This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015] See more...

Aliases for NANOS1 Gene

Aliases for NANOS1 Gene

  • Nanos C2HC-Type Zinc Finger 1 2 3 5
  • Nanos Homolog 1 3 4
  • EC_Rep1a 3 4
  • NOS-1 3 4
  • NOS1 3 4
  • Nanos Homolog 1 (Drosophila) 2
  • ZC2HC12A 3
  • SPGF12 3

External Ids for NANOS1 Gene

Previous GeneCards Identifiers for NANOS1 Gene

  • GC10U900443
  • GC10P120453
  • GC10P120779
  • GC10P114419

Summaries for NANOS1 Gene

Entrez Gene Summary for NANOS1 Gene

  • This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]

GeneCards Summary for NANOS1 Gene

NANOS1 (Nanos C2HC-Type Zinc Finger 1) is a Protein Coding gene. Diseases associated with NANOS1 include Spermatogenic Failure 12 and Male Infertility With Teratozoospermia Due To Single Gene Mutation. Gene Ontology (GO) annotations related to this gene include RNA binding and translation repressor activity. An important paralog of this gene is NANOS3.

UniProtKB/Swiss-Prot Summary for NANOS1 Gene

  • May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.

Additional gene information for NANOS1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NANOS1 Gene

Genomics for NANOS1 Gene

GeneHancer (GH) Regulatory Elements for NANOS1 Gene

Promoters and enhancers for NANOS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NANOS1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NANOS1

Top Transcription factor binding sites by QIAGEN in the NANOS1 gene promoter:
  • C/EBPalpha
  • E47
  • Egr-2
  • FOXJ2
  • GATA-6
  • HEN1
  • Pax-3
  • Tal-1
  • TBP
  • TFIID

Genomic Locations for NANOS1 Gene

Genomic Locations for NANOS1 Gene
chr10:119,029,714-119,034,342
(GRCh38/hg38)
Size:
4,629 bases
Orientation:
Plus strand
chr10:120,789,228-120,793,854
(GRCh37/hg19)
Size:
4,627 bases
Orientation:
Plus strand

Genomic View for NANOS1 Gene

Genes around NANOS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NANOS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NANOS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NANOS1 Gene

Proteins for NANOS1 Gene

  • Protein details for NANOS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY41-NANO1_HUMAN
    Recommended name:
    Nanos homolog 1
    Protein Accession:
    Q8WY41

    Protein attributes for NANOS1 Gene

    Size:
    292 amino acids
    Molecular mass:
    30230 Da
    Quaternary structure:
    • Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1. Interacts with DDX20 (via N-terminal region).

    Three dimensional structures from OCA and Proteopedia for NANOS1 Gene

neXtProt entry for NANOS1 Gene

Post-translational modifications for NANOS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NANOS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NANOS1 Gene

Domains & Families for NANOS1 Gene

Gene Families for NANOS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for NANOS1 Gene

Blocks:
  • Nanos RNA-binding
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NANOS1 Gene

GenScript: Design optimal peptide antigens:
  • EC_Rep1a (NANO1_HUMAN)
  • Nanos homolog 1 (Drosophila) (Q5T9H5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WY41

UniProtKB/Swiss-Prot:

NANO1_HUMAN :
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • Belongs to the nanos family.
Domain:
  • The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
  • The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.
Family:
  • Belongs to the nanos family.
genes like me logo Genes that share domains with NANOS1: view

Function for NANOS1 Gene

Molecular function for NANOS1 Gene

UniProtKB/Swiss-Prot Function:
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
UniProtKB/Swiss-Prot Induction:
Down-regulated by E-cadherin.

Phenotypes From GWAS Catalog for NANOS1 Gene

Gene Ontology (GO) - Molecular Function for NANOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 17047063
GO:0008270 zinc ion binding IEA --
GO:0030371 translation repressor activity ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NANOS1: view
genes like me logo Genes that share phenotypes with NANOS1: view

Human Phenotype Ontology for NANOS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NANOS1 Gene

MGI Knock Outs for NANOS1:

Animal Model Products

CRISPR Products

miRNA for NANOS1 Gene

miRTarBase miRNAs that target NANOS1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NANOS1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NANOS1 Gene

Localization for NANOS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NANOS1 Gene

Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000269 PubMed:12690449, ECO:0000269 PubMed:19168546}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NANOS1 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NANOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 12690449
GO:0048471 perinuclear region of cytoplasm IEA,IDA 17047063
genes like me logo Genes that share ontologies with NANOS1: view

Pathways & Interactions for NANOS1 Gene

PathCards logo

SuperPathways for NANOS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NANOS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001894 tissue homeostasis IEA --
GO:0006417 regulation of translation IEA --
GO:0010608 posttranscriptional regulation of gene expression IEA,IDA 25100735
GO:0010631 epithelial cell migration IDA 17047063
genes like me logo Genes that share ontologies with NANOS1: view

