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Aliases for NAP1L1 Gene

Aliases for NAP1L1 Gene

  • Nucleosome Assembly Protein 1 Like 1 2 3 5
  • Nucleosome Assembly Protein 1-Like 1 2 3
  • NAP-1-Related Protein 3 4
  • NRP 3 4
  • HSP22-Like Protein Interacting Protein 3
  • NAP1L 3
  • NAP1 3
  • HNRP 4

External Ids for NAP1L1 Gene

Previous GeneCards Identifiers for NAP1L1 Gene

  • GC12M073514
  • GC12P075989
  • GC12M076156
  • GC12M074726
  • GC12M076438

Summaries for NAP1L1 Gene

Entrez Gene Summary for NAP1L1 Gene

  • This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]

GeneCards Summary for NAP1L1 Gene

NAP1L1 (Nucleosome Assembly Protein 1 Like 1) is a Protein Coding gene. Diseases associated with NAP1L1 include Antenatal Bartter Syndrome. An important paralog of this gene is NAP1L4.

UniProtKB/Swiss-Prot for NAP1L1 Gene

  • May be involved in modulating chromatin formation and contribute to regulation of cell proliferation.

Gene Wiki entry for NAP1L1 Gene

Additional gene information for NAP1L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAP1L1 Gene

Genomics for NAP1L1 Gene

GeneHancer (GH) Regulatory Elements for NAP1L1 Gene

Promoters and enhancers for NAP1L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I076081 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 891 4.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B NAP1L1 PHLDA1 GC12P076058
GH12I075974 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +105.9 105915 10.2 HDGF PKNOX1 FOXA2 ARNT MLX ARID4B NEUROD1 SIN3A DMAP1 IRF4 ENSG00000258077 PHLDA1 NAP1L1 ENSG00000251893 GLIPR1 LOC100289143
GH12I076124 Enhancer 0.6 Ensembl 11.9 -39.5 -39468 0.2 SMARCA5 ZNF639 MCM3 MTA2 MCM5 FOSL1 MTA1 EGR1 IKZF1 NAP1L1 KRR1 ENSG00000257497 ENSG00000258304 LOC641695
GH12I076151 Enhancer 0.6 Ensembl 11.3 -67.3 -67267 1 EBF1 BATF ZNF316 IKZF1 ETV6 RUNX3 IKZF2 BCLAF1 SPI1 NAP1L1 BBS10 ENSG00000251893 GC12P076140 LINC02407
GH12I075861 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +221.5 221456 4.1 FOXA2 JUN FOSL1 CTBP1 FOS FOSL2 ZNF3 HLF CBFA2T3 CEBPB PHLDA1 ENSG00000251893 NAP1L1 ENSG00000258091 LOC105369846 ENSG00000258077
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAP1L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAP1L1 gene promoter:

Genomic Locations for NAP1L1 Gene

Genomic Locations for NAP1L1 Gene
chr12:76,036,587-76,085,033
(GRCh38/hg38)
Size:
48,447 bases
Orientation:
Minus strand
chr12:76,438,670-76,478,813
(GRCh37/hg19)

Genomic View for NAP1L1 Gene

Genes around NAP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAP1L1 Gene

Proteins for NAP1L1 Gene

  • Protein details for NAP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55209-NP1L1_HUMAN
    Recommended name:
    Nucleosome assembly protein 1-like 1
    Protein Accession:
    P55209
    Secondary Accessions:
    • B3KNT8
    • B3KV44

    Protein attributes for NAP1L1 Gene

    Size:
    391 amino acids
    Molecular mass:
    45374 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAP1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAP1L1 Gene

Post-translational modifications for NAP1L1 Gene

  • Monoglycylated on glutamate residues. Cannot be polyglycylated due to the absence of functional TTLL10 in human (By similarity).
  • Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and monoglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.
  • Ubiquitination at Lys32, Lys82, Lys87, Lys105, and isoforms=2, 3165

No data available for DME Specific Peptides for NAP1L1 Gene

Domains & Families for NAP1L1 Gene

Gene Families for NAP1L1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NAP1L1 Gene

Graphical View of Domain Structure for InterPro Entry

P55209

UniProtKB/Swiss-Prot:

NP1L1_HUMAN :
  • The acidic domains are probably involved in the interaction with histones.
  • Belongs to the nucleosome assembly protein (NAP) family.
Domain:
  • The acidic domains are probably involved in the interaction with histones.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with NAP1L1: view

Function for NAP1L1 Gene

Molecular function for NAP1L1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in modulating chromatin formation and contribute to regulation of cell proliferation.

Phenotypes From GWAS Catalog for NAP1L1 Gene

Gene Ontology (GO) - Molecular Function for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 11940655
genes like me logo Genes that share ontologies with NAP1L1: view
genes like me logo Genes that share phenotypes with NAP1L1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAP1L1 Gene

Localization for NAP1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAP1L1 Gene

Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAP1L1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IDA,HDA 19946888
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with NAP1L1: view

Pathways & Interactions for NAP1L1 Gene

SuperPathways for NAP1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication TAS 8297347
GO:0006334 nucleosome assembly TAS,IEA --
GO:0008284 positive regulation of cell proliferation TAS 8297347
genes like me logo Genes that share ontologies with NAP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for NAP1L1 Gene

