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Aliases for NAMPTP1 Gene

Aliases for NAMPTP1 Gene

  • Nicotinamide Phosphoribosyltransferase Pseudogene 1 2 3 5
  • Nicotinamide Phosphoribosyltransferase-Like 2 3
  • Pre-B-Cell Colony Enhancing Factor 2 2 3
  • BA92J19.4 3
  • NAMPTL 3
  • PBEF2 3

External Ids for NAMPTP1 Gene

Previous HGNC Symbols for NAMPTP1 Gene

  • PBEF2
  • NAMPTL

Summaries for NAMPTP1 Gene

GeneCards Summary for NAMPTP1 Gene

NAMPTP1 (Nicotinamide Phosphoribosyltransferase Pseudogene 1) is a Pseudogene.

Additional gene information for NAMPTP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAMPTP1 Gene

Genomics for NAMPTP1 Gene

GeneHancer (GH) Regulatory Elements for NAMPTP1 Gene

Promoters and enhancers for NAMPTP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I036524 Promoter 0.5 Ensembl 550.8 -0.2 -165 0.4 NAMPTP1 GC10P036570
GH10I036525 Enhancer 0.2 ENCODE 550.8 -1.9 -1915 0.6 NAMPTP1 GC10P036570
GH10I036533 Enhancer 1 FANTOM5 Ensembl ENCODE 0.4 -10.2 -10160 2.4 HLF MAX CEBPB BATF GABPA POLR2A CEBPA FOS ETV6 PRDM4 NAMPTP1 GC10P036570
GH10I036492 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.3 +30.4 30390 2.7 CTCF ZBTB21 JUN INSM2 HIC1 ZFHX2 POLR2A ZNF366 FOSL2 ZNF391 NAMPTP1 ENSG00000274458
GH10I036538 Enhancer 0.8 Ensembl ENCODE 0.4 -14.7 -14670 1.3 CTCF USF1 ZNF189 JUN HLF USF2 KLF17 RBAK ZNF629 MYC FZD8 NAMPTP1 GC10P036570
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAMPTP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NAMPTP1 Gene

Genomic Locations for NAMPTP1 Gene
chr10:36,521,721-36,524,236
(GRCh38/hg38)
Size:
2,516 bases
Orientation:
Minus strand
chr10:36,810,649-36,813,164
(GRCh37/hg19)

Genomic View for NAMPTP1 Gene

Genes around NAMPTP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAMPTP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAMPTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAMPTP1 Gene

Proteins for NAMPTP1 Gene

Post-translational modifications for NAMPTP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NAMPTP1 Gene

Domains & Families for NAMPTP1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NAMPTP1 Gene

Function for NAMPTP1 Gene

Phenotypes From GWAS Catalog for NAMPTP1 Gene

Animal Model Products

miRNA for NAMPTP1 Gene

miRTarBase miRNAs that target NAMPTP1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAMPTP1 Gene

Localization for NAMPTP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAMPTP1 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NAMPTP1 Gene

Pathways & Interactions for NAMPTP1 Gene

SuperPathways for NAMPTP1 Gene

No Data Available

Interacting Proteins for NAMPTP1 Gene

Gene Ontology (GO) - Biological Process for NAMPTP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAMPTP1 Gene

Drugs & Compounds for NAMPTP1 Gene

(2) Drugs for NAMPTP1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FK866 (APO866) Pharma NAMPT inhibitor,non-competitive, highly specific 0
GNE-617 Pharma NAMPT inhibitor 0

(2) ApexBio Compounds for NAMPTP1 Gene

Compound Action Cas Number
FK866 (APO866) NAMPT inhibitor,non-competitive, highly specific 658084-64-1
GNE-617 NAMPT inhibitor 1362154-70-8
genes like me logo Genes that share compounds with NAMPTP1: view

Drug Products

Transcripts for NAMPTP1 Gene

mRNA/cDNA for NAMPTP1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAMPTP1 Gene

No ASD Table

Relevant External Links for NAMPTP1 Gene

GeneLoc Exon Structure for
NAMPTP1
ECgene alternative splicing isoforms for
NAMPTP1

Expression for NAMPTP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAMPTP1 Gene

Protein differential expression in normal tissues from HIPED for NAMPTP1 Gene

This gene is overexpressed in Urine (29.8), Heart (24.1), and Saliva (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for NAMPTP1 Gene



Protein tissue co-expression partners for NAMPTP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAMPTP1 Gene:

NAMPTP1

Evidence on tissue expression from TISSUES for NAMPTP1 Gene

  • Blood(2.3)
  • Intestine(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with NAMPTP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAMPTP1 Gene

Orthologs for NAMPTP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAMPTP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAMPTL 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAMPT 34
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nampt 34
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves PBEF1 34
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nampta 34
  • 82 (a)
ManyToMany
BX248331.2 34
  • 75 (a)
ManyToMany
CT033790.1 34
  • 75 (a)
ManyToMany
CT033790.3 34
  • 75 (a)
ManyToMany
si:dkey-145c18.3 34
  • 50 (a)
ManyToMany
si:dkey-145c18.2 34
  • 38 (a)
ManyToMany
Species where no ortholog for NAMPTP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAMPTP1 Gene

ENSEMBL:
Gene Tree for NAMPTP1 (if available)
TreeFam:
Gene Tree for NAMPTP1 (if available)

Paralogs for NAMPTP1 Gene

No data available for Paralogs for NAMPTP1 Gene

Variants for NAMPTP1 Gene

Variation tolerance for NAMPTP1 Gene

Gene Damage Index Score: 5.35; 70.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAMPTP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAMPTP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for NAMPTP1 Gene

Disorders for NAMPTP1 Gene

No disorders were found for NAMPTP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for NAMPTP1 Gene

Publications for NAMPTP1 Gene

  1. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. (PMID: 8289818) Samal B … McNiece I (Molecular and cellular biology 1994) 2 3 58
  2. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B … Wang LS (Journal of proteome research 2012) 3 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. (PMID: 27591049) Elliott PR … Gyrd-Hansen M (Molecular cell 2016) 3

Products for NAMPTP1 Gene

Sources for NAMPTP1 Gene

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