This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by Re... See more...

Aliases for NAP1L1 Gene

Aliases for NAP1L1 Gene

  • Nucleosome Assembly Protein 1 Like 1 2 3 5
  • Nucleosome Assembly Protein 1-Like 1 2 3 4
  • NRP 2 3 4
  • NAP-1-Related Protein 3 4
  • NAP1L 2 3
  • NAP1 2 3
  • HSP22-Like Protein Interacting Protein 3
  • MGC23410 2
  • MGC8688 2
  • NAP1L1 5
  • HNRP 4

External Ids for NAP1L1 Gene

Previous GeneCards Identifiers for NAP1L1 Gene

  • GC12M073514
  • GC12P075989
  • GC12M076156
  • GC12M074726
  • GC12M076438

Summaries for NAP1L1 Gene

Entrez Gene Summary for NAP1L1 Gene

  • This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]

GeneCards Summary for NAP1L1 Gene

NAP1L1 (Nucleosome Assembly Protein 1 Like 1) is a Protein Coding gene. Diseases associated with NAP1L1 include Human Herpesvirus 8 and Leukodystrophy, Hypomyelinating, 4. An important paralog of this gene is NAP1L4.

UniProtKB/Swiss-Prot Summary for NAP1L1 Gene

  • Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:26841755). Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).
  • (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression.
  • (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA.

Gene Wiki entry for NAP1L1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAP1L1 Gene

Genomics for NAP1L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NAP1L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J076080 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.1 1120 5.6 ZNF207 MYC NCOR1 IKZF1 ZNF600 JUND ATF2 POLR2A ZNF10 ZSCAN16 HQ292150 NAP1L1 lnc-GLIPR1-10 lnc-PHLDA1-2 PHLDA1
GH12J075974 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +105.6 105617 10.2 BCLAF1 SP1 ZNF207 ZNF600 JUND ZNF592 CEBPA ATF3 ZIC2 YY1 ENSG00000258077 PHLDA1 ZDHHC17 NAP1L1 ENSG00000251893 GLIPR1 LOC105369844 ENSG00000198923 ENSG00000257329 KRR1
GH12J076450 Enhancer 0.9 Ensembl ENCODE 9.8 -365.4 -365366 3.4 NCOR1 IKZF1 CEBPB NFATC3 ZNF316 NFE2 JUND SMARCA4 EHMT2 SMARCE1 BBS10 NAP1L1 OSBPL8 LNCOG RF00994-248 MN309486 lnc-BBS10-5
GH12J076124 Enhancer 0.6 Ensembl 11.9 -39.1 -39066 2.4 IKZF1 MCM3 NKRF ZNF316 MCM5 MAFK JUND EGR1 EP300 MTA2 NAP1L1 KRR1 ENSG00000257497 ENSG00000258304 HSALNG0092531 LOC641695 HSALNG0092532 BBS10
GH12J076055 Enhancer 0.6 Ensembl ENCODE 11.4 +29.3 29285 0.5 CTCF RAD21 NANOG LOC100652897 NAP1L1 PHLDA1 lnc-PHLDA1-1-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAP1L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAP1L1

Top Transcription factor binding sites by QIAGEN in the NAP1L1 gene promoter:
  • AP-4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-1
  • p300
  • YY1

Genomic Locations for NAP1L1 Gene

Latest Assembly
chr12:76,036,585-76,084,735
(GRCh38/hg38)
Size:
48,151 bases
Orientation:
Minus strand

Previous Assembly
chr12:76,430,365-76,478,465
(GRCh37/hg19 by Entrez Gene)
Size:
48,101 bases
Orientation:
Minus strand

chr12:76,438,670-76,478,813
(GRCh37/hg19 by Ensembl)
Size:
40,144 bases
Orientation:
Minus strand

Genomic View for NAP1L1 Gene

Genes around NAP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L1 Gene

Proteins for NAP1L1 Gene

  • Protein details for NAP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55209-NP1L1_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 1
    Protein Accession:
    P55209
    Secondary Accessions:
    • B3KNT8
    • B3KV44

    Protein attributes for NAP1L1 Gene

    Size:
    391 amino acids
    Molecular mass:
    45374 Da
    Quaternary structure:
    • Homodimer (PubMed:26841755). The dimer binds strongly and sequentially to single and double H2A-H2B heterodimers (PubMed:26841755). Interacts with ERCC6; this interaction increases ERCC6 processivity (PubMed:28369616). Interacts with RAD54 (PubMed:24798879). Interacts with SETD1A (By similarity).
    • (Microbial infection) Interacts with human herpesvirus 8 protein LANA1 (via N-terminus); this interaction is required for LANA1-dependent DNA replication.
    • (Microbial infection) Interacts with hepatitis virus protein NS5A (via C-terminus); this interaction sequesters NAP1L1 in the cytoplasm, blocking its nuclear translocation.

