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Aliases for NAP1L4 Gene

Aliases for NAP1L4 Gene

  • Nucleosome Assembly Protein 1 Like 4 2 3 5
  • Nucleosome Assembly Protein 1-Like 4 2 3 4
  • Nucleosome Assembly Protein 2 3 4
  • NAP-2 3 4
  • NAP2 3 4
  • Nucleosome Assembly Protein 1-Like 4b 3
  • NAP1L4b 3
  • NAP2L 3
  • HNAP2 3

External Ids for NAP1L4 Gene

Previous GeneCards Identifiers for NAP1L4 Gene

  • GC11M003025
  • GC11M003216
  • GC11M002924
  • GC11M002929
  • GC11M002919
  • GC11M002922
  • GC11M002754
  • GC11M002965

Summaries for NAP1L4 Gene

Entrez Gene Summary for NAP1L4 Gene

  • This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAP1L4 Gene

NAP1L4 (Nucleosome Assembly Protein 1 Like 4) is a Protein Coding gene. Diseases associated with NAP1L4 include Beckwith-Wiedemann Syndrome and Wilms Tumor 5. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is NAP1L1.

UniProtKB/Swiss-Prot for NAP1L4 Gene

Gene Wiki entry for NAP1L4 Gene

Additional gene information for NAP1L4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L4 Gene

Genomics for NAP1L4 Gene

GeneHancer (GH) Regulatory Elements for NAP1L4 Gene

Promoters and enhancers for NAP1L4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002986 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 614.6 +2.1 2057 7 HDGF SP1 ZFX MNT NKRF POLR2A MLLT1 GTF2F1 CSDE1 FOS ENSG00000183562 NAP1L4 CARS SLC22A18 SNORA54 PHLDA2 GC11M002982
GH11J003055 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 616 -65.1 -65122 4.2 ZFX ELF3 MNT SIX5 NKRF MLLT1 CEBPG POLR2A GTF2F1 CSDE1 NAP1L4 CARS ENSG00000285644 NUP98 ENSG00000183562 GC11M003048 RNU1-91P
GH11J003035 Enhancer 1.1 Ensembl ENCODE dbSUPER 28 -44.2 -44218 3.2 CTCF MAFK MLLT1 RAD21 IKZF1 ARID2 ZNF143 REST TRIM22 ZNF316 NAP1L4 SNORA54 CARS-AS1 GC11M003048 RNU1-91P CARS
GH11J002939 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 25.2 +51.4 51404 2 MAFK SP1 POLR2A RXRA NFE2L2 RFX1 PKNOX1 ZNF341 ZNF316 ZFX NAP1L4 ENSG00000183562 SLC22A18AS SNORA54 SLC22A18 KCNQ1 PHLDA2 KCNQ1-AS1 GC11M002963 GC11M002964
GH11J003048 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 16.7 -58.1 -58089 3.9 ZNF687 NFIB CTCF MAFK SP7 CREM PRDM1 MLLT1 RAD21 RELA GC11M003048 RNU1-91P NAP1L4 ENSG00000183562 NUP98 ENSG00000285644 CARS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAP1L4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAP1L4 gene promoter:
  • C/EBPalpha
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CHOP-10
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA

Genomic Locations for NAP1L4 Gene

Genomic Locations for NAP1L4 Gene
chr11:2,944,430-2,992,377
(GRCh38/hg38)
Size:
47,948 bases
Orientation:
Minus strand
chr11:2,965,660-3,013,607
(GRCh37/hg19)
Size:
47,948 bases
Orientation:
Minus strand

Genomic View for NAP1L4 Gene

Genes around NAP1L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L4 Gene

Proteins for NAP1L4 Gene

  • Protein details for NAP1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99733-NP1L4_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 4
    Protein Accession:
    Q99733
    Secondary Accessions:
    • B2R6J4
    • F5HFY4

    Protein attributes for NAP1L4 Gene

    Size:
    375 amino acids
    Molecular mass:
    42823 Da
    Quaternary structure:
    • Interacts with core (H2A, H2B, H3, H4) and linker (H1) histones.