Drugs & Compounds for NAP1L1 Gene

No Compound Related Data Available

Transcripts for NAP1L1 Gene

Unigene Clusters for NAP1L1 Gene

Nucleosome assembly protein 1-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAP1L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: -
SP9: - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - -
SP15:
SP16:
SP17:
SP18: - - - - - - -
SP19:
SP20:
SP21:
SP22:

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - -
SP17: - - -
SP18:
SP19: - -
SP20: -
SP21:
SP22:

Relevant External Links for NAP1L1 Gene

GeneLoc Exon Structure for
NAP1L1
ECgene alternative splicing isoforms for
NAP1L1

Expression for NAP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAP1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAP1L1 Gene

This gene is overexpressed in Bone marrow stromal cell (11.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAP1L1 Gene



Protein tissue co-expression partners for NAP1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAP1L1 Gene:

NAP1L1

SOURCE GeneReport for Unigene cluster for NAP1L1 Gene:

Hs.524599

mRNA Expression by UniProt/SwissProt for NAP1L1 Gene:

P55209-NP1L1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for NAP1L1 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Lung(4.5)
  • Muscle(4.5)
  • Eye(4.4)
  • Intestine(4.4)
  • Kidney(4.2)
  • Skin(4.1)
  • Pancreas(3.9)
  • Blood(3.2)
  • Bone(3.1)
  • Stomach(2.6)
  • Heart(2.4)
  • Lymph node(2.4)
  • Spleen(2.4)
  • Adrenal gland(2.2)
  • Bone marrow(2.1)
  • Gall bladder(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with NAP1L1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAP1L1 Gene

Orthologs for NAP1L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAP1L1 33 34
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia NAP1L1 33 34
  • 96.42 (n)
cow
(Bos Taurus)
Mammalia NAP1L1 33 34
  • 96.16 (n)
-- 34
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nap1l1 33
  • 94.46 (n)
mouse
(Mus musculus)
Mammalia Nap1l1 33 16 34
  • 93.27 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
ManyToMany
-- 34
  • 89 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 92 (a)
OneToMany
NAP1L1 33
  • 85.85 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nap1l1 33
  • 80.82 (n)
Str.10809 33
African clawed frog
(Xenopus laevis)
Amphibia nap1l1-prov 33
zebrafish
(Danio rerio)
Actinopterygii nap1l1 33 34
  • 75.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001928 33
  • 53.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nap1 35 33 34
  • 53.41 (n)
EG:BACR7A4.18 35
  • 35 (a)
CG5017 34
  • 35 (a)
ManyToMany
CG3708 34
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nap-1 34
  • 43 (a)
OneToMany
D2096.8 35
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP1 33 34
  • 50 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15049g 33
  • 49.06 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL109W 33
  • 45.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NAP1;1 33
  • 52.93 (n)
rice
(Oryza sativa)
Liliopsida Os05g0539700 33
  • 51.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.925 34
  • 58 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nap1 33
  • 48.94 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01438 33
  • 48.29 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12175 33
Species where no ortholog for NAP1L1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAP1L1 Gene

ENSEMBL:
Gene Tree for NAP1L1 (if available)
TreeFam:
Gene Tree for NAP1L1 (if available)

Paralogs for NAP1L1 Gene

Variants for NAP1L1 Gene

Sequence variations from dbSNP and Humsavar for NAP1L1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000025562 -- 76,084,334(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000030196 -- 76,048,274(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000048849 -- 76,053,087(-) T/G intron_variant
rs1000133232 -- 76,061,492(-) T/C intron_variant
rs1000177672 -- 76,066,219(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NAP1L1 Gene

Variant ID Type Subtype PubMed ID
nsv973093 CNV duplication 23825009
nsv559423 CNV loss 21841781
nsv481434 CNV novel sequence insertion 20440878
nsv481078 CNV novel sequence insertion 20440878
nsv480625 CNV novel sequence insertion 20440878
nsv480601 CNV novel sequence insertion 20440878
nsv479829 CNV novel sequence insertion 20440878
nsv479685 CNV novel sequence insertion 20440878
nsv478113 CNV novel sequence insertion 20440878
nsv477998 CNV novel sequence insertion 20440878
nsv474626 CNV novel sequence insertion 20440878
nsv474261 CNV novel sequence insertion 20440878
nsv474137 CNV novel sequence insertion 20440878
nsv474068 CNV novel sequence insertion 20440878

Variation tolerance for NAP1L1 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAP1L1 Gene

Disorders for NAP1L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAP1L1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
antenatal bartter syndrome
  • bartter syndrome, furosemide type
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NAP1L1

genes like me logo Genes that share disorders with NAP1L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAP1L1 Gene

Publications for NAP1L1 Gene

  1. Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation. (PMID: 8297347) Simon HU … Siminovitch KA (The Biochemical journal 1994) 2 3 4 58
  2. Functional characterization of human nucleosome assembly protein 1-like proteins as histone chaperones. (PMID: 20002496) Okuwaki M … Nagata K (Genes to cells : devoted to molecular & cellular mechanisms 2010) 3 22 58
  3. The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription. (PMID: 18226242) Vardabasso C … Giacca M (Retrovirology 2008) 3 4 58
  4. The nucleosome assembly activity of NAP1 is enhanced by Alien. (PMID: 17339334) Eckey M … Baniahmad A (Molecular and cellular biology 2007) 3 22 58
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58

Products for NAP1L1 Gene

Sources for NAP1L1 Gene

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