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Aliases for NAP1L3 Gene

Aliases for NAP1L3 Gene

  • Nucleosome Assembly Protein 1 Like 3 2 3 5
  • Nucleosome Assembly Protein 1-Like 3 2 3
  • MB20 3
  • NPL3 3
  • BNAP 4

External Ids for NAP1L3 Gene

Previous GeneCards Identifiers for NAP1L3 Gene

  • GC0XM088209
  • GC0XM089906
  • GC0XM090961
  • GC0XM091697
  • GC0XM092732
  • GC0XM092925
  • GC0XM082748

Summaries for NAP1L3 Gene

Entrez Gene Summary for NAP1L3 Gene

  • This gene is intronless and encodes a member of the nucleosome assembly protein (NAP) family. This gene is linked closely to a region of genes responsible for several X-linked cognitive disability syndromes. [provided by RefSeq, Dec 2010]

GeneCards Summary for NAP1L3 Gene

NAP1L3 (Nucleosome Assembly Protein 1 Like 3) is a Protein Coding gene. An important paralog of this gene is NAP1L1.

Additional gene information for NAP1L3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L3 Gene

Genomics for NAP1L3 Gene

GeneHancer (GH) Regulatory Elements for NAP1L3 Gene

Promoters and enhancers for NAP1L3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ093672 Promoter/Enhancer 1.1 Ensembl ENCODE 650.7 +0.2 184 2.3 PKNOX1 ZNF362 L3MBTL2 NFYC SP2 SIN3A ZNF384 YY1 ZNF335 SP1 GC0XP093675 NAP1L3 FAM133A GC0XM093663
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAP1L3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAP1L3 gene promoter:
  • Bach1
  • TBP
  • GCNF-2
  • GCNF-1
  • GCNF
  • IRF-2
  • ATF
  • GATA-1
  • STAT5A
  • GR-beta

Genomic Locations for NAP1L3 Gene

Genomic Locations for NAP1L3 Gene
chrX:93,670,926-93,673,683
(GRCh38/hg38)
Size:
2,758 bases
Orientation:
Minus strand
chrX:92,925,925-92,928,682
(GRCh37/hg19)
Size:
2,758 bases
Orientation:
Minus strand

Genomic View for NAP1L3 Gene

Genes around NAP1L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L3 Gene

Proteins for NAP1L3 Gene

  • Protein details for NAP1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99457-NP1L3_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 3
    Protein Accession:
    Q99457
    Secondary Accessions:
    • B2RCM0
    • O60788

    Protein attributes for NAP1L3 Gene

    Size:
    506 amino acids
    Molecular mass:
    57593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAP1L3 Gene

Post-translational modifications for NAP1L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAP1L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L3 Gene

Domains & Families for NAP1L3 Gene

Gene Families for NAP1L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAP1L3 Gene

Suggested Antigen Peptide Sequences for NAP1L3 Gene

Graphical View of Domain Structure for InterPro Entry

Q99457

UniProtKB/Swiss-Prot:

NP1L3_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L3: view

Function for NAP1L3 Gene

Molecular function for NAP1L3 Gene

GENATLAS Biochemistry:
nucleosome assembly protein-like 3,tightly linked to DXS990
genes like me logo Genes that share phenotypes with NAP1L3: view

Animal Model Products

miRNA for NAP1L3 Gene

miRTarBase miRNAs that target NAP1L3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L3 Gene

Localization for NAP1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L3 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAP1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NAP1L3: view

Pathways & Interactions for NAP1L3 Gene

SuperPathways for NAP1L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
genes like me logo Genes that share ontologies with NAP1L3: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L3 Gene

Drugs & Compounds for NAP1L3 Gene

No Compound Related Data Available

Transcripts for NAP1L3 Gene

mRNA/cDNA for NAP1L3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAP1L3 Gene

Nucleosome assembly protein 1-like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L3 Gene

No ASD Table

Relevant External Links for NAP1L3 Gene

GeneLoc Exon Structure for
NAP1L3
ECgene alternative splicing isoforms for
NAP1L3

Expression for NAP1L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.6), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Hypothalamus (x5.4), and Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for NAP1L3 Gene

This gene is overexpressed in Fetal gut (50.5) and Gallbladder (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NAP1L3 Gene



Protein tissue co-expression partners for NAP1L3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAP1L3 Gene:

NAP1L3

SOURCE GeneReport for Unigene cluster for NAP1L3 Gene:

Hs.21365

Evidence on tissue expression from TISSUES for NAP1L3 Gene

  • Nervous system(4.9)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with NAP1L3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L3 Gene

Orthologs for NAP1L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAP1L3 34 33
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NAP1L3 34 33
  • 85.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NAP1L3 34 33
  • 82.34 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nap1l3 33
  • 80.19 (n)
mouse
(Mus musculus)
Mammalia Nap1l3 16 34 33
  • 80.03 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 38 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nap1l1 34
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5017 34
  • 31 (a)
ManyToMany
Nap1 34
  • 31 (a)
ManyToMany
CG3708 34
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nap-1 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.925 34
  • 32 (a)
OneToMany
Species where no ortholog for NAP1L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAP1L3 Gene

ENSEMBL:
Gene Tree for NAP1L3 (if available)
TreeFam:
Gene Tree for NAP1L3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAP1L3: view image

Paralogs for NAP1L3 Gene

Paralogs for NAP1L3 Gene

(2) SIMAP similar genes for NAP1L3 Gene using alignment to 4 proteins:

  • NP1L3_HUMAN
  • L0R6L2_HUMAN
  • Q8IYV1_HUMAN
  • V9GYL6_HUMAN
genes like me logo Genes that share paralogs with NAP1L3: view

Variants for NAP1L3 Gene

Sequence variations from dbSNP and Humsavar for NAP1L3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs863223375 benign, Abnormality of neuronal migration 93,671,995(-) G/C coding_sequence_variant, missense_variant
rs1001253882 -- 93,671,039(-) C/T 3_prime_UTR_variant
rs1001994084 -- 93,674,648(-) T/C upstream_transcript_variant
rs1002288948 -- 93,671,512(-) G/A 3_prime_UTR_variant
rs1003326723 -- 93,673,944(-) T/C upstream_transcript_variant

Variation tolerance for NAP1L3 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAP1L3 Gene

Human Gene Mutation Database (HGMD)
NAP1L3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAP1L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAP1L3 Gene

Disorders for NAP1L3 Gene

Additional Disease Information for NAP1L3

No disorders were found for NAP1L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAP1L3 Gene

Publications for NAP1L3 Gene

  1. Cloning, expression pattern and mapping to Xq of NAP1L3, a gene encoding a peptide homologous to human and yeast nucleosome assembly proteins. (PMID: 8976385) Watanabe TK … Takahashi E (Cytogenetics and cell genetics 1996) 2 3 4 22 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for NAP1L3 Gene

Sources for NAP1L3 Gene

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