.2 HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 USF1 POLR2G SP1 ZNF541 NAPA NOP53 SNORD23 BBC3 BICRA INAFM1 lnc-BICRA-2 RF00017-3032
GH19J047775 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10 -263.5 -263468 5.5 FOXK2 ZNF217 EP300 ZSCAN5C SIN3A NRF1 POLR2G SP1 BCLAF1 NONO SELENOW lnc-NOP53-2 NOP53 SEC1P MEIS3 NAPA NTN5 lnc-SELENOW-1 RF00017-3037
GH19J047312 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 13 +201.7 201713 1.7 TCF12 NCOR1 ZBTB5 AFF1 TARDBP REST HES1 ZBTB25 ZNF740 TOE1 DHX34 C5AR2 C5AR1 ZC3H4 NAPA ENSG00000268810 BICRA PPP5C CCDC9 BBC3
GH19J047329 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 12.2 +184.1 184112 3.7 POLR2A RBM25 NR2F2 MAX ZNF592 TBP CHD2 SPI1 NFE2 FOSL1 C5AR2 NAPA PPP5C DHX34 C5AR1 ZC3H4 CCDC9 BICRA NOP53 piR-48389-012
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAPA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAPA

Top Transcription factor binding sites by QIAGEN in the NAPA gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for NAPA Gene

Genomic Locations for NAPA Gene
chr19:47,487,634-47,515,258
(GRCh38/hg38)
Size:
27,625 bases
Orientation:
Minus strand
chr19:47,990,891-48,018,515
(GRCh37/hg19)
Size:
27,625 bases
Orientation:
Minus strand

Genomic View for NAPA Gene

Genes around NAPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPA Gene

Proteins for NAPA Gene

  • Protein details for NAPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54920-SNAA_HUMAN
    Recommended name:
    Alpha-soluble NSF attachment protein
    Protein Accession:
    P54920
    Secondary Accessions:
    • A8K879
    • Q96IK3
    • Q9BVJ3

    Protein attributes for NAPA Gene

    Size:
    295 amino acids
    Molecular mass:
    33233 Da
    Quaternary structure:
    • Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2 (By similarity). Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha (PubMed:15029241). Interacts with VTI1A (By similarity). Interacts with STX12 (By similarity). Interacts with GNA12 (via N-terminus); the interaction promotes CDH5 localization to plasma membrane (PubMed:15980433).

neXtProt entry for NAPA Gene

Post-translational modifications for NAPA Gene

  • Ubiquitination at Lys22 and Lys227
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAPA Gene

Domains & Families for NAPA Gene

Gene Families for NAPA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAPA Gene

Blocks:
  • NSF attachment protein signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAPA Gene

GenScript: Design optimal peptide antigens:
  • N-ethylmaleimide-sensitive factor attachment protein alpha (SNAA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54920

UniProtKB/Swiss-Prot:

SNAA_HUMAN :
  • Belongs to the SNAP family.
Family:
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPA: view

Function for NAPA Gene

Molecular function for NAPA Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433).

Phenotypes From GWAS Catalog for NAPA Gene

Gene Ontology (GO) - Molecular Function for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS --
GO:0005483 soluble NSF attachment protein activity IBA 21873635
GO:0005515 protein binding IEA,IPI 15029241
GO:0019905 syntaxin binding IBA 21873635
GO:0044877 protein-containing complex binding ISS --
genes like me logo Genes that share ontologies with NAPA: view
genes like me logo Genes that share phenotypes with NAPA: view

Animal Models for NAPA Gene

MGI Knock Outs for NAPA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAPA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NAPA Gene

Localization for NAPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPA Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAPA gene
Compartment Confidence
cytosol 5
plasma membrane 4
golgi apparatus 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005623 cell IEA --
GO:0005774 vacuolar membrane IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with NAPA: view

Pathways & Interactions for NAPA Gene

genes like me logo Genes that share pathways with NAPA: view

Gene Ontology (GO) - Biological Process for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA,IBA 21873635
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006891 intra-Golgi vesicle-mediated transport TAS 8455721
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with NAPA: view

No data available for SIGNOR curated interactions for NAPA Gene

Drugs & Compounds for NAPA Gene

(4) Drugs for NAPA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for NAPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAPA: view

Transcripts for NAPA Gene

mRNA/cDNA for NAPA Gene

1 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAPA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - -
SP16: - -
SP17:
SP18:

ExUns: 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -

Relevant External Links for NAPA Gene

GeneLoc Exon Structure for
NAPA

Expression for NAPA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPA Gene

This gene is overexpressed in Bone (10.1) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAPA Gene



Protein tissue co-expression partners for NAPA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAPA

SOURCE GeneReport for Unigene cluster for NAPA Gene:

Hs.730799

Evidence on tissue expression from TISSUES for NAPA Gene

  • Nervous system(5)
  • Lung(4.7)
  • Liver(4.4)
  • Blood(4.2)
  • Pancreas(4)
  • Intestine(3.1)
  • Adrenal gland(2.9)
  • Eye(2.7)
  • Kidney(2.6)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with NAPA: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPA Gene

Orthologs for NAPA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAPA 31 30
  • 99.66 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAPA 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPA 31 30
  • 92.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NAPA 31 30
  • 92.09 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Napa 30
  • 90.73 (n)
mouse
(Mus musculus)
Mammalia Napa 17 31 30
  • 90.51 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 90 (a)
OneToMany
-- 31
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia napa 30
  • 80 (n)
Str.15791 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16759 30
zebrafish
(Danio rerio)
Actinopterygii napa 31
  • 84 (a)
OneToMany
napab 30
  • 75.82 (n)
NAPA (2 of 2) 31
  • 75 (a)
OneToMany
wufa26c04 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003192 30
  • 65.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Snap 31 32 30
  • 65.58 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snap-1 31 30
  • 55.35 (n)
OneToMany
D1014.3 32
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR155C 30
  • 49.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC17 31 30
  • 47.09 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05919g 30
  • 45.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2218 31
  • 59 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01674 30
  • 49.94 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec17 30
  • 47.45 (n)
Species where no ortholog for NAPA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPA Gene

ENSEMBL:
Gene Tree for NAPA (if available)
TreeFam:
Gene Tree for NAPA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAPA: view image

Paralogs for NAPA Gene

Paralogs for NAPA Gene

(1) SIMAP similar genes for NAPA Gene using alignment to 10 proteins:

  • SNAA_HUMAN
  • M0QZM9_HUMAN
  • M0QZN5_HUMAN
  • M0R027_HUMAN
  • M0R031_HUMAN
  • M0R058_HUMAN
  • M0R0I4_HUMAN
  • M0R0Y2_HUMAN
  • M0R213_HUMAN
  • M0R2M1_HUMAN
genes like me logo Genes that share paralogs with NAPA: view

Variants for NAPA Gene

Additional dbSNP identifiers (rs#s) for NAPA Gene

Structural Variations from Database of Genomic Variants (DGV) for NAPA Gene

Variant ID Type Subtype PubMed ID
esv2131971 CNV deletion 18987734
esv2718664 CNV deletion 23290073
esv2718665 CNV deletion 23290073
esv2758765 CNV loss 17122850
esv3346749 CNV duplication 20981092
esv3556493 CNV deletion 23714750
nsv1056887 CNV gain 25217958
nsv1116643 CNV deletion 24896259
nsv138407 CNV deletion 16902084
nsv428366 CNV loss 18775914
nsv579888 CNV gain 21841781
nsv953591 CNV deletion 24416366

Variation tolerance for NAPA Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAPA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAPA Gene

Disorders for NAPA Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAPA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tetanus
  • clostridial tetanus
- elite association - COSMIC cancer census association via MalaCards
Search NAPA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAPA

genes like me logo Genes that share disorders with NAPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAPA Gene

Publications for NAPA Gene

  1. G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. (PMID: 15980433) Andreeva AV … Voyno-Yasenetskaya T (The Journal of biological chemistry 2005) 3 4 23 54
  2. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PMID: 9269766) Lemons PP … Whiteheart SW (Blood 1997) 2 3 4 54
  3. alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PMID: 15542541) Tomes CN … Mayorga LS (Molecular human reproduction 2005) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K … Tagaya M (The EMBO journal 2004) 3 23 54

Products for NAPA Gene

Sources for NAPA Gene