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Aliases for NANP Gene

Aliases for NANP Gene

  • N-Acetylneuraminic Acid Phosphatase 2 3 5
  • Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 4 3 4
  • Haloacid Dehalogenase-Like Hydrolase Domain Containing 4 2 3
  • Neu5Ac-9-Pase 3 4
  • C20orf147 3 4
  • HDHD4 3 4
  • Chromosome 20 Open Reading Frame 147 2
  • N-Acylneuraminate-9-Phosphatase 3
  • EC 4
  • DJ694B14.3 3

External Ids for NANP Gene

Previous HGNC Symbols for NANP Gene

  • C20orf147
  • HDHD4

Previous GeneCards Identifiers for NANP Gene

  • GC20M025543

Summaries for NANP Gene

GeneCards Summary for NANP Gene

NANP (N-Acetylneuraminic Acid Phosphatase) is a Protein Coding gene. Diseases associated with NANP include Parasitic Protozoa Infectious Disease. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include hydrolase activity and N-acylneuraminate-9-phosphatase activity.

Additional gene information for NANP Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANP Gene

Genomics for NANP Gene

GeneHancer (GH) Regulatory Elements for NANP Gene

Promoters and enhancers for NANP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I025622 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 564 +0.5 495 2.9 PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 NANP ZNF337-AS1 ZNF337 NINL VN1R108P FAM182B RNU6ATAC17P
GH20I025625 Enhancer 0.4 ENCODE 550.8 -1.5 -1516 0.1 PAF1 MNT NANP ZNF337-AS1 FAM182B ZNF337 RN7SL594P
GH20I025406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.8 +216.0 215962 2.5 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B GINS1 LOC105372581 PIR61298 ABHD12 NANP PYGB ZNF337 FAM182B ZNF337-AS1
GH20I025232 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.6 +387.7 387655 7.8 PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 LOC105372579 ABHD12 ZNF337 ZNF337-AS1 NANP PYGB NINL ENTPD6 FAM182B FAM182A
GH20I026009 Promoter/Enhancer 1.5 Ensembl ENCODE 19.1 -386.1 -386077 2.3 HDGF ARID4B SIN3A DMAP1 ZNF2 ZBTB7B BRCA1 ZNF48 TCF12 GLIS2 ENSG00000231081 LOC100134868 FAM182B NANP ABHD12 NINL ZNF337 GC20P025998
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NANP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NANP gene promoter:

Genomic Locations for NANP Gene

Genomic Locations for NANP Gene
11,241 bases
Minus strand

Genomic View for NANP Gene

Genes around NANP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANP Gene

Proteins for NANP Gene

  • Protein details for NANP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KP12
    • Q5JYN8
    • Q8TE97
    • Q9Y3N0

    Protein attributes for NANP Gene

    248 amino acids
    Molecular mass:
    27813 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic DNA and not from cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NANP Gene

neXtProt entry for NANP Gene

Post-translational modifications for NANP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANP Gene

Domains & Families for NANP Gene

Suggested Antigen Peptide Sequences for NANP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily. NANP family.
  • Belongs to the HAD-like hydrolase superfamily. NANP family.
genes like me logo Genes that share domains with NANP: view

Function for NANP Gene

Molecular function for NANP Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P {ECO:0000269 PubMed:16237198}; KM=19.2 mM for fructose 1,6-P2 {ECO:0000269 PubMed:16237198}; KM=2.7 mM for 6-P-gluconate {ECO:0000269 PubMed:16237198}; KM=5.9 mM for N-acetylglucosamine 6-P {ECO:0000269 PubMed:16237198}; Vmax=112 umol/min/mg enzyme with N-acetylneuraminate 9-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate {ECO:0000269 PubMed:16237198}; Vmax=2.79 umol/min/mg enzyme with 6-P-gluconate as substrate {ECO:0000269 PubMed:16237198}; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.140 umol/min/mg enzyme with 3-P glycerate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.094 umol/min/mg enzyme with glycerol 3-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.072 umol/min/mg enzyme with N-acetylmannosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.042 umol/min/mg enzyme with ribose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.023 umol/min/mg enzyme with glucosamine 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.019 umol/min/mg enzyme with fructose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.016 umol/min/mg enzyme with glucose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.004 umol/min/mg enzyme with glucose 1-P as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.002 umol/min/mg enzyme with P-enolpyruvate as substrate {ECO:0000269 PubMed:16237198}; Vmax=0.001 umol/min/mg enzyme with ATP as substrate {ECO:0000269 PubMed:16237198};
UniProtKB/Swiss-Prot CatalyticActivity:
N-acylneuraminate 9-phosphate + H(2)O = N-acylneuraminate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate and calcium.

