Aliases for NANOS3 Gene
External Ids for NANOS3 Gene
Previous GeneCards Identifiers for NANOS3 Gene
GeneCards Summary for NANOS3 Gene
NANOS3 (Nanos C2HC-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with NANOS3 include Freemartinism and Pediatric Germ Cell Cancer. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.
UniProtKB/Swiss-Prot Summary for NANOS3 Gene
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.