NANOS3 Gene (Protein Coding)

Nanos C2HC-Type Zinc Finger 3

GC19P013862
GIFtS:
36
See more...

Aliases for NANOS3 Gene

Aliases for NANOS3 Gene

  • Nanos C2HC-Type Zinc Finger 3 2 3 5
  • NOS3 2 3 4
  • Nanos Homolog 3 3 4
  • ZC2HC12C 2 3
  • NANOS1L 2 3
  • Nanos Homolog 3 (Drosophila) 2
  • NANOS3 5
  • NOS-3 4

External Ids for NANOS3 Gene

Previous GeneCards Identifiers for NANOS3 Gene

  • GC19P013850
  • GC19P013851
  • GC19P013852
  • GC19P013854
  • GC19P013857
  • GC19P013988
  • GC19P013559
  • GC19P013972

Summaries for NANOS3 Gene

GeneCards Summary for NANOS3 Gene

NANOS3 (Nanos C2HC-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with NANOS3 include Freemartinism and Brain Germinoma. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot Summary for NANOS3 Gene

  • Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Additional gene information for NANOS3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NANOS3 Gene

Genomics for NANOS3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NANOS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NANOS3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NANOS3

Top Transcription factor binding sites by QIAGEN in the NANOS3 gene promoter:
  • AhR
  • Arnt
  • CP2
  • LyF-1
  • MyoD
  • NF-kappaB1
  • PPAR-alpha
  • Sox9
  • SRF
  • SRF (504 AA)

Genomic Locations for NANOS3 Gene

Latest Assembly
chr19:13,862,036-13,880,757
(GRCh38/hg38)
Size:
18,722 bases
Orientation:
Plus strand

Previous Assembly
chr19:13,972,850-13,991,571
(GRCh37/hg19 by Entrez Gene)
Size:
18,722 bases
Orientation:
Plus strand

chr19:13,972,877-13,991,571
(GRCh37/hg19 by Ensembl)
Size:
18,695 bases
Orientation:
Plus strand

Genomic View for NANOS3 Gene

Genes around NANOS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NANOS3 Gene

Proteins for NANOS3 Gene

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  3. Assay products for research

  • Protein details for NANOS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60323-NANO3_HUMAN
    Recommended name:
    Nanos homolog 3
    Protein Accession:
    P60323
    Secondary Accessions:
    • Q495E5

    Protein attributes for NANOS3 Gene

    Size:
    173 amino acids
    Molecular mass:
    18844 Da
    Quaternary structure:
    • Binds mRNA from germ cells. Interacts with PUM2 (By similarity).

    Alternative splice isoforms for NANOS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOS3 Gene

Protein Expression for NANOS3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NANOS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOS3 Gene

Domains & Families for NANOS3 Gene

Gene Families for NANOS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NANOS3 Gene

InterPro:
Blocks:
  • Nanos RNA-binding
ProtoNet:

Suggested Antigen Peptide Sequences for NANOS3 Gene

GenScript: Design optimal peptide antigens:
  • Nanos homolog 3 (NANO3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60323

UniProtKB/Swiss-Prot:

NANO3_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
genes like me logo Genes that share domains with NANOS3: view

Function for NANOS3 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for NANOS3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Phenotypes From GWAS Catalog for NANOS3 Gene

Gene Ontology (GO) - Molecular Function for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0003729 mRNA binding IBA 21873635
GO:0005515 protein binding IPI 24736845
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NANOS3: view
genes like me logo Genes that share phenotypes with NANOS3: view

Animal Models for NANOS3 Gene

MGI Knock Outs for NANOS3:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NANOS3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NANOS3 Gene

Localization for NANOS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS3 Gene

Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250 UniProtKB:P60324}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANOS3 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 0

Gene Ontology (GO) - Cellular Components for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS --
GO:0005634 nucleus IEA,IDA 21421998
GO:0005737 cytoplasm IEA,IDA 21421998
GO:0010494 cytoplasmic stress granule ISS --
GO:0048471 perinuclear region of cytoplasm IBA,IDA 22899867
genes like me logo Genes that share ontologies with NANOS3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NANOS3 Gene