    Alternative splice isoforms for NAP1L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAP1L4 Gene

Post-translational modifications for NAP1L4 Gene

  • Phosphorylated at the G0/G1 boundary but it is not phosphorylated in S-phase. Phosphorylated protein remains in the cytoplasm in a complex with histones during the G0/G1 transition, whereas dephosphorylation triggers its transport into the nucleus at the G1/S-boundary.
  • Polyglutamylated by TTLL4, a modification that occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Some residues may also be monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human (By similarity).
  • Ubiquitination at isoforms=2146, isoforms=2105, isoforms=271, posLast=2626, posLast=282282, and isoforms=294
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAP1L4 Gene

Domains & Families for NAP1L4 Gene

Gene Families for NAP1L4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NAP1L4 Gene

Suggested Antigen Peptide Sequences for NAP1L4 Gene

GenScript: Design optimal peptide antigens:
  • Nucleosome assembly protein 1-like 4 (A8CGI3_HUMAN)
  • Nucleosome assembly protein 2 (NP1L4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99733

UniProtKB/Swiss-Prot:

NP1L4_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L4: view

Function for NAP1L4 Gene

Molecular function for NAP1L4 Gene

UniProtKB/Swiss-Prot Function:
Acts as histone chaperone in nucleosome assembly.
GENATLAS Biochemistry:
nucleosome assembly protein 1-like 4, excluded of the imprinting domain,interacting with core and linker histones,putative chaperone

Phenotypes From GWAS Catalog for NAP1L4 Gene

Gene Ontology (GO) - Molecular Function for NAP1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 22190034
GO:0031491 nucleosome binding IDA 9325046
GO:0051082 unfolded protein binding TAS 9325046
genes like me logo Genes that share ontologies with NAP1L4: view
genes like me logo Genes that share phenotypes with NAP1L4: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NAP1L4 - Now 50% OFF >
  • * NAP1L4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NAP1L4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L4 Gene

Localization for NAP1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L4 Gene

Nucleus. Cytoplasm. Note=Present in the cytoplasm and excluded from the nucleus during G0/G1 phase, then relocates to the nucleus by the time cells are in S phase (PubMed:9325046). Phosphorylated form localizes in the cytoplasm during the G0/G1 transition, whereas dephosphorylation leads to relocalization into the nucleus at the G1/S-boundary (PubMed:10764593). {ECO:0000269 PubMed:10764593, ECO:0000269 PubMed:9325046}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L4 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAP1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9325046
GO:0005737 cytoplasm IEA,IDA 9325046
genes like me logo Genes that share ontologies with NAP1L4: view

Pathways & Interactions for NAP1L4 Gene

PathCards logo

SuperPathways for NAP1L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IDA 9325046
genes like me logo Genes that share ontologies with NAP1L4: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L4 Gene

Drugs & Compounds for NAP1L4 Gene

(1) Drugs for NAP1L4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NAP1L4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAP1L4: view

Transcripts for NAP1L4 Gene

Unigene Clusters for NAP1L4 Gene

Nucleosome assembly protein 1-like 4:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NAP1L4 - Now 50% OFF >
  • * NAP1L4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NAP1L4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L4 Gene

No ASD Table

Relevant External Links for NAP1L4 Gene

GeneLoc Exon Structure for
NAP1L4
ECgene alternative splicing isoforms for
NAP1L4

Expression for NAP1L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAP1L4 Gene



Protein tissue co-expression partners for NAP1L4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAP1L4 Gene:

NAP1L4

SOURCE GeneReport for Unigene cluster for NAP1L4 Gene:

Hs.731784

mRNA Expression by UniProt/SwissProt for NAP1L4 Gene:

Q99733-NP1L4_HUMAN
Tissue specificity: Ubiquitous. Biallelically expressed in fetal and adult tissues. Highest levels in testis.

