Aliases for NAMPTP1 Gene

Aliases for NAMPTP1 Gene

  • Nicotinamide Phosphoribosyltransferase Pseudogene 1 2 3 5
  • Nicotinamide Phosphoribosyltransferase-Like 2 3
  • Pre-B-Cell Colony Enhancing Factor 2 2 3
  • BA92J19.4 3
  • NAMPTL 3
  • PBEF2 3

External Ids for NAMPTP1 Gene

Previous HGNC Symbols for NAMPTP1 Gene

  • PBEF2
  • NAMPTL

Summaries for NAMPTP1 Gene

GeneCards Summary for NAMPTP1 Gene

NAMPTP1 (Nicotinamide Phosphoribosyltransferase Pseudogene 1) is a Pseudogene.

Additional gene information for NAMPTP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAMPTP1 Gene

Genomics for NAMPTP1 Gene

GeneHancer (GH) Regulatory Elements for NAMPTP1 Gene

Promoters and enhancers for NAMPTP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J036524 Promoter 0.3 Ensembl 500.7 -0.1 -65 0.6 NAMPTP1 RF00017-655
GH10J036525 Enhancer 0.2 ENCODE 500.7 -1.9 -1915 0.6 NAMPTP1 RF00017-655
GH10J036533 Enhancer 1 FANTOM5 Ensembl ENCODE 0.4 -10.5 -10458 3 FOS CEBPB POLR2A SPI1 BATF GABPA MAX PAX5 GATA2 SMARCA4 NAMPTP1 RF00017-655
GH10J036492 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.3 +30.5 30535 3.8 JUND FOS ZNF639 TRIM28 OSR2 FOSL2 POLR2A NR3C1 ZBTB1 EZH2 piR-58297-042 NAMPTP1
GH10J036538 Enhancer 0.8 Ensembl ENCODE 0.4 -14.8 -14765 1.6 USF1 RBAK TRIM28 CTCF FOS ZNF189 KLF17 USF2 GATA2 JUN FZD8 NAMPTP1 RF00017-655
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAMPTP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NAMPTP1 Gene

Genomic Locations for NAMPTP1 Gene
chr10:36,521,721-36,524,236
(GRCh38/hg38)
Size:
2,516 bases
Orientation:
Minus strand
chr10:36,810,649-36,813,164
(GRCh37/hg19)
Size:
2,516 bases
Orientation:
Minus strand

Genomic View for NAMPTP1 Gene

Genes around NAMPTP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAMPTP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAMPTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAMPTP1 Gene

Proteins for NAMPTP1 Gene

Post-translational modifications for NAMPTP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NAMPTP1 Gene

Domains & Families for NAMPTP1 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NAMPTP1 Gene

Function for NAMPTP1 Gene

Phenotypes From GWAS Catalog for NAMPTP1 Gene

Animal Model Products

CRISPR Products

miRNA for NAMPTP1 Gene

miRTarBase miRNAs that target NAMPTP1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAMPTP1 Gene

Localization for NAMPTP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NAMPTP1 Gene

Pathways & Interactions for NAMPTP1 Gene

PathCards logo

SuperPathways for NAMPTP1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for NAMPTP1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for NAMPTP1 Gene

Drugs & Compounds for NAMPTP1 Gene

(2) Drugs for NAMPTP1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FK866 (APO866) Pharma NAMPT inhibitor,non-competitive, highly specific 0
GNE-617 Pharma NAMPT inhibitor 0

(2) ApexBio Compounds for NAMPTP1 Gene

Compound Action Cas Number
FK866 (APO866) NAMPT inhibitor,non-competitive, highly specific 658084-64-1
GNE-617 NAMPT inhibitor 1362154-70-8
genes like me logo Genes that share compounds with NAMPTP1: view

Drug Products

Transcripts for NAMPTP1 Gene

mRNA/cDNA for NAMPTP1 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAMPTP1 Gene

No ASD Table

Relevant External Links for NAMPTP1 Gene

GeneLoc Exon Structure for
NAMPTP1

Expression for NAMPTP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAMPTP1 Gene

Protein differential expression in normal tissues from HIPED for NAMPTP1 Gene

This gene is overexpressed in Urine (29.8), Heart (24.1), and Saliva (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for NAMPTP1 Gene



Protein tissue co-expression partners for NAMPTP1 Gene

- Elite partner

Evidence on tissue expression from TISSUES for NAMPTP1 Gene

  • Blood(2.3)
  • Intestine(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with NAMPTP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAMPTP1 Gene

Orthologs for NAMPTP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAMPTP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAMPTL 31
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAMPT 31
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nampt 31
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves PBEF1 31
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 90 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nampta 31
  • 82 (a)
ManyToMany
CT033790.1 31
  • 75 (a)
ManyToMany
CT033790.3 31
  • 75 (a)
ManyToMany
BX248331.2 31
  • 75 (a)
ManyToMany
si:dkey-145c18.3 31
  • 50 (a)
ManyToMany
si:dkey-145c18.2 31
  • 38 (a)
ManyToMany
Species where no ortholog for NAMPTP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAMPTP1 Gene

ENSEMBL:
Gene Tree for NAMPTP1 (if available)
TreeFam:
Gene Tree for NAMPTP1 (if available)

Paralogs for NAMPTP1 Gene

No data available for Paralogs for NAMPTP1 Gene

Variants for NAMPTP1 Gene

Variation tolerance for NAMPTP1 Gene

Gene Damage Index Score: 5.35; 70.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAMPTP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAMPTP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Structural Variations from Database of Genomic Variants (DGV) for NAMPTP1 Gene

Disorders for NAMPTP1 Gene

No disorders were found for NAMPTP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for NAMPTP1 Gene

Publications for NAMPTP1 Gene

  1. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. (PMID: 8289818) Samal B … McNiece I (Molecular and cellular biology 1994) 2 3 54
  2. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. (PMID: 27591049) Elliott PR … Gyrd-Hansen M (Molecular cell 2016) 3 54
  3. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B … Wang LS (Journal of proteome research 2012) 3 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for NAMPTP1 Gene

Sources for NAMPTP1 Gene