Enzyme Numbers (IUBMB) for NANP Gene

Phenotypes From GWAS Catalog for NANP Gene

Gene Ontology (GO) - Molecular Function for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0050124 N-acylneuraminate-9-phosphatase activity TAS --
genes like me logo Genes that share ontologies with NANP: view
genes like me logo Genes that share phenotypes with NANP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NANP

Clone Products

  • Addgene plasmids for NANP

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NANP Gene

Localization for NANP Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANP gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NANP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NANP Gene

Pathways & Interactions for NANP Gene

genes like me logo Genes that share pathways with NANP: view

UniProtKB/Swiss-Prot Q8TBE9-NANP_HUMAN

  • Pathway: Amino-sugar metabolism; N-acetylneuraminate biosynthesis.

Gene Ontology (GO) - Biological Process for NANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006045 N-acetylglucosamine biosynthetic process IEA --
GO:0008152 metabolic process IEA --
GO:0016311 dephosphorylation IEA --
GO:0046380 N-acetylneuraminate biosynthetic process IDA,IEA 16237198
genes like me logo Genes that share ontologies with NANP: view

No data available for SIGNOR curated interactions for NANP Gene

Drugs & Compounds for NANP Gene

(5) Drugs for NANP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0
Aceneuramic acid Investigational Pharma 0

(3) Additional Compounds for NANP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylneuraminate 9-phosphate
N-Acetylneuraminic acid 9-phosphate
  • 5-(Acetylamino)-3,5-dideoxy-D-glycero-D-galacto-2-Nonulosonic acid 9-(dihydrogen phosphate)
  • N-Acetyl- 9-(dihydrogen phosphate)-Neuraminic acid
  • N-Acetyl-Neuraminic acid-9-phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with NANP: view

Transcripts for NANP Gene

mRNA/cDNA for NANP Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANP Gene

N-acetylneuraminic acid phosphatase:
Representative Sequences:

Clone Products

  • Addgene plasmids for NANP

Alternative Splicing Database (ASD) splice patterns (SP) for NANP Gene

No ASD Table

Relevant External Links for NANP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NANP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NANP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NANP Gene

This gene is overexpressed in Adrenal (47.2) and Heart (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NANP Gene

NURSA nuclear receptor signaling pathways regulating expression of NANP Gene:


SOURCE GeneReport for Unigene cluster for NANP Gene:


Evidence on tissue expression from TISSUES for NANP Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NANP: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANP Gene

Orthologs for NANP Gene

This gene was present in the common ancestor of animals.

Orthologs for NANP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NANP 33 34
  • 96.37 (n)
(Mus musculus)
Mammalia Gm6741 34
  • 94 (a)
Nanp 33 16 34
  • 86.5 (n)
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
-- 34
  • 89 (a)
  • 88.84 (n)
(Bos Taurus)
Mammalia NANP 33 34
  • 88.71 (n)
(Rattus norvegicus)
Mammalia Nanp 33
  • 86.91 (n)
(Monodelphis domestica)
Mammalia NANP 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia NANP 34
  • 71 (a)
(Gallus gallus)
Aves NANP 33 34
  • 65.17 (n)
(Anolis carolinensis)
Reptilia NANP 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nanp 33
  • 62.32 (n)
Str.17170 33
(Danio rerio)
Actinopterygii nanp 33 34
  • 54.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15771 33 34
  • 45.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004391 33
  • 44.15 (n)
Species where no ortholog for NANP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANP Gene

Gene Tree for NANP (if available)
Gene Tree for NANP (if available)

Paralogs for NANP Gene Pseudogenes for NANP Gene

genes like me logo Genes that share paralogs with NANP: view

No data available for Paralogs for NANP Gene

Variants for NANP Gene

Sequence variations from dbSNP and Humsavar for NANP Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000069696 -- 25,620,724(-) T/G intron_variant
rs1000190628 -- 25,625,351(-) C/G upstream_transcript_variant
rs1000228916 -- 25,612,497(-) A/G downstream_transcript_variant
rs1000281565 -- 25,619,167(-) C/A intron_variant
rs1000834130 -- 25,614,325(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for NANP Gene

Variant ID Type Subtype PubMed ID
esv2762069 CNV loss 21179565
esv3645589 CNV loss 21293372
esv3893324 CNV gain 25118596
nsv3342 CNV insertion 18451855
nsv522873 CNV gain 19592680
nsv964384 CNV duplication 23825009

Variation tolerance for NANP Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NANP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANP Gene

Disorders for NANP Gene

MalaCards: The human disease database

(1) MalaCards diseases for NANP Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
parasitic protozoa infectious disease
  • mastigophora infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search NANP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NANP

genes like me logo Genes that share disorders with NANP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANP Gene

Publications for NANP Gene

  1. Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase. (PMID: 16237198) Maliekal P … Van Schaftingen E (Glycobiology 2006) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for NANP Gene

  • Addgene plasmids for NANP

Sources for NANP Gene

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