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Aliases for NAP1L2 Gene

Aliases for NAP1L2 Gene

  • Nucleosome Assembly Protein 1 Like 2 2 3 5
  • Nucleosome Assembly Protein 1-Like 2 2 3
  • Brain-Specific Protein, X-Linked 3 4
  • BPX 3 4
  • Brain Specific Gene BPX 3

External Ids for NAP1L2 Gene

Previous GeneCards Identifiers for NAP1L2 Gene

  • GC0XM068245
  • GC0XM069606
  • GC0XM070646
  • GC0XM071298
  • GC0XM072215
  • GC0XM072348
  • GC0XM066066

Summaries for NAP1L2 Gene

Entrez Gene Summary for NAP1L2 Gene

  • The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAP1L2 Gene

NAP1L2 (Nucleosome Assembly Protein 1 Like 2) is a Protein Coding gene. Diseases associated with NAP1L2 include Neural Tube Defects. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is NAP1L1.

UniProtKB/Swiss-Prot for NAP1L2 Gene

  • Acidic protein which may be involved in interactions with other proteins or DNA.

Additional gene information for NAP1L2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L2 Gene

Genomics for NAP1L2 Gene

GeneHancer (GH) Regulatory Elements for NAP1L2 Gene

Promoters and enhancers for NAP1L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI073213 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.1 119 1.9 PKNOX1 BACH1 SIN3A YY1 ZFHX2 POLR2A ZNF143 NFE2 ZNF362 SP2 NAP1L2 FAM226B PIR55030
GH0XI073943 Promoter/Enhancer 1.7 Ensembl ENCODE 26.5 -729.7 -729739 2.4 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 JPX ENSG00000274430 ENSG00000276784 ENSG00000271199 FTX RAB11FIP1P1 DDX3P1 CHIC1 ENSG00000234969 ENSG00000271533
GH0XI072271 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17 +940.0 939969 6 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B RPS4X TAF1 NONO LOC100420758 ERCC6L OGT RTL5 LOC392489 ENSG00000229601 TOMM20P4
GH0XI073566 Enhancer 0.3 FANTOM5 3 -352.0 -351968 0.2 CHIC1 NAP1L2 CDX4 PIR39676 GC0XM073547
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAP1L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAP1L2 gene promoter:

Genomic Locations for NAP1L2 Gene

Genomic Locations for NAP1L2 Gene
2,576 bases
Minus strand

Genomic View for NAP1L2 Gene

Genes around NAP1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L2 Gene

Proteins for NAP1L2 Gene

  • Protein details for NAP1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleosome assembly protein 1-like 2
    Protein Accession:
    Secondary Accessions:
    • B2RE61
    • B4E161
    • Q8TAN6

    Protein attributes for NAP1L2 Gene

    460 amino acids
    Molecular mass:
    52542 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAP1L2 Gene


neXtProt entry for NAP1L2 Gene

Post-translational modifications for NAP1L2 Gene

  • Ubiquitination at Lys267
  • Modification sites at PhosphoSitePlus

Other Protein References for NAP1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAP1L2 Gene

Domains & Families for NAP1L2 Gene

Gene Families for NAP1L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAP1L2 Gene

Suggested Antigen Peptide Sequences for NAP1L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L2: view

Function for NAP1L2 Gene

Molecular function for NAP1L2 Gene

GENATLAS Biochemistry:
nucleosome assembly protein 1-like 2,murine Bpx homolog
UniProtKB/Swiss-Prot Function:
Acidic protein which may be involved in interactions with other proteins or DNA.

Gene Ontology (GO) - Molecular Function for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 18985028
GO:0042393 histone binding IEA --
genes like me logo Genes that share ontologies with NAP1L2: view
genes like me logo Genes that share phenotypes with NAP1L2: view

Animal Models for NAP1L2 Gene

MGI Knock Outs for NAP1L2:

Animal Model Products

miRNA for NAP1L2 Gene

miRTarBase miRNAs that target NAP1L2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAP1L2 Gene

Localization for NAP1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA --
genes like me logo Genes that share ontologies with NAP1L2: view

Pathways & Interactions for NAP1L2 Gene

SuperPathways for NAP1L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA,TAS --
GO:0035066 positive regulation of histone acetylation IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
GO:0071442 positive regulation of histone H3-K14 acetylation IEA --
GO:2000035 regulation of stem cell division IEA --
genes like me logo Genes that share ontologies with NAP1L2: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L2 Gene

Drugs & Compounds for NAP1L2 Gene

No Compound Related Data Available

Transcripts for NAP1L2 Gene

mRNA/cDNA for NAP1L2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NAP1L2 Gene

Nucleosome assembly protein 1-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L2 Gene

No ASD Table

Relevant External Links for NAP1L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAP1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAP1L2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.4), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Cerebellar Hemisphere (x4.9).

Protein differential expression in normal tissues from HIPED for NAP1L2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAP1L2 Gene

Protein tissue co-expression partners for NAP1L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAP1L2 Gene:


SOURCE GeneReport for Unigene cluster for NAP1L2 Gene:


Evidence on tissue expression from TISSUES for NAP1L2 Gene

  • Nervous system(4.9)
  • Kidney(4.2)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with NAP1L2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L2 Gene

Orthologs for NAP1L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAP1L2 34 33
  • 99.71 (n)
(Canis familiaris)
Mammalia NAP1L2 34 33
  • 89.67 (n)
(Rattus norvegicus)
Mammalia Nap1l2 33
  • 84.71 (n)
(Mus musculus)
Mammalia Nap1l2 33 16 34
  • 84.53 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
-- 34
  • 45 (a)
(Bos Taurus)
Mammalia -- 34
  • 46 (a)
-- 34
  • 30 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
(Gallus gallus)
Aves -- 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
(Danio rerio)
Actinopterygii nap1l1 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nap1 34
  • 33 (a)
CG5017 34
  • 32 (a)
CG3708 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea nap-1 34
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.925 34
  • 35 (a)
Species where no ortholog for NAP1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAP1L2 Gene

Gene Tree for NAP1L2 (if available)
Gene Tree for NAP1L2 (if available)

Paralogs for NAP1L2 Gene

Paralogs for NAP1L2 Gene

(4) SIMAP similar genes for NAP1L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NAP1L2: view

Variants for NAP1L2 Gene

Sequence variations from dbSNP and Humsavar for NAP1L2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs34995284 uncertain-significance, Abnormality of neuronal migration 73,213,985(-) A/G coding_sequence_variant, missense_variant
rs1000794539 -- 73,212,643(-) C/G/T 3_prime_UTR_variant
rs1000899772 -- 73,213,249(-) G/T coding_sequence_variant, missense_variant
rs1001098442 -- 73,212,079(-) G/T downstream_transcript_variant
rs1001984002 -- 73,212,799(-) A/G/T 3_prime_UTR_variant

Variation tolerance for NAP1L2 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAP1L2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAP1L2 Gene

Disorders for NAP1L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAP1L2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neural tube defects
  • neural tube defects, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NAP1L2

genes like me logo Genes that share disorders with NAP1L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L2 Gene

Publications for NAP1L2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Control of neurulation by the nucleosome assembly protein-1-like 2. (PMID: 10932189) Rogner UC … Avner P (Nature genetics 2000) 3 22 58
  3. Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. (PMID: 8789438) Rougeulle C … Avner P (Human molecular genetics 1996) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Identification of candidate genes in atopic dermatitis based on bioinformatic methods. (PMID: 26967585) Ding Y … Fang H (International journal of dermatology 2016) 3 58

Products for NAP1L2 Gene

Sources for NAP1L2 Gene

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