This gene encodes a protein that shares sequence similarity to nucleosome assembly factors, but may be localized to the cytoplasm rather than the nucleus. Expression of this gene is downregulated in hepatocellular carcinomas. This gene is located within a differentially methylated region (DMR) and is imprinted and paternally expressed. There is a related pseudogene on chromosom... See more...

Aliases for NAP1L5 Gene

Aliases for NAP1L5 Gene

  • Nucleosome Assembly Protein 1 Like 5 2 3 5
  • Nucleosome Assembly Protein 1-Like 5 2 3 4
  • DRLM 2 3 4
  • Down-Regulated In Liver Malignancy 3 4
  • NAP1L5 5

External Ids for NAP1L5 Gene

Previous GeneCards Identifiers for NAP1L5 Gene

  • GC04M090075
  • GC04M089974
  • GC04M089836
  • GC04M089617
  • GC04M085368

Summaries for NAP1L5 Gene

Entrez Gene Summary for NAP1L5 Gene

  • This gene encodes a protein that shares sequence similarity to nucleosome assembly factors, but may be localized to the cytoplasm rather than the nucleus. Expression of this gene is downregulated in hepatocellular carcinomas. This gene is located within a differentially methylated region (DMR) and is imprinted and paternally expressed. There is a related pseudogene on chromosome 4. [provided by RefSeq, Nov 2015]

GeneCards Summary for NAP1L5 Gene

NAP1L5 (Nucleosome Assembly Protein 1 Like 5) is a Protein Coding gene. Diseases associated with NAP1L5 include Beckwith-Wiedemann Syndrome. An important paralog of this gene is NAP1L2.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAP1L5 Gene

Genomics for NAP1L5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NAP1L5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J088696 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 259.6 +0.3 298 2.3 IKZF1 ZNF513 SIN3A TAL1 KMT2B GABPB1 YY1 DMAP1 SUPT5H ZNF205 NAP1L5 RF00026-806 RNU6-33P HERC3
GH04J088522 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 15.1 +174.6 174550 3 TBP ZBTB10 SP1 MXD4 FEZF1 NR2C1 IKZF1 SMAD5 ETS1 IRF2 HERC3 PYURF PIGY PIGY-DT NAP1L5 MEPE NCOA4P2 lnc-HERC5-3 HERC5
GH04J088736 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 19 -40.2 -40222 3.8 SIN3A MAFF RXRA ZNF316 MAFK PKNOX1 MAFG SP1 GATA2 POU5F1 lnc-NAP1L5-1 NAP1L5 FAM13A-AS1 HSALNG0035769 FAM13A TIGD2
GH04J088997 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -302.2 -302186 5.5 FEZF1 CEBPA IKZF1 HOMEZ CEBPB ELK1 ZNF395 REST VEZF1 GABPA FAM13A FAM13A-AS1 TIGD2 NAP1L5 SNCA HSALNG0035775 lnc-NAP1L5-4
GH04J088608 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 10.3 +86.2 86221 6 ZSCAN16 BCL11A FEZF1 NR2C1 IKZF1 CEBPB MAX IRF4 TRIM22 EP300 ENSG00000249755 PIGY PYURF NAP1L5 HERC3 FAM13A-AS1 PPM1K RF00017-4362 HSALNG0035767
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAP1L5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAP1L5

Top Transcription factor binding sites by QIAGEN in the NAP1L5 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • JunB
  • Lmo2
  • POU2F1
  • POU2F1a
  • TBP

Genomic Locations for NAP1L5 Gene

Latest Assembly
chr4:88,695,913-88,697,829
(GRCh38/hg38)
Size:
1,917 bases
Orientation:
Minus strand

Previous Assembly
chr4:89,617,064-89,618,980
(GRCh37/hg19 by Entrez Gene)
Size:
1,917 bases
Orientation:
Minus strand

chr4:89,617,066-89,619,386
(GRCh37/hg19 by Ensembl)
Size:
2,321 bases
Orientation:
Minus strand

Genomic View for NAP1L5 Gene

Genes around NAP1L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L5 Gene

Proteins for NAP1L5 Gene

  • Protein details for NAP1L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NT1-NP1L5_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 5
    Protein Accession:
    Q96NT1

    Protein attributes for NAP1L5 Gene

    Size:
    182 amino acids
    Molecular mass:
    19593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAP1L5 Gene

