Aliases for NANOS3 Gene
Aliases for NANOS3 Gene
External Ids for NANOS3 Gene
- HGNC: 22048
- Entrez Gene: 342977
- Ensembl: ENSG00000187556
- OMIM: 608229
- UniProtKB: P60323
Previous GeneCards Identifiers for NANOS3 Gene
- GC19P013850
- GC19P013851
- GC19P013852
- GC19P013854
- GC19P013988
- GC19P013559
- GC19P013972
Summaries for NANOS3 Gene
GeneCards Summary for NANOS3 Gene
NANOS3 (Nanos C2HC-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with NANOS3 include Spermatocytoma. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.
UniProtKB/Swiss-Prot for NANOS3 Gene
-
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
Additional gene information for NANOS3 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NANOS3 Gene
Genomics for NANOS3 Gene
GeneHancer (GH) Regulatory Elements for NANOS3 Gene
Promoters and enhancers for NANOS3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NANOS3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NANOS3 gene promoter:
Regulatory Element Products
Genomic Locations for NANOS3 Gene
Genomic Locations for NANOS3 Gene
- chr19:13,862,063-13,880,757
- (GRCh38/hg38)
- Size:
- 18,695 bases
- Orientation:
- Plus strand
- chr19:13,972,877-13,991,571
- (GRCh37/hg19)
Genomic View for NANOS3 Gene
Genes around NANOS3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by Ensembl
- 19p13.12 by Entrez Gene
- 19p13.13 by HGNC
NANOS3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NANOS3 Gene
Proteins for NANOS3 Gene
-
Protein details for NANOS3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P60323-NANO3_HUMAN
- Recommended name:
- Nanos homolog 3
- Protein Accession:
- P60323
- Q495E5
Protein attributes for NANOS3 Gene
- Size:
- 173 amino acids
- Molecular mass:
- 18844 Da
- Quaternary structure:
-
- Binds mRNA from germ cells. Interacts with PUM2 (By similarity).
Protein Expression for NANOS3 Gene
Post-translational modifications for NANOS3 Gene
Other Protein References for NANOS3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NANOS3
- Novus Biologicals Antibodies for NANOS3
-
Abcam antibodies for NANOS3
- Invitrogen Antibodies for NANOS3
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-
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Protein Products
-
OriGene Purified Proteins for NANOS3
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- Search GeneTex for Proteins for NANOS3
-
Abcam proteins for NANOS3
Assay Products
No data available for DME Specific Peptides for NANOS3 Gene
Domains & Families for NANOS3 Gene
Gene Families for NANOS3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NANOS3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NANOS3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P60323UniProtKB/Swiss-Prot:
NANO3_HUMAN :- The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
- Belongs to the nanos family.
- Domain:
-
- The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
- Family:
-
- Belongs to the nanos family.
Function for NANOS3 Gene
Molecular function for NANOS3 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
Phenotypes From GWAS Catalog for NANOS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | ISS | -- |
| GO:0005515 | protein binding | IPI | 24736845 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for NANOS3 Gene
- MGI mutant phenotypes for NANOS3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for NANOS3:
Animal Models for NANOS3 Gene
- MGI Knock Outs for NANOS3:
-
- Nanos3 tm1Ysa
Animal Model Products
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-
-
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-
ViGene Biosciences ready-to-package AAV shRNAs for NANOS3 gene
- Search ViGene Biosciences for NANOS3
CRISPR Products
-
OriGene CRISPR knockouts for NANOS3
- genomics-online: gRNA clones - Search results for 84 available NANOS3 gene related products
- Overview of 84 available NANOS3 gene related products
- Applied Biological Materials CRISPR for NANOS3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NANOS3
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miRNA for NANOS3 Gene
- miRTarBase miRNAs that target NANOS3
miRNA Products
- Search ViGene Biosciences for NANOS3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NANOS3
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- genomics-online: shRNA clones - Search results for 84 available NANOS3 gene related products
- Overview of 84 available NANOS3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NANOS3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for NANOS3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NANOS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NANOS3
-
ViGene Biosciences adenoviral particle packaged cDNA for NANOS3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NANOS3 gene
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NANOS3 Gene
Localization for NANOS3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NANOS3 Gene
- Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250 UniProtKB:P60324}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | ISS | -- |
| GO:0005634 | nucleus | IEA,IDA | 21421998 |
| GO:0005737 | cytoplasm | IDA,IEA | 21421998 |
| GO:0010494 | cytoplasmic stress granule | ISS | -- |
| GO:0048471 | perinuclear region of cytoplasm | IDA | 22899867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NANOS3 Gene
Pathways & Interactions for NANOS3 Gene
No Data Available
Interacting Proteins for NANOS3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006417 | regulation of translation | ISS | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007281 | germ cell development | IMP | 21421998 |
| GO:0007283 | spermatogenesis | ISS | -- |
| GO:0017148 | negative regulation of translation | IDA | 24736845 |
