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Aliases for NANOS3 Gene

Aliases for NANOS3 Gene

  • Nanos C2HC-Type Zinc Finger 3 2 3 5
  • NOS3 3 4
  • Nanos Homolog 3 (Drosophila) 2
  • Nanos Homolog 3 3
  • ZC2HC12C 3
  • NANOS1L 3
  • NOS-3 4

External Ids for NANOS3 Gene

Previous GeneCards Identifiers for NANOS3 Gene

  • GC19P013850
  • GC19P013851
  • GC19P013852
  • GC19P013854
  • GC19P013988
  • GC19P013559
  • GC19P013972

Summaries for NANOS3 Gene

GeneCards Summary for NANOS3 Gene

NANOS3 (Nanos C2HC-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with NANOS3 include Spermatocytoma. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.

UniProtKB/Swiss-Prot for NANOS3 Gene

  • Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Additional gene information for NANOS3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS3 Gene

Genomics for NANOS3 Gene

GeneHancer (GH) Regulatory Elements for NANOS3 Gene

Promoters and enhancers for NANOS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I013860 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.2 -179 2.6 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF207 ZNF143 FOS NANOS3 SNRPGP15 CCDC130 ZSWIM4 RFX1 DCAF15 IL27RA PRKACA GC19M013921
GH19I013011 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 -841.9 -841868 17.2 HDGF FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF213 NFIX ZNF136 ZNF709 ZNF791 TRMT1 CCDC130 MRI1 ZNF44 ZNF564 ZNF625
GH19I013115 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 -743.1 -743127 7.7 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 TRMT1 NACC1 ZNF791 ZNF136 ZNF442 CCDC130 MRI1 ZNF564 WDR83OS ZNF44
GH19I013773 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.7 -87.4 -87391 2.7 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 C19orf53 ENSG00000267633 MRI1 CCDC130 ADGRL1 NANOS3 ZNF333 TRMT1 RPS6P25 GC19P013795
GH19I013747 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.6 -113.8 -113844 2.2 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CCDC130 TRMT1 DDX39A MRI1 DCAF15 RFX1 LOC284454 ZNF333 ADGRL1 RNASEH2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NANOS3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NANOS3 gene promoter:

Genomic Locations for NANOS3 Gene

Genomic Locations for NANOS3 Gene
chr19:13,862,063-13,880,757
(GRCh38/hg38)
Size:
18,695 bases
Orientation:
Plus strand
chr19:13,972,877-13,991,571
(GRCh37/hg19)

Genomic View for NANOS3 Gene

Genes around NANOS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS3 Gene

Proteins for NANOS3 Gene

  • Protein details for NANOS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60323-NANO3_HUMAN
    Recommended name:
    Nanos homolog 3
    Protein Accession:
    P60323
    Secondary Accessions:
    • Q495E5

    Protein attributes for NANOS3 Gene

    Size:
    173 amino acids
    Molecular mass:
    18844 Da
    Quaternary structure:
    • Binds mRNA from germ cells. Interacts with PUM2 (By similarity).

    Alternative splice isoforms for NANOS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NANOS3 Gene

Post-translational modifications for NANOS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOS3 Gene

Domains & Families for NANOS3 Gene

Gene Families for NANOS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NANOS3 Gene

Suggested Antigen Peptide Sequences for NANOS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60323

UniProtKB/Swiss-Prot:

NANO3_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
genes like me logo Genes that share domains with NANOS3: view

Function for NANOS3 Gene

Molecular function for NANOS3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Phenotypes From GWAS Catalog for NANOS3 Gene

Gene Ontology (GO) - Molecular Function for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0005515 protein binding IPI 24736845
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NANOS3: view
genes like me logo Genes that share phenotypes with NANOS3: view

Animal Models for NANOS3 Gene

MGI Knock Outs for NANOS3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NANOS3 Gene

Localization for NANOS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS3 Gene

Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250 UniProtKB:P60324}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANOS3 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS --
GO:0005634 nucleus IEA,IDA 21421998
GO:0005737 cytoplasm IDA,IEA 21421998
GO:0010494 cytoplasmic stress granule ISS --
GO:0048471 perinuclear region of cytoplasm IDA 22899867
genes like me logo Genes that share ontologies with NANOS3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NANOS3 Gene

Pathways & Interactions for NANOS3 Gene

SuperPathways for NANOS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NANOS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IMP 21421998
GO:0007283 spermatogenesis ISS --
GO:0017148 negative regulation of translation IDA 24736845
genes like me logo Genes that share ontologies with NANOS3: view

No data available for Pathways by source and SIGNOR curated interactions for NANOS3 Gene

Drugs & Compounds for NANOS3 Gene

No Compound Related Data Available

Transcripts for NANOS3 Gene

mRNA/cDNA for NANOS3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NANOS3 Gene

Nanos homolog 3 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS3 Gene

No ASD Table

Relevant External Links for NANOS3 Gene

GeneLoc Exon Structure for
NANOS3
ECgene alternative splicing isoforms for
NANOS3

Expression for NANOS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NANOS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS3 Gene

This gene is overexpressed in Brain - Amygdala (x5.9), Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Hippocampus (x5.0).

Protein differential expression in normal tissues from HIPED for NANOS3 Gene

This gene is overexpressed in Heart (58.4) and Fetal testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NANOS3 Gene



Protein tissue co-expression partners for NANOS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NANOS3 Gene:

NANOS3

SOURCE GeneReport for Unigene cluster for NANOS3 Gene:

Hs.127982

mRNA Expression by UniProt/SwissProt for NANOS3 Gene:

P60323-NANO3_HUMAN
Tissue specificity: Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
genes like me logo Genes that share expression patterns with NANOS3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOS3 Gene

Orthologs for NANOS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NANOS3 33 34
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia NANOS3 33 34
  • 83.56 (n)
rat
(Rattus norvegicus)
Mammalia Nanos3 33
  • 79.2 (n)
mouse
(Mus musculus)
Mammalia Nanos3 33 16 34
  • 78.72 (n)
cow
(Bos Taurus)
Mammalia NANOS3 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NANOS3 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NANOS3 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves NANOS3 34
  • 15 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nanos3 33 34
  • 52.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta nos 34
  • 9 (a)
OneToMany
Species where no ortholog for NANOS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANOS3 Gene

ENSEMBL:
Gene Tree for NANOS3 (if available)
TreeFam:
Gene Tree for NANOS3 (if available)

Paralogs for NANOS3 Gene

Paralogs for NANOS3 Gene

(2) SIMAP similar genes for NANOS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NANOS3: view

Variants for NANOS3 Gene

Sequence variations from dbSNP and Humsavar for NANOS3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000108848 -- 13,877,147(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000294725 -- 13,876,323(+) T/C upstream_transcript_variant
rs1001517292 -- 13,878,426(+) A/G intron_variant
rs1001818064 -- 13,876,244(+) T/C upstream_transcript_variant
rs1002045743 -- 13,881,158(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NANOS3 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv833760 CNV loss 17160897
nsv953979 CNV deletion 24416366

Variation tolerance for NANOS3 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NANOS3 Gene

Human Gene Mutation Database (HGMD)
NANOS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS3 Gene

Disorders for NANOS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NANOS3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
spermatocytoma
  • spermatocytic seminoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NANOS3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NANOS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANOS3 Gene

Publications for NANOS3 Gene

  1. NANOS3 function in human germ cell development. (PMID: 21421998) Julaton VT … Reijo Pera RA (Human molecular genetics 2011) 3 4 58
  2. Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. (PMID: 17418157) Qin Y … Rajkovic A (Fertility and sterility 2007) 3 44 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 4 58
  5. Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. (PMID: 27768780) Panula S … Hovatta O (PloS one 2016) 3 58

Products for NANOS3 Gene

Sources for NANOS3 Gene

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