    Alternative splice isoforms for NAP1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAP1L1 Gene

Post-translational modifications for NAP1L1 Gene

  • Monoglycylated on glutamate residues. Cannot be polyglycylated due to the absence of functional TTLL10 in human (By similarity).
  • Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and monoglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.
  • Ubiquitination at Lys32, Lys82, Lys87, Lys105, Lys165, and Lys116
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAP1L1 Gene

Domains & Families for NAP1L1 Gene

Gene Families for NAP1L1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NAP1L1 Gene

InterPro:
Blocks:
  • Nucleosome assembly protein (NAP)

Suggested Antigen Peptide Sequences for NAP1L1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ30458 fis, clone BRACE2009421, highly similar to NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 1 (B3KNT8_HUMAN)
  • cDNA FLJ16112 fis, clone 3NB692001853, highly similar to NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 1 (B3KV44_HUMAN)
  • cDNA FLJ59349, highly similar to Nucleosome assembly protein 1-like 1 (B7Z4K9_HUMAN)
  • cDNA FLJ58569, highly similar to Nucleosome assembly protein 1-like 1 (B7Z9C2_HUMAN)
  • NAP-1-related protein (NP1L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P55209

UniProtKB/Swiss-Prot:

NP1L1_HUMAN :
  • The acidic domains are probably involved in the interaction with histones.
  • Belongs to the nucleosome assembly protein (NAP) family.
Domain:
  • The acidic domains are probably involved in the interaction with histones.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L1: view

Function for NAP1L1 Gene

Molecular function for NAP1L1 Gene

UniProtKB/Swiss-Prot Function:
Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:26841755). Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA.

Phenotypes From GWAS Catalog for NAP1L1 Gene

Gene Ontology (GO) - Molecular Function for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 11940655
GO:0042393 histone binding IBA 21873635
genes like me logo Genes that share ontologies with NAP1L1: view
genes like me logo Genes that share phenotypes with NAP1L1: view

Animal Models for research

  • Taconic Biosciences Mouse Models for NAP1L1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAP1L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L1 Gene

Localization for NAP1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L1 Gene

Nucleus. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA 21873635
GO:0005634 nucleus IEA,ISS --
GO:0005737 cytoplasm ISS --
GO:0016020 membrane HDA 19946888
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with NAP1L1: view

Pathways & Interactions for NAP1L1 Gene

PathCards logo

SuperPathways for NAP1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication TAS 8297347
GO:0006334 nucleosome assembly IEA,IBA 21873635
GO:0007399 nervous system development IEA --
GO:0008284 positive regulation of cell proliferation TAS 8297347
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with NAP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L1 Gene

Drugs & Compounds for NAP1L1 Gene

No Compound Related Data Available

Transcripts for NAP1L1 Gene

mRNA/cDNA for NAP1L1 Gene

5 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAP1L1

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: -
SP9: - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15:
SP16:
SP17:
SP18: - - - - - - -
SP19:
SP20:
SP21:
SP22:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - -
SP17: - - -
SP18:
SP19: - -
SP20: -
SP21:
SP22:

Relevant External Links for NAP1L1 Gene

GeneLoc Exon Structure for
NAP1L1

Expression for NAP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAP1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAP1L1 Gene

This gene is overexpressed in Bone marrow stromal cell (11.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAP1L1 Gene



Protein tissue co-expression partners for NAP1L1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAP1L1

SOURCE GeneReport for Unigene cluster for NAP1L1 Gene:

Hs.524599

mRNA Expression by UniProt/SwissProt for NAP1L1 Gene:

P55209-NP1L1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for NAP1L1 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Blood(4.7)
  • Muscle(4.6)
  • Lung(4.6)
  • Intestine(4.5)
  • Eye(4.4)
  • Kidney(4.3)
  • Skin(4.3)
  • Pancreas(3.9)
  • Bone(3.3)
  • Heart(2.9)
  • Lymph node(2.7)
  • Stomach(2.6)
  • Spleen(2.4)
  • Adrenal gland(2.2)
  • Gall bladder(2.1)
  • Bone marrow(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with NAP1L1: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L1 Gene