No data available for Pathways by source and SIGNOR curated interactions for NANOS3 Gene
Transcripts for NANOS3 Gene
mRNA/cDNA for NANOS3 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (12) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NANOS3 Gene
- Nanos homolog 3 (Drosophila):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for NANOS3
- genomics-online: gRNA clones - Search results for 84 available NANOS3 gene related products
- Overview of 84 available NANOS3 gene related products
- Applied Biological Materials CRISPR for NANOS3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NANOS3
- GenScript: Design CRISPR guide RNA sequences for NANOS3
miRNA Products
- Search ViGene Biosciences for NANOS3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NANOS3
- Browse OriGene Inhibitory RNA Products For NANOS3
- genomics-online: shRNA clones - Search results for 84 available NANOS3 gene related products
- Overview of 84 available NANOS3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NANOS3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for NANOS3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NANOS3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NANOS3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NANOS3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad
- Primordial germ cell-like cells(Hayashi K et. al. 2011)
- Primordial Germ Cells Allantois
- Primordial Germ Cells Primitive Gonad
- Spermatogonium Type A Seminiferous Tubules
- Germ Cells (Reproductive System)
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Testis (Reproductive System)
- Spermatogonium Type A Seminiferous Tubules
mRNA differential expression in normal tissues according to GTEx for NANOS3 Gene
This gene is overexpressed in Brain - Amygdala (x5.9), Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Hippocampus (x5.0).
This gene is overexpressed in Heart (58.4) and Fetal testis (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NANOS3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NANOS3 Gene:
NANOS3SOURCE GeneReport for Unigene cluster for NANOS3 Gene:
Hs.127982mRNA Expression by UniProt/SwissProt for NANOS3 Gene:
P60323-NANO3_HUMAN
Tissue specificity:
Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
Primer Products
-
OriGene qPCR primer pairs for NANOS3
- genomics-online: primer clones - Search results for 84 available NANOS3 gene related products
- Overview of 84 available NANOS3 gene related products
Gene Expression Assay Products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOS3 Gene
Orthologs for NANOS3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NANOS3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NANOS3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nanos3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Nanos3 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NANOS3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NANOS3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NANOS3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NANOS3 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | nanos3 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | nos 34 |
|
OneToMany |
- Species where no ortholog for NANOS3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NANOS3 Gene
Variants for NANOS3 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000108848 | -- | 13,877,147(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000294725 | -- | 13,876,323(+) | T/C | upstream_transcript_variant | |
| rs1001517292 | -- | 13,878,426(+) | A/G | intron_variant | |
| rs1001818064 | -- | 13,876,244(+) | T/C | upstream_transcript_variant | |
| rs1002045743 | -- | 13,881,158(+) | A/G | downstream_transcript_variant |
Residual Variation Intolerance Score:
33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.03;
50.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NANOS3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS3 Gene
Disorders for NANOS3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spermatocytoma |
|
|
Search NANOS3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NANOS3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NANOS3 Gene
Publications for NANOS3 Gene
- NANOS3 function in human germ cell development. (PMID: 21421998) Julaton VT … Reijo Pera RA (Human molecular genetics 2011) 3 4 58
- Mutation analysis of NANOS3 in 80 Chinese and 88 Caucasian women with premature ovarian failure. (PMID: 17418157) Qin Y … Rajkovic A (Fertility and sterility 2007) 3 44 58
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
- Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 4 58
- Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. (PMID: 27768780) Panula S … Hovatta O (PloS one 2016) 3 58
Products for NANOS3 Gene
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- VectorBuilder custom plasmid, inducible vectors for NANOS3
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 32 available NANOS3 Antibodies ranked by validation data
- Compare Top NANOS3 Antibodies
- antibodies-online: Search results for available NANOS3 related products ranked by validation data
- antibodies-online: Search results for 3 available NANOS3 Proteins ranked by validation data
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- Search GeneTex for Proteins for NANOS3
- ViGene Biosciences adenoviral particle packaged cDNA for NANOS3 gene
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- Overview of 84 available NANOS3 gene related products
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- Overview of 84 available NANOS3 gene related products
Sources for NANOS3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
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