Aliases for NAMPT Gene
External Ids for NAMPT Gene
Previous HGNC Symbols for NAMPT Gene
Previous GeneCards Identifiers for NAMPT Gene
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
GeneCards Summary for NAMPT Gene
NAMPT (Nicotinamide Phosphoribosyltransferase) is a Protein Coding gene. Diseases associated with NAMPT include Aging and Gestational Diabetes. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and NAD metabolism, sirtuins and aging. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and drug binding. An important paralog of this gene is NAPRT.
UniProtKB/Swiss-Prot Summary for NAMPT Gene
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
Nicotinamide phosphoribosyltransferase (NAMPT), EC 22.214.171.124, is an enzyme that catalyzes the transfer of a phosphoribosyl group from 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinamide, forming nicotinamide mononucleotide (NMN) a key NAD pathway intermediate.