Pathways & Interactions for NANOS3 Gene

PathCards logo

SuperPathways for NANOS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IMP 21421998
GO:0007283 spermatogenesis ISS --
GO:0017148 negative regulation of translation IDA 24736845
genes like me logo Genes that share ontologies with NANOS3: view

No data available for Pathways by source and SIGNOR curated interactions for NANOS3 Gene

Drugs & Compounds for NANOS3 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for NANOS3 Gene

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  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for NANOS3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NANOS3

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS3 Gene

No ASD Table

Relevant External Links for NANOS3 Gene

GeneLoc Exon Structure for
NANOS3

Expression for NANOS3 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NANOS3 Gene

mRNA expression in normal human tissues for NANOS3 Gene
mRNA expression by BioGPS for NANOS3 GenemRNA expression by GTEx for NANOS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS3 Gene

This gene is overexpressed in Brain - Amygdala (x5.9), Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Hippocampus (x5.0).

Protein differential expression in normal tissues from HIPED for NANOS3 Gene

This gene is overexpressed in Heart (58.4) and Fetal testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NANOS3 Gene



Protein tissue co-expression partners for NANOS3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NANOS3

SOURCE GeneReport for Unigene cluster for NANOS3 Gene:

Hs.127982

mRNA Expression by UniProt/SwissProt for NANOS3 Gene:

P60323-NANO3_HUMAN
Tissue specificity: Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
genes like me logo Genes that share expression patterns with NANOS3: view

Primer products for research

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOS3 Gene

Orthologs for NANOS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NANOS3 30 31
  • 99.18 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NANOS3 30 31
  • 83.56 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nanos3 30
  • 79.2 (n)
Mouse
(Mus musculus)
 Mammalia Nanos3 30 17 31
  • 78.72 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NANOS3 31
  • 77 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NANOS3 31
  • 56 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia NANOS3 31
  • 52 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NANOS3 31
  • 15 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii nanos3 30 31
  • 52.21 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta nos 31
  • 9 (a)
 OneToMany
Species where no ortholog for NANOS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NANOS3 Gene

ENSEMBL:
Gene Tree for NANOS3 (if available)
TreeFam:
Gene Tree for NANOS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NANOS3: view image

Paralogs for NANOS3 Gene

Paralogs for NANOS3 Gene

(2) SIMAP similar genes for NANOS3 Gene using alignment to 1 proteins:

  • NANO3_HUMAN
genes like me logo Genes that share paralogs with NANOS3: view

Variants for NANOS3 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NANOS3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs148122339 Benign: not provided 13,877,744(+) C/CGAG
NC_000019.10:g.13877745_13877747GAG[7] 		NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INSERTION
rs371590850 Benign: not provided 13,877,367(+) T/TGGAGCCGGTGTCA
NM_001098622.2(NANOS3):c.134_135insGCCGGAGCCGGTGTCAGC (p.Leu46_Glu47insProGluProValSerAla) 		INFRAME_INSERTION

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NANOS3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NANOS3 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Variation tolerance for NANOS3 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NANOS3 Gene

Human Gene Mutation Database (HGMD)
NANOS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOS3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS3 Gene

Disorders for NANOS3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NANOS3 Gene - From: COP

Disorder Aliases PubMed IDs
freemartinism
brain germinoma
  • germinoma of the brain
pediatric germ cell cancer
  • paediatric germ cell cancer
premature menopause
  • menopause - premature
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NANOS3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NANOS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANOS3 Gene

Publications for NANOS3 Gene

  1. NANOS3 function in human germ cell development. (PMID: 21421998) Julaton VT … Reijo Pera RA (Human molecular genetics 2011) 3 4
  2. Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. (PMID: 17418157) Qin Y … Rajkovic A (Fertility and sterility 2007) 3 41
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

ExternalLinks

View latest publications for NANOS3 gene in Mastermind

Products for NANOS3 Gene

Sources for NANOS3 Gene