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This gene encodes a protein that shares sequence similarity to nucleosome assembly factors, but may be localized to the cytoplasm rather than the nucleus. Expression of this gene is downregulated in hepatocellular carcinomas. This gene is located within a differentially methylated region (DMR) and is imprinted and paternally expressed. There is a related pseudogene on chromosome 4. [provided by RefSeq, Nov 2015]
NAP1L5 (Nucleosome Assembly Protein 1 Like 5) is a Protein Coding gene. Diseases associated with NAP1L5 include Beckwith-Wiedemann Syndrome. An important paralog of this gene is NAP1L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IBA | 21873635 |
GO:0042393 | histone binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006334 | nucleosome assembly | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NAP1L5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NAP1L5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NAP1L5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Nap1l5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nap1l5 30 |
|
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
773709 | Likely Benign: not provided | 88,697,328(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
rs13109442 | - | p.Glu154Gln |
Disorder | Aliases | PubMed IDs |
---|---|---|
beckwith-wiedemann syndrome |
|
|