Aliases for NAIF1 Gene

Aliases for NAIF1 Gene

  • Nuclear Apoptosis Inducing Factor 1 2 3 5
  • Nuclear Apoptosis-Inducing Factor 1 2 3 4
  • BA379C10.2 2 3
  • C9orf90 3 4
  • Chromosome 9 Open Reading Frame 90 2
  • DKFZp762G199 2
  • NAIF1 5

External Ids for NAIF1 Gene

Previous HGNC Symbols for NAIF1 Gene

  • C9orf90

Previous GeneCards Identifiers for NAIF1 Gene

  • GC09M129864
  • GC09M130823
  • GC09M100438

Summaries for NAIF1 Gene

GeneCards Summary for NAIF1 Gene

NAIF1 (Nuclear Apoptosis Inducing Factor 1) is a Protein Coding gene. Diseases associated with NAIF1 include Necatoriasis and Vulva Squamous Cell Carcinoma.

UniProtKB/Swiss-Prot Summary for NAIF1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NAIF1 Gene

Genomics for NAIF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NAIF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J128065 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 276.2 -2.1 -2086 10 SP1 ZNF207 NCOR1 MYC IKZF1 SSRP1 ATF2 CEBPA ZNF10 ATF3 NAIF1 SLC25A25 ZNF79 NUP188 SNORA65 CIZ1 GLE1 GOLGA2 CDK9 FPGS
GH09J127446 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 37.7 +618.7 618676 7.5 BCLAF1 SP1 ZNF207 NCOR1 MYC SIX5 SSRP1 ATF2 POLR2A CEBPA SNORA65 RPL12 HSALNG0074499 NONHSAG053479.2 LRSAM1 lnc-FAM129B-4 ZNF79 NAIF1 LOC102723566 FPGS
GH09J128817 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 29.2 -750.6 -750560 2.3 SP1 ZNF207 ZNF600 MYC ZNF592 KLF9 POLR2A ZNF10 NFIC ZIC2 ENDOG NAIF1 NUP188 SPOUT1 GLE1 ODF2 TOR1B TBC1D13 URM1 CIZ1
GH09J128339 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 28.4 -272.5 -272495 2.2 BCLAF1 SP1 ZNF207 ZNF600 MYC IKZF1 SIX5 SSRP1 ZNF580 CEBPA SLC27A4 TMSB4XP4 TRR-TCT3-1 lnc-COQ4-1 ZNF79 NUP188 NAIF1 SNORA65 GLE1 CIZ1
GH09J128655 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 23 -588.3 -588314 2.6 BCLAF1 ZNF207 MYC NCOR1 IKZF1 SIX5 ZNF580 ZNF10 ZSCAN16 BRCA1 DYNC2I2 lnc-ZDHHC12-1 NUP188 SPOUT1 CDK9 NAIF1 ODF2 GLE1 URM1 CIZ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NAIF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NAIF1

Top Transcription factor binding sites by QIAGEN in the NAIF1 gene promoter:
  • c-Ets-1
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • Elk-1
  • NF-E2
  • NF-E2 p45
  • NF-Y
  • NRF-2

Genomic Locations for NAIF1 Gene

Latest Assembly
6,974 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
6,088 bases
Minus strand

(GRCh37/hg19 by Ensembl)
6,974 bases
Minus strand

Genomic View for NAIF1 Gene

Genes around NAIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAIF1 Gene

Proteins for NAIF1 Gene

  • Protein details for NAIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear apoptosis-inducing factor 1
    Protein Accession:
    Secondary Accessions:
    • B3KV81
    • Q8WU12

    Protein attributes for NAIF1 Gene

    327 amino acids
    Molecular mass:
    35164 Da
    Quaternary structure:
    • Interacts with HARBI1.

    Alternative splice isoforms for NAIF1 Gene


neXtProt entry for NAIF1 Gene

Post-translational modifications for NAIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for NAIF1

No data available for DME Specific Peptides for NAIF1 Gene

Domains & Families for NAIF1 Gene

Gene Families for NAIF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAIF1 Gene


Suggested Antigen Peptide Sequences for NAIF1 Gene

GenScript: Design optimal peptide antigens:
  • Nuclear apoptosis-inducing factor 1 (NAIF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NAIF1 family.
  • Belongs to the NAIF1 family.
genes like me logo Genes that share domains with NAIF1: view

Function for NAIF1 Gene

Molecular function for NAIF1 Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis.

Phenotypes From GWAS Catalog for NAIF1 Gene

Gene Ontology (GO) - Molecular Function for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with NAIF1: view
genes like me logo Genes that share phenotypes with NAIF1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAIF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAIF1 Gene

Localization for NAIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAIF1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAIF1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 16378748
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NAIF1: view

Pathways & Interactions for NAIF1 Gene

PathCards logo

SuperPathways for NAIF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0030308 negative regulation of cell growth IDA 16378748
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IDA 16378748
genes like me logo Genes that share ontologies with NAIF1: view

No data available for Pathways by source and SIGNOR curated interactions for NAIF1 Gene

Drugs & Compounds for NAIF1 Gene

No Compound Related Data Available

Transcripts for NAIF1 Gene

mRNA/cDNA for NAIF1 Gene

7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NAIF1

Alternative Splicing Database (ASD) splice patterns (SP) for NAIF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6
SP1: - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for NAIF1 Gene

GeneLoc Exon Structure for

Expression for NAIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAIF1 Gene

Protein differential expression in normal tissues from HIPED for NAIF1 Gene

This gene is overexpressed in Heart (37.7), Peripheral blood mononuclear cells (19.5), and Blymphocyte (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAIF1 Gene

Protein tissue co-expression partners for NAIF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NAIF1

SOURCE GeneReport for Unigene cluster for NAIF1 Gene:


mRNA Expression by UniProt/SwissProt for NAIF1 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for NAIF1 Gene

  • Liver(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with NAIF1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAIF1 Gene

Orthologs for NAIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAIF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAIF1 29 30
  • 99.29 (n)
(Bos Taurus)
Mammalia NAIF1 29 30
  • 91.03 (n)
(Canis familiaris)
Mammalia NAIF1 29 30
  • 90.62 (n)
(Mus musculus)
Mammalia Naif1 29 16 30
  • 88.07 (n)
(Ornithorhynchus anatinus)
Mammalia NAIF1 30
  • 88 (a)
(Rattus norvegicus)
Mammalia Naif1 29
  • 87.67 (n)
(Monodelphis domestica)
Mammalia NAIF1 30
  • 86 (a)
(Gallus gallus)
Aves NAIF1 29 30
  • 72.56 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia naif1 29
  • 69.12 (n)
(Danio rerio)
Actinopterygii naif1 29 30
  • 69.97 (n)
NAIF1 (2 of 3) 30
  • 20 (a)
NAIF1 (1 of 3) 30
  • 18 (a)
Species where no ortholog for NAIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NAIF1 Gene

Gene Tree for NAIF1 (if available)
Gene Tree for NAIF1 (if available)
Evolutionary constrained regions (ECRs) for NAIF1: view image
Alliance of Genome Resources:
Additional Orthologs for NAIF1

Paralogs for NAIF1 Gene

No data available for Paralogs for NAIF1 Gene

Variants for NAIF1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NAIF1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NAIF1 Gene

Variant ID Type Subtype PubMed ID
nsv1054891 CNV gain 25217958
nsv471324 CNV gain 18288195
nsv831727 CNV loss 17160897

Variation tolerance for NAIF1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAIF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NAIF1 Gene

Disorders for NAIF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NAIF1 Gene - From: COP

Disorder Aliases PubMed IDs
vulva squamous cell carcinoma
  • squamous cell carcinoma of vulva
- elite association - COSMIC cancer census association via MalaCards
Search NAIF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NAIF1

genes like me logo Genes that share disorders with NAIF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAIF1 Gene

Publications for NAIF1 Gene

  1. Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis. (PMID: 16378748) Lv B … Lou Y (The international journal of biochemistry & cell biology 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4
  3. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L … Ivics Z (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4

Products for NAIF1 Gene

Sources for NAIF1 Gene