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NANOS3 (Nanos C2HC-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with NANOS3 include Freemartinism and Brain Germinoma. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is NANOS2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | ISS | -- |
GO:0003729 | mRNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 24736845 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | ISS | -- |
GO:0005634 | nucleus | IEA,IDA | 21421998 |
GO:0005737 | cytoplasm | IEA,IDA | 21421998 |
GO:0010494 | cytoplasmic stress granule | ISS | -- |
GO:0048471 | perinuclear region of cytoplasm | IBA,IDA | 22899867 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006417 | regulation of translation | ISS | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007281 | germ cell development | IMP | 21421998 |
GO:0007283 | spermatogenesis | ISS | -- |
GO:0017148 | negative regulation of translation | IDA | 24736845 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NANOS3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NANOS3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nanos3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nanos3 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NANOS3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NANOS3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NANOS3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NANOS3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | nanos3 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | nos 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs148122339 | Benign: not provided | 13,877,744(+) |
C/CGAG NC_000019.10:g.13877745_13877747GAG[7] |
NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INSERTION | |
rs371590850 | Benign: not provided | 13,877,367(+) |
T/TGGAGCCGGTGTCA
NM_001098622.2(NANOS3):c.134_135insGCCGGAGCCGGTGTCAGC (p.Leu46_Glu47insProGluProValSerAla) |
INFRAME_INSERTION |
Disorder | Aliases | PubMed IDs |
---|---|---|
freemartinism |
|
|
brain germinoma |
|
|
pediatric germ cell cancer |
|
|
premature menopause |
|
|