Aliases for NAGK Gene
External Ids for NAGK Gene
Previous GeneCards Identifiers for NAGK Gene
This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011]
GeneCards Summary for NAGK Gene
NAGK (N-Acetylglucosamine Kinase) is a Protein Coding gene. Diseases associated with NAGK include Sialuria. Among its related pathways are Metabolism of proteins and Amino sugar and nucleotide sugar metabolism. Gene Ontology (GO) annotations related to this gene include N-acylmannosamine kinase activity and N-acetylglucosamine kinase activity.
UniProtKB/Swiss-Prot Summary for NAGK Gene
Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.