Aliases for NANOS2 Gene

Aliases for NANOS2 Gene

  • Nanos C2HC-Type Zinc Finger 2 2 3 5
  • NOS2 2 3 4
  • Nanos Homolog 2 3 4
  • ZC2HC12B 2 3
  • NOS-2 3 4
  • Nanos Homolog 2 (Drosophila) 2
  • NANOS2 5

External Ids for NANOS2 Gene

Previous GeneCards Identifiers for NANOS2 Gene

  • GC19U900395
  • GC19M051108
  • GC19M046416
  • GC19M042844

Summaries for NANOS2 Gene

GeneCards Summary for NANOS2 Gene

NANOS2 (Nanos C2HC-Type Zinc Finger 2) is a Protein Coding gene. Diseases associated with NANOS2 include Spermatocytoma and Spermatogenic Failure, X-Linked, 1. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is NANOS3.

UniProtKB/Swiss-Prot Summary for NANOS2 Gene

  • Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NANOS2 Gene

Genomics for NANOS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NANOS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NANOS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NANOS2

Top Transcription factor binding sites by QIAGEN in the NANOS2 gene promoter:
  • c-Myc
  • COMP1
  • E47
  • FOXO4
  • Lmo2
  • Max
  • NRSF form 1
  • NRSF form 2
  • Tal-1
  • XBP-1

Genomic Locations for NANOS2 Gene

Genomic Locations for NANOS2 Gene
chr19:45,913,214-45,914,778
(GRCh38/hg38)
Size:
1,565 bases
Orientation:
Minus strand
chr19:46,416,472-46,418,036
(GRCh37/hg19)
Size:
1,565 bases
Orientation:
Minus strand

Genomic View for NANOS2 Gene

Genes around NANOS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS2 Gene

Proteins for NANOS2 Gene

  • Protein details for NANOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60321-NANO2_HUMAN
    Recommended name:
    Nanos homolog 2
    Protein Accession:
    P60321
    Secondary Accessions:
    • Q17R30
    • Q4G0P8

    Protein attributes for NANOS2 Gene

    Size:
    138 amino acids
    Molecular mass:
    15132 Da
    Quaternary structure:
    • Interacts with CNOT1, CNOT3, CNOT6L, CNOT7 and CNOT9.

neXtProt entry for NANOS2 Gene

Post-translational modifications for NANOS2 Gene

No Post-translational modifications

Other Protein References for NANOS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NANOS2

No data available for DME Specific Peptides for NANOS2 Gene

Domains & Families for NANOS2 Gene

Gene Families for NANOS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NANOS2 Gene

InterPro:
Blocks:
  • Nanos RNA-binding
ProtoNet:

Suggested Antigen Peptide Sequences for NANOS2 Gene

GenScript: Design optimal peptide antigens:
  • Nanos homolog 2 (NANO2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P60321

UniProtKB/Swiss-Prot:

NANO2_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
Family:
  • Belongs to the nanos family.
genes like me logo Genes that share domains with NANOS2: view

Function for NANOS2 Gene

Molecular function for NANOS2 Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

Phenotypes From GWAS Catalog for NANOS2 Gene

Gene Ontology (GO) - Molecular Function for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 24736845
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NANOS2: view
genes like me logo Genes that share phenotypes with NANOS2: view

Animal Models for NANOS2 Gene

MGI Knock Outs for NANOS2:

Animal Model Products

CRISPR Products

miRNA for NANOS2 Gene

miRTarBase miRNAs that target NANOS2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NANOS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NANOS2 Gene

Localization for NANOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS2 Gene

Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region. Note=Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANOS2 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS --
GO:0005634 nucleus IDA 22899867
GO:0005737 cytoplasm IEA,IDA 19168545
GO:0048471 perinuclear region of cytoplasm IEA,IDA 19168545
genes like me logo Genes that share ontologies with NANOS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NANOS2 Gene

Pathways & Interactions for NANOS2 Gene

PathCards logo

SuperPathways for NANOS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NANOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process IEA,ISS --
GO:0006417 regulation of translation IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis ISS --
GO:0017148 negative regulation of translation IDA 24736845
genes like me logo Genes that share ontologies with NANOS2: view

No data available for Pathways by source and SIGNOR curated interactions for NANOS2 Gene

Drugs & Compounds for NANOS2 Gene

No Compound Related Data Available

Transcripts for NANOS2 Gene

mRNA/cDNA for NANOS2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NANOS2

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS2 Gene

No ASD Table

Relevant External Links for NANOS2 Gene

GeneLoc Exon Structure for
NANOS2

Expression for NANOS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NANOS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS2 Gene

This gene is overexpressed in Testis (x38.9).

Protein differential expression in normal tissues from HIPED for NANOS2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NANOS2 Gene



Protein tissue co-expression partners for NANOS2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NANOS2

SOURCE GeneReport for Unigene cluster for NANOS2 Gene:

Hs.434218

mRNA Expression by UniProt/SwissProt for NANOS2 Gene:

P60321-NANO2_HUMAN
Tissue specificity: Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).
genes like me logo Genes that share expression patterns with NANOS2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOS2 Gene

Orthologs for NANOS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NANOS2 30 31
  • 99.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NANOS2 30 31
  • 85.99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NANOS2 30 31
  • 85.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nanos2 30 17 31
  • 75.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nanos2 30
  • 75 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 28 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 59 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta nos 31
  • 9 (a)
OneToMany
Species where no ortholog for NANOS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NANOS2 Gene

ENSEMBL:
Gene Tree for NANOS2 (if available)
TreeFam:
Gene Tree for NANOS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NANOS2: view image

Paralogs for NANOS2 Gene

Paralogs for NANOS2 Gene

(2) SIMAP similar genes for NANOS2 Gene using alignment to 1 proteins:

  • NANO2_HUMAN
genes like me logo Genes that share paralogs with NANOS2: view

Variants for NANOS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NANOS2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs148451980 - p.His68Gln

Additional dbSNP identifiers (rs#s) for NANOS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NANOS2 Gene

Variant ID Type Subtype PubMed ID
nsv2507 CNV insertion 18451855
nsv510770 CNV deletion 20534489

Variation tolerance for NANOS2 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NANOS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS2 Gene

Disorders for NANOS2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NANOS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spermatocytoma
  • spermatocytic seminoma
spermatogenic failure, x-linked, 1
  • spgfx1
spermatogenic failure, y-linked, 2
  • spgfy2
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with NANOS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NANOS2 Gene

Publications for NANOS2 Gene

  1. The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction. (PMID: 19168545) Kusz KM … Jaruzelska J (Molecular human reproduction 2009) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PMID: 12690449) Jaruzelska J … Reijo Pera RA (Development genes and evolution 2003) 2 3
  4. Conserved role of nanos proteins in germ cell development. (PMID: 12947200) Tsuda M … Saga Y (Science (New York, N.Y.) 2003) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for NANOS2 Gene

Sources for NANOS2 Gene