No data available for Pathways by source and SIGNOR curated interactions for NANOS1 Gene

Drugs & Compounds for NANOS1 Gene

(1) Drugs for NANOS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NANOS1: view

Transcripts for NANOS1 Gene

mRNA/cDNA for NANOS1 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NANOS1

Alternative Splicing Database (ASD) splice patterns (SP) for NANOS1 Gene

No ASD Table

Relevant External Links for NANOS1 Gene

GeneLoc Exon Structure for
NANOS1

Expression for NANOS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NANOS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NANOS1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NANOS1

SOURCE GeneReport for Unigene cluster for NANOS1 Gene:

Hs.591918

mRNA Expression by UniProt/SwissProt for NANOS1 Gene:

Q8WY41-NANO1_HUMAN
Tissue specificity: Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.

Evidence on tissue expression from TISSUES for NANOS1 Gene

  • Stomach(2.6)
  • Heart(2.2)
  • Nervous system(2.2)
  • Muscle(2.1)
  • Liver(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NANOS1 Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Regions:
Pelvis:
  • ovary
  • penis
  • prostate
  • testicle
  • vas deferens
genes like me logo Genes that share expression patterns with NANOS1: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NANOS1 Gene

Orthologs for NANOS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NANOS1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NANOS1 31 30
  • 94.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NANOS1 30
  • 93.15 (n)
rat
(Rattus norvegicus)
Mammalia Nanos1 30
  • 84.86 (n)
mouse
(Mus musculus)
Mammalia Nanos1 17 31 30
  • 84.6 (n)
chimpanzee
(Pan troglodytes)
Mammalia NANOS1 31
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NANOS1 31
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves NANOS1 31 30
  • 71.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NANOS1 31
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xcat-2 30
tropical clawed frog
(Silurana tropicalis)
Amphibia Xcat-2 30
zebrafish
(Danio rerio)
Actinopterygii nanos1 31
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nos 31
  • 13 (a)
OneToMany
Species where no ortholog for NANOS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NANOS1 Gene

ENSEMBL:
Gene Tree for NANOS1 (if available)
TreeFam:
Gene Tree for NANOS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NANOS1: view image

Paralogs for NANOS1 Gene

Paralogs for NANOS1 Gene

(2) SIMAP similar genes for NANOS1 Gene using alignment to 2 proteins:

  • NANO1_HUMAN
  • Q5T9H5_HUMAN
genes like me logo Genes that share paralogs with NANOS1: view

Variants for NANOS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NANOS1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
744589 Likely Benign: not provided 119,030,647(+) C/T SYNONYMOUS_VARIANT
768395 Benign: not provided 119,030,036(+) T/A MISSENSE_VARIANT
768396 Benign: not provided 119,030,548(+) T/C SYNONYMOUS_VARIANT
776547 Benign: not provided 119,030,300(+) C/CCCGCCG INFRAME_INSERTION
rs538539239 Pathogenic: Spermatogenic failure 12 119,030,300(+) CCCG/C INFRAME_DELETION

Additional dbSNP identifiers (rs#s) for NANOS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NANOS1 Gene

Variant ID Type Subtype PubMed ID
nsv1041093 CNV gain 25217958
nsv1069517 CNV deletion 25765185
nsv1143522 CNV deletion 24896259
nsv825582 CNV gain 20364138

Variation tolerance for NANOS1 Gene

Gene Damage Index Score: 3.16; 51.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NANOS1 Gene

Human Gene Mutation Database (HGMD)
NANOS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NANOS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NANOS1 Gene

Disorders for NANOS1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NANOS1 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

UniProtKB/Swiss-Prot

NANO1_HUMAN
  • Spermatogenic failure 12 (SPGF12) [MIM:615413]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients. {ECO:0000269 PubMed:23315541}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NANOS1

genes like me logo Genes that share disorders with NANOS1: view

No data available for Genatlas for NANOS1 Gene

Publications for NANOS1 Gene

  1. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. (PMID: 12690449) Jaruzelska J … Reijo Pera RA (Development genes and evolution 2003) 2 3 4 23 54
  2. Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia. (PMID: 23315541) Kusz-Zamelczyk K … Jaruzelska J (Journal of medical genetics 2013) 3 4 54
  3. NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells. (PMID: 21800163) Ginter-Matuszewska B … Jaruzelska J (Histochemistry and cell biology 2011) 3 4 54
  4. The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells. (PMID: 19168546) Ginter-Matuszewska B … Jaruzelska J (Molecular human reproduction 2009) 3 4 54
  5. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. (PMID: 18223680) Bonnomet A … Nawrocki-Raby B (Oncogene 2008) 3 4 54

Products for NANOS1 Gene

Sources for NANOS1 Gene