Evidence on tissue expression from TISSUES for NAP1L4 Gene

  • Nervous system(5)
  • Liver(4.5)
  • Muscle(4.4)
  • Kidney(2.6)
  • Lung(2.4)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with NAP1L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L4 Gene

Orthologs for NAP1L4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAP1L4 35 34
  • 99.02 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAP1L4 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAP1L4 35 34
  • 88.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NAP1L4 35 34
  • 87.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nap1l4 17 35 34
  • 85.74 (n)
rat
(Rattus norvegicus)
Mammalia Nap1l4 34
  • 85.74 (n)
chicken
(Gallus gallus)
Aves NAP1L4 35 34
  • 83.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAP1L4 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nap1l4 34
  • 74.14 (n)
zebrafish
(Danio rerio)
Actinopterygii nap1l4b 35 34
  • 71.7 (n)
OneToMany
nap1l4a 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nap1 35 36
  • 44 (a)
ManyToMany
EG:BACR7A4.18 36
  • 34 (a)
CG5017 35
  • 33 (a)
ManyToMany
CG3708 35
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nap-1 35 34
  • 51.78 (n)
OneToMany
D2096.8 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 37 35
  • 30 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nap2 34
  • 48.97 (n)
Species where no ortholog for NAP1L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAP1L4 Gene

ENSEMBL:
Gene Tree for NAP1L4 (if available)
TreeFam:
Gene Tree for NAP1L4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAP1L4: view image

Paralogs for NAP1L4 Gene

(5) SIMAP similar genes for NAP1L4 Gene using alignment to 14 proteins:

  • NP1L4_HUMAN
  • A8CGI3_HUMAN
  • A8MXH2_HUMAN
  • C9J1B1_HUMAN
  • C9J6D1_HUMAN
  • C9JZI7_HUMAN
  • E9PJJ2_HUMAN
  • E9PKI2_HUMAN
  • E9PKT8_HUMAN
  • E9PNJ7_HUMAN
  • E9PNW0_HUMAN
  • E9PP22_HUMAN
  • E9PS34_HUMAN
  • H0YCI4_HUMAN

Pseudogenes.org Pseudogenes for NAP1L4 Gene

genes like me logo Genes that share paralogs with NAP1L4: view

Variants for NAP1L4 Gene

Sequence variations from dbSNP and Humsavar for NAP1L4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000005175 -- 2,969,462(-) G/A/T intron_variant
rs1000046712 -- 2,966,214(-) G/C intron_variant
rs1000077871 -- 2,966,012(-) A/G intron_variant
rs1000222533 -- 2,944,264(-) G/A downstream_transcript_variant
rs1000301354 -- 2,986,835(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NAP1L4 Gene

Variant ID Type Subtype PubMed ID
esv2744026 CNV deletion 23290073
esv3625132 CNV gain 21293372
nsv472060 CNV novel sequence insertion 20440878
nsv7648 CNV insertion 18451855
nsv832050 CNV loss 17160897
nsv8766 CNV loss 18304495

Variation tolerance for NAP1L4 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAP1L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAP1L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAP1L4 Gene

Disorders for NAP1L4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NAP1L4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • bws
wilms tumor 5
  • nephroblastoma
antenatal bartter syndrome
  • bartter syndrome, furosemide type
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NAP1L4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NAP1L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L4 Gene

Publications for NAP1L4 Gene

  1. NAP-2: histone chaperone function and phosphorylation state through the cell cycle. (PMID: 10764593) Rodriguez P … Zannis-Hadjopoulos M (Journal of molecular biology 2000) 3 4 23 58
  2. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. (PMID: 9325046) Rodriguez P … Pelletier J (Genomics 1997) 3 4 23 58
  3. A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues. (PMID: 8923002) Hu RJ … Feinberg AP (Human molecular genetics 1996) 2 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for NAP1L4 Gene

Sources for NAP1L4 Gene

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