Orthologs for NAP1L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NAP1L1 29 30
  • 99.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NAP1L1 29 30
  • 96.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NAP1L1 29 30
  • 96.16 (n)
OneToMany
-- 30
  • 96 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Nap1l1 29
  • 94.46 (n)
Mouse
(Mus musculus)
Mammalia Nap1l1 29 16 30
  • 93.27 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 92 (a)
ManyToMany
-- 30
  • 89 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 90 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 92 (a)
OneToMany
NAP1L1 29
  • 85.85 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 85 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nap1l1 29
  • 80.82 (n)
Str.10809 29
African clawed frog
(Xenopus laevis)
Amphibia nap1l1-prov 29
Zebrafish
(Danio rerio)
Actinopterygii nap1l1 29 30
  • 75.42 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001928 29
  • 53.72 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Nap1 29 30 31
  • 53.41 (n)
ManyToMany
CG5017 30
  • 35 (a)
ManyToMany
EG:BACR7A4.18 31
  • 35 (a)
CG3708 30
  • 31 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea nap-1 30
  • 43 (a)
OneToMany
D2096.8 31
  • 41 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 29 30
  • 50 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15049g 29
  • 49.06 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AEL109W 29
  • 45.68 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NAP1;1 29
  • 52.93 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0539700 29
  • 51.53 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.925 30
  • 58 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nap1 29
  • 48.94 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01438 29
  • 48.29 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.12175 29
Species where no ortholog for NAP1L1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NAP1L1 Gene

ENSEMBL:
Gene Tree for NAP1L1 (if available)
TreeFam:
Gene Tree for NAP1L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NAP1L1: view image
Alliance of Genome Resources:
Additional Orthologs for NAP1L1

Paralogs for NAP1L1 Gene

(4) SIMAP similar genes for NAP1L1 Gene using alignment to 19 proteins:

  • NP1L1_HUMAN
  • B3KV44_HUMAN
  • B7Z4K9_HUMAN
  • B7Z9C2_HUMAN
  • F5H4R6_HUMAN
  • F8VRJ2_HUMAN
  • F8VUC3_HUMAN
  • F8VUX1_HUMAN
  • F8VV59_HUMAN
  • F8VVB5_HUMAN
  • F8VXI6_HUMAN
  • F8VY35_HUMAN
  • F8W020_HUMAN
  • F8W0J6_HUMAN
  • F8W118_HUMAN
  • F8W543_HUMAN
  • H0YH88_HUMAN
  • H0YHC3_HUMAN
  • H0YIV4_HUMAN
genes like me logo Genes that share paralogs with NAP1L1: view

Variants for NAP1L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAP1L1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs181964842 Likely Benign: not provided 76,068,940(-) T/C
NM_004537.7(NAP1L1):c.72A>G (p.Glu24=)
SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NAP1L1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NAP1L1 Gene

Variant ID Type Subtype PubMed ID
nsv474068 CNV novel sequence insertion 20440878
nsv474137 CNV novel sequence insertion 20440878
nsv474261 CNV novel sequence insertion 20440878
nsv474626 CNV novel sequence insertion 20440878
nsv477998 CNV novel sequence insertion 20440878
nsv478113 CNV novel sequence insertion 20440878
nsv479685 CNV novel sequence insertion 20440878
nsv479829 CNV novel sequence insertion 20440878
nsv480601 CNV novel sequence insertion 20440878
nsv480625 CNV novel sequence insertion 20440878
nsv481078 CNV novel sequence insertion 20440878
nsv481434 CNV novel sequence insertion 20440878
nsv559423 CNV loss 21841781
nsv973093 CNV duplication 23825009

Variation tolerance for NAP1L1 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAP1L1
Leiden Open Variation Database (LOVD)
NAP1L1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAP1L1 Gene

Disorders for NAP1L1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NAP1L1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
human herpesvirus 8
  • human herpesvirus 8, susceptibility to
leukodystrophy, hypomyelinating, 4
  • hld4
polyhydramnios
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NAP1L1

genes like me logo Genes that share disorders with NAP1L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L1 Gene

Publications for NAP1L1 Gene

  1. Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones. (PMID: 20002496) Okuwaki M … Nagata K (Genes to cells : devoted to molecular & cellular mechanisms 2010) 3 4 22
  2. Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation. (PMID: 8297347) Simon HU … Siminovitch KA (The Biochemical journal 1994) 2 3 4
  3. Hepatitis C Virus NS5A Targets Nucleosome Assembly Protein NAP1L1 To Control the Innate Cellular Response. (PMID: 28659470) Çevik RE … Marcello A (Journal of virology 2017) 3 4
  4. NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB. (PMID: 28369616) Lee JY … Hohng S (Nucleic acids research 2017) 3 4
  5. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1. (PMID: 24798879) Machida S … Kurumizaka H (Scientific reports 2014) 3 4

Products for NAP1L1 Gene

Sources for NAP1L1 Gene