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Aliases for NAP1L5 Gene

Aliases for NAP1L5 Gene

  • Nucleosome Assembly Protein 1 Like 5 2 3 5
  • Nucleosome Assembly Protein 1-Like 5 2 3
  • Down-Regulated In Liver Malignancy 3 4
  • DRLM 3 4

External Ids for NAP1L5 Gene

Previous GeneCards Identifiers for NAP1L5 Gene

  • GC04M090075
  • GC04M089974
  • GC04M089836
  • GC04M089617
  • GC04M085368

Summaries for NAP1L5 Gene

Entrez Gene Summary for NAP1L5 Gene

  • This gene encodes a protein that shares sequence similarity to nucleosome assembly factors, but may be localized to the cytoplasm rather than the nucleus. Expression of this gene is downregulated in hepatocellular carcinomas. This gene is located within a differentially methylated region (DMR) and is imprinted and paternally expressed. There is a related pseudogene on chromosome 4. [provided by RefSeq, Nov 2015]

GeneCards Summary for NAP1L5 Gene

NAP1L5 (Nucleosome Assembly Protein 1 Like 5) is a Protein Coding gene.

Additional gene information for NAP1L5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L5 Gene

Genomics for NAP1L5 Gene

GeneHancer (GH) Regulatory Elements for NAP1L5 Gene

Promoters and enhancers for NAP1L5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J088696 Promoter/Enhancer 1.3 Ensembl ENCODE 659.7 +0.3 251 2.1 PKNOX1 ATF1 SIN3A NFXL1 YY1 TCF12 EGR1 CREM ZNF263 ZBTB2 NAP1L5 GC04M088685 RNU6-33P HERC3
GH04J088736 Enhancer 1 Ensembl ENCODE dbSUPER 19 -40.2 -40179 3.8 PKNOX1 TAF1 RXRA MAX MAFG SIN3A SP1 MAFF ZNF316 POLR2A NAP1L5 FAM13A-AS1 PIR43353 LOC105377327 FAM13A
GH04J088608 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +86.3 86264 6 PKNOX1 SMAD1 FEZF1 IRF4 ATF7 FOS RUNX3 JUNB ZNF518A ATF4 LOC100129137 PIGY PYURF NAP1L5 HERC3 FAM13A-AS1 PPM1K RNU6-33P GC04M088685 ENSG00000285385
GH04J088997 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -302.1 -302143 5.5 PKNOX1 ATF1 FOXA2 FEZF1 ELK1 ZFP91 ATF7 REST TSHZ1 ZNF592 FAM13A FAM13A-AS1 TIGD2 NAP1L5 SNCA GC04M088970 GC04P089101
GH04J088791 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -94.8 -94803 2.4 CTCF NR2F1 HLF BACH1 DPF2 BATF RAD21 ZNF217 BCL11A IKZF1 FAM13A-AS1 NAP1L5 FAM13A HERC6 HERC5 PIR43353 LOC105377327
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAP1L5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAP1L5 gene promoter:
  • Lmo2
  • TBP
  • POU2F1a
  • POU2F1
  • Fra-1
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • JunB

Genomic Locations for NAP1L5 Gene

Genomic Locations for NAP1L5 Gene
1,958 bases
Minus strand
2,321 bases
Minus strand

Genomic View for NAP1L5 Gene

Genes around NAP1L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L5 Gene

Proteins for NAP1L5 Gene

  • Protein details for NAP1L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleosome assembly protein 1-like 5
    Protein Accession:

    Protein attributes for NAP1L5 Gene

    182 amino acids
    Molecular mass:
    19593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAP1L5 Gene

Post-translational modifications for NAP1L5 Gene

  • Ubiquitination at Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for NAP1L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L5 Gene

Domains & Families for NAP1L5 Gene

Gene Families for NAP1L5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAP1L5 Gene


Suggested Antigen Peptide Sequences for NAP1L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L5: view

