Aliases for NANOS2 Gene
External Ids for NANOS2 Gene
Previous GeneCards Identifiers for NANOS2 Gene
GeneCards Summary for NANOS2 Gene
NANOS2 (Nanos C2HC-Type Zinc Finger 2) is a Protein Coding gene. Diseases associated with NANOS2 include Spermatocytoma and Spermatogenic Failure, X-Linked, 1. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is NANOS3.
UniProtKB/Swiss-Prot Summary for NANOS2 Gene
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).