Post-translational modifications for NAP1L5 Gene

  • Ubiquitination at Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for NAP1L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L5 Gene

Domains & Families for NAP1L5 Gene

Gene Families for NAP1L5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAP1L5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAP1L5 Gene

GenScript: Design optimal peptide antigens:
  • Nucleosome assembly protein 1-like 5 (NP1L5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NT1

UniProtKB/Swiss-Prot:

NP1L5_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L5: view

Function for NAP1L5 Gene

Phenotypes From GWAS Catalog for NAP1L5 Gene

Gene Ontology (GO) - Molecular Function for NAP1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0042393 histone binding IBA 21873635
genes like me logo Genes that share ontologies with NAP1L5: view
genes like me logo Genes that share phenotypes with NAP1L5: view

miRNA for NAP1L5 Gene

miRTarBase miRNAs that target NAP1L5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAP1L5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L5 Gene

Localization for NAP1L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L5 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAP1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA 21873635
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with NAP1L5: view

Pathways & Interactions for NAP1L5 Gene

PathCards logo

SuperPathways for NAP1L5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
genes like me logo Genes that share ontologies with NAP1L5: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L5 Gene

Drugs & Compounds for NAP1L5 Gene

No Compound Related Data Available

Transcripts for NAP1L5 Gene

mRNA/cDNA for NAP1L5 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAP1L5

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L5 Gene

No ASD Table

Relevant External Links for NAP1L5 Gene

GeneLoc Exon Structure for
NAP1L5

Expression for NAP1L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAP1L5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L5 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.3), Brain - Frontal Cortex (BA9) (x5.6), and Brain - Anterior cingulate cortex (BA24) (x5.6).

Protein differential expression in normal tissues from HIPED for NAP1L5 Gene

This gene is overexpressed in Frontal cortex (17.1), Retina (13.0), Spinal cord (8.9), Fetal Brain (7.9), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAP1L5 Gene



Protein tissue co-expression partners for NAP1L5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAP1L5

SOURCE GeneReport for Unigene cluster for NAP1L5 Gene:

Hs.12554

mRNA Expression by UniProt/SwissProt for NAP1L5 Gene:

Q96NT1-NP1L5_HUMAN
Tissue specificity: Predominantly expressed in brain.

Evidence on tissue expression from TISSUES for NAP1L5 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with NAP1L5: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L5 Gene

Orthologs for NAP1L5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NAP1L5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NAP1L5 30 31
  • 98.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NAP1L5 30 31
  • 89.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NAP1L5 30 31
  • 89.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nap1l5 30 17 31
  • 79.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nap1l5 30
  • 78.79 (n)
Species where no ortholog for NAP1L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NAP1L5 Gene

ENSEMBL:
Gene Tree for NAP1L5 (if available)
TreeFam:
Gene Tree for NAP1L5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAP1L5: view image

Paralogs for NAP1L5 Gene

(4) SIMAP similar genes for NAP1L5 Gene using alignment to 1 proteins:

  • NP1L5_HUMAN

Pseudogenes.org Pseudogenes for NAP1L5 Gene

genes like me logo Genes that share paralogs with NAP1L5: view

Variants for NAP1L5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAP1L5 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs187220478 Likely Benign: not provided 88,697,328(-) C/T
NM_153757.4(NAP1L5):c.427G>A (p.Glu143Lys)
MISSENSE_VARIANT,INTRON
rs13109442 - p.Glu154Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NAP1L5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NAP1L5 Gene

Variant ID Type Subtype PubMed ID
nsv461576 CNV gain 19166990
nsv594806 CNV gain 21841781

Variation tolerance for NAP1L5 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAP1L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAP1L5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAP1L5 Gene

Disorders for NAP1L5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAP1L5 Gene - From: COP

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • bws
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NAP1L5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NAP1L5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L5 Gene

Publications for NAP1L5 Gene

  1. Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein. (PMID: 12383514) Harada H … Emi M (Gene 2002) 2 3 4
  2. Large copy-number variations are enriched in cases with moderate to extreme obesity. (PMID: 20622171) Wang K … Price RA (Diabetes 2010) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling. (PMID: 28675297) Kumar P … Maddika S (Journal of proteome research 2017) 3

Products for NAP1L5 Gene

Sources for NAP1L5 Gene