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Aliases for NAIF1 Gene

Aliases for NAIF1 Gene

  • Nuclear Apoptosis Inducing Factor 1 2 3 5
  • Nuclear Apoptosis-Inducing Factor 1 2 3
  • C9orf90 3 4
  • Chromosome 9 Open Reading Frame 90 2
  • BA379C10.2 3

External Ids for NAIF1 Gene

Previous HGNC Symbols for NAIF1 Gene

  • C9orf90

Previous GeneCards Identifiers for NAIF1 Gene

  • GC09M129864
  • GC09M130823
  • GC09M100438

Summaries for NAIF1 Gene

GeneCards Summary for NAIF1 Gene

NAIF1 (Nuclear Apoptosis Inducing Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NAIF1 Gene

  • Induces apoptosis.

Additional gene information for NAIF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAIF1 Gene

Genomics for NAIF1 Gene

GeneHancer (GH) Regulatory Elements for NAIF1 Gene

Promoters and enhancers for NAIF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I128065 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 581.6 +0.6 610 4.6 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A ZBTB7B NAIF1 PIR61166 SLC25A25 ZNF79 NUP188 GLE1 ODF2 SNORA65 CIZ1 SLC25A25-AS1
GH09I128722 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.8 -656.2 -656177 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B LOC100506100 ZDHHC12 NUP188 NAIF1 GLE1 ODF2 CIZ1 GOLGA2 PKN3 TBC1D13
GH09I127962 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.1 +94.9 94858 22.2 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A MEF2D FAM102A PIP5KL1 NAIF1 DPM2 ENSG00000272593 NUP188 ENSG00000227218 ZNF79 ODF2 GLE1
GH09I128339 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 28.4 -272.5 -272453 2.1 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC27A4 TMSB4XP4 TRR-TCT3-1 ZNF79 NUP188 NAIF1 SNORA65 GLE1 CIZ1 RPL12
GH09I128817 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 29.2 -750.5 -750518 1.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ENDOG NAIF1 NUP188 SPOUT1 GLE1 ODF2 TOR1B TBC1D13 URM1 CIZ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NAIF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NAIF1 gene promoter:

Genomic Locations for NAIF1 Gene

Genomic Locations for NAIF1 Gene
chr9:128,061,233-128,068,206
(GRCh38/hg38)
Size:
6,974 bases
Orientation:
Minus strand
chr9:130,823,512-130,830,485
(GRCh37/hg19)

Genomic View for NAIF1 Gene

Genes around NAIF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAIF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAIF1 Gene

Proteins for NAIF1 Gene

  • Protein details for NAIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YI7-NAIF1_HUMAN
    Recommended name:
    Nuclear apoptosis-inducing factor 1
    Protein Accession:
    Q69YI7
    Secondary Accessions:
    • B3KV81
    • Q8WU12

    Protein attributes for NAIF1 Gene

    Size:
    327 amino acids
    Molecular mass:
    35164 Da
    Quaternary structure:
    • Interacts with HARBI1.

    Alternative splice isoforms for NAIF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAIF1 Gene

Post-translational modifications for NAIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAIF1 Gene

Domains & Families for NAIF1 Gene

Gene Families for NAIF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAIF1 Gene

Suggested Antigen Peptide Sequences for NAIF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q69YI7

UniProtKB/Swiss-Prot:

NAIF1_HUMAN :
  • Belongs to the NAIF1 family.
Family:
  • Belongs to the NAIF1 family.
genes like me logo Genes that share domains with NAIF1: view

Function for NAIF1 Gene

Molecular function for NAIF1 Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis.

Phenotypes From GWAS Catalog for NAIF1 Gene

Gene Ontology (GO) - Molecular Function for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with NAIF1: view
genes like me logo Genes that share phenotypes with NAIF1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAIF1 Gene

Localization for NAIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAIF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAIF1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
mitochondrion 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16378748
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NAIF1: view

Pathways & Interactions for NAIF1 Gene

SuperPathways for NAIF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0030308 negative regulation of cell growth IDA 16378748
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IDA 16378748
genes like me logo Genes that share ontologies with NAIF1: view

No data available for Pathways by source and SIGNOR curated interactions for NAIF1 Gene

Drugs & Compounds for NAIF1 Gene

No Compound Related Data Available

Transcripts for NAIF1 Gene

Unigene Clusters for NAIF1 Gene

Nuclear apoptosis inducing factor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAIF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for NAIF1 Gene

GeneLoc Exon Structure for
NAIF1
ECgene alternative splicing isoforms for
NAIF1

Expression for NAIF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAIF1 Gene

Protein differential expression in normal tissues from HIPED for NAIF1 Gene

This gene is overexpressed in Heart (37.7), Peripheral blood mononuclear cells (19.5), and Blymphocyte (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAIF1 Gene



Protein tissue co-expression partners for NAIF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAIF1 Gene:

NAIF1

SOURCE GeneReport for Unigene cluster for NAIF1 Gene:

Hs.373606

mRNA Expression by UniProt/SwissProt for NAIF1 Gene:

Q69YI7-NAIF1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for NAIF1 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with NAIF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAIF1 Gene

Orthologs for NAIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAIF1 33 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia NAIF1 33 34
  • 91.03 (n)
dog
(Canis familiaris)
Mammalia NAIF1 33 34
  • 90.62 (n)
mouse
(Mus musculus)
Mammalia Naif1 33 16 34
  • 88.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAIF1 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naif1 33
  • 87.67 (n)
oppossum
(Monodelphis domestica)
Mammalia NAIF1 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAIF1 33 34
  • 72.56 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia naif1 33
  • 69.12 (n)
zebrafish
(Danio rerio)
Actinopterygii naif1 33 34
  • 69.97 (n)
NAIF1 (2 of 3) 34
  • 20 (a)
OneToMany
NAIF1 (1 of 3) 34
  • 18 (a)
OneToMany
Species where no ortholog for NAIF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAIF1 Gene

ENSEMBL:
Gene Tree for NAIF1 (if available)
TreeFam:
Gene Tree for NAIF1 (if available)

Paralogs for NAIF1 Gene

No data available for Paralogs for NAIF1 Gene

Variants for NAIF1 Gene

Sequence variations from dbSNP and Humsavar for NAIF1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000191648 -- 128,068,882(-) C/A upstream_transcript_variant
rs1000257794 -- 128,063,332(-) G/A 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000690611 -- 128,064,496(-) T/C intron_variant
rs1001619776 -- 128,066,120(-) A/T intron_variant
rs1001766678 -- 128,062,929(-) G/A 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NAIF1 Gene

Variant ID Type Subtype PubMed ID
nsv1054891 CNV gain 25217958
nsv471324 CNV gain 18288195
nsv831727 CNV loss 17160897

Variation tolerance for NAIF1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NAIF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAIF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAIF1 Gene

Disorders for NAIF1 Gene

Additional Disease Information for NAIF1

No disorders were found for NAIF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAIF1 Gene

Publications for NAIF1 Gene

  1. Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis. (PMID: 16378748) Lv B … Lou Y (The international journal of biochemistry & cell biology 2006) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  3. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L … Ivics Z (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NAIF1 Gene

Sources for NAIF1 Gene

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