Function for NAP1L5 Gene

Phenotypes From GWAS Catalog for NAP1L5 Gene

genes like me logo Genes that share phenotypes with NAP1L5: view

Animal Model Products

miRNA for NAP1L5 Gene

miRTarBase miRNAs that target NAP1L5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L5 Gene

Localization for NAP1L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAP1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NAP1L5: view

Pathways & Interactions for NAP1L5 Gene

SuperPathways for NAP1L5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
genes like me logo Genes that share ontologies with NAP1L5: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L5 Gene

Drugs & Compounds for NAP1L5 Gene

No Compound Related Data Available

Transcripts for NAP1L5 Gene

mRNA/cDNA for NAP1L5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(88) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAP1L5 Gene

Nucleosome assembly protein 1-like 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L5 Gene

No ASD Table

Relevant External Links for NAP1L5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAP1L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L5 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.3), Brain - Frontal Cortex (BA9) (x5.6), and Brain - Anterior cingulate cortex (BA24) (x5.6).

Protein differential expression in normal tissues from HIPED for NAP1L5 Gene

This gene is overexpressed in Frontal cortex (17.1), Retina (13.0), Spinal cord (8.9), Fetal Brain (7.9), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAP1L5 Gene

Protein tissue co-expression partners for NAP1L5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAP1L5 Gene:


SOURCE GeneReport for Unigene cluster for NAP1L5 Gene:


mRNA Expression by UniProt/SwissProt for NAP1L5 Gene:

Tissue specificity: Predominantly expressed in brain.

Evidence on tissue expression from TISSUES for NAP1L5 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with NAP1L5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L5 Gene

Orthologs for NAP1L5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NAP1L5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAP1L5 34 33
  • 98.35 (n)
(Canis familiaris)
Mammalia NAP1L5 34 33
  • 89.52 (n)
(Bos Taurus)
Mammalia NAP1L5 34 33
  • 89.05 (n)
(Mus musculus)
Mammalia Nap1l5 16 34 33
  • 79.34 (n)
(Rattus norvegicus)
Mammalia Nap1l5 33
  • 78.79 (n)
Species where no ortholog for NAP1L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NAP1L5 Gene

Gene Tree for NAP1L5 (if available)
Gene Tree for NAP1L5 (if available)
Evolutionary constrained regions (ECRs) for NAP1L5: view image

Paralogs for NAP1L5 Gene

(4) SIMAP similar genes for NAP1L5 Gene using alignment to 1 proteins:

  • NP1L5_HUMAN Pseudogenes for NAP1L5 Gene

genes like me logo Genes that share paralogs with NAP1L5: view

No data available for Paralogs for NAP1L5 Gene

Variants for NAP1L5 Gene

Sequence variations from dbSNP and Humsavar for NAP1L5 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000895558 -- 88,699,439(-) T/G upstream_transcript_variant
rs1001161230 -- 88,697,759(-) GAGGAG/GAG 5_prime_UTR_variant
rs1001213706 -- 88,697,992(-) C/T 5_prime_UTR_variant
rs1002932270 -- 88,696,551(-) C/T 3_prime_UTR_variant
rs1005326998 -- 88,696,469(-) A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for NAP1L5 Gene

Variant ID Type Subtype PubMed ID
nsv461576 CNV gain 19166990
nsv594806 CNV gain 21841781

Variation tolerance for NAP1L5 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAP1L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAP1L5 Gene

Disorders for NAP1L5 Gene

Additional Disease Information for NAP1L5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NAP1L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAP1L5 Gene

Publications for NAP1L5 Gene

  1. Down-regulation of a novel gene, DRLM, in human liver malignancy from 4q22 that encodes a NAP-like protein. (PMID: 12383514) Harada H … Emi M (Gene 2002) 2 3 4 58
  2. Large copy-number variations are enriched in cases with moderate to extreme obesity. (PMID: 20622171) Wang K … Price RA (Diabetes 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. (PMID: 26514267) Benleulmi-Chaachoua A … Jockers R (Journal of pineal research 2016) 3 58

Products for NAP1L5 Gene

Sources for NAP1